UniProtKB - O95071 (UBR5_HUMAN)
E3 ubiquitin-protein ligase UBR5
UBR5
Functioni
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity).
Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.
By similarity3 PublicationsMiscellaneous
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.26
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 2768 | Glycyl thioester intermediatePROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1177 – 1245 | UBR-typePROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- RNA binding Source: InterPro
- ubiquitin binding Source: InterPro
- ubiquitin protein ligase activity Source: FlyBase
- ubiquitin-ubiquitin ligase activity Source: BHF-UCL
- zinc ion binding Source: InterPro
GO - Biological processi
- cellular response to DNA damage stimulus Source: HGNC-UCL
- DNA repair Source: UniProtKB-KW
- negative regulation of double-strand break repair Source: UniProtKB
- negative regulation of histone H2A K63-linked ubiquitination Source: UniProtKB
- positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
- positive regulation of gene expression Source: MGI
- positive regulation of protein import into nucleus Source: BHF-UCL
- progesterone receptor signaling pathway Source: HGNC-UCL
- protein K48-linked ubiquitination Source: FlyBase
- protein polyubiquitination Source: BHF-UCL
- regulation of double-strand break repair Source: GO_Central
Keywordsi
Molecular function | Transferase |
Biological process | DNA damage, DNA repair, Host-virus interaction, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O95071 |
SignaLinki | O95071 |
SIGNORi | O95071 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase UBR5 (EC:2.3.2.26)Alternative name(s): E3 ubiquitin-protein ligase, HECT domain-containing 1 HECT-type E3 ubiquitin transferase UBR5 Hyperplastic discs protein homolog Short name: hHYD Progestin-induced protein |
Gene namesi | Name:UBR5 Synonyms:EDD, EDD1, HYD, KIAA0896 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16806, UBR5 |
MIMi | 608413, gene |
neXtProti | NX_O95071 |
VEuPathDBi | HostDB:ENSG00000104517 |
Subcellular locationi
Nucleus
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: HGNC-UCL
Other locations
- membrane Source: UniProtKB
- perinuclear region of cytoplasm Source: MGI
- protein-containing complex Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 2768 | C → A: Loss of ubiquitin binding. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 51366 |
OpenTargetsi | ENSG00000104517 |
PharmGKBi | PA162408175 |
Miscellaneous databases
Pharosi | O95071, Tbio |
Genetic variation databases
BioMutai | UBR5 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000086931 | 2 – 2799 | E3 ubiquitin-protein ligase UBR5Add BLAST | 2798 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylthreonineCombined sources | 1 | |
Modified residuei | 110 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 327 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 352 | Phosphoserine1 Publication | 1 | |
Modified residuei | 578 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 612 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 637 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 808 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 928 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1018 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1115 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 1135 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 1227 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1308 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 1355 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1375 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1481 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1549 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1736 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 1741 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1746 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 1780 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1969 | PhosphothreonineCombined sources1 Publication | 1 | |
Modified residuei | 1990 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2026 | Phosphoserine1 Publication | 1 | |
Modified residuei | 2028 | Phosphoserine1 Publication | 1 | |
Modified residuei | 2030 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 2076 | Phosphoserine1 Publication | 1 | |
Modified residuei | 2213 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 2241 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2289 | Phosphoserine1 Publication | 1 | |
Modified residuei | 2469 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2484 | Phosphoserine1 Publication | 1 | |
Modified residuei | 2486 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O95071 |
jPOSTi | O95071 |
MassIVEi | O95071 |
MaxQBi | O95071 |
PaxDbi | O95071 |
PeptideAtlasi | O95071 |
PRIDEi | O95071 |
ProteomicsDBi | 50641 [O95071-1] |
PTM databases
GlyGeni | O95071, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O95071 |
PhosphoSitePlusi | O95071 |
SwissPalmi | O95071 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000104517, Expressed in testis and 238 other tissues |
ExpressionAtlasi | O95071, baseline and differential |
Genevisiblei | O95071, HS |
Organism-specific databases
HPAi | ENSG00000104517, Low tissue specificity |
Interactioni
Subunit structurei
Binds TOPBP1. Associates with CDK9 and TFIIS/TCEA1 and forms a transcription regulatory complex made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription (e.g. gamma fibrinogen/FGG) by recruiting their promoters. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex).
