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Protein

Zinc finger protein 202

Gene

ZNF202

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri397 – 419C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway
SignaLinkiO95125
SIGNORiO95125

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 202
Alternative name(s):
Zinc finger protein with KRAB and SCAN domains 10
Gene namesi
Name:ZNF202
Synonyms:ZKSCAN10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166261.10
HGNCiHGNC:12994 ZNF202
MIMi603430 gene
neXtProtiNX_O95125

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7753
OpenTargetsiENSG00000166261
PharmGKBiPA37574

Polymorphism and mutation databases

BioMutaiZNF202

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474501 – 648Zinc finger protein 202Add BLAST648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki22Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki454Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki460Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei466PhosphoserineCombined sources1
Cross-linki507Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki521Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO95125
MaxQBiO95125
PaxDbiO95125
PeptideAtlasiO95125
PRIDEiO95125
ProteomicsDBi50655
50656 [O95125-2]

PTM databases

iPTMnetiO95125
PhosphoSitePlusiO95125

Expressioni

Tissue specificityi

Highly expressed in testis. Also expressed in breast carcinoma cell lines.

Gene expression databases

BgeeiENSG00000166261 Expressed in 167 organ(s), highest expression level in amniotic fluid
CleanExiHS_ZNF202
ExpressionAtlasiO95125 baseline and differential
GenevisibleiO95125 HS

Interactioni

Subunit structurei

Interacts with SDP1.

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1625EBI-751960,EBI-10171697

Protein-protein interaction databases

BioGridi113537, 13 interactors
IntActiO95125, 19 interactors
STRINGi9606.ENSP00000337724

Structurei

3D structure databases

ProteinModelPortaliO95125
SMRiO95125
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 127SCAN boxPROSITE-ProRule annotationAdd BLAST82
Domaini237 – 308KRABPROSITE-ProRule annotationAdd BLAST72

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri397 – 419C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144000
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiO95125
KOiK09229
OMAiPFFCTIC
OrthoDBiEOG091G034X
PhylomeDBiO95125
TreeFamiTF350829

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 7 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform Beta (identifier: O95125-1) [UniParc]FASTAAdd to basket
Also known as: 2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATAVEPEDQ DLWEEEGILM VKLEDDFTCR PESVLQRDDP VLETSHQNFR
60 70 80 90 100
RFRYQEAASP REALIRLREL CHQWLRPERR TKEQILELLV LEQFLTVLPG
110 120 130 140 150
ELQSWVRGQR PESGEEAVTL VEGLQKQPRR PRRWVTVHVH GQEVLSEETV
160 170 180 190 200
HLGVEPESPN ELQDPVQSST PEQSPEETTQ SPDLGAPAEQ RPHQEEELQT
210 220 230 240 250
LQESEVPVPE DPDLPAERSS GDSEMVALLT ALSQGLVTFK DVAVCFSQDQ
260 270 280 290 300
WSDLDPTQKE FYGEYVLEED CGIVVSLSFP IPRPDEISQV REEEPWVPDI
310 320 330 340 350
QEPQETQEPE ILSFTYTGDR SKDEEECLEQ EDLSLEDIHR PVLGEPEIHQ
360 370 380 390 400
TPDWEIVFED NPGRLNERRF GTNISQVNSF VNLRETTPVH PLLGRHHDCS
410 420 430 440 450
VCGKSFTCNS HLVRHLRTHT GEKPYKCMEC GKSYTRSSHL ARHQKVHKMN
460 470 480 490 500
APYKYPLNRK NLEETSPVTQ AERTPSVEKP YRCDDCGKHF RWTSDLVRHQ
510 520 530 540 550
RTHTGEKPFF CTICGKSFSQ KSVLTTHQRI HLGGKPYLCG ECGEDFSEHR
560 570 580 590 600
RYLAHRKTHA AEELYLCSEC GRCFTHSAAF AKHLRGHASV RPCRCNECGK
610 620 630 640
SFSRRDHLVR HQRTHTGEKP FTCPTCGKSF SRGYHLIRHQ RTHSEKTS
Length:648
Mass (Da):74,720
Last modified:May 16, 2006 - v4
Checksum:iE738506D71DAFAE9
GO
Isoform Alpha (identifier: O95125-2) [UniParc]FASTAAdd to basket
Also known as: 1

The sequence of this isoform differs from the canonical sequence as follows:
     1-224: Missing.

Show »
Length:424
Mass (Da):48,952
Checksum:i843C23B240D19DF0
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PM99E9PM99_HUMAN
Zinc finger protein 202
ZNF202
126Annotation score:
E9PJL4E9PJL4_HUMAN
Zinc finger protein 202
ZNF202
45Annotation score:
A0A1D5RMT9A0A1D5RMT9_HUMAN
Zinc finger protein 202
ZNF202
10Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15E → P in CAB82384 (PubMed:17974005).Curated1
Sequence conflicti205Missing in CAC21447 (Ref. 2) Curated1
Sequence conflicti278S → AA (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_007818154V → A5 PublicationsCorresponds to variant dbSNP:rs1144507Ensembl.1
Natural variantiVAR_023975533G → A1 PublicationCorresponds to variant dbSNP:rs34111365Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0069021 – 224Missing in isoform Alpha. 1 PublicationAdd BLAST224

