We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - O95084 (PRS23_HUMAN)
Protein
Serine protease 23
Gene
PRSS23
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 175 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Active sitei | 240 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Active sitei | 316 | Charge relay systemPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- serine-type endopeptidase activity Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Enzyme and pathway databases
PathwayCommonsi | O95084 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
SignaLinki | O95084 |
Protein family/group databases
MEROPSi | S01.309 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine protease 23 (EC:3.4.21.-)Alternative name(s): Putative secreted protein Zsig13 |
Gene namesi | Name:PRSS23 Synonyms:ZSIG13 ORF Names:UNQ270/PRO307 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14370, PRSS23 |
MIMi | 618376, gene |
neXtProti | NX_O95084 |
VEuPathDBi | HostDB:ENSG00000150687 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: LIFEdb
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 11098 |
MalaCardsi | PRSS23 |
OpenTargetsi | ENSG00000150687 |
PharmGKBi | PA134952846 |
Miscellaneous databases
Pharosi | O95084, Tbio |
Genetic variation databases
BioMutai | PRSS23 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000027847 | 20 – 383 | Serine protease 23Add BLAST | 364 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 93 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 109 | Phosphoserine; by FAM20C1 Publication | 1 | |
Disulfide bondi | 160 ↔ 176 | By similarity | ||
Glycosylationi | 207 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | O95084 |
MassIVEi | O95084 |
MaxQBi | O95084 |
PaxDbi | O95084 |
PeptideAtlasi | O95084 |
PRIDEi | O95084 |
ProteomicsDBi | 50649 [O95084-1] 5825 |
TopDownProteomicsi | O95084-1 [O95084-1] |
PTM databases
GlyConnecti | 1736, 2 N-Linked glycans (2 sites) |
GlyGeni | O95084, 2 sites, 2 N-linked glycans (2 sites) |
iPTMneti | O95084 |
PhosphoSitePlusi | O95084 |
Expressioni
Gene expression databases
Bgeei | ENSG00000150687, Expressed in nasal cavity epithelium and 245 other tissues |
ExpressionAtlasi | O95084, baseline and differential |
Genevisiblei | O95084, HS |
Organism-specific databases
HPAi | ENSG00000150687, Tissue enhanced (cervix) |
Interactioni
Binary interactionsi
O95084
With | #Exp. | IntAct |
---|---|---|
SEC11C [Q9BY50] | 3 | EBI-712503,EBI-2855401 |
Protein-protein interaction databases
BioGRIDi | 116279, 56 interactors |
IntActi | O95084, 44 interactors |
STRINGi | 9606.ENSP00000280258 |
Miscellaneous databases
RNActi | O95084, protein |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase S1 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QTW6, Eukaryota |
GeneTreei | ENSGT00390000000155 |
HOGENOMi | CLU_055829_0_0_1 |
InParanoidi | O95084 |
OMAi | RQQQKWE |
OrthoDBi | 1245017at2759 |
PhylomeDBi | O95084 |
TreeFami | TF329011 |
Family and domain databases
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS00134, TRYPSIN_HIS, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O95084-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGIPGLLFL LFFLLCAVGQ VSPYSAPWKP TWPAYRLPVV LPQSTLNLAK
60 70 80 90 100
PDFGAEAKLE VSSSCGPQCH KGTPLPTYEE AKQYLSYETL YANGSRTETQ
110 120 130 140 150
VGIYILSSSG DGAQHRDSGS SGKSRRKRQI YGYDSRFSIF GKDFLLNYPF
160 170 180 190 200
STSVKLSTGC TGTLVAEKHV LTAAHCIHDG KTYVKGTQKL RVGFLKPKFK
210 220 230 240 250
DGGRGANDST SAMPEQMKFQ WIRVKRTHVP KGWIKGNAND IGMDYDYALL
260 270 280 290 300
ELKKPHKRKF MKIGVSPPAK QLPGGRIHFS GYDNDRPGNL VYRFCDVKDE
310 320 330 340 350
TYDLLYQQCD AQPGASGSGV YVRMWKRQQQ KWERKIIGIF SGHQWVDMNG
360 370 380
SPQDFNVAVR ITPLKYAQIC YWIKGNYLDC REG
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PMX2 | E9PMX2_HUMAN | Serine protease 23 | PRSS23 | 91 | Annotation score: | ||
E9PIB7 | E9PIB7_HUMAN | Serine protease 23 | PRSS23 | 82 | Annotation score: | ||