Interacts directly with DYRK2.
Interacts with PIH1D1 (PubMed:24656813).
4 Publications(Microbial infection) Interacts with human T-cell leukemia virus 1/HTLV-1 protein HBZ; this interaction modulates HBZ stability.
1 PublicationBinary interactionsi
O95071
With | #Exp. | IntAct |
---|---|---|
CTNNB1 [P35222] | 6 | EBI-358329,EBI-491549 |
GSK3B [P49841] | 8 | EBI-358329,EBI-373586 |
PAIP2 [Q9BPZ3] | 5 | EBI-358329,EBI-2957445 |
GO - Molecular functioni
- ubiquitin binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 119501, 395 interactors |
CORUMi | O95071 |
DIPi | DIP-32930N |
ELMi | O95071 |
IntActi | O95071, 109 interactors |
MINTi | O95071 |
STRINGi | 9606.ENSP00000429084 |
Miscellaneous databases
RNActi | O95071, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O95071 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O95071 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2377 – 2454 | PABCPROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 2462 – 2799 | HECTPROSITE-ProRule annotationAdd BLAST | 338 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 77 – 175 | DisorderedSequence analysisAdd BLAST | 99 | |
Regioni | 328 – 352 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 579 – 648 | DisorderedSequence analysisAdd BLAST | 70 | |
Regioni | 999 – 1031 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 1052 – 1075 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 1299 – 1318 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1515 – 1740 | DisorderedSequence analysisAdd BLAST | 226 | |
Regioni | 1859 – 1890 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 1984 – 2021 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 2117 – 2142 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 2323 – 2392 | DisorderedSequence analysisAdd BLAST | 70 | |
Regioni | 2473 – 2493 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 87 – 151 | Polar residuesSequence analysisAdd BLAST | 65 | |
Compositional biasi | 328 – 344 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 583 – 602 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 611 – 632 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1017 – 1031 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1052 – 1072 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 1521 – 1551 | Polar residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 1563 – 1577 | Acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1578 – 1607 | Basic and acidic residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 1622 – 1651 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 1660 – 1685 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 1693 – 1740 | Polar residuesSequence analysisAdd BLAST | 48 | |
Compositional biasi | 1876 – 1890 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1996 – 2014 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 2329 – 2370 | Basic and acidic residuesSequence analysisAdd BLAST | 42 | |
