Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - O95071 (UBR5_HUMAN)

Entry version 211 (12 Aug 2020)
Sequence version 2 (01 Oct 2001)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

E3 ubiquitin-protein ligase UBR5

Gene

UBR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.By similarity3 Publications

Miscellaneous

A cysteine residue is required for ubiquitin-thioester formation.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2768Glycyl thioester intermediatePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1177 – 1245UBR-typePROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processDNA damage, DNA repair, Host-virus interaction, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		6.3.2.19, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O95071

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O95071

SIGNOR Signaling Network Open Resource

More...SIGNORi		O95071

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase UBR5 (EC:2.3.2.26)
Alternative name(s):
E3 ubiquitin-protein ligase, HECT domain-containing 1
HECT-type E3 ubiquitin transferase UBR5
Hyperplastic discs protein homolog
Short name:
hHYD
Progestin-induced protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UBR5
Synonyms:EDD, EDD1, HYD, KIAA0896
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000104517.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:16806, UBR5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608413, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95071

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2768C → A: Loss of ubiquitin binding. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		51366

Open Targets

More...OpenTargetsi		ENSG00000104517

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162408175

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O95071, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		UBR5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000869312 – 2799E3 ubiquitin-protein ligase UBR5Add BLAST2798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylthreonineCombined sources1
Modified residuei110PhosphoserineCombined sources1 Publication1
Modified residuei327PhosphoserineCombined sources1 Publication1
Modified residuei352Phosphoserine1 Publication1
Modified residuei578PhosphoserineCombined sources1 Publication1
Modified residuei612PhosphoserineCombined sources1 Publication1
Modified residuei637Phosphothreonine1 Publication1
Modified residuei808PhosphoserineCombined sources1 Publication1
Modified residuei928Phosphoserine1 Publication1
Modified residuei1018Phosphoserine1 Publication1
Modified residuei1115Phosphothreonine1 Publication1
Modified residuei1135Phosphothreonine1 Publication1
Modified residuei1227Phosphoserine1 Publication1
Modified residuei1308PhosphoserineCombined sources1 Publication1
Modified residuei1355Phosphoserine1 Publication1
Modified residuei1375Phosphoserine1 Publication1
Modified residuei1481Phosphoserine1 Publication1
Modified residuei1549PhosphoserineCombined sources1
Modified residuei1736Phosphothreonine1 Publication1
Modified residuei1741Phosphoserine1 Publication1
Modified residuei1746PhosphotyrosineCombined sources1
Modified residuei1780Phosphoserine1 Publication1
Modified residuei1969PhosphothreonineCombined sources1 Publication1
Modified residuei1990PhosphoserineCombined sources1
Modified residuei2026Phosphoserine1 Publication1
Modified residuei2028Phosphoserine1 Publication1
Modified residuei2030Phosphothreonine1 Publication1
Modified residuei2076Phosphoserine1 Publication1
Modified residuei2213Phosphothreonine1 Publication1
Modified residuei2241PhosphoserineCombined sources1
Modified residuei2289Phosphoserine1 Publication1
Modified residuei2469PhosphoserineCombined sources1
Modified residuei2484Phosphoserine1 Publication1
Modified residuei2486PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O95071

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O95071

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O95071

MaxQB - The MaxQuant DataBase

More...MaxQBi		O95071

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95071

PeptideAtlas

More...PeptideAtlasi		O95071

PRoteomics IDEntifications database

More...PRIDEi		O95071

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50641 [O95071-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95071

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95071

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O95071

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000104517, Expressed in testis and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O95071, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95071, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000104517, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds TOPBP1. Associates with CDK9 and TFIIS/TCEA1 and forms a transcription regulatory complex made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription (e.g. gamma fibrinogen/FGG) by recruiting their promoters. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex).

Interacts directly with DYRK2.

Interacts with PIH1D1 (PubMed:24656813).

