NKX2-2

Functionⁱ

Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	128 – 187	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

chromatin binding Source: UniProtKB
proximal promoter sequence-specific DNA binding Source: UniProtKB
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcription coactivator activity Source: UniProtKB
transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

astrocyte differentiation Source: Ensembl
brain development
Source: ProtInc
Traceable author statementⁱ
- 1346742
digestive tract development Source: Ensembl
endocrine pancreas development Source: Reactome
negative regulation of neuron differentiation Source: Ensembl
neuron fate specification Source: Ensembl
oligodendrocyte development Source: Ensembl
optic nerve development Source: Ensembl
pancreatic A cell fate commitment Source: Ensembl
pancreatic PP cell fate commitment Source: Ensembl
positive regulation of DNA-binding transcription factor activity Source: UniProtKB
positive regulation of neuron differentiation Source: Ensembl
positive regulation of oligodendrocyte differentiation Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
response to glucose Source: Ensembl
response to progesterone Source: Ensembl
smoothened signaling pathway Source: Ensembl
spinal cord motor neuron differentiation Source: Ensembl
spinal cord oligodendrocyte cell fate specification Source: Ensembl
transcription, DNA-templated Source: UniProtKB-KW
type B pancreatic cell development Source: Ensembl
type B pancreatic cell fate commitment Source: Ensembl
ventral spinal cord interneuron fate determination Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-210745 Regulation of gene expression in beta cells R-HSA-210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

Reactomeⁱ

R-HSA-210745 Regulation of gene expression in beta cells
R-HSA-210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein Nkx-2.2 Alternative name(s): Homeobox protein NK-2 homolog B
Gene namesⁱ	Name:NKX2-2 Synonyms:NKX2.2, NKX2B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000125820.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7835 NKX2-2
MIMⁱ	604612 gene
neXtProtⁱ	NX_O95096

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4821
Open Targets More...OpenTargetsⁱ	ENSG00000125820
PharmGKBⁱ	PA31642

Polymorphism and mutation databases

BioMutaⁱ	NKX2-2

BioMutaⁱ

NKX2-2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000048929	1 – 273	Homeobox protein Nkx-2.2Add BLAST		273

Proteomic databases

PaxDbⁱ	O95096
PeptideAtlas More...PeptideAtlasⁱ	O95096
PRIDEⁱ	O95096
ProteomicsDBⁱ	50652

PTM databases

iPTMnetⁱ	O95096
PhosphoSitePlusⁱ	O95096

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000125820 Expressed in 73 organ(s), highest expression level in inferior vagus X ganglion
CleanExⁱ	HS_NKX2-2
Genevisibleⁱ	O95096 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003468

HPAⁱ

HPA003468

Interactionⁱ

Subunit structureⁱ

Interacts with OLIG2.By similarity

GO - Molecular functionⁱ

transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110886, 2 interactors
IntActⁱ	O95096, 1 interactor
Molecular INTeraction database More...MINTⁱ	O95096
STRINGⁱ	9606.ENSP00000366347

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O95096
SMRⁱ	O95096
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domainⁱ

The homeodomain is essential for interaction with OLIG2.By similarity

Sequence similaritiesⁱ

Belongs to the NK-2 homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0842 Eukaryota ENOG410XR21 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144003
HOGENOMⁱ	HOG000231923
HOVERGENⁱ	HBG006689
InParanoidⁱ	O95096
KEGG Orthology (KO) More...KOⁱ	K08029
OMAⁱ	HHLVQAQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LZ2
PhylomeDBⁱ	O95096
TreeFamⁱ	TF351204

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O95096-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLTNTKTGF SVKDILDLPD TNDEEGSVAE GPEEENEGPE PAKRAGPLGQ 
        60         70         80         90        100
GALDAVQSLP LKNPFYDSSD NPYTRWLAST EGLQYSLHGL AAGAPPQDSS 
       110        120        130        140        150
SKSPEPSADE SPDNDKETPG GGGDAGKKRK RRVLFSKAQT YELERRFRQQ 
       160        170        180        190        200
RYLSAPEREH LASLIRLTPT QVKIWFQNHR YKMKRARAEK GMEVTPLPSP 
       210        220        230        240        250
RRVAVPVLVR DGKPCHALKA QDLAAATFQA GIPFSAYSAQ SLQHMQYNAQ 
       260        270 
YSSASTPQYP TAHPLVQAQQ WTW