E9PRR2 | E9PRR2_HUMAN | Serine protease 23 | PRSS23 | 154 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056628 | 49 – 80 | Missing in isoform 2. 1 PublicationAdd BLAST | 32 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF015287 mRNA Translation: AAD01553.1 AF193611 mRNA Translation: AAF07186.1 AL136914 mRNA Translation: CAB66848.1 AY359033 mRNA Translation: AAQ89392.1 CR456824 mRNA Translation: CAG33105.1 AK304301 mRNA Translation: BAG65155.1 AK315562 mRNA Translation: BAG37938.1 AP000654 Genomic DNA No translation available. AP001528 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW75145.1 BC001278 mRNA Translation: AAH01278.1 |
CCDSi | CCDS8278.1 [O95084-1] |
RefSeqi | NP_001280107.1, NM_001293178.1 NP_001280108.1, NM_001293179.1 [O95084-1] NP_001280109.1, NM_001293180.1 [O95084-1] NP_009104.2, NM_007173.5 [O95084-1] |
Genome annotation databases
Ensembli | ENST00000280258; ENSP00000280258; ENSG00000150687 |
GeneIDi | 11098 |
KEGGi | hsa:11098 |
MANE-Selecti | ENST00000280258.6; ENSP00000280258.4; NM_007173.6; NP_009104.3 |
UCSCi | uc001pcb.4, human [O95084-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF015287 mRNA Translation: AAD01553.1 AF193611 mRNA Translation: AAF07186.1 AL136914 mRNA Translation: CAB66848.1 AY359033 mRNA Translation: AAQ89392.1 CR456824 mRNA Translation: CAG33105.1 AK304301 mRNA Translation: BAG65155.1 AK315562 mRNA Translation: BAG37938.1 AP000654 Genomic DNA No translation available. AP001528 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW75145.1 BC001278 mRNA Translation: AAH01278.1 |
CCDSi | CCDS8278.1 [O95084-1] |
RefSeqi | NP_001280107.1, NM_001293178.1 NP_001280108.1, NM_001293179.1 [O95084-1] NP_001280109.1, NM_001293180.1 [O95084-1] NP_009104.2, NM_007173.5 [O95084-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 116279, 56 interactors |
IntActi | O95084, 44 interactors |
STRINGi | 9606.ENSP00000280258 |
Protein family/group databases
MEROPSi | S01.309 |
PTM databases
GlyConnecti | 1736, 2 N-Linked glycans (2 sites) |
GlyGeni | O95084, 2 sites, 2 N-linked glycans (2 sites) |
iPTMneti | O95084 |
PhosphoSitePlusi | O95084 |
Genetic variation databases
BioMutai | PRSS23 |
Proteomic databases
jPOSTi | O95084 |
MassIVEi | O95084 |
MaxQBi | O95084 |
PaxDbi | O95084 |
PeptideAtlasi | O95084 |
PRIDEi | O95084 |
ProteomicsDBi | 50649 [O95084-1] 5825 |
TopDownProteomicsi | O95084-1 [O95084-1] |
Protocols and materials databases
Antibodypediai | 31454, 78 antibodies from 19 providers |
DNASUi | 11098 |
Genome annotation databases
Ensembli | ENST00000280258; ENSP00000280258; ENSG00000150687 |
GeneIDi | 11098 |
KEGGi | hsa:11098 |
MANE-Selecti | ENST00000280258.6; ENSP00000280258.4; NM_007173.6; NP_009104.3 |
UCSCi | uc001pcb.4, human [O95084-1] |
Organism-specific databases
CTDi | 11098 |
DisGeNETi | 11098 |
GeneCardsi | PRSS23 |
HGNCi | HGNC:14370, PRSS23 |
HPAi | ENSG00000150687, Tissue enhanced (cervix) |
MalaCardsi | PRSS23 |
MIMi | 618376, gene |
neXtProti | NX_O95084 |
OpenTargetsi | ENSG00000150687 |
PharmGKBi | PA134952846 |
VEuPathDBi | HostDB:ENSG00000150687 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTW6, Eukaryota |
GeneTreei | ENSGT00390000000155 |
HOGENOMi | CLU_055829_0_0_1 |
InParanoidi | O95084 |
OMAi | RQQQKWE |
OrthoDBi | 1245017at2759 |
PhylomeDBi | O95084 |
TreeFami | TF329011 |
Enzyme and pathway databases
PathwayCommonsi | O95084 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
SignaLinki | O95084 |
Miscellaneous databases
BioGRID-ORCSi | 11098, 7 hits in 1040 CRISPR screens |
ChiTaRSi | PRSS23, human |
GeneWikii | PRSS23 |
GenomeRNAii | 11098 |
Pharosi | O95084, Tbio |
PROi | PR:O95084 |
RNActi | O95084, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000150687, Expressed in nasal cavity epithelium and 245 other tissues |
ExpressionAtlasi | O95084, baseline and differential |
Genevisiblei | O95084, HS |
Family and domain databases
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS00134, TRYPSIN_HIS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PRS23_HUMAN | |
Accessioni | O95084Primary (citable) accession number: O95084 Secondary accession number(s): B2RDJ1, B4E2J3, Q6IBI0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2002 |
Last sequence update: | May 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families