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Protein

Splicing factor, arginine/serine-rich 15

Gene

SCAF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act to physically and functionally link transcription and pre-mRNA processing.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Splicing factor, arginine/serine-rich 15
Alternative name(s):
CTD-binding SR-like protein RA4
SR-related and CTD-associated factor 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SCAF4
Synonyms:KIAA1172, SFRS15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000156304.14

Human Gene Nomenclature Database

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HGNCi
HGNC:19304 SCAF4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616023 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95104

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57466

Open Targets

More...
OpenTargetsi
ENSG00000156304

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134903281

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SCAF4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000819431 – 1147Splicing factor, arginine/serine-rich 15Add BLAST1147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei49N6-acetyllysineCombined sources1
Modified residuei154PhosphoserineCombined sources1
Modified residuei656PhosphoserineCombined sources1
Modified residuei1004PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O95104

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O95104

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95104

PeptideAtlas

More...
PeptideAtlasi
O95104

PRoteomics IDEntifications database

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PRIDEi
O95104

ProteomicsDB human proteome resource

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ProteomicsDBi
50653
50654 [O95104-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95104

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O95104

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000156304 Expressed in 211 organ(s), highest expression level in tendon

CleanEx database of gene expression profiles

More...
CleanExi
HS_SFRS15

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O95104 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA018319
HPA018668
HPA021504
HPA028807

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the repetitive C-terminal domain (CTD) of RNA polymerase II.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121536, 38 interactors

Protein interaction database and analysis system

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IntActi
O95104, 4 interactors

Molecular INTeraction database

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MINTi
O95104

STRING: functional protein association networks

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STRINGi
9606.ENSP00000286835

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O95104

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O95104

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 139CIDPROSITE-ProRule annotationAdd BLAST139
Domaini508 – 582RRMPROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi155 – 158Poly-Pro4
Compositional biasi304 – 311Poly-Ala8
Compositional biasi313 – 316Poly-Pro4
Compositional biasi716 – 723Poly-Pro8
Compositional biasi740 – 746Poly-Pro7
Compositional biasi957 – 966Poly-Gln10

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0132 Eukaryota
ENOG410XT48 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063946

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000143432

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG055644

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95104

KEGG Orthology (KO)

