We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - O95096 (NKX22_HUMAN)
Protein
Homeobox protein Nkx-2.2
Gene
NKX2-2
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity).
May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 128 – 187 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- astrocyte differentiation Source: Ensembl
- brain development Source: ProtInc
- cell differentiation Source: GO_Central
- digestive tract development Source: Ensembl
- negative regulation of neuron differentiation Source: Ensembl
- neuron fate specification Source: Ensembl
- oligodendrocyte development Source: Ensembl
- optic nerve development Source: Ensembl
- pancreatic A cell fate commitment Source: Ensembl
- pancreatic PP cell fate commitment Source: Ensembl
- positive regulation of gene expression Source: Ensembl
- positive regulation of neuron differentiation Source: Ensembl
- positive regulation of oligodendrocyte differentiation Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to glucose Source: Ensembl
- response to progesterone Source: Ensembl
- smoothened signaling pathway Source: Ensembl
- spinal cord motor neuron differentiation Source: Ensembl
- spinal cord oligodendrocyte cell fate specification Source: Ensembl
- type B pancreatic cell development Source: Ensembl
- type B pancreatic cell fate commitment Source: Ensembl
- ventral spinal cord interneuron fate determination Source: Ensembl
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | O95096 |
Reactomei | R-HSA-210745, Regulation of gene expression in beta cells R-HSA-210746, Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells |
SignaLinki | O95096 |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Nkx-2.2Alternative name(s): Homeobox protein NK-2 homolog B |
Gene namesi | Name:NKX2-2 Synonyms:NKX2.2, NKX2B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7835, NKX2-2 |
MIMi | 604612, gene |
neXtProti | NX_O95096 |
VEuPathDBi | HostDB:ENSG00000125820 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 4821 |
OpenTargetsi | ENSG00000125820 |
PharmGKBi | PA31642 |
Miscellaneous databases
Pharosi | O95096, Tbio |
Genetic variation databases
BioMutai | NKX2-2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048929 | 1 – 273 | Homeobox protein Nkx-2.2Add BLAST | 273 |
Proteomic databases
MassIVEi | O95096 |
PaxDbi | O95096 |
PeptideAtlasi | O95096 |
PRIDEi | O95096 |
PTM databases
iPTMneti | O95096 |
PhosphoSitePlusi | O95096 |
Expressioni
Gene expression databases
Bgeei | ENSG00000125820, Expressed in inferior vagus X ganglion and 86 other tissues |
Genevisiblei | O95096, HS |
Organism-specific databases
HPAi | ENSG00000125820, Tissue enriched (brain) |
Interactioni
Subunit structurei
Interacts with OLIG2.
By similarityProtein-protein interaction databases
BioGRIDi | 110886, 2 interactors |
IntActi | O95096, 1 interactor |
MINTi | O95096 |
STRINGi | 9606.ENSP00000366347 |
Miscellaneous databases
RNActi | O95096, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 56 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 90 – 131 | DisorderedSequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 21 – 35 | Acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 108 – 131 | Basic and acidic residuesSequence analysisAdd BLAST | 24 |
Domaini
The homeodomain is essential for interaction with OLIG2.By similarity
Sequence similaritiesi
Belongs to the NK-2 homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0842, Eukaryota |
GeneTreei | ENSGT00940000159727 |
HOGENOMi | CLU_049543_0_2_1 |
InParanoidi | O95096 |
