UniProtKB - O95081 (AGFG2_HUMAN)

BLAST

>sp|O95081|AGFG2_HUMAN Arf-GAP domain and FG repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=AGFG2 PE=1 SV=2
MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGSASTPVQGSIPEGKPLRTLLG
DPAPSLSVAASTSSQPVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAAPQMA
PAFAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQPTPAGSSQGTPF
GATPLAPASQPNSLADVGSFLGPGVPAAGVPSSLFGMAGQVPPLQSVTMGGGGGSSTGLA
FGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGPGFPQAVPPTGAFASSFPAP
LFPPQTPLVQQQNGSSFGDLGSAKLGQRPLSQPAGISTNPFMTGPSSSPFASKPPTTNPF
L

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History
Entry version 135 (07 Nov 2018)
Sequence version 2 (21 Jun 2004)
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Protein

Arf-GAP domain and FG repeat-containing protein 2

Gene

AGFG2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	47 – 70	C4-typePROSITE-ProRule annotationAdd BLAST		24

GO - Molecular functionⁱ

GTPase activator activity Source: InterPro
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Arf-GAP domain and FG repeat-containing protein 2 Alternative name(s): HIV-1 Rev-binding protein-like protein Rev/Rex activation domain-binding protein related Short name: RAB-R
Gene namesⁱ	Name:AGFG2 Synonyms:HRBL, RABR
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000106351.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5177 AGFG2
MIMⁱ	604019 gene
neXtProtⁱ	NX_O95081

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3268
Open Targets More...OpenTargetsⁱ	ENSG00000106351
PharmGKBⁱ	PA29451

Polymorphism and mutation databases

BioMutaⁱ	AGFG2

BioMutaⁱ

AGFG2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000204828	1 – 481	Arf-GAP domain and FG repeat-containing protein 2Add BLAST		481

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	173	N6-acetyllysineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	O95081
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O95081
PaxDbⁱ	O95081
PeptideAtlas More...PeptideAtlasⁱ	O95081
PRIDEⁱ	O95081
ProteomicsDBⁱ	50647 50648 [O95081-2]

PTM databases

iPTMnetⁱ	O95081
PhosphoSitePlusⁱ	O95081

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000106351 Expressed in 169 organ(s), highest expression level in parotid gland
CleanExⁱ	HS_AGFG2
ExpressionAtlasⁱ	O95081 baseline and differential
Genevisibleⁱ	O95081 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA019689

HPAⁱ

HPA019689

Interactionⁱ

Subunit structureⁱ

Interacts with EPS15R.By similarity

Protein-protein interaction databases

BioGridⁱ	109504, 11 interactors
ELMⁱ	O95081
IntActⁱ	O95081, 2 interactors
STRINGⁱ	9606.ENSP00000300176

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O95081
SMRⁱ	O95081
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	27 – 153	Arf-GAPPROSITE-ProRule annotationAdd BLAST		127

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	367 – 427	Pro-richAdd BLAST		61

Domainⁱ

Contains FG repeats and 4 N-P-F repeats.

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	47 – 70	C4-typePROSITE-ProRule annotationAdd BLAST		24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG0702 Eukaryota ENOG41122WA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00560000077249
HOGENOMⁱ	HOG000253009
HOVERGENⁱ	HBG006551
InParanoidⁱ	O95081
OMAⁱ	SDCKRNK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09LC
PhylomeDBⁱ	O95081
TreeFamⁱ	TF325357

Family and domain databases

Gene3Dⁱ	3.30.40.160, 1 hit
InterProⁱ	View protein in InterPro IPR037278 ARFGAP/RecO IPR001164 ArfGAP_dom IPR038508 ArfGAP_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01412 ArfGap, 1 hit
PRINTSⁱ	PR00405 REVINTRACTNG
SMARTⁱ	View protein in SMART SM00105 ArfGap, 1 hit
SUPFAMⁱ	SSF57863 SSF57863, 1 hit
PROSITEⁱ	View protein in PROSITE PS50115 ARFGAP, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O95081-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVMAAKKGPG PGGGVSGGKA EAEAASEVWC RRVRELGGCS QAGNRHCFEC 
        60         70         80         90        100
AQRGVTYVDI TVGSFVCTTC SGLLRGLNPP HRVKSISMTT FTEPEVVFLQ 
       110        120        130        140        150
SRGNEVCRKI WLGLFDARTS LVPDSRDPQK VKEFLQEKYE KKRWYVPPDQ 
       160        170        180        190        200
VKGPTYTKGS ASTPVQGSIP EGKPLRTLLG DPAPSLSVAA STSSQPVSQS 
       210        220        230        240        250
HARTSQARST QPPPHSSVKK ASTDLLADIG GDPFAAPQMA PAFAAFPAFG 
       260        270        280        290        300
GQTPSQGGFA NFDAFSSGPS SSVFGSLPPA GQASFQAQPT PAGSSQGTPF 
       310        320        330        340        350
GATPLAPASQ PNSLADVGSF LGPGVPAAGV PSSLFGMAGQ VPPLQSVTMG 
       360        370        380        390        400
GGGGSSTGLA FGAFTNPFTA PAAQSPLPST NPFQPNGLAP GPGFGMSSAG 
       410        420        430        440        450
PGFPQAVPPT GAFASSFPAP LFPPQTPLVQ QQNGSSFGDL GSAKLGQRPL 
       460        470        480 
SQPAGISTNP FMTGPSSSPF ASKPPTTNPF L

