UniProtKB - O95081 (AGFG2_HUMAN)
Protein
Arf-GAP domain and FG repeat-containing protein 2
Gene
AGFG2
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 47 – 70 | C4-typePROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- GTPase activator activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O95081 |
Names & Taxonomyi
Protein namesi | Recommended name: Arf-GAP domain and FG repeat-containing protein 2Alternative name(s): HIV-1 Rev-binding protein-like protein Rev/Rex activation domain-binding protein related Short name: RAB-R |
Gene namesi | Name:AGFG2 Synonyms:HRBL, RABR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000106351.12 |
HGNCi | HGNC:5177, AGFG2 |
MIMi | 604019, gene |
neXtProti | NX_O95081 |
Subcellular locationi
Other locations
- membrane Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 3268 |
NIAGADSi | ENSG00000106351 |
OpenTargetsi | ENSG00000106351 |
PharmGKBi | PA29451 |
Miscellaneous databases
Pharosi | O95081, Tbio |
Polymorphism and mutation databases
BioMutai | AGFG2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204828 | 1 – 481 | Arf-GAP domain and FG repeat-containing protein 2Add BLAST | 481 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 173 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | O95081 |
jPOSTi | O95081 |
MassIVEi | O95081 |
MaxQBi | O95081 |
PaxDbi | O95081 |
PeptideAtlasi | O95081 |
PRIDEi | O95081 |
ProteomicsDBi | 50647 [O95081-1] 50648 [O95081-2] |
PTM databases
GlyGeni | O95081, 4 sites, 1 O-linked glycan (4 sites) |
iPTMneti | O95081 |
PhosphoSitePlusi | O95081 |
Expressioni
Gene expression databases
Bgeei | ENSG00000106351, Expressed in saliva-secreting gland and 182 other tissues |
ExpressionAtlasi | O95081, baseline and differential |
Genevisiblei | O95081, HS |
Organism-specific databases
HPAi | ENSG00000106351, Tissue enriched (salivary) |
Interactioni
Subunit structurei
Interacts with EPS15R.
By similarityProtein-protein interaction databases
BioGRIDi | 109504, 12 interactors |
ELMi | O95081 |
IntActi | O95081, 5 interactors |
STRINGi | 9606.ENSP00000300176 |
Miscellaneous databases
RNActi | O95081, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 153 | Arf-GAPPROSITE-ProRule annotationAdd BLAST | 127 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 367 – 427 | Pro-richAdd BLAST | 61 |
Domaini
Contains FG repeats and 4 N-P-F repeats.
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 47 – 70 | C4-typePROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0702, Eukaryota |
GeneTreei | ENSGT00940000161071 |
HOGENOMi | CLU_027801_0_0_1 |
InParanoidi | O95081 |
OMAi | SDCKRNK |
OrthoDBi | 1226524at2759 |
PhylomeDBi | O95081 |
TreeFami | TF325357 |
Family and domain databases
Gene3Di | 3.30.40.160, 1 hit |
InterProi | View protein in InterPro IPR037278, ARFGAP/RecO IPR001164, ArfGAP_dom IPR038508, ArfGAP_dom_sf |
Pfami | View protein in Pfam PF01412, ArfGap, 1 hit |
PRINTSi | PR00405, REVINTRACTNG |
SMARTi | View protein in SMART SM00105, ArfGap, 1 hit |
SUPFAMi | SSF57863, SSF57863, 1 hit |
PROSITEi | View protein in PROSITE PS50115, ARFGAP, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O95081-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVMAAKKGPG PGGGVSGGKA EAEAASEVWC RRVRELGGCS QAGNRHCFEC
60 70 80 90 100
AQRGVTYVDI TVGSFVCTTC SGLLRGLNPP HRVKSISMTT FTEPEVVFLQ
110 120 130 140 150
SRGNEVCRKI WLGLFDARTS LVPDSRDPQK VKEFLQEKYE KKRWYVPPDQ
160 170 180 190 200
VKGPTYTKGS ASTPVQGSIP EGKPLRTLLG DPAPSLSVAA STSSQPVSQS
210 220 230 240 250
HARTSQARST QPPPHSSVKK ASTDLLADIG GDPFAAPQMA PAFAAFPAFG
260 270 280 290 300
GQTPSQGGFA NFDAFSSGPS SSVFGSLPPA GQASFQAQPT PAGSSQGTPF
310 320 330 340 350
GATPLAPASQ PNSLADVGSF LGPGVPAAGV PSSLFGMAGQ VPPLQSVTMG
360 370 380 390 400
GGGGSSTGLA FGAFTNPFTA PAAQSPLPST NPFQPNGLAP GPGFGMSSAG
410 420 430 440 450
PGFPQAVPPT GAFASSFPAP LFPPQTPLVQ QQNGSSFGDL GSAKLGQRPL
460 470 480
SQPAGISTNP FMTGPSSSPF ASKPPTTNPF L
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7BZA5 | H7BZA5_HUMAN | Arf-GAP domain and FG repeat-contai... | AGFG2 | 223 | Annotation score: | ||
A0A0C4DG34 | A0A0C4DG34_HUMAN | Arf-GAP domain and FG repeat-contai... | AGFG2 HRBL, hCG_20457 | 155 | Annotation score: |