Compositional biasi | 2473 – 2491 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1177 – 1245 | UBR-typePROSITE-ProRule annotationAdd BLAST | 69 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG0943, Eukaryota |
GeneTreei | ENSGT00940000156357 |
InParanoidi | O95071 |
OMAi | EAKFRRD |
OrthoDBi | 717at2759 |
PhylomeDBi | O95071 |
TreeFami | TF314406 |
Family and domain databases
CDDi | cd14423, CUE_UBR5, 1 hit |
Gene3Di | 2.130.10.30, 1 hit |
IDEALi | IID00191 |
InterProi | View protein in InterPro IPR024725, E3_UbLigase_EDD_UBA IPR000569, HECT_dom IPR035983, Hect_E3_ubiquitin_ligase IPR036053, PABP-dom IPR002004, PABP_HYD IPR009091, RCC1/BLIP-II IPR003126, Znf_UBR |
Pfami | View protein in Pfam PF11547, E3_UbLigase_EDD, 1 hit PF00632, HECT, 1 hit PF00658, PABP, 1 hit |
SMARTi | View protein in SMART SM00119, HECTc, 1 hit SM00517, PolyA, 1 hit SM00396, ZnF_UBR1, 1 hit |
SUPFAMi | SSF50985, SSF50985, 1 hit SSF56204, SSF56204, 1 hit SSF63570, SSF63570, 1 hit |
PROSITEi | View protein in PROSITE PS50237, HECT, 1 hit PS51309, PABC, 1 hit PS51157, ZF_UBR, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTSIHFVVHP LPGTEDQLND RLREVSEKLN KYNLNSHPPL NVLEQATIKQ
60 70 80 90 100
CVVGPNHAAF LLEDGRVCRI GFSVQPDRLE LGKPDNNDGS KLNSNSGAGR
110 120 130 140 150
TSRPGRTSDS PWFLSGSETL GRLAGNTLGS RWSSGVGGSG GGSSGRSSAG
160 170 180 190 200
ARDSRRQTRV IRTGRDRGSG LLGSQPQPVI PASVIPEELI SQAQVVLQGK
210 220 230 240 250
SRSVIIRELQ RTNLDVNLAV NNLLSRDDED GDDGDDTASE SYLPGEDLMS
260 270 280 290 300
LLDADIHSAH PSVIIDADAM FSEDISYFGY PSFRRSSLSR LGSSRVLLLP
310 320 330 340 350
LERDSELLRE RESVLRLRER RWLDGASFDN ERGSTSKEGE PNLDKKNTPV
360 370 380 390 400
QSPVSLGEDL QWWPDKDGTK FICIGALYSE LLAVSSKGEL YQWKWSESEP
410 420 430 440 450
YRNAQNPSLH HPRATFLGLT NEKIVLLSAN SIRATVATEN NKVATWVDET
460 470 480 490 500
LSSVASKLEH TAQTYSELQG ERIVSLHCCA LYTCAQLENS LYWWGVVPFS
510 520 530 540 550
QRKKMLEKAR AKNKKPKSSA GISSMPNITV GTQVCLRNNP LYHAGAVAFS
560 570 580 590 600
ISAGIPKVGV LMESVWNMND SCRFQLRSPE SLKNMEKASK TTEAKPESKQ
610 620 630 640 650
EPVKTEMGPP PSPASTCSDA SSIASSASMP YKRRRSTPAP KEEEKVNEEQ
660 670 680 690 700
WSLREVVFVE DVKNVPVGKV LKVDGAYVAV KFPGTSSNTN CQNSSGPDAD
710 720 730 740 750
PSSLLQDCRL LRIDELQVVK TGGTPKVPDC FQRTPKKLCI PEKTEILAVN
760 770 780 790 800
VDSKGVHAVL KTGNWVRYCI FDLATGKAEQ ENNFPTSSIA FLGQNERNVA
810 820 830 840 850
IFTAGQESPI ILRDGNGTIY PMAKDCMGGI RDPDWLDLPP ISSLGMGVHS
860 870 880 890 900
LINLPANSTI KKKAAVIIMA VEKQTLMQHI LRCDYEACRQ YLMNLEQAVV
910 920 930 940 950
LEQNLQMLQT FISHRCDGNR NILHACVSVC FPTSNKETKE EEEAERSERN
960 970 980 990 1000
TFAERLSAVE AIANAISVVS SNGPGNRAGS SSSRSLRLRE MMRRSLRAAG
1010 1020 1030 1040 1050
LGRHEAGASS SDHQDPVSPP IAPPSWVPDP PAMDPDGDID FILAPAVGSL
1060 1070 1080 1090 1100
TTAATGTGQG PSTSTIPGPS TEPSVVESKD RKANAHFILK LLCDSVVLQP
1110 1120 1130 1140 1150
YLRELLSAKD ARGMTPFMSA VSGRAYPAAI TILETAQKIA KAEISSSEKE
1160 1170 1180 1190 1200
