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Protein

Arf-GAP domain and FG repeat-containing protein 2

Gene

AGFG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri47 – 70C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP domain and FG repeat-containing protein 2
Alternative name(s):
HIV-1 Rev-binding protein-like protein
Rev/Rex activation domain-binding protein related
Short name:
RAB-R
Gene namesi
Name:AGFG2
Synonyms:HRBL, RABR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106351.12
HGNCiHGNC:5177 AGFG2
MIMi604019 gene
neXtProtiNX_O95081

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi3268
OpenTargetsiENSG00000106351
PharmGKBiPA29451

Polymorphism and mutation databases

BioMutaiAGFG2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002048281 – 481Arf-GAP domain and FG repeat-containing protein 2Add BLAST481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO95081
MaxQBiO95081
PaxDbiO95081
PeptideAtlasiO95081
PRIDEiO95081
ProteomicsDBi50647
50648 [O95081-2]

PTM databases

iPTMnetiO95081
PhosphoSitePlusiO95081

Expressioni

Gene expression databases

BgeeiENSG00000106351 Expressed in 169 organ(s), highest expression level in parotid gland
CleanExiHS_AGFG2
ExpressionAtlasiO95081 baseline and differential
GenevisibleiO95081 HS

Organism-specific databases

HPAiHPA019689

Interactioni

Subunit structurei

Interacts with EPS15R.By similarity

Protein-protein interaction databases

BioGridi109504, 11 interactors
ELMiO95081
IntActiO95081, 2 interactors
STRINGi9606.ENSP00000300176

Structurei

3D structure databases

ProteinModelPortaliO95081
SMRiO95081
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 153Arf-GAPPROSITE-ProRule annotationAdd BLAST127

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi367 – 427Pro-richAdd BLAST61

Domaini

Contains FG repeats and 4 N-P-F repeats.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri47 – 70C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0702 Eukaryota
ENOG41122WA LUCA
GeneTreeiENSGT00560000077249
HOGENOMiHOG000253009
HOVERGENiHBG006551
InParanoidiO95081
OMAiSDCKRNK
OrthoDBiEOG091G09LC
PhylomeDBiO95081
TreeFamiTF325357

Family and domain databases

Gene3Di3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SUPFAMiSSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95081-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVMAAKKGPG PGGGVSGGKA EAEAASEVWC RRVRELGGCS QAGNRHCFEC
60 70 80 90 100
AQRGVTYVDI TVGSFVCTTC SGLLRGLNPP HRVKSISMTT FTEPEVVFLQ
110 120 130 140 150
SRGNEVCRKI WLGLFDARTS LVPDSRDPQK VKEFLQEKYE KKRWYVPPDQ
160 170 180 190 200
VKGPTYTKGS ASTPVQGSIP EGKPLRTLLG DPAPSLSVAA STSSQPVSQS
210 220 230 240 250
HARTSQARST QPPPHSSVKK ASTDLLADIG GDPFAAPQMA PAFAAFPAFG
260 270 280 290 300
GQTPSQGGFA NFDAFSSGPS SSVFGSLPPA GQASFQAQPT PAGSSQGTPF
310 320 330 340 350
GATPLAPASQ PNSLADVGSF LGPGVPAAGV PSSLFGMAGQ VPPLQSVTMG
360 370 380 390 400
GGGGSSTGLA FGAFTNPFTA PAAQSPLPST NPFQPNGLAP GPGFGMSSAG
410 420 430 440 450
PGFPQAVPPT GAFASSFPAP LFPPQTPLVQ QQNGSSFGDL GSAKLGQRPL
460 470 480
SQPAGISTNP FMTGPSSSPF ASKPPTTNPF L
Length:481
Mass (Da):48,963
Last modified:June 21, 2004 - v2
Checksum:iA89202A0F0924FE2
GO
Isoform 2 (identifier: O95081-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-155: YVPPDQVKGPT → PDTFPRRLCQL
     157-481: Missing.