Sequence cautioni
The sequence AAC78803 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 96 | V → L in AAD01550 (PubMed:9303539).Curated | 1 | |
Sequence conflicti | 124 | D → N in AAD01550 (PubMed:9303539).Curated | 1 | |
Sequence conflicti | 206 | Q → H in AAC78803 (PubMed:9799793).Curated | 1 | |
Sequence conflicti | 349 | M → T in AAH17329 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050566 | 365 | T → N. Corresponds to variant dbSNP:rs34731997Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010667 | 145 – 155 | YVPPDQVKGPT → PDTFPRRLCQL in isoform 2. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_010668 | 157 – 481 | Missing in isoform 2. 1 PublicationAdd BLAST | 325 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF015042 mRNA Translation: AAD01550.1 BC009393 mRNA Translation: AAH09393.1 BC017329 mRNA Translation: AAH17329.1 AF053356 Genomic DNA Translation: AAC78803.1 Sequence problems. |
CCDSi | CCDS5697.1 [O95081-1] |
RefSeqi | NP_006067.3, NM_006076.4 [O95081-1] |
Genome annotation databases
Ensembli | ENST00000300176; ENSP00000300176; ENSG00000106351 [O95081-1] |
GeneIDi | 3268 |
KEGGi | hsa:3268 |
UCSCi | uc003uvf.4, human [O95081-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF015042 mRNA Translation: AAD01550.1 BC009393 mRNA Translation: AAH09393.1 BC017329 mRNA Translation: AAH17329.1 AF053356 Genomic DNA Translation: AAC78803.1 Sequence problems. |
CCDSi | CCDS5697.1 [O95081-1] |
RefSeqi | NP_006067.3, NM_006076.4 [O95081-1] |
3D structure databases
SMRi | O95081 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109504, 12 interactors |
ELMi | O95081 |
IntActi | O95081, 5 interactors |
STRINGi | 9606.ENSP00000300176 |
PTM databases
GlyGeni | O95081, 4 sites, 1 O-linked glycan (4 sites) |
iPTMneti | O95081 |
PhosphoSitePlusi | O95081 |
Polymorphism and mutation databases
BioMutai | AGFG2 |
Proteomic databases
EPDi | O95081 |
jPOSTi | O95081 |
MassIVEi | O95081 |
MaxQBi | O95081 |
PaxDbi | O95081 |
PeptideAtlasi | O95081 |
PRIDEi | O95081 |
ProteomicsDBi | 50647 [O95081-1] 50648 [O95081-2] |
Protocols and materials databases
Antibodypediai | 16493, 141 antibodies |
Genome annotation databases
Ensembli | ENST00000300176; ENSP00000300176; ENSG00000106351 [O95081-1] |
GeneIDi | 3268 |
KEGGi | hsa:3268 |
UCSCi | uc003uvf.4, human [O95081-1] |
Organism-specific databases
CTDi | 3268 |
DisGeNETi | 3268 |
EuPathDBi | HostDB:ENSG00000106351.12 |
GeneCardsi | AGFG2 |
HGNCi | HGNC:5177, AGFG2 |
HPAi | ENSG00000106351, Tissue enriched (salivary) |
MIMi | 604019, gene |
neXtProti | NX_O95081 |
NIAGADSi | ENSG00000106351 |
OpenTargetsi | ENSG00000106351 |
PharmGKBi | PA29451 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0702, Eukaryota |
GeneTreei | ENSGT00940000161071 |
HOGENOMi | CLU_027801_0_0_1 |
InParanoidi | O95081 |
OMAi | SDCKRNK |
OrthoDBi | 1226524at2759 |
PhylomeDBi | O95081 |
TreeFami | TF325357 |
Enzyme and pathway databases
PathwayCommonsi | O95081 |
Miscellaneous databases
BioGRID-ORCSi | 3268, 7 hits in 845 CRISPR screens |
ChiTaRSi | AGFG2, human |
GeneWikii | HRBL |
GenomeRNAii | 3268 |
Pharosi | O95081, Tbio |
PROi | PR:O95081 |
RNActi | O95081, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000106351, Expressed in saliva-secreting gland and 182 other tissues |
ExpressionAtlasi | O95081, baseline and differential |
Genevisiblei | O95081, HS |
Family and domain databases
Gene3Di | 3.30.40.160, 1 hit |
InterProi | View protein in InterPro IPR037278, ARFGAP/RecO IPR001164, ArfGAP_dom IPR038508, ArfGAP_dom_sf |
Pfami | View protein in Pfam PF01412, ArfGap, 1 hit |
PRINTSi | PR00405, REVINTRACTNG |
SMARTi | View protein in SMART SM00105, ArfGap, 1 hit |
SUPFAMi | SSF57863, SSF57863, 1 hit |
PROSITEi | View protein in PROSITE PS50115, ARFGAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AGFG2_HUMAN | |
Accessioni | O95081Primary (citable) accession number: O95081 Secondary accession number(s): O75429, Q96AB9, Q96GL4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2004 |
Last sequence update: | June 21, 2004 | |
Last modified: | December 2, 2020 | |
This is version 148 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations