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Protein

Fibrinogen silencer-binding protein

Gene

FSBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1.1 Publication

Miscellaneous

Intragenic, in the second intron of RAB54B gene.

GO - Molecular functioni

  • identical protein binding Source: IntAct

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrinogen silencer-binding protein
Gene namesi
Name:FSBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000265817.1
HGNCiHGNC:43653 FSBP
MIMi616306 gene
neXtProtiNX_O95073

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi100861412
25788
OpenTargetsiENSG00000265817

Polymorphism and mutation databases

BioMutaiFSBP

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000873521 – 299Fibrinogen silencer-binding proteinAdd BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiO95073
PaxDbiO95073
PeptideAtlasiO95073
PRIDEiO95073
ProteomicsDBi50644
50645 [O95073-2]

PTM databases

iPTMnetiO95073
PhosphoSitePlusiO95073

Expressioni

Tissue specificityi

Expressed in multiple tissues including brain.1 Publication

Gene expression databases

BgeeiENSG00000265817 Expressed in 90 organ(s), highest expression level in corpus callosum
ExpressionAtlasiO95073 baseline
GenevisibleiO95073 HS

Organism-specific databases

HPAiHPA025059
HPA026509

Interactioni

Subunit structurei

Interacts with APBA1 (via PDZ 1 and 2 domains).1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117321, 38 interactors
IntActiO95073, 15 interactors
STRINGi9606.ENSP00000420405

Structurei

3D structure databases

ProteinModelPortaliO95073
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IVMX Eukaryota
ENOG4111FZT LUCA
GeneTreeiENSGT00920000149014
HOGENOMiHOG000112654
HOVERGENiHBG051662
InParanoidiO95073
OMAiCWDIIAD
OrthoDBiEOG091G0EVL
PhylomeDBiO95073
TreeFamiTF331896

Family and domain databases

InterProiView protein in InterPro
IPR028002 Myb_DNA-bind_5
PfamiView protein in Pfam
PF13873 Myb_DNA-bind_5, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95073-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVGKARSSNF TLSEKLDLLK LVKPYVKILE EHTNKHSVIV EKNRCWDIIA
60 70 80 90 100
VNYNAIGVDR PPRTAQGLRT LYKRLKEYAK QELLQQKETQ SDFKSNISEP
110 120 130 140 150
TKKVMEMIPQ ISSFCLVRDR NHIQSANLDE EAQAGTSSLQ VMLDHHPVAI
160 170 180 190 200
TVEVKQEEDI KPPPPLVLNS QQSDTLEQRE EHELVHVMER SLSPSLSSVD
210 220 230 240 250
MRMTSSPSSI PRRDDFFRHE SGEHFRSLLG YDPQILQMLK EEHQIILENQ
260 270 280 290
KNFGLYVQEK RDGLKRRQQL EEELLRAKIE VEKLKAIRLR HDLPEYNSL
Length:299
Mass (Da):34,768
Last modified:May 1, 1999 - v1
Checksum:i3CC89EC32A377B2F
GO
Isoform 2 (identifier: O95073-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-141: Missing.

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):18,626
Checksum:i974DA0DC61B99879
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0H2A0A087X0H2_HUMAN
Fibrinogen silencer-binding protein
FSBP hCG_2009220
726Annotation score:
J3KSW4J3KSW4_HUMAN
Fibrinogen silencer-binding protein
FSBP
129Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019301226R → K1 PublicationCorresponds to variant dbSNP:rs3136422Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0107741 – 141Missing in isoform 2. 1 PublicationAdd BLAST141

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007866 mRNA Translation: AAD09313.1
AF487652 Genomic DNA Translation: AAL96666.1
AC023632 Genomic DNA No translation available.
BC033710 mRNA Translation: AAH33710.2
CCDSiCCDS59106.1 [O95073-1]
RefSeqiNP_001192191.1, NM_001205262.2
NP_001243070.1, NM_001256141.1 [O95073-1]
UniGeneiHs.30561
Hs.744229

Genome annotation databases

EnsembliENST00000481490; ENSP00000420405; ENSG00000265817 [O95073-1]
GeneIDi100861412
25788
KEGGihsa:100861412
UCSCiuc003ygm.4 human [O95073-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007866 mRNA Translation: AAD09313.1
AF487652 Genomic DNA Translation: AAL96666.1
AC023632 Genomic DNA No translation available.
BC033710 mRNA Translation: AAH33710.2
CCDSiCCDS59106.1 [O95073-1]
RefSeqiNP_001192191.1, NM_001205262.2
NP_001243070.1, NM_001256141.1 [O95073-1]
UniGeneiHs.30561
Hs.744229

3D structure databases

ProteinModelPortaliO95073
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117321, 38 interactors
IntActiO95073, 15 interactors
STRINGi9606.ENSP00000420405

PTM databases

iPTMnetiO95073
PhosphoSitePlusiO95073

Polymorphism and mutation databases

BioMutaiFSBP

Proteomic databases

EPDiO95073
PaxDbiO95073
PeptideAtlasiO95073
PRIDEiO95073
ProteomicsDBi50644
50645 [O95073-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000481490; ENSP00000420405; ENSG00000265817 [O95073-1]
GeneIDi100861412
25788
KEGGihsa:100861412
UCSCiuc003ygm.4 human [O95073-1]

Organism-specific databases

CTDi100861412
25788
DisGeNETi100861412
25788
EuPathDBiHostDB:ENSG00000265817.1
GeneCardsiFSBP
HGNCiHGNC:43653 FSBP
HPAiHPA025059
HPA026509
MIMi616306 gene
neXtProtiNX_O95073
OpenTargetsiENSG00000265817
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVMX Eukaryota
ENOG4111FZT LUCA
GeneTreeiENSGT00920000149014
HOGENOMiHOG000112654
HOVERGENiHBG051662
InParanoidiO95073
OMAiCWDIIAD
OrthoDBiEOG091G0EVL
PhylomeDBiO95073
TreeFamiTF331896

Miscellaneous databases

GeneWikiiRAD54B
PROiPR:O95073
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000265817 Expressed in 90 organ(s), highest expression level in corpus callosum
ExpressionAtlasiO95073 baseline
GenevisibleiO95073 HS

Family and domain databases

InterProiView protein in InterPro
IPR028002 Myb_DNA-bind_5
PfamiView protein in Pfam
PF13873 Myb_DNA-bind_5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFSBP_HUMAN
AccessioniPrimary (citable) accession number: O95073
Secondary accession number(s): Q8N4S5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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