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Protein

Zinc finger protein 202

Gene

ZNF202

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri397 – 419C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-212436 Generic Transcription Pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O95125

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O95125

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 202
Alternative name(s):
Zinc finger protein with KRAB and SCAN domains 10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF202
Synonyms:ZKSCAN10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000166261.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12994 ZNF202

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603430 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95125

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7753

Open Targets

More...
OpenTargetsi
ENSG00000166261

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37574

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF202

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474501 – 648Zinc finger protein 202Add BLAST648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki22Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki454Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki460Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei466PhosphoserineCombined sources1
Cross-linki507Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki521Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O95125

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O95125

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O95125

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95125

PeptideAtlas

More...
PeptideAtlasi
O95125

PRoteomics IDEntifications database

More...
PRIDEi
O95125

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50655
50656 [O95125-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O95125

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O95125

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis. Also expressed in breast carcinoma cell lines.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166261 Expressed in 167 organ(s), highest expression level in amniotic fluid

CleanEx database of gene expression profiles

More...
CleanExi
HS_ZNF202

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O95125 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95125 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SDP1.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1625EBI-751960,EBI-10171697

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113537, 13 interactors

Protein interaction database and analysis system

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IntActi
O95125, 19 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000337724

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O95125

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O95125

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 127SCAN boxPROSITE-ProRule annotationAdd BLAST82
Domaini237 – 308KRABPROSITE-ProRule annotationAdd BLAST72

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri397 – 419C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161189

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234619

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG018163

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O95125

KEGG Orthology (KO)

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KOi
K09229

Identification of Orthologs from Complete Genome Data

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OMAi
PFFCTIC

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95125

TreeFam database of animal gene trees

More...
TreeFami
TF350829

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform Beta (identifier: O95125-1) [UniParc]FASTAAdd to basket
Also known as: 2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATAVEPEDQ DLWEEEGILM VKLEDDFTCR PESVLQRDDP VLETSHQNFR
60 70 80 90 100
RFRYQEAASP REALIRLREL CHQWLRPERR TKEQILELLV LEQFLTVLPG
110 120 130 140 150
ELQSWVRGQR PESGEEAVTL VEGLQKQPRR PRRWVTVHVH GQEVLSEETV
160 170 180 190 200
HLGVEPESPN ELQDPVQSST PEQSPEETTQ SPDLGAPAEQ RPHQEEELQT
210 220 230 240 250
LQESEVPVPE DPDLPAERSS GDSEMVALLT ALSQGLVTFK DVAVCFSQDQ
260 270 280 290 300
WSDLDPTQKE FYGEYVLEED CGIVVSLSFP IPRPDEISQV REEEPWVPDI
310 320 330 340 350
QEPQETQEPE ILSFTYTGDR SKDEEECLEQ EDLSLEDIHR PVLGEPEIHQ
360 370 380 390 400
TPDWEIVFED NPGRLNERRF GTNISQVNSF VNLRETTPVH PLLGRHHDCS
410 420 430 440 450
VCGKSFTCNS HLVRHLRTHT GEKPYKCMEC GKSYTRSSHL ARHQKVHKMN
460 470 480 490 500
APYKYPLNRK NLEETSPVTQ AERTPSVEKP YRCDDCGKHF RWTSDLVRHQ
510 520 530 540 550
RTHTGEKPFF CTICGKSFSQ KSVLTTHQRI HLGGKPYLCG ECGEDFSEHR
560 570 580 590 600
RYLAHRKTHA AEELYLCSEC GRCFTHSAAF AKHLRGHASV RPCRCNECGK
610 620 630 640
SFSRRDHLVR HQRTHTGEKP FTCPTCGKSF SRGYHLIRHQ RTHSEKTS
Length:648
Mass (Da):74,720
Last modified:May 16, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE738506D71DAFAE9
GO
Isoform Alpha (identifier: O95125-2) [UniParc]FASTAAdd to basket
Also known as: 1

The sequence of this isoform differs from the canonical sequence as follows:
     1-224: Missing.

Show »
Length:424
Mass (Da):48,952
Checksum:i843C23B240D19DF0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PM99E9PM99_HUMAN
Zinc finger protein 202
ZNF202
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJL4E9PJL4_HUMAN
Zinc finger protein 202
ZNF202
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RMT9A0A1D5RMT9_HUMAN
Zinc finger protein 202
ZNF202
10Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15E → P in CAB82384 (PubMed:17974005).Curated1
Sequence conflicti205Missing in CAC21447 (Ref. 2) Curated1
Sequence conflicti278S → AA (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_007818154V → A5 PublicationsCorresponds to variant dbSNP:rs1144507Ensembl.1
Natural variantiVAR_023975533G → A1 PublicationCorresponds to variant dbSNP:rs34111365Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0069021 – 224Missing in isoform Alpha. 1 PublicationAdd BLAST224

