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Protein

Homeobox protein aristaless-like 3

Gene

ALX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator with a possible role in patterning of mesoderm during development.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi153 – 212HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein aristaless-like 3
Alternative name(s):
Proline-rich transcription factor ALX3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ALX3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000156150.6

Human Gene Nomenclature Database

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HGNCi
HGNC:449 ALX3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606014 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95076

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Frontonasal dysplasia 1 (FND1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionThe term frontonasal dysplasia describes an array of abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of formation of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widow's peak frontal hairline.
See also OMIM:136760
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_063226168L → V in FND1. 1 PublicationCorresponds to variant dbSNP:rs121908167EnsemblClinVar.1
Natural variantiVAR_063227183R → W in FND1. 1 PublicationCorresponds to variant dbSNP:rs121908168EnsemblClinVar.1
Natural variantiVAR_063228196R → W in FND1. 1 PublicationCorresponds to variant dbSNP:rs121908170EnsemblClinVar.1
Natural variantiVAR_063229203N → S in FND1. 1 PublicationCorresponds to variant dbSNP:rs121908166EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
257

MalaCards human disease database

More...
MalaCardsi
ALX3
MIMi136760 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000156150

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
391474 Frontorhiny

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24754

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ALX3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000488121 – 343Homeobox protein aristaless-like 3Add BLAST343

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O95076

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O95076

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95076

PeptideAtlas

More...
PeptideAtlasi
O95076

PRoteomics IDEntifications database

More...
PRIDEi
O95076

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50646

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95076

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95076

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000156150 Expressed in 30 organ(s), highest expression level in adenohypophysis

CleanEx database of gene expression profiles

More...
CleanExi
HS_ALX3

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95076 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106755, 19 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358807

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O95076

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O95076

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0490 Eukaryota
ENOG410YIJ3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160669

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231518

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004213

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95076

KEGG Orthology (KO)

More...
KOi
K09323

Identification of Orthologs from Complete Genome Data

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OMAi
SIHGFPP

Database of Orthologous Groups

More...
OrthoDBi
738339at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O95076

TreeFam database of animal gene trees

More...
TreeFami
TF350743

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086 homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033211 ALX3
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom

The PANTHER Classification System

More...
PANTHERi
PTHR24329:SF340 PTHR24329:SF340, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046 Homeodomain, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389 HOX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O95076-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPEHCAPFR VGPAPGPYVA SGDEPPGPQG TPAAAPHLHP APPRGPRLTR
60 70 80 90 100
FPACGPLEPY LPEPAKPPAK YLQDLGPGPA LNGGHFYEGP AEAEEKTSKA
110 120 130 140 150
ASFPQLPLDC RGGPRDGPSN LQGSPGPCLA SLHLPLSPGL PDSMELAKNK
160 170 180 190 200
SKKRRNRTTF STFQLEELEK VFQKTHYPDV YAREQLALRT DLTEARVQVW
210 220 230 240 250
FQNRRAKWRK RERYGKIQEG RNPFTAAYDI SVLPRTDSHP QLQNSLWASP
260 270 280 290 300
GSGSPGGPCL VSPEGIPSPC MSPYSHPHGS VAGFMGVPAP SAAHPGIYSI
310 320 330 340
HGFPPTLGGH SFEPSSDGDY KSPSLVSLRV KPKEPPGLLN WTT
Length:343
Mass (Da):36,935
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0BB20630D5CB817B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3IS30A0A3B3IS30_HUMAN
Homeobox protein aristaless-like 3
ALX3
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti72L → M in AAD01417 (PubMed:11807986).Curated1
Sequence conflicti86F → L in AAD01417 (PubMed:11807986).Curated1
Sequence conflicti249S → G in AAD01418 (PubMed:11807986).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063226168L → V in FND1. 1 PublicationCorresponds to variant dbSNP:rs121908167EnsemblClinVar.1
Natural variantiVAR_063227183R → W in FND1. 1 PublicationCorresponds to variant dbSNP:rs121908168EnsemblClinVar.1
Natural variantiVAR_063228196R → W in FND1. 1 PublicationCorresponds to variant dbSNP:rs121908170EnsemblClinVar.1
Natural variantiVAR_063229203N → S in FND1. 1 PublicationCorresponds to variant dbSNP:rs121908166EnsemblClinVar.1
Natural variantiVAR_047475234P → A. Corresponds to variant dbSNP:rs12749726Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF008202 Genomic DNA Translation: AAD01417.2
AF008203 mRNA Translation: AAD01418.1
AL160006 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56430.1
BC112007 mRNA Translation: AAI12008.1
BC113428 mRNA Translation: AAI13429.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS819.1

NCBI Reference Sequences

More...
RefSeqi
NP_006483.2, NM_006492.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.669953

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369792; ENSP00000358807; ENSG00000156150
ENST00000647563; ENSP00000497310; ENSG00000156150

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
257

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:257

UCSC genome browser

More...
UCSCi
uc001dzb.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008202 Genomic DNA Translation: AAD01417.2
AF008203 mRNA Translation: AAD01418.1
AL160006 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56430.1
BC112007 mRNA Translation: AAI12008.1
BC113428 mRNA Translation: AAI13429.1
CCDSiCCDS819.1
RefSeqiNP_006483.2, NM_006492.2
UniGeneiHs.669953

3D structure databases

ProteinModelPortaliO95076
SMRiO95076
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106755, 19 interactors
STRINGi9606.ENSP00000358807

PTM databases

iPTMnetiO95076
PhosphoSitePlusiO95076

Polymorphism and mutation databases

BioMutaiALX3

Proteomic databases

EPDiO95076
jPOSTiO95076
PaxDbiO95076
PeptideAtlasiO95076
PRIDEiO95076
ProteomicsDBi50646

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369792; ENSP00000358807; ENSG00000156150
ENST00000647563; ENSP00000497310; ENSG00000156150
GeneIDi257
KEGGihsa:257
UCSCiuc001dzb.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
257
DisGeNETi257
EuPathDBiHostDB:ENSG00000156150.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ALX3

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0023725
HIX0159682
HGNCiHGNC:449 ALX3
MalaCardsiALX3
MIMi136760 phenotype
606014 gene
neXtProtiNX_O95076
OpenTargetsiENSG00000156150
Orphaneti391474 Frontorhiny
PharmGKBiPA24754

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00940000160669
HOGENOMiHOG000231518
HOVERGENiHBG004213
InParanoidiO95076
KOiK09323
OMAiSIHGFPP
OrthoDBi738339at2759
PhylomeDBiO95076
TreeFamiTF350743

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
257

Protein Ontology

More...
PROi
PR:O95076

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000156150 Expressed in 30 organ(s), highest expression level in adenohypophysis
CleanExiHS_ALX3
GenevisibleiO95076 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR033211 ALX3
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PANTHERiPTHR24329:SF340 PTHR24329:SF340, 1 hit
PfamiView protein in Pfam
PF00046 Homeodomain, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALX3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95076
Secondary accession number(s): O95075, Q5T8M4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 25, 2008
Last modified: January 16, 2019
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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