Length:273

Mass (Da):30,133

Last modified:May 1, 1999 - v1

Checksum:ⁱ91BDA220BAFA63D1

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF019415, AF019414 Genomic DNA Translation: AAC83132.1 AL133325 Genomic DNA No translation available. BC075092 mRNA Translation: AAH75092.1 BC075093 mRNA Translation: AAH75093.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13145.1
NCBI Reference Sequences More...RefSeqⁱ	NP_002500.1, NM_002509.3
UniGeneⁱ	Hs.516922

Genome annotation databases

Ensemblⁱ	ENST00000377142; ENSP00000366347; ENSG00000125820
GeneIDⁱ	4821
KEGGⁱ	hsa:4821
UCSC genome browser More...UCSCⁱ	uc002wsi.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95096	NK2 homeobox 2		PANTR		273	UniRef100_O95096
Homeobox protein NK-2-like protein B		MACFA		273
Homeobox protein NK-2-like protein B		MACMU		273
Uncharacterized protein		CERAT		273
Uncharacterized protein		RHIRO		273
+7

Protein	Similar proteins		Species	Score	Length	Source
O95096	Homeobox protein Nkx-2.2		MOUSE		273	UniRef90_P42586
Homeobox protein Nkx-2.2		MESAU		273
NK2 homeobox 2		PANTR		273
Homeobox protein NK-2-like protein B		MACFA		273
Homeobox protein NK-2-like protein B		MACMU		273
+97

Protein	Similar proteins		Species	Score	Length	Source
O95096	Homeobox protein Nkx-2.2		MOUSE		273	UniRef50_P42586
Homeobox protein Nkx-2.2		MESAU		273
Homeobox protein Nkx-2.2a		DANRE		269
Uncharacterized protein		AOTNA		273
NK2 homeobox 2		RAT		273
+252

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF019415, AF019414 Genomic DNA Translation: AAC83132.1 AL133325 Genomic DNA No translation available. BC075092 mRNA Translation: AAH75092.1 BC075093 mRNA Translation: AAH75093.1
CCDSⁱ	CCDS13145.1
RefSeqⁱ	NP_002500.1, NM_002509.3
UniGeneⁱ	Hs.516922

3D structure databases

ProteinModelPortalⁱ	O95096
SMRⁱ	O95096
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110886, 2 interactors
IntActⁱ	O95096, 1 interactor
MINTⁱ	O95096
STRINGⁱ	9606.ENSP00000366347

PTM databases

iPTMnetⁱ	O95096
PhosphoSitePlusⁱ	O95096

Polymorphism and mutation databases

BioMutaⁱ	NKX2-2

BioMutaⁱ

NKX2-2

Proteomic databases

PaxDbⁱ	O95096
PeptideAtlasⁱ	O95096
PRIDEⁱ	O95096
ProteomicsDBⁱ	50652

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4821
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000377142; ENSP00000366347; ENSG00000125820
GeneIDⁱ	4821
KEGGⁱ	hsa:4821
UCSCⁱ	uc002wsi.4 human

Organism-specific databases

CTDⁱ	4821
DisGeNETⁱ	4821
EuPathDBⁱ	HostDB:ENSG00000125820.5
GeneCardsⁱ	NKX2-2
HGNCⁱ	HGNC:7835 NKX2-2
HPAⁱ	HPA003468
MIMⁱ	604612 gene
neXtProtⁱ	NX_O95096
OpenTargetsⁱ	ENSG00000125820
PharmGKBⁱ	PA31642
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0842 Eukaryota ENOG410XR21 LUCA
GeneTreeⁱ	ENSGT00910000144003
HOGENOMⁱ	HOG000231923
HOVERGENⁱ	HBG006689
InParanoidⁱ	O95096
KOⁱ	K08029
OMAⁱ	HHLVQAQ
OrthoDBⁱ	EOG091G0LZ2
PhylomeDBⁱ	O95096
TreeFamⁱ	TF351204

Enzyme and pathway databases

Reactomeⁱ	R-HSA-210745 Regulation of gene expression in beta cells R-HSA-210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

Reactomeⁱ

R-HSA-210745 Regulation of gene expression in beta cells
R-HSA-210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

Miscellaneous databases

ChiTaRSⁱ	NKX2-2 human
GeneWikiⁱ	NKX2-2
GenomeRNAiⁱ	4821
Protein Ontology More...PROⁱ	PR:O95096
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000125820 Expressed in 73 organ(s), highest expression level in inferior vagus X ganglion
CleanExⁱ	HS_NKX2-2
Genevisibleⁱ	O95096 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NKX22_HUMAN
Accessionⁱ	O95096Primary (citable) accession number: O95096
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	May 1, 1999
	Last modified:	October 10, 2018
	This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O95096 (NKX22_HUMAN)

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Homeobox protein Nkx-2.2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