4 Publications

(Microbial infection) Interacts with human T-cell leukemia virus 1/HTLV-1 protein HBZ; this interaction modulates HBZ stability.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119501, 229 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O95071

Database of interacting proteins

More...DIPi		DIP-32930N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		O95071

Protein interaction database and analysis system

More...IntActi		O95071, 102 interactors

Molecular INTeraction database

More...MINTi		O95071

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000429084

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O95071, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12799
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O95071

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O95071

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2377 – 2454PABCPROSITE-ProRule annotationAdd BLAST78
Domaini2462 – 2799HECTPROSITE-ProRule annotationAdd BLAST338

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi940 – 945Poly-Glu6
Compositional biasi980 – 985Poly-Ser6
Compositional biasi1528 – 1537Poly-Ser10
Compositional biasi1671 – 1681Poly-SerAdd BLAST11
Compositional biasi1762 – 1768Poly-Ala7
Compositional biasi1986 – 1997Asp/Glu-rich (acidic)Add BLAST12
Compositional biasi2036 – 2059Pro-richAdd BLAST24
Compositional biasi2329 – 2348Arg/Glu-rich (mixed charge)Add BLAST20
Compositional biasi2357 – 2366Arg/Asp-rich (mixed charge)10
Compositional biasi2489 – 2500Asp/Glu-rich (acidic)Add BLAST12
Compositional biasi2737 – 2757Pro-richAdd BLAST21

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1177 – 1245UBR-typePROSITE-ProRule annotationAdd BLAST69

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0943, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156357

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95071

KEGG Orthology (KO)

More...KOi		K10593

Identification of Orthologs from Complete Genome Data

More...OMAi		EAKFRRD

Database of Orthologous Groups

More...OrthoDBi		717at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95071

TreeFam database of animal gene trees

More...TreeFami		TF314406

Family and domain databases

Conserved Domains Database

More...CDDi		cd14423, CUE_UBR5, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00191

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024725, E3_UbLigase_EDD_UBA
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR036053, PABP-dom
IPR002004, PABP_HYD
IPR009091, RCC1/BLIP-II
IPR003126, Znf_UBR