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KOi
K13167

Identification of Orthologs from Complete Genome Data

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OMAi
FPPMAQS

Database of Orthologous Groups

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OrthoDBi
EOG091G0377

Database for complete collections of gene phylogenies

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PhylomeDBi
O95104

TreeFam database of animal gene trees

More...
TreeFami
TF324527

Family and domain databases

Conserved Domains Database

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CDDi
cd03562 CID, 1 hit
cd12461 RRM_SCAF4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.90, 1 hit
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006569 CID_dom
IPR008942 ENTH_VHS
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR006903 RNA_pol_II-bd
IPR000504 RRM_dom
IPR034369 SCAF4_RRM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04818 CTD_bind, 1 hit
PF00076 RRM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00582 RPR, 1 hit
SM00360 RRM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48464 SSF48464, 1 hit
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51391 CID, 1 hit
PS50102 RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O95104-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDAVNAFNQE LFSLMDMKPP ISRAKMILIT KAAIKAIKLY KHVVQIVEKF
60 70 80 90 100
IKKCKPEYKV PGLYVIDSIV RQSRHQFGTD KDVFGPRFSK NITATFQYLY
110 120 130 140 150
LCPSEDKSKI VRVLNLWQKN GVFKIEIIQP LLDMAAGTSN AAPVAENVTN
160 170 180 190 200
NEGSPPPPVK VSSEPPTQAT PNSVPAVPQL PSSDAFAAVA QLFQTTQGQQ
210 220 230 240 250
LQQILQTFQQ PPKPQSPALD NAVMAQVQAI TAQLKTTPTQ PSEQKAAFPP
260 270 280 290 300
PEQKTAFDKK LLDRFDYDDE PEAVEESKKE DTTAVTTTAP AAAVPPAPTA
310 320 330 340 350
TVPAAAAPAA ASPPPPQAPF GFPGDGMQQP AYTQHQNMDQ FQPRMMGIQQ
360 370 380 390 400
DPMHHQVPLP PNGQMPGFGL LPTPPFPPMA QPVIPPTPPV QQPFQASFQA
410 420 430 440 450
QNEPLTQKPH QQEMEVEQPC IQEVKRHMSD NRKSRSRSAS RSPKRRRSRS
460 470 480 490 500
GSRSRRSRHR RSRSRSRDRR RHSPRSRSQE RRDREKERER RQKGLPQVKP
510 520 530 540 550
ETASVCSTTL WVGQLDKRTT QQDVASLLEE FGPIESINMI PPRGCAYIVM
560 570 580 590 600
VHRQDAYRAL QKLSRGNYKV NQKSIKIAWA LNKGIKADYK QYWDVELGVT
610 620 630 640 650
YIPWDKVKPE ELESFCEGGM LDSDTLNPDW KGIPKKPENE VAQNGGAETS
660 670 680 690 700
HTEPVSPIPK PLPVPVPPIP VPAPITVPPP QVPPHQPGPP VVGALQPPAF
710 720 730 740 750
TPPLGIPPPG FGPGVPPPPP PPPFLRPGFN PMHLPPGFLP PGPPPPITPP
760 770 780 790 800
VSIPPPHTPP ISIPNSTIAG INEDTTKDLS IGNPIPTVVS GARGNAESGD
810 820 830 840 850
SVKMYGSAVP PAAPTNLPTP PVTQPVSLLG TQGVAPGPVI GLQAPSTGLL
860 870 880 890 900
GARPGLIPLQ RPPGMPPPHL QRFPLMPPRP MPPHMMHRGP PPGPGGFAMP
910 920 930 940 950
PPHGMKGPFP PHGPFVRPGG MPGLGGPGPG PGGPEDRDGR QQPPQQPQQQ
960 970 980 990 1000
PQPQAPQQPQ QQQQQQPPPS QQPPPTQQQP QQFRNDNRQQ FNSGRDQERF
1010 1020 1030 1040 1050
GRRSFGNRVE NDRERYGNRN DDRDNSNRDR REWGRRSPDR DRHRDLEERN
1060 1070 1080 1090 1100
RRSSGHRDRE RDSRDRESRR EKEEARGKEK PEVTDRAGGN KTVEPPISQV
1110 1120 1130 1140
GNVDTASELE KGVSEAAVLK PSEELPAEAT SSVEPEKDSG SAAEAPR
Length:1,147
Mass (Da):125,869
Last modified:February 15, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDED5EEAB45DB4B83
GO
Isoform 2 (identifier: O95104-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     766-788: STIAGINEDTTKDLSIGNPIPTV → L

Note: No experimental confirmation available.
Show »
Length:1,125
Mass (Da):123,643
Checksum:iD771D62662D7B0C6
GO
Isoform 3 (identifier: O95104-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-52: Missing.

Note: No experimental confirmation available.
Show »
Length:1,132
Mass (Da):124,014
Checksum:iF19B820E11955748
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD09327 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1M → W in AAD09327 (Ref. 1) Curated1
Sequence conflicti260 – 264Missing in CAB55911 (PubMed:17974005).Curated5
Sequence conflicti283T → I in AAD09327 (Ref. 1) Curated1
Sequence conflicti286T → A in AAD09327 (Ref. 1) Curated1
Sequence conflicti299T → A in AAD09327 (Ref. 1) Curated1
Sequence conflicti302V → L in BAA86486 (PubMed:10574461).Curated1
Sequence conflicti552H → Y in AAD09327 (Ref. 1) Curated1
Sequence conflicti560L → V in AAD09327 (Ref. 1) Curated1
Sequence conflicti571N → T (Ref. 1) Curated1
Sequence conflicti598 – 600GVT → CVI in AAD09327 (Ref. 1) Curated3
Sequence conflicti604 – 606WDK → CDN in AAD09327 (Ref. 1) Curated3
Sequence conflicti612L → M in AAD09327 (Ref. 1) Curated1
Sequence conflicti616C → Y in AAD09327 (Ref. 1) Curated1
Sequence conflicti624D → N in AK308406 (PubMed:17974005).Curated1
Sequence conflicti808 – 826AVPPA…VTQPV → TCCTHESAHPSCNPACLPC in AAD09327 (Ref. 1) CuratedAdd BLAST19
Sequence conflicti844A → E in AAD09327 (Ref. 1) Curated1
Sequence conflicti1139S → G (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052234846S → Y. Corresponds to variant dbSNP:rs12152067Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04735138 – 52Missing in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_005879766 – 788STIAG…PIPTV → L in isoform 2. 2 PublicationsAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF023142 mRNA Translation: AAD09327.1 Different initiation.
AK308406 mRNA No translation available.
AL834304 mRNA Translation: CAD38974.2
AL117417 mRNA Translation: CAB55911.1 Sequence problems.
AP001711 Genomic DNA No translation available.
BC014921 mRNA Translation: AAH14921.1
BC052286 mRNA Translation: AAH52286.1
BC064990 mRNA Translation: AAH64990.1
AB032998 mRNA Translation: BAA86486.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33537.1 [O95104-1]
CCDS46644.1 [O95104-2]
CCDS54482.1 [O95104-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001138916.1, NM_001145444.1 [O95104-3]
NP_001138917.1, NM_001145445.1 [O95104-2]
NP_065757.1, NM_020706.2 [O95104-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.17255