EDVFMGMVCP SGTNPDDSPL YVLCCNDTCS FTWTGAEHIN QDIFECRTCG
1210 1220 1230 1240 1250
LLESLCCCTE CARVCHKGHD CKLKRTSPTA YCDCWEKCKC KTLIAGQKSA
1260 1270 1280 1290 1300
RLDLLYRLLT ATNLVTLPNS RGEHLLLFLV QTVARQTVEH CQYRPPRIRE
1310 1320 1330 1340 1350
DRNRKTASPE DSDMPDHDLE PPRFAQLALE RVLQDWNALK SMIMFGSQEN
1360 1370 1380 1390 1400
KDPLSASSRI GHLLPEEQVY LNQQSGTIRL DCFTHCLIVK CTADILLLDT
1410 1420 1430 1440 1450
LLGTLVKELQ NKYTPGRREE AIAVTMRFLR SVARVFVILS VEMASSKKKN
1460 1470 1480 1490 1500
NFIPQPIGKC KRVFQALLPY AVEELCNVAE SLIVPVRMGI ARPTAPFTLA
1510 1520 1530 1540 1550
STSIDAMQGS EELFSVEPLP PRPSSDQSSS SSQSQSSYII RNPQQRRISQ
1560 1570 1580 1590 1600
SQPVRGRDEE QDDIVSADVE EVEVVEGVAG EEDHHDEQEE HGEENAEAEG
1610 1620 1630 1640 1650
QHDEHDEDGS DMELDLLAAA ETESDSESNH SNQDNASGRR SVVTAATAGS
1660 1670 1680 1690 1700
EAGASSVPAF FSEDDSQSND SSDSDSSSSQ SDDIEQETFM LDEPLERTTN
1710 1720 1730 1740 1750
SSHANGAAQA PRSMQWAVRN TQHQRAASTA PSSTSTPAAS SAGLIYIDPS
1760 1770 1780 1790 1800
NLRRSGTIST SAAAAAAALE ASNASSYLTS ASSLARAYSI VIRQISDLMG
1810 1820 1830 1840 1850
LIPKYNHLVY SQIPAAVKLT YQDAVNLQNY VEEKLIPTWN WMVSIMDSTE
1860 1870 1880 1890 1900
AQLRYGSALA SAGDPGHPNH PLHASQNSAR RERMTAREEA SLRTLEGRRR
1910 1920 1930 1940 1950
ATLLSARQGM MSARGDFLNY ALSLMRSHND EHSDVLPVLD VCSLKHVAYV
1960 1970 1980 1990 2000
FQALIYWIKA MNQQTTLDTP QLERKRTREL LELGIDNEDS EHENDDDTNQ
2010 2020 2030 2040 2050
SATLNDKDDD SLPAETGQNH PFFRRSDSMT FLGCIPPNPF EVPLAEAIPL
2060 2070 2080 2090 2100
ADQPHLLQPN ARKEDLFGRP SQGLYSSSAS SGKCLMEVTV DRNCLEVLPT
2110 2120 2130 2140 2150
KMSYAANLKN VMNMQNRQKK EGEEQPVLPE ETESSKPGPS AHDLAAQLKS
2160 2170 2180 2190 2200
SLLAEIGLTE SEGPPLTSFR PQCSFMGMVI SHDMLLGRWR LSLELFGRVF
2210 2220 2230 2240 2250
MEDVGAEPGS ILTELGGFEV KESKFRREME KLRNQQSRDL SLEVDRDRDL
2260 2270 2280 2290 2300
LIQQTMRQLN NHFGRRCATT PMAVHRVKVT FKDEPGEGSG VARSFYTAIA
2310 2320 2330 2340 2350
QAFLSNEKLP NLECIQNANK GTHTSLMQRL RNRGERDRER EREREMRRSS
2360 2370 2380 2390 2400
GLRAGSRRDR DRDFRRQLSI DTRPFRPASE GNPSDDPEPL PAHRQALGER
2410 2420 2430 2440 2450
LYPRVQAMQP AFASKITGML LELSPAQLLL LLASEDSLRA RVDEAMELII
2460 2470 2480 2490 2500
AHGRENGADS ILDLGLVDSS EKVQQENRKR HGSSRSVVDM DLDDTDDGDD
2510 2520 2530 2540 2550
NAPLFYQPGK RGFYTPRPGK NTEARLNCFR NIGRILGLCL LQNELCPITL
2560 2570 2580 2590 2600
NRHVIKVLLG RKVNWHDFAF FDPVMYESLR QLILASQSSD ADAVFSAMDL
2610 2620 2630 2640 2650
AFAIDLCKEE GGGQVELIPN GVNIPVTPQN VYEYVRKYAE HRMLVVAEQP
2660 2670 2680 2690 2700
LHAMRKGLLD VLPKNSLEDL TAEDFRLLVN GCGEVNVQML ISFTSFNDES
2710 2720 2730 2740 2750
GENAEKLLQF KRWFWSIVEK MSMTERQDLV YFWTSSPSLP ASEEGFQPMP
2760 2770 2780 2790
SITIRPPDDQ HLPTANTCIS RLYVPLYSSK QILKQKLLLA IKTKNFGFV
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EMW7 | E7EMW7_HUMAN | E3 ubiquitin-protein ligase UBR5 | UBR5 | 2,792 | Annotation score: | ||
E7ET84 | E7ET84_HUMAN | E3 ubiquitin-protein ligase UBR5 | UBR5 | 527 | Annotation score: | ||
H0YAV7 | H0YAV7_HUMAN | E3 ubiquitin-protein ligase UBR5 | UBR5 | 201 | Annotation score: | ||
