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Protein

Serine protease 23

Gene

PRSS23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei175Charge relay systemPROSITE-ProRule annotation1
Active sitei240Charge relay systemPROSITE-ProRule annotation1
Active sitei316Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiS01.309

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease 23 (EC:3.4.21.-)
Alternative name(s):
Putative secreted protein Zsig13
Gene namesi
Name:PRSS23
Synonyms:ZSIG13
ORF Names:UNQ270/PRO307
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000150687.11
HGNCiHGNC:14370 PRSS23
neXtProtiNX_O95084

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi11098
OpenTargetsiENSG00000150687
PharmGKBiPA134952846

Polymorphism and mutation databases

BioMutaiPRSS23

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002784720 – 383Serine protease 23Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei109Phosphoserine; by FAM20C1 Publication1
Disulfide bondi160 ↔ 176By similarity
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO95084
MaxQBiO95084
PaxDbiO95084
PeptideAtlasiO95084
PRIDEiO95084
ProteomicsDBi50649
TopDownProteomicsiO95084-1 [O95084-1]

PTM databases

GlyConnecti1736
iPTMnetiO95084
PhosphoSitePlusiO95084

Expressioni

Gene expression databases

BgeeiENSG00000150687 Expressed in 233 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_PRSS23
ExpressionAtlasiO95084 baseline and differential
GenevisibleiO95084 HS

Organism-specific databases

HPAiHPA030591

Interactioni

Protein-protein interaction databases

BioGridi116279, 45 interactors
IntActiO95084, 37 interactors
STRINGi9606.ENSP00000280258

Structurei

3D structure databases

ProteinModelPortaliO95084
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IF0G Eukaryota
ENOG410ZRQ7 LUCA
GeneTreeiENSGT00390000000155
HOGENOMiHOG000059661
HOVERGENiHBG053702
InParanoidiO95084
KOiK09627
OMAiNANDIGM
OrthoDBiEOG091G0BVQ
PhylomeDBiO95084
TreeFamiTF329011

Family and domain databases

InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS00134 TRYPSIN_HIS, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95084-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGIPGLLFL LFFLLCAVGQ VSPYSAPWKP TWPAYRLPVV LPQSTLNLAK
60 70 80 90 100
PDFGAEAKLE VSSSCGPQCH KGTPLPTYEE AKQYLSYETL YANGSRTETQ
110 120 130 140 150
VGIYILSSSG DGAQHRDSGS SGKSRRKRQI YGYDSRFSIF GKDFLLNYPF
160 170 180 190 200
STSVKLSTGC TGTLVAEKHV LTAAHCIHDG KTYVKGTQKL RVGFLKPKFK
210 220 230 240 250
DGGRGANDST SAMPEQMKFQ WIRVKRTHVP KGWIKGNAND IGMDYDYALL
260 270 280 290 300
ELKKPHKRKF MKIGVSPPAK QLPGGRIHFS GYDNDRPGNL VYRFCDVKDE
310 320 330 340 350
TYDLLYQQCD AQPGASGSGV YVRMWKRQQQ KWERKIIGIF SGHQWVDMNG
360 370 380
SPQDFNVAVR ITPLKYAQIC YWIKGNYLDC REG
Length:383
Mass (Da):43,001
Last modified:May 1, 1999 - v1
Checksum:i46EB6C11ABFD5E8F
GO
Isoform 2 (identifier: O95084-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-80: Missing.