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF027219 mRNA Translation: AAC79941.1
AF027218 mRNA Translation: AAC79940.1
AJ276177
, AJ276178, AJ276179, AJ276180, AJ276181, AJ276182 Genomic DNA Translation: CAC21447.1
DQ093962 Genomic DNA Translation: AAY88738.1
EU332869 Genomic DNA Translation: ABY87558.1
BC013382 mRNA Translation: AAH13382.1
AL162031 mRNA Translation: CAB82384.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS8443.1 [O95125-1]

Protein sequence database of the Protein Information Resource

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PIRi
T47156

NCBI Reference Sequences

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RefSeqi
NP_001288708.1, NM_001301779.1 [O95125-1]
NP_001288709.1, NM_001301780.1 [O95125-1]
NP_001288748.1, NM_001301819.1 [O95125-2]
NP_003446.2, NM_003455.3 [O95125-1]
XP_005271716.1, XM_005271659.1 [O95125-1]
XP_005271717.1, XM_005271660.1 [O95125-1]
XP_005271718.1, XM_005271661.1 [O95125-1]
XP_005271721.1, XM_005271664.1 [O95125-2]
XP_006718964.1, XM_006718901.2 [O95125-1]
XP_011541274.1, XM_011542972.1 [O95125-1]
XP_011541275.1, XM_011542973.1 [O95125-1]
XP_011541277.1, XM_011542975.1 [O95125-1]
XP_011541278.1, XM_011542976.1
XP_016873757.1, XM_017018268.1 [O95125-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.112556

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000336139; ENSP00000337724; ENSG00000166261 [O95125-1]
ENST00000529691; ENSP00000433881; ENSG00000166261 [O95125-1]
ENST00000530393; ENSP00000432504; ENSG00000166261 [O95125-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7753

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7753

UCSC genome browser

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UCSCi
uc001pzd.2 human [O95125-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027219 mRNA Translation: AAC79941.1
AF027218 mRNA Translation: AAC79940.1
AJ276177
, AJ276178, AJ276179, AJ276180, AJ276181, AJ276182 Genomic DNA Translation: CAC21447.1
DQ093962 Genomic DNA Translation: AAY88738.1
EU332869 Genomic DNA Translation: ABY87558.1
BC013382 mRNA Translation: AAH13382.1
AL162031 mRNA Translation: CAB82384.1
CCDSiCCDS8443.1 [O95125-1]
PIRiT47156
RefSeqiNP_001288708.1, NM_001301779.1 [O95125-1]
NP_001288709.1, NM_001301780.1 [O95125-1]
NP_001288748.1, NM_001301819.1 [O95125-2]
NP_003446.2, NM_003455.3 [O95125-1]
XP_005271716.1, XM_005271659.1 [O95125-1]
XP_005271717.1, XM_005271660.1 [O95125-1]
XP_005271718.1, XM_005271661.1 [O95125-1]
XP_005271721.1, XM_005271664.1 [O95125-2]
XP_006718964.1, XM_006718901.2 [O95125-1]
XP_011541274.1, XM_011542972.1 [O95125-1]
XP_011541275.1, XM_011542973.1 [O95125-1]
XP_011541277.1, XM_011542975.1 [O95125-1]
XP_011541278.1, XM_011542976.1
XP_016873757.1, XM_017018268.1 [O95125-1]
UniGeneiHs.112556

3D structure databases

ProteinModelPortaliO95125
SMRiO95125
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113537, 13 interactors
IntActiO95125, 19 interactors
STRINGi9606.ENSP00000337724

PTM databases

iPTMnetiO95125
PhosphoSitePlusiO95125

Polymorphism and mutation databases

BioMutaiZNF202

Proteomic databases

EPDiO95125
jPOSTiO95125
MaxQBiO95125
PaxDbiO95125
PeptideAtlasiO95125
PRIDEiO95125
ProteomicsDBi50655
50656 [O95125-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
7753
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336139; ENSP00000337724; ENSG00000166261 [O95125-1]
ENST00000529691; ENSP00000433881; ENSG00000166261 [O95125-1]
ENST00000530393; ENSP00000432504; ENSG00000166261 [O95125-1]
GeneIDi7753
KEGGihsa:7753
UCSCiuc001pzd.2 human [O95125-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7753
DisGeNETi7753
EuPathDBiHostDB:ENSG00000166261.10

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF202
HGNCiHGNC:12994 ZNF202
MIMi603430 gene
neXtProtiNX_O95125
OpenTargetsiENSG00000166261
PharmGKBiPA37574

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000161189
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiO95125
KOiK09229
OMAiPFFCTIC
OrthoDBi1318335at2759
PhylomeDBiO95125
TreeFamiTF350829

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway
SignaLinkiO95125
SIGNORiO95125

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF202 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZNF202

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7753

Protein Ontology

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PROi
PR:O95125

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166261 Expressed in 167 organ(s), highest expression level in amniotic fluid
CleanExiHS_ZNF202
ExpressionAtlasiO95125 baseline and differential
GenevisibleiO95125 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 7 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN202_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95125
Secondary accession number(s): B0LPH9
, Q4JG21, Q9H1B9, Q9NSM4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 16, 2006
Last modified: January 16, 2019
This is version 181 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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