H0YBB4 | H0YBB4_HUMAN | E3 ubiquitin-protein ligase UBR5 | UBR5 | 194 | Annotation score: | ||
E5RFK7 | E5RFK7_HUMAN | E3 ubiquitin-protein ligase UBR5 | UBR5 | 166 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 134 | S → P in AAF88143 (PubMed:11714696).Curated | 1 | |
Sequence conflicti | 229 | E → K in AAF88143 (PubMed:11714696).Curated | 1 | |
Sequence conflicti | 258 | S → Y in AAF88143 (PubMed:11714696).Curated | 1 | |
Sequence conflicti | 374 – 375 | IG → M in AAF88143 (PubMed:11714696).Curated | 2 | |
Sequence conflicti | 772 | D → H in AAF88143 (PubMed:11714696).Curated | 1 | |
Sequence conflicti | 780 | Q → R in AAF88143 (PubMed:11714696).Curated | 1 | |
Sequence conflicti | 884 | D → G in AAF88143 (PubMed:11714696).Curated | 1 | |
Sequence conflicti | 1811 | S → P in AAF88143 (PubMed:11714696).Curated | 1 | |
Sequence conflicti | 2144 | L → H in AAF88143 (PubMed:11714696).Curated | 1 | |
Sequence conflicti | 2282 | K → R in AAF88143 (PubMed:11714696).Curated | 1 | |
Sequence conflicti | 2489 | D → N in AAF88143 (PubMed:11714696).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051466 | 2150 | S → R. Corresponds to variant dbSNP:rs1062822Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054399 | 2474 | Missing in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF006010 mRNA Translation: AAD01259.2 U95000 mRNA Translation: AAF88143.1 AB020703 mRNA Translation: BAA74919.3 Different initiation. AP002907 Genomic DNA No translation available. AP002981 Genomic DNA No translation available. BC137234 mRNA Translation: AAI37235.1 |
CCDSi | CCDS34933.1 [O95071-1] CCDS64946.1 [O95071-2] |
RefSeqi | NP_001269802.1, NM_001282873.1 [O95071-2] NP_056986.2, NM_015902.5 [O95071-1] |
Genome annotation databases
Ensembli | ENST00000220959; ENSP00000220959; ENSG00000104517 [O95071-2] ENST00000520539; ENSP00000429084; ENSG00000104517 |
GeneIDi | 51366 |
KEGGi | hsa:51366 |
MANE-Selecti | ENST00000520539.6; ENSP00000429084.1; NM_015902.6; NP_056986.2 |
UCSCi | uc003ykr.3, human [O95071-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF006010 mRNA Translation: AAD01259.2 U95000 mRNA Translation: AAF88143.1 AB020703 mRNA Translation: BAA74919.3 Different initiation. AP002907 Genomic DNA No translation available. AP002981 Genomic DNA No translation available. BC137234 mRNA Translation: AAI37235.1 |
CCDSi | CCDS34933.1 [O95071-1] CCDS64946.1 [O95071-2] |
RefSeqi | NP_001269802.1, NM_001282873.1 [O95071-2] NP_056986.2, NM_015902.5 [O95071-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1I2T | X-ray | 1.04 | A | 2393-2453 | [»] | |
2QHO | X-ray | 1.85 | B/D/F/H | 180-230 | [»] | |
3PT3 | X-ray | 1.97 | A/B | 2687-2799 | [»] | |
SMRi | O95071 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119501, 395 interactors |
CORUMi | O95071 |
DIPi | DIP-32930N |
ELMi | O95071 |
IntActi | O95071, 109 interactors |
MINTi | O95071 |
STRINGi | 9606.ENSP00000429084 |
PTM databases