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027219 mRNA Translation: AAC79941.1
AF027218 mRNA Translation: AAC79940.1
AJ276177
, AJ276178, AJ276179, AJ276180, AJ276181, AJ276182 Genomic DNA Translation: CAC21447.1
DQ093962 Genomic DNA Translation: AAY88738.1
EU332869 Genomic DNA Translation: ABY87558.1
BC013382 mRNA Translation: AAH13382.1
AL162031 mRNA Translation: CAB82384.1
CCDSiCCDS8443.1 [O95125-1]
PIRiT47156
RefSeqiNP_001288708.1, NM_001301779.1 [O95125-1]
NP_001288709.1, NM_001301780.1 [O95125-1]
NP_001288748.1, NM_001301819.1 [O95125-2]
NP_003446.2, NM_003455.3 [O95125-1]
XP_005271716.1, XM_005271659.1 [O95125-1]
XP_005271717.1, XM_005271660.1 [O95125-1]
XP_005271718.1, XM_005271661.1 [O95125-1]
XP_005271721.1, XM_005271664.1 [O95125-2]
XP_006718964.1, XM_006718901.2 [O95125-1]
XP_011541274.1, XM_011542972.1 [O95125-1]
XP_011541275.1, XM_011542973.1 [O95125-1]
XP_011541277.1, XM_011542975.1 [O95125-1]
XP_011541278.1, XM_011542976.1
XP_016873757.1, XM_017018268.1 [O95125-1]
UniGeneiHs.112556

Genome annotation databases

EnsembliENST00000336139; ENSP00000337724; ENSG00000166261 [O95125-1]
ENST00000529691; ENSP00000433881; ENSG00000166261 [O95125-1]
ENST00000530393; ENSP00000432504; ENSG00000166261 [O95125-1]
GeneIDi7753
KEGGihsa:7753
UCSCiuc001pzd.2 human [O95125-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027219 mRNA Translation: AAC79941.1
AF027218 mRNA Translation: AAC79940.1
AJ276177
, AJ276178, AJ276179, AJ276180, AJ276181, AJ276182 Genomic DNA Translation: CAC21447.1
DQ093962 Genomic DNA Translation: AAY88738.1
EU332869 Genomic DNA Translation: ABY87558.1
BC013382 mRNA Translation: AAH13382.1
AL162031 mRNA Translation: CAB82384.1
CCDSiCCDS8443.1 [O95125-1]
PIRiT47156
RefSeqiNP_001288708.1, NM_001301779.1 [O95125-1]
NP_001288709.1, NM_001301780.1 [O95125-1]
NP_001288748.1, NM_001301819.1 [O95125-2]
NP_003446.2, NM_003455.3 [O95125-1]
XP_005271716.1, XM_005271659.1 [O95125-1]
XP_005271717.1, XM_005271660.1 [O95125-1]
XP_005271718.1, XM_005271661.1 [O95125-1]
XP_005271721.1, XM_005271664.1 [O95125-2]
XP_006718964.1, XM_006718901.2 [O95125-1]
XP_011541274.1, XM_011542972.1 [O95125-1]
XP_011541275.1, XM_011542973.1 [O95125-1]
XP_011541277.1, XM_011542975.1 [O95125-1]
XP_011541278.1, XM_011542976.1
XP_016873757.1, XM_017018268.1 [O95125-1]
UniGeneiHs.112556

3D structure databases

ProteinModelPortaliO95125
SMRiO95125
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113537, 13 interactors
IntActiO95125, 19 interactors
STRINGi9606.ENSP00000337724

PTM databases

iPTMnetiO95125
PhosphoSitePlusiO95125

Polymorphism and mutation databases

BioMutaiZNF202

Proteomic databases

EPDiO95125
MaxQBiO95125
PaxDbiO95125
PeptideAtlasiO95125
PRIDEiO95125
ProteomicsDBi50655
50656 [O95125-2]

Protocols and materials databases

DNASUi7753
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336139; ENSP00000337724; ENSG00000166261 [O95125-1]
ENST00000529691; ENSP00000433881; ENSG00000166261 [O95125-1]
ENST00000530393; ENSP00000432504; ENSG00000166261 [O95125-1]
GeneIDi7753
KEGGihsa:7753
UCSCiuc001pzd.2 human [O95125-1]

Organism-specific databases

CTDi7753
DisGeNETi7753
EuPathDBiHostDB:ENSG00000166261.10
GeneCardsiZNF202
HGNCiHGNC:12994 ZNF202
MIMi603430 gene
neXtProtiNX_O95125
OpenTargetsiENSG00000166261
PharmGKBiPA37574
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144000
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiO95125
KOiK09229
OMAiPFFCTIC
OrthoDBiEOG091G034X
PhylomeDBiO95125
TreeFamiTF350829

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway
SignaLinkiO95125
SIGNORiO95125

Miscellaneous databases

ChiTaRSiZNF202 human
GeneWikiiZNF202
GenomeRNAii7753
PROiPR:O95125
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166261 Expressed in 167 organ(s), highest expression level in amniotic fluid
CleanExiHS_ZNF202
ExpressionAtlasiO95125 baseline and differential
GenevisibleiO95125 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 7 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN202_HUMAN
AccessioniPrimary (citable) accession number: O95125
Secondary accession number(s): B0LPH9
, Q4JG21, Q9H1B9, Q9NSM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 16, 2006
Last modified: November 7, 2018
This is version 179 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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