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UniProtKB - O95084 (PRS23_HUMAN)

Entry version 161 (13 Feb 2019)
Sequence version 1 (01 May 1999)
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Protein

Serine protease 23

Gene

PRSS23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei175Charge relay systemPROSITE-ProRule annotation1
Active sitei240Charge relay systemPROSITE-ProRule annotation1
Active sitei316Charge relay systemPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPS protease database

More...MEROPSi		S01.309

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine protease 23 (EC:3.4.21.-)
Alternative name(s):
Putative secreted protein Zsig13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRSS23
Synonyms:ZSIG13
ORF Names:UNQ270/PRO307
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000150687.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:14370 PRSS23

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95084

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		11098

Open Targets

More...OpenTargetsi		ENSG00000150687

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134952846

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PRSS23

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002784720 – 383Serine protease 23Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei109Phosphoserine; by FAM20C1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi160 ↔ 176By similarity
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O95084

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O95084

MaxQB - The MaxQuant DataBase

More...MaxQBi		O95084

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95084

PeptideAtlas

More...PeptideAtlasi		O95084

PRoteomics IDEntifications database

More...PRIDEi		O95084

ProteomicsDB human proteome resource

More...ProteomicsDBi		50649

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O95084-1 [O95084-1]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1736

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95084

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95084

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000150687 Expressed in 233 organ(s), highest expression level in nasal cavity epithelium

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O95084 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95084 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA030591

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		116279, 45 interactors

Protein interaction database and analysis system

More...IntActi		O95084, 38 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000280258

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		O95084

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IF0G Eukaryota
ENOG410ZRQ7 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000155

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000059661

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG053702

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95084

KEGG Orthology (KO)

More...KOi		K09627

Identification of Orthologs from Complete Genome Data

More...OMAi		NANDIGM

Database of Orthologous Groups

More...OrthoDBi		1245017at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95084

TreeFam database of animal gene trees

More...TreeFami		TF329011

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00089 Trypsin, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50494 SSF50494, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00134 TRYPSIN_HIS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95084-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGIPGLLFL LFFLLCAVGQ VSPYSAPWKP TWPAYRLPVV LPQSTLNLAK 
        60         70         80         90        100
PDFGAEAKLE VSSSCGPQCH KGTPLPTYEE AKQYLSYETL YANGSRTETQ 
       110        120        130        140        150
VGIYILSSSG DGAQHRDSGS SGKSRRKRQI YGYDSRFSIF GKDFLLNYPF 
       160        170        180        190        200
STSVKLSTGC TGTLVAEKHV LTAAHCIHDG KTYVKGTQKL RVGFLKPKFK 
       210        220        230        240        250
DGGRGANDST SAMPEQMKFQ WIRVKRTHVP KGWIKGNAND IGMDYDYALL 
       260        270        280        290        300
ELKKPHKRKF MKIGVSPPAK QLPGGRIHFS GYDNDRPGNL VYRFCDVKDE 
       310        320        330        340        350
TYDLLYQQCD AQPGASGSGV YVRMWKRQQQ KWERKIIGIF SGHQWVDMNG 
       360        370        380 
SPQDFNVAVR ITPLKYAQIC YWIKGNYLDC REG
Length:383
Mass (Da):43,001
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46EB6C11ABFD5E8F
GO
Isoform 2 (identifier: O95084-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-80: Missing.

Note: No experimental confirmation available.
Show »
Length:351
Mass (Da):39,642
Checksum:i54D3D95CF6B3A526
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PRR2E9PRR2_HUMAN
Serine protease 23
PRSS23
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMX2E9PMX2_HUMAN
Serine protease 23
PRSS23
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIB7E9PIB7_HUMAN
Serine protease 23
PRSS23
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05662849 – 80Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF015287 mRNA Translation: AAD01553.1
AF193611 mRNA Translation: AAF07186.1
AL136914 mRNA Translation: CAB66848.1
AY359033 mRNA Translation: AAQ89392.1
CR456824 mRNA Translation: CAG33105.1
AK304301 mRNA Translation: BAG65155.1
AK315562 mRNA Translation: BAG37938.1
AP000654 Genomic DNA No translation available.
AP001528 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW75145.1
BC001278 mRNA Translation: AAH01278.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8278.1 [O95084-1]

NCBI Reference Sequences

More...RefSeqi		NP_001280107.1, NM_001293178.1
NP_001280108.1, NM_001293179.1 [O95084-1]
NP_001280109.1, NM_001293180.1 [O95084-1]
NP_009104.2, NM_007173.5 [O95084-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.25338
Hs.729257

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000280258; ENSP00000280258; ENSG00000150687 [O95084-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11098

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:11098

UCSC genome browser

More...UCSCi		uc001pcb.4 human [O95084-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015287 mRNA Translation: AAD01553.1
AF193611 mRNA Translation: AAF07186.1
AL136914 mRNA Translation: CAB66848.1
AY359033 mRNA Translation: AAQ89392.1
CR456824 mRNA Translation: CAG33105.1
AK304301 mRNA Translation: BAG65155.1
AK315562 mRNA Translation: BAG37938.1
AP000654 Genomic DNA No translation available.
AP001528 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW75145.1
BC001278 mRNA Translation: AAH01278.1
CCDSiCCDS8278.1 [O95084-1]
RefSeqiNP_001280107.1, NM_001293178.1
NP_001280108.1, NM_001293179.1 [O95084-1]
NP_001280109.1, NM_001293180.1 [O95084-1]
NP_009104.2, NM_007173.5 [O95084-1]
UniGeneiHs.25338
Hs.729257

3D structure databases

ProteinModelPortaliO95084
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116279, 45 interactors
IntActiO95084, 38 interactors
STRINGi9606.ENSP00000280258

Protein family/group databases

MEROPSiS01.309

PTM databases

GlyConnecti1736
iPTMnetiO95084
PhosphoSitePlusiO95084

Polymorphism and mutation databases

BioMutaiPRSS23

Proteomic databases

EPDiO95084
jPOSTiO95084
MaxQBiO95084
PaxDbiO95084
PeptideAtlasiO95084
PRIDEiO95084
ProteomicsDBi50649
TopDownProteomicsiO95084-1 [O95084-1]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		11098
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280258; ENSP00000280258; ENSG00000150687 [O95084-1]
GeneIDi11098
KEGGihsa:11098
UCSCiuc001pcb.4 human [O95084-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		11098
DisGeNETi11098
EuPathDBiHostDB:ENSG00000150687.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		PRSS23
HGNCiHGNC:14370 PRSS23
HPAiHPA030591
neXtProtiNX_O95084
OpenTargetsiENSG00000150687
PharmGKBiPA134952846

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IF0G Eukaryota
ENOG410ZRQ7 LUCA
GeneTreeiENSGT00390000000155
HOGENOMiHOG000059661
HOVERGENiHBG053702
InParanoidiO95084
KOiK09627
OMAiNANDIGM
OrthoDBi1245017at2759
PhylomeDBiO95084
TreeFamiTF329011

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PRSS23 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PRSS23

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		11098

Protein Ontology

More...PROi		PR:O95084

Gene expression databases

BgeeiENSG00000150687 Expressed in 233 organ(s), highest expression level in nasal cavity epithelium
ExpressionAtlasiO95084 baseline and differential
GenevisibleiO95084 HS

Family and domain databases

InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS00134 TRYPSIN_HIS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRS23_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95084
Secondary accession number(s): B2RDJ1, B4E2J3, Q6IBI0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: May 1, 1999
Last modified: February 13, 2019
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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