GlyGeni | O95071, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O95071 |
PhosphoSitePlusi | O95071 |
SwissPalmi | O95071 |
Genetic variation databases
BioMutai | UBR5 |
Proteomic databases
EPDi | O95071 |
jPOSTi | O95071 |
MassIVEi | O95071 |
MaxQBi | O95071 |
PaxDbi | O95071 |
PeptideAtlasi | O95071 |
PRIDEi | O95071 |
ProteomicsDBi | 50641 [O95071-1] |
Protocols and materials databases
Antibodypediai | 13236, 285 antibodies from 37 providers |
DNASUi | 51366 |
Genome annotation databases
Ensembli | ENST00000220959; ENSP00000220959; ENSG00000104517 [O95071-2] ENST00000520539; ENSP00000429084; ENSG00000104517 |
GeneIDi | 51366 |
KEGGi | hsa:51366 |
MANE-Selecti | ENST00000520539.6; ENSP00000429084.1; NM_015902.6; NP_056986.2 |
UCSCi | uc003ykr.3, human [O95071-1] |
Organism-specific databases
CTDi | 51366 |
DisGeNETi | 51366 |
GeneCardsi | UBR5 |
HGNCi | HGNC:16806, UBR5 |
HPAi | ENSG00000104517, Low tissue specificity |
MIMi | 608413, gene |
neXtProti | NX_O95071 |
OpenTargetsi | ENSG00000104517 |
PharmGKBi | PA162408175 |
VEuPathDBi | HostDB:ENSG00000104517 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0943, Eukaryota |
GeneTreei | ENSGT00940000156357 |
InParanoidi | O95071 |
OMAi | EAKFRRD |
OrthoDBi | 717at2759 |
PhylomeDBi | O95071 |
TreeFami | TF314406 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | O95071 |
SignaLinki | O95071 |
SIGNORi | O95071 |
Miscellaneous databases
BioGRID-ORCSi | 51366, 284 hits in 1104 CRISPR screens |
ChiTaRSi | UBR5, human |
EvolutionaryTracei | O95071 |
GeneWikii | UBR5 |
GenomeRNAii | 51366 |
Pharosi | O95071, Tbio |
PROi | PR:O95071 |
RNActi | O95071, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000104517, Expressed in testis and 238 other tissues |
ExpressionAtlasi | O95071, baseline and differential |
Genevisiblei | O95071, HS |
Family and domain databases
CDDi | cd14423, CUE_UBR5, 1 hit |
Gene3Di | 2.130.10.30, 1 hit |
IDEALi | IID00191 |
InterProi | View protein in InterPro IPR024725, E3_UbLigase_EDD_UBA IPR000569, HECT_dom IPR035983, Hect_E3_ubiquitin_ligase IPR036053, PABP-dom IPR002004, PABP_HYD IPR009091, RCC1/BLIP-II IPR003126, Znf_UBR |
Pfami | View protein in Pfam PF11547, E3_UbLigase_EDD, 1 hit PF00632, HECT, 1 hit PF00658, PABP, 1 hit |
SMARTi | View protein in SMART SM00119, HECTc, 1 hit SM00517, PolyA, 1 hit SM00396, ZnF_UBR1, 1 hit |
SUPFAMi | SSF50985, SSF50985, 1 hit SSF56204, SSF56204, 1 hit SSF63570, SSF63570, 1 hit |
PROSITEi | View protein in PROSITE PS50237, HECT, 1 hit PS51309, PABC, 1 hit PS51157, ZF_UBR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UBR5_HUMAN | |
Accessioni | O95071Primary (citable) accession number: O95071 Secondary accession number(s): B2RP24 Q9NPL3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 5, 2002 |
Last sequence update: | October 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 218 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references