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11547, E3_UbLigase_EDD, 1 hit
PF00632, HECT, 1 hit
PF00658, PABP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00119, HECTc, 1 hit
SM00517, PolyA, 1 hit
SM00396, ZnF_UBR1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50985, SSF50985, 1 hit
SSF56204, SSF56204, 1 hit
SSF63570, SSF63570, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50237, HECT, 1 hit
PS51309, PABC, 1 hit
PS51157, ZF_UBR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95071-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSIHFVVHP LPGTEDQLND RLREVSEKLN KYNLNSHPPL NVLEQATIKQ 
        60         70         80         90        100
CVVGPNHAAF LLEDGRVCRI GFSVQPDRLE LGKPDNNDGS KLNSNSGAGR 
       110        120        130        140        150
TSRPGRTSDS PWFLSGSETL GRLAGNTLGS RWSSGVGGSG GGSSGRSSAG 
       160        170        180        190        200
ARDSRRQTRV IRTGRDRGSG LLGSQPQPVI PASVIPEELI SQAQVVLQGK 
       210        220        230        240        250
SRSVIIRELQ RTNLDVNLAV NNLLSRDDED GDDGDDTASE SYLPGEDLMS 
       260        270        280        290        300
LLDADIHSAH PSVIIDADAM FSEDISYFGY PSFRRSSLSR LGSSRVLLLP 
       310        320        330        340        350
LERDSELLRE RESVLRLRER RWLDGASFDN ERGSTSKEGE PNLDKKNTPV 
       360        370        380        390        400
QSPVSLGEDL QWWPDKDGTK FICIGALYSE LLAVSSKGEL YQWKWSESEP 
       410        420        430        440        450
YRNAQNPSLH HPRATFLGLT NEKIVLLSAN SIRATVATEN NKVATWVDET 
       460        470        480        490        500
LSSVASKLEH TAQTYSELQG ERIVSLHCCA LYTCAQLENS LYWWGVVPFS 
       510        520        530        540        550
QRKKMLEKAR AKNKKPKSSA GISSMPNITV GTQVCLRNNP LYHAGAVAFS 
       560        570        580        590        600
ISAGIPKVGV LMESVWNMND SCRFQLRSPE SLKNMEKASK TTEAKPESKQ 
       610        620        630        640        650
EPVKTEMGPP PSPASTCSDA SSIASSASMP YKRRRSTPAP KEEEKVNEEQ 
       660        670        680        690        700
WSLREVVFVE DVKNVPVGKV LKVDGAYVAV KFPGTSSNTN CQNSSGPDAD 
       710        720        730        740        750
PSSLLQDCRL LRIDELQVVK TGGTPKVPDC FQRTPKKLCI PEKTEILAVN 
       760        770        780        790        800
VDSKGVHAVL KTGNWVRYCI FDLATGKAEQ ENNFPTSSIA FLGQNERNVA 
       810        820        830        840        850
IFTAGQESPI ILRDGNGTIY PMAKDCMGGI RDPDWLDLPP ISSLGMGVHS 
       860        870        880        890        900
LINLPANSTI KKKAAVIIMA VEKQTLMQHI LRCDYEACRQ YLMNLEQAVV 
       910        920        930        940        950
LEQNLQMLQT FISHRCDGNR NILHACVSVC FPTSNKETKE EEEAERSERN 
       960        970        980        990       1000
TFAERLSAVE AIANAISVVS SNGPGNRAGS SSSRSLRLRE MMRRSLRAAG 
      1010       1020       1030       1040       1050
LGRHEAGASS SDHQDPVSPP IAPPSWVPDP PAMDPDGDID FILAPAVGSL 
      1060       1070       1080       1090       1100
TTAATGTGQG PSTSTIPGPS TEPSVVESKD RKANAHFILK LLCDSVVLQP 
      1110       1120       1130       1140       1150
YLRELLSAKD ARGMTPFMSA VSGRAYPAAI TILETAQKIA KAEISSSEKE 
      1160       1170       1180       1190       1200
EDVFMGMVCP SGTNPDDSPL YVLCCNDTCS FTWTGAEHIN QDIFECRTCG 
      1210       1220       1230       1240       1250
LLESLCCCTE CARVCHKGHD CKLKRTSPTA YCDCWEKCKC KTLIAGQKSA 
      1260       1270       1280       1290       1300
RLDLLYRLLT ATNLVTLPNS RGEHLLLFLV QTVARQTVEH CQYRPPRIRE 
      1310       1320       1330       1340       1350
DRNRKTASPE DSDMPDHDLE PPRFAQLALE RVLQDWNALK SMIMFGSQEN 
      1360       1370       1380       1390       1400
KDPLSASSRI GHLLPEEQVY LNQQSGTIRL DCFTHCLIVK CTADILLLDT 
      1410       1420       1430       1440       1450
LLGTLVKELQ NKYTPGRREE AIAVTMRFLR SVARVFVILS VEMASSKKKN 
      1460       1470       1480       1490       1500
NFIPQPIGKC KRVFQALLPY AVEELCNVAE SLIVPVRMGI ARPTAPFTLA 
      1510       1520       1530       1540       1550
STSIDAMQGS EELFSVEPLP PRPSSDQSSS SSQSQSSYII RNPQQRRISQ 
      1560       1570       1580       1590       1600
SQPVRGRDEE QDDIVSADVE EVEVVEGVAG EEDHHDEQEE HGEENAEAEG 
      1610       1620       1630       1640       1650
QHDEHDEDGS DMELDLLAAA ETESDSESNH SNQDNASGRR SVVTAATAGS 
      1660       1670       1680       1690       1700
EAGASSVPAF FSEDDSQSND SSDSDSSSSQ SDDIEQETFM LDEPLERTTN 
      1710       1720       1730       1740       1750
SSHANGAAQA PRSMQWAVRN TQHQRAASTA PSSTSTPAAS SAGLIYIDPS 
      1760       1770       1780       1790       1800
NLRRSGTIST SAAAAAAALE ASNASSYLTS ASSLARAYSI VIRQISDLMG 
      1810       1820       1830       1840       1850
LIPKYNHLVY SQIPAAVKLT YQDAVNLQNY VEEKLIPTWN WMVSIMDSTE 
      1860       1870       1880       1890       1900
AQLRYGSALA SAGDPGHPNH PLHASQNSAR RERMTAREEA SLRTLEGRRR 
      1910       1920       1930       1940       1950
ATLLSARQGM MSARGDFLNY ALSLMRSHND EHSDVLPVLD VCSLKHVAYV 
      1960       1970       1980       1990       2000
FQALIYWIKA MNQQTTLDTP QLERKRTREL LELGIDNEDS EHENDDDTNQ 
      2010       2020       2030       2040       2050
SATLNDKDDD SLPAETGQNH PFFRRSDSMT FLGCIPPNPF EVPLAEAIPL 
      2060       2070       2080       2090       2100
ADQPHLLQPN ARKEDLFGRP SQGLYSSSAS SGKCLMEVTV DRNCLEVLPT 
      2110       2120       2130       2140       2150
KMSYAANLKN VMNMQNRQKK EGEEQPVLPE ETESSKPGPS AHDLAAQLKS 
      2160       2170       2180       2190       2200
SLLAEIGLTE SEGPPLTSFR PQCSFMGMVI SHDMLLGRWR LSLELFGRVF 
      2210       2220       2230       2240       2250
MEDVGAEPGS ILTELGGFEV KESKFRREME KLRNQQSRDL SLEVDRDRDL 
      2260       2270       2280       2290       2300
LIQQTMRQLN NHFGRRCATT PMAVHRVKVT FKDEPGEGSG VARSFYTAIA 
      2310       2320       2330       2340       2350
QAFLSNEKLP NLECIQNANK GTHTSLMQRL RNRGERDRER EREREMRRSS 
      2360       2370       2380       2390       2400
GLRAGSRRDR DRDFRRQLSI DTRPFRPASE GNPSDDPEPL PAHRQALGER 
      2410       2420       2430       2440       2450
LYPRVQAMQP AFASKITGML LELSPAQLLL LLASEDSLRA RVDEAMELII 
      2460       2470       2480       2490       2500
AHGRENGADS ILDLGLVDSS EKVQQENRKR HGSSRSVVDM DLDDTDDGDD 
      2510       2520       2530       2540       2550
NAPLFYQPGK RGFYTPRPGK NTEARLNCFR NIGRILGLCL LQNELCPITL 
      2560       2570       2580       2590       2600
NRHVIKVLLG RKVNWHDFAF FDPVMYESLR QLILASQSSD ADAVFSAMDL 
      2610       2620       2630       2640       2650
AFAIDLCKEE GGGQVELIPN GVNIPVTPQN VYEYVRKYAE HRMLVVAEQP 
      2660       2670       2680       2690       2700
LHAMRKGLLD VLPKNSLEDL TAEDFRLLVN GCGEVNVQML ISFTSFNDES 
      2710       2720       2730       2740       2750
GENAEKLLQF KRWFWSIVEK MSMTERQDLV YFWTSSPSLP ASEEGFQPMP 
      2760       2770       2780       2790 
SITIRPPDDQ HLPTANTCIS RLYVPLYSSK QILKQKLLLA IKTKNFGFV
Length:2,799
Mass (Da):309,352
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i871300DB404FF561
GO
Isoform 2 (identifier: O95071-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2474-2474: Missing.