Note: No experimental confirmation available.
Show »
Length:351
Mass (Da):39,642
Checksum:i54D3D95CF6B3A526
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PRR2E9PRR2_HUMAN
Serine protease 23
PRSS23
154Annotation score:
E9PMX2E9PMX2_HUMAN
Serine protease 23
PRSS23
91Annotation score:
E9PIB7E9PIB7_HUMAN
Serine protease 23
PRSS23
82Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05662849 – 80Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015287 mRNA Translation: AAD01553.1
AF193611 mRNA Translation: AAF07186.1
AL136914 mRNA Translation: CAB66848.1
AY359033 mRNA Translation: AAQ89392.1
CR456824 mRNA Translation: CAG33105.1
AK304301 mRNA Translation: BAG65155.1
AK315562 mRNA Translation: BAG37938.1
AP000654 Genomic DNA No translation available.
AP001528 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW75145.1
BC001278 mRNA Translation: AAH01278.1
CCDSiCCDS8278.1 [O95084-1]
RefSeqiNP_001280107.1, NM_001293178.1
NP_001280108.1, NM_001293179.1 [O95084-1]
NP_001280109.1, NM_001293180.1 [O95084-1]
NP_009104.2, NM_007173.5 [O95084-1]
UniGeneiHs.25338
Hs.729257

Genome annotation databases

EnsembliENST00000280258; ENSP00000280258; ENSG00000150687 [O95084-1]
GeneIDi11098
KEGGihsa:11098
UCSCiuc001pcb.4 human [O95084-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015287 mRNA Translation: AAD01553.1
AF193611 mRNA Translation: AAF07186.1
AL136914 mRNA Translation: CAB66848.1
AY359033 mRNA Translation: AAQ89392.1
CR456824 mRNA Translation: CAG33105.1
AK304301 mRNA Translation: BAG65155.1
AK315562 mRNA Translation: BAG37938.1
AP000654 Genomic DNA No translation available.
AP001528 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW75145.1
BC001278 mRNA Translation: AAH01278.1
CCDSiCCDS8278.1 [O95084-1]
RefSeqiNP_001280107.1, NM_001293178.1
NP_001280108.1, NM_001293179.1 [O95084-1]
NP_001280109.1, NM_001293180.1 [O95084-1]
NP_009104.2, NM_007173.5 [O95084-1]
UniGeneiHs.25338
Hs.729257

3D structure databases

ProteinModelPortaliO95084
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116279, 45 interactors
IntActiO95084, 37 interactors
STRINGi9606.ENSP00000280258

Protein family/group databases

MEROPSiS01.309

PTM databases

GlyConnecti1736
iPTMnetiO95084
PhosphoSitePlusiO95084

Polymorphism and mutation databases

BioMutaiPRSS23

Proteomic databases

EPDiO95084
MaxQBiO95084
PaxDbiO95084
PeptideAtlasiO95084
PRIDEiO95084
ProteomicsDBi50649
TopDownProteomicsiO95084-1 [O95084-1]

Protocols and materials databases

DNASUi11098
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280258; ENSP00000280258; ENSG00000150687 [O95084-1]
GeneIDi11098
KEGGihsa:11098
UCSCiuc001pcb.4 human [O95084-1]

Organism-specific databases

CTDi11098
DisGeNETi11098
EuPathDBiHostDB:ENSG00000150687.11
GeneCardsiPRSS23
HGNCiHGNC:14370 PRSS23
HPAiHPA030591
neXtProtiNX_O95084
OpenTargetsiENSG00000150687
PharmGKBiPA134952846
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF0G Eukaryota
ENOG410ZRQ7 LUCA
GeneTreeiENSGT00390000000155
HOGENOMiHOG000059661
HOVERGENiHBG053702
InParanoidiO95084
KOiK09627
OMAiNANDIGM
OrthoDBiEOG091G0BVQ
PhylomeDBiO95084
TreeFamiTF329011

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSiPRSS23 human
GeneWikiiPRSS23
GenomeRNAii11098
PROiPR:O95084

Gene expression databases

BgeeiENSG00000150687 Expressed in 233 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_PRSS23
ExpressionAtlasiO95084 baseline and differential
GenevisibleiO95084 HS

Family and domain databases

InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS00134 TRYPSIN_HIS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRS23_HUMAN
AccessioniPrimary (citable) accession number: O95084
Secondary accession number(s): B2RDJ1, B4E2J3, Q6IBI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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