Show »
Length:156
Mass (Da):17,344
Checksum:i3FB8EBEDE73DD1EB
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DG34A0A0C4DG34_HUMAN
Arf-GAP domain and FG repeat-contai...
AGFG2 HRBL, hCG_20457
155Annotation score:
H7BZA5H7BZA5_HUMAN
Arf-GAP domain and FG repeat-contai...
AGFG2
223Annotation score:

Sequence cautioni

The sequence AAC78803 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96V → L in AAD01550 (PubMed:9303539).Curated1
Sequence conflicti124D → N in AAD01550 (PubMed:9303539).Curated1
Sequence conflicti206Q → H in AAC78803 (PubMed:9799793).Curated1
Sequence conflicti349M → T in AAH17329 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050566365T → N. Corresponds to variant dbSNP:rs34731997Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010667145 – 155YVPPDQVKGPT → PDTFPRRLCQL in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_010668157 – 481Missing in isoform 2. 1 PublicationAdd BLAST325

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015042 mRNA Translation: AAD01550.1
BC009393 mRNA Translation: AAH09393.1
BC017329 mRNA Translation: AAH17329.1
AF053356 Genomic DNA Translation: AAC78803.1 Sequence problems.
CCDSiCCDS5697.1 [O95081-1]
RefSeqiNP_006067.3, NM_006076.4 [O95081-1]
UniGeneiHs.521083

Genome annotation databases

EnsembliENST00000300176; ENSP00000300176; ENSG00000106351 [O95081-1]
GeneIDi3268
KEGGihsa:3268
UCSCiuc003uvf.4 human [O95081-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015042 mRNA Translation: AAD01550.1
BC009393 mRNA Translation: AAH09393.1
BC017329 mRNA Translation: AAH17329.1
AF053356 Genomic DNA Translation: AAC78803.1 Sequence problems.
CCDSiCCDS5697.1 [O95081-1]
RefSeqiNP_006067.3, NM_006076.4 [O95081-1]
UniGeneiHs.521083

3D structure databases

ProteinModelPortaliO95081
SMRiO95081
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109504, 11 interactors
ELMiO95081
IntActiO95081, 2 interactors
STRINGi9606.ENSP00000300176

PTM databases

iPTMnetiO95081
PhosphoSitePlusiO95081

Polymorphism and mutation databases

BioMutaiAGFG2

Proteomic databases

EPDiO95081
MaxQBiO95081
PaxDbiO95081
PeptideAtlasiO95081
PRIDEiO95081
ProteomicsDBi50647
50648 [O95081-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300176; ENSP00000300176; ENSG00000106351 [O95081-1]
GeneIDi3268
KEGGihsa:3268
UCSCiuc003uvf.4 human [O95081-1]

Organism-specific databases

CTDi3268
DisGeNETi3268
EuPathDBiHostDB:ENSG00000106351.12
GeneCardsiAGFG2
HGNCiHGNC:5177 AGFG2
HPAiHPA019689
MIMi604019 gene
neXtProtiNX_O95081
OpenTargetsiENSG00000106351
PharmGKBiPA29451
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0702 Eukaryota
ENOG41122WA LUCA
GeneTreeiENSGT00560000077249
HOGENOMiHOG000253009
HOVERGENiHBG006551
InParanoidiO95081
OMAiSDCKRNK
OrthoDBiEOG091G09LC
PhylomeDBiO95081
TreeFamiTF325357

Miscellaneous databases

ChiTaRSiAGFG2 human
GeneWikiiHRBL
GenomeRNAii3268
PROiPR:O95081
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106351 Expressed in 169 organ(s), highest expression level in parotid gland
CleanExiHS_AGFG2
ExpressionAtlasiO95081 baseline and differential
GenevisibleiO95081 HS

Family and domain databases

Gene3Di3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SUPFAMiSSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAGFG2_HUMAN
AccessioniPrimary (citable) accession number: O95081
Secondary accession number(s): O75429, Q96AB9, Q96GL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: November 7, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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