Show »
Length:2,798
Mass (Da):309,224
Checksum:iD0743129ECF82394
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EMW7E7EMW7_HUMAN
E3 ubiquitin-protein ligase UBR5
UBR5
2,792Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ET84E7ET84_HUMAN
E3 ubiquitin-protein ligase UBR5
UBR5
527Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAV7H0YAV7_HUMAN
E3 ubiquitin-protein ligase UBR5
UBR5
201Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBB4H0YBB4_HUMAN
E3 ubiquitin-protein ligase UBR5
UBR5
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFK7E5RFK7_HUMAN
E3 ubiquitin-protein ligase UBR5
UBR5
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA74919 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti134S → P in AAF88143 (PubMed:11714696).Curated1
Sequence conflicti229E → K in AAF88143 (PubMed:11714696).Curated1
Sequence conflicti258S → Y in AAF88143 (PubMed:11714696).Curated1
Sequence conflicti374 – 375IG → M in AAF88143 (PubMed:11714696).Curated2
Sequence conflicti772D → H in AAF88143 (PubMed:11714696).Curated1
Sequence conflicti780Q → R in AAF88143 (PubMed:11714696).Curated1
Sequence conflicti884D → G in AAF88143 (PubMed:11714696).Curated1
Sequence conflicti1811S → P in AAF88143 (PubMed:11714696).Curated1
Sequence conflicti2144L → H in AAF88143 (PubMed:11714696).Curated1
Sequence conflicti2282K → R in AAF88143 (PubMed:11714696).Curated1
Sequence conflicti2489D → N in AAF88143 (PubMed:11714696).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0514662150S → R. Corresponds to variant dbSNP:rs1062822Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0543992474Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF006010 mRNA Translation: AAD01259.2
U95000 mRNA Translation: AAF88143.1
AB020703 mRNA Translation: BAA74919.3 Different initiation.
AP002907 Genomic DNA No translation available.
AP002981 Genomic DNA No translation available.
BC137234 mRNA Translation: AAI37235.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34933.1 [O95071-1]
CCDS64946.1 [O95071-2]