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000286835; ENSP00000286835; ENSG00000156304 [O95104-1]
ENST00000399804; ENSP00000382703; ENSG00000156304 [O95104-2]
ENST00000434667; ENSP00000402377; ENSG00000156304 [O95104-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57466

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57466

UCSC genome browser

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UCSCi
uc002ypd.3 human [O95104-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023142 mRNA Translation: AAD09327.1 Different initiation.
AK308406 mRNA No translation available.
AL834304 mRNA Translation: CAD38974.2
AL117417 mRNA Translation: CAB55911.1 Sequence problems.
AP001711 Genomic DNA No translation available.
BC014921 mRNA Translation: AAH14921.1
BC052286 mRNA Translation: AAH52286.1
BC064990 mRNA Translation: AAH64990.1
AB032998 mRNA Translation: BAA86486.1
CCDSiCCDS33537.1 [O95104-1]
CCDS46644.1 [O95104-2]
CCDS54482.1 [O95104-3]
RefSeqiNP_001138916.1, NM_001145444.1 [O95104-3]
NP_001138917.1, NM_001145445.1 [O95104-2]
NP_065757.1, NM_020706.2 [O95104-1]
UniGeneiHs.17255

3D structure databases

ProteinModelPortaliO95104
SMRiO95104
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121536, 38 interactors
IntActiO95104, 4 interactors
MINTiO95104
STRINGi9606.ENSP00000286835

PTM databases

iPTMnetiO95104
PhosphoSitePlusiO95104

Polymorphism and mutation databases

BioMutaiSCAF4

Proteomic databases

EPDiO95104
MaxQBiO95104
PaxDbiO95104
PeptideAtlasiO95104
PRIDEiO95104
ProteomicsDBi50653
50654 [O95104-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286835; ENSP00000286835; ENSG00000156304 [O95104-1]
ENST00000399804; ENSP00000382703; ENSG00000156304 [O95104-2]
ENST00000434667; ENSP00000402377; ENSG00000156304 [O95104-3]
GeneIDi57466
KEGGihsa:57466
UCSCiuc002ypd.3 human [O95104-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57466
DisGeNETi57466
EuPathDBiHostDB:ENSG00000156304.14

GeneCards: human genes, protein and diseases

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GeneCardsi
SCAF4
HGNCiHGNC:19304 SCAF4
HPAiHPA018319
HPA018668
HPA021504
HPA028807
MIMi616023 gene
neXtProtiNX_O95104
OpenTargetsiENSG00000156304
PharmGKBiPA134903281

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0132 Eukaryota
ENOG410XT48 LUCA
GeneTreeiENSGT00530000063946
HOGENOMiHOG000143432
HOVERGENiHBG055644
InParanoidiO95104
KOiK13167
OMAiFPPMAQS
OrthoDBiEOG091G0377
PhylomeDBiO95104
TreeFamiTF324527

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SCAF4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57466

Protein Ontology

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PROi
PR:O95104

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000156304 Expressed in 211 organ(s), highest expression level in tendon
CleanExiHS_SFRS15
GenevisibleiO95104 HS

Family and domain databases

CDDicd03562 CID, 1 hit
cd12461 RRM_SCAF4, 1 hit
Gene3Di1.25.40.90, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006569 CID_dom
IPR008942 ENTH_VHS
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR006903 RNA_pol_II-bd
IPR000504 RRM_dom
IPR034369 SCAF4_RRM
PfamiView protein in Pfam
PF04818 CTD_bind, 1 hit
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00582 RPR, 1 hit
SM00360 RRM, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS51391 CID, 1 hit
PS50102 RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSFR15_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95104
Secondary accession number(s): C9JLZ0
, Q0P5W8, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 15, 2005
Last modified: November 7, 2018
This is version 162 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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