OMAi | PQYPSAH |
OrthoDBi | 1072653at2759 |
PhylomeDBi | O95096 |
TreeFami | TF351204 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O95096-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLTNTKTGF SVKDILDLPD TNDEEGSVAE GPEEENEGPE PAKRAGPLGQ
60 70 80 90 100
GALDAVQSLP LKNPFYDSSD NPYTRWLAST EGLQYSLHGL AAGAPPQDSS
110 120 130 140 150
SKSPEPSADE SPDNDKETPG GGGDAGKKRK RRVLFSKAQT YELERRFRQQ
160 170 180 190 200
RYLSAPEREH LASLIRLTPT QVKIWFQNHR YKMKRARAEK GMEVTPLPSP
210 220 230 240 250
RRVAVPVLVR DGKPCHALKA QDLAAATFQA GIPFSAYSAQ SLQHMQYNAQ
260 270
YSSASTPQYP TAHPLVQAQQ WTW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF019415, AF019414 Genomic DNA Translation: AAC83132.1 AL133325 Genomic DNA No translation available. BC075092 mRNA Translation: AAH75092.1 BC075093 mRNA Translation: AAH75093.1 |
CCDSi | CCDS13145.1 |
RefSeqi | NP_002500.1, NM_002509.3 |
Genome annotation databases
Ensembli | ENST00000377142; ENSP00000366347; ENSG00000125820 |
GeneIDi | 4821 |
KEGGi | hsa:4821 |
MANE-Selecti | ENST00000377142.5; ENSP00000366347.4; NM_002509.4; NP_002500.1 |
UCSCi | uc002wsi.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF019415, AF019414 Genomic DNA Translation: AAC83132.1 AL133325 Genomic DNA No translation available. BC075092 mRNA Translation: AAH75092.1 BC075093 mRNA Translation: AAH75093.1 |
CCDSi | CCDS13145.1 |
RefSeqi | NP_002500.1, NM_002509.3 |
3D structure databases
SMRi | O95096 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110886, 2 interactors |
IntActi | O95096, 1 interactor |
MINTi | O95096 |
STRINGi | 9606.ENSP00000366347 |
PTM databases
iPTMneti | O95096 |
PhosphoSitePlusi | O95096 |
Genetic variation databases
BioMutai | NKX2-2 |
Proteomic databases
MassIVEi | O95096 |
PaxDbi | O95096 |
PeptideAtlasi | O95096 |
PRIDEi | O95096 |
Protocols and materials databases
Antibodypediai | 908, 863 antibodies from 36 providers |
DNASUi | 4821 |
Genome annotation databases
Ensembli | ENST00000377142; ENSP00000366347; ENSG00000125820 |
GeneIDi | 4821 |
KEGGi | hsa:4821 |
MANE-Selecti | ENST00000377142.5; ENSP00000366347.4; NM_002509.4; NP_002500.1 |
UCSCi | uc002wsi.4, human |
Organism-specific databases
CTDi | 4821 |
DisGeNETi | 4821 |
GeneCardsi | NKX2-2 |
HGNCi | HGNC:7835, NKX2-2 |
HPAi | ENSG00000125820, Tissue enriched (brain) |
MIMi | 604612, gene |
neXtProti | NX_O95096 |
OpenTargetsi | ENSG00000125820 |
PharmGKBi | PA31642 |
VEuPathDBi | HostDB:ENSG00000125820 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0842, Eukaryota |
GeneTreei | ENSGT00940000159727 |
HOGENOMi | CLU_049543_0_2_1 |
InParanoidi | O95096 |
OMAi | PQYPSAH |
OrthoDBi | 1072653at2759 |
PhylomeDBi | O95096 |
TreeFami | TF351204 |
Enzyme and pathway databases
PathwayCommonsi | O95096 |
Reactomei | R-HSA-210745, Regulation of gene expression in beta cells R-HSA-210746, Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells |
SignaLinki | O95096 |
Miscellaneous databases
BioGRID-ORCSi | 4821, 9 hits in 1036 CRISPR screens |
ChiTaRSi | NKX2-2, human |
GeneWikii | NKX2-2 |
GenomeRNAii | 4821 |
Pharosi | O95096, Tbio |
PROi | PR:O95096 |
RNActi | O95096, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125820, Expressed in inferior vagus X ganglion and 86 other tissues |
Genevisiblei | O95096, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NKX22_HUMAN | |
Accessioni | O95096Primary (citable) accession number: O95096 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | May 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 178 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families