NCBI Reference Sequences

More...RefSeqi		NP_001269802.1, NM_001282873.1 [O95071-2]
NP_056986.2, NM_015902.5 [O95071-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000220959; ENSP00000220959; ENSG00000104517 [O95071-2]
ENST00000520539; ENSP00000429084; ENSG00000104517 [O95071-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51366

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51366

UCSC genome browser

More...UCSCi		uc003ykr.3, human [O95071-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006010 mRNA Translation: AAD01259.2
U95000 mRNA Translation: AAF88143.1
AB020703 mRNA Translation: BAA74919.3 Different initiation.
AP002907 Genomic DNA No translation available.
AP002981 Genomic DNA No translation available.
BC137234 mRNA Translation: AAI37235.1
CCDSiCCDS34933.1 [O95071-1]
CCDS64946.1 [O95071-2]
RefSeqiNP_001269802.1, NM_001282873.1 [O95071-2]
NP_056986.2, NM_015902.5 [O95071-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I2TX-ray1.04A2393-2453[»]
2QHOX-ray1.85B/D/F/H180-230[»]
3PT3X-ray1.97A/B2687-2799[»]
SMRiO95071
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119501, 229 interactors
CORUMiO95071
DIPiDIP-32930N
ELMiO95071
IntActiO95071, 102 interactors
MINTiO95071
STRINGi9606.ENSP00000429084

PTM databases

iPTMnetiO95071
PhosphoSitePlusiO95071
SwissPalmiO95071

Polymorphism and mutation databases

BioMutaiUBR5

Proteomic databases

EPDiO95071
jPOSTiO95071
MassIVEiO95071
MaxQBiO95071
PaxDbiO95071
PeptideAtlasiO95071
PRIDEiO95071
ProteomicsDBi50641 [O95071-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		13236, 277 antibodies

Genome annotation databases

EnsembliENST00000220959; ENSP00000220959; ENSG00000104517 [O95071-2]
ENST00000520539; ENSP00000429084; ENSG00000104517 [O95071-1]
GeneIDi51366
KEGGihsa:51366
UCSCiuc003ykr.3, human [O95071-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51366
DisGeNETi51366
EuPathDBiHostDB:ENSG00000104517.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		UBR5
HGNCiHGNC:16806, UBR5
HPAiENSG00000104517, Low tissue specificity
MIMi608413, gene
neXtProtiNX_O95071
OpenTargetsiENSG00000104517
PharmGKBiPA162408175

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0943, Eukaryota
GeneTreeiENSGT00940000156357
InParanoidiO95071
KOiK10593
OMAiEAKFRRD
OrthoDBi717at2759
PhylomeDBiO95071
TreeFamiTF314406

Enzyme and pathway databases

UniPathwayiUPA00143
BRENDAi6.3.2.19, 2681
PathwayCommonsiO95071
SignaLinkiO95071
SIGNORiO95071

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51366, 265 hits in 885 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		UBR5, human
EvolutionaryTraceiO95071

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		UBR5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51366
PharosiO95071, Tbio

Protein Ontology

More...PROi		PR:O95071
RNActiO95071, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000104517, Expressed in testis and 237 other tissues
ExpressionAtlasiO95071, baseline and differential
GenevisibleiO95071, HS

Family and domain databases

CDDicd14423, CUE_UBR5, 1 hit
IDEALiIID00191
InterProiView protein in InterPro
IPR024725, E3_UbLigase_EDD_UBA
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR036053, PABP-dom
IPR002004, PABP_HYD
IPR009091, RCC1/BLIP-II
IPR003126, Znf_UBR
PfamiView protein in Pfam
PF11547, E3_UbLigase_EDD, 1 hit
PF00632, HECT, 1 hit
PF00658, PABP, 1 hit
SMARTiView protein in SMART
SM00119, HECTc, 1 hit
SM00517, PolyA, 1 hit
SM00396, ZnF_UBR1, 1 hit
SUPFAMiSSF50985, SSF50985, 1 hit
SSF56204, SSF56204, 1 hit
SSF63570, SSF63570, 1 hit
PROSITEiView protein in PROSITE
PS50237, HECT, 1 hit
PS51309, PABC, 1 hit
PS51157, ZF_UBR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBR5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95071
Secondary accession number(s): B2RP24
, J3KMW7, O94970, Q9NPL3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: October 1, 2001
Last modified: August 12, 2020
This is version 211 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again