Length:481

Mass (Da):48,963

Last modified:June 21, 2004 - v2

Checksum:ⁱA89202A0F0924FE2

Isoform 2 (identifier: O95081-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
145-155: YVPPDQVKGPT → PDTFPRRLCQL
157-481: Missing.

« Hide

        10         20         30         40         50
MVMAAKKGPG PGGGVSGGKA EAEAASEVWC RRVRELGGCS QAGNRHCFEC 
        60         70         80         90        100
AQRGVTYVDI TVGSFVCTTC SGLLRGLNPP HRVKSISMTT FTEPEVVFLQ 
       110        120        130        140        150
SRGNEVCRKI WLGLFDARTS LVPDSRDPQK VKEFLQEKYE KKRWPDTFPR 

RLCQLY

Show »

Length:156

Mass (Da):17,344

Checksum:ⁱ3FB8EBEDE73DD1EB

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0C4DG34	A0A0C4DG34_HUMAN	Arf-GAP domain and FG repeat-contai... Arf-GAP domain and FG repeat-containing protein 2 (HIV-1 Rev binding protein-like, isoform CRA_c)	AGFG2 HRBL, hCG_20457	155	Annotation score:
H7BZA5	H7BZA5_HUMAN	Arf-GAP domain and FG repeat-contai... Arf-GAP domain and FG repeat-containing protein 2	AGFG2	223	Annotation score:

Sequence cautionⁱ

The sequence AAC78803 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	96	V → L in AAD01550 (PubMed:9303539).Curated	1
Sequence conflictⁱ	124	D → N in AAD01550 (PubMed:9303539).Curated	1
Sequence conflictⁱ	206	Q → H in AAC78803 (PubMed:9799793).Curated	1
Sequence conflictⁱ	349	M → T in AAH17329 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050566	365	T → N. Corresponds to variant dbSNP:rs34731997Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_010667	145 – 155	YVPPDQVKGPT → PDTFPRRLCQL in isoform 2. 1 PublicationAdd BLAST		11
Alternative sequenceⁱVSP_010668	157 – 481	Missing in isoform 2. 1 PublicationAdd BLAST		325

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF015042 mRNA Translation: AAD01550.1 BC009393 mRNA Translation: AAH09393.1 BC017329 mRNA Translation: AAH17329.1 AF053356 Genomic DNA Translation: AAC78803.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5697.1 [O95081-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_006067.3, NM_006076.4 [O95081-1]
UniGeneⁱ	Hs.521083

Genome annotation databases

Ensemblⁱ	ENST00000300176; ENSP00000300176; ENSG00000106351 [O95081-1]
GeneIDⁱ	3268
KEGGⁱ	hsa:3268
UCSC genome browser More...UCSCⁱ	uc003uvf.4 human [O95081-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
O95081	HIV-1 Rev binding protein-like		HUMAN		481	UniRef100_O95081
UPI00004244E2		HUMAN		394
O95081-2	Arf-GAP domain and FG repeat-containing protein 2		HUMAN		155	UniRef100_A0A0C4DG34
AGFG2 isoform 4		PANTR		155

Protein	Similar proteins		Species	Score	Length	Source
O95081	HIV-1 Rev binding protein-like		HUMAN		481	UniRef90_O95081
Arf-GAP domain and FG repeat-containing protein 2		CALJA		481
AGFG2 isoform 1		PANTR		480
Uncharacterized protein		PANPA		480
Uncharacterized protein		MACMU		479
+22
O95081-2	Arf-GAP domain and FG repeat-containing protein 2		HUMAN		155	UniRef90_A0A0C4DG34
AGFG2 isoform 4		PANTR		155
ArfGAP with FG repeats 2		CALJA		157
Uncharacterized protein		PROCO		155
AGFG2 isoform 4		PONAB		155
+3

Protein	Similar proteins		Species	Score	Length	Source
O95081	Arf-GAP domain and FG repeat-containing protein 2		MOUSE		479	UniRef50_O95081
HIV-1 Rev binding protein-like		HUMAN		481
Arf-GAP domain and FG repeat-containing protein 2		CALJA		481
AGFG2 isoform 1		PANTR		480
Uncharacterized protein		PANPA		480
+279
O95081-2	Arf-GAP domain and FG repeat-containing protein 2		HUMAN		155	UniRef50_A0A0C4DG34
AGFG2 isoform 4		PANTR		155
ArfGAP with FG repeats 2		CALJA		157
Uncharacterized protein		PROCO		155
AGFG2 isoform 4		PONAB		155
+5

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF015042 mRNA Translation: AAD01550.1 BC009393 mRNA Translation: AAH09393.1 BC017329 mRNA Translation: AAH17329.1 AF053356 Genomic DNA Translation: AAC78803.1 Sequence problems.
CCDSⁱ	CCDS5697.1 [O95081-1]
RefSeqⁱ	NP_006067.3, NM_006076.4 [O95081-1]
UniGeneⁱ	Hs.521083

3D structure databases

ProteinModelPortalⁱ	O95081
SMRⁱ	O95081
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109504, 11 interactors
ELMⁱ	O95081
IntActⁱ	O95081, 2 interactors
STRINGⁱ	9606.ENSP00000300176

PTM databases

iPTMnetⁱ	O95081
PhosphoSitePlusⁱ	O95081

Polymorphism and mutation databases

BioMutaⁱ	AGFG2

BioMutaⁱ

AGFG2

Proteomic databases

EPDⁱ	O95081
MaxQBⁱ	O95081
PaxDbⁱ	O95081
PeptideAtlasⁱ	O95081
PRIDEⁱ	O95081
ProteomicsDBⁱ	50647 50648 [O95081-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000300176; ENSP00000300176; ENSG00000106351 [O95081-1]
GeneIDⁱ	3268
KEGGⁱ	hsa:3268
UCSCⁱ	uc003uvf.4 human [O95081-1]

Organism-specific databases

CTDⁱ	3268
DisGeNETⁱ	3268
EuPathDBⁱ	HostDB:ENSG00000106351.12
GeneCardsⁱ	AGFG2
HGNCⁱ	HGNC:5177 AGFG2
HPAⁱ	HPA019689
MIMⁱ	604019 gene
neXtProtⁱ	NX_O95081
OpenTargetsⁱ	ENSG00000106351
PharmGKBⁱ	PA29451
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0702 Eukaryota ENOG41122WA LUCA
GeneTreeⁱ	ENSGT00560000077249
HOGENOMⁱ	HOG000253009
HOVERGENⁱ	HBG006551
InParanoidⁱ	O95081
OMAⁱ	SDCKRNK
OrthoDBⁱ	EOG091G09LC
PhylomeDBⁱ	O95081
TreeFamⁱ	TF325357

Miscellaneous databases

ChiTaRSⁱ	AGFG2 human
GeneWikiⁱ	HRBL
GenomeRNAiⁱ	3268
Protein Ontology More...PROⁱ	PR:O95081
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000106351 Expressed in 169 organ(s), highest expression level in parotid gland
CleanExⁱ	HS_AGFG2
ExpressionAtlasⁱ	O95081 baseline and differential
Genevisibleⁱ	O95081 HS

Family and domain databases

Gene3Dⁱ	3.30.40.160, 1 hit
InterProⁱ	View protein in InterPro IPR037278 ARFGAP/RecO IPR001164 ArfGAP_dom IPR038508 ArfGAP_dom_sf
Pfamⁱ	View protein in Pfam PF01412 ArfGap, 1 hit
PRINTSⁱ	PR00405 REVINTRACTNG
SMARTⁱ	View protein in SMART SM00105 ArfGap, 1 hit
SUPFAMⁱ	SSF57863 SSF57863, 1 hit
PROSITEⁱ	View protein in PROSITE PS50115 ARFGAP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AGFG2_HUMAN
Accessionⁱ	O95081Primary (citable) accession number: O95081 Secondary accession number(s): O75429, Q96AB9, Q96GL4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 21, 2004
	Last sequence update:	June 21, 2004
	Last modified:	November 7, 2018
	This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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UniProtKB - O95081 (AGFG2_HUMAN)

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Arf-GAP domain and FG repeat-containing protein 2

AGFG2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