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Protein

Protein YIF1A

Gene

YIF1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possible role in transport between endoplasmic reticulum and Golgi.1 Publication

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: GO_Central
  • IRE1-mediated unfolded protein response Source: Reactome
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-381038 XBP1(S) activates chaperone genes

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YIF1A
Alternative name(s):
54TMp
YIP1-interacting factor homolog A
Gene namesi
Name:YIF1A
Synonyms:54TM, HYIF1P, YIF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000174851.14
HGNCiHGNC:16688 YIF1A
MIMi611484 gene
neXtProtiNX_O95070

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 138CytoplasmicSequence analysisAdd BLAST137
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 174LumenalCuratedAdd BLAST15
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 203CytoplasmicCurated8
Transmembranei204 – 226HelicalSequence analysisAdd BLAST23
Topological domaini227 – 229LumenalCurated3
Transmembranei230 – 249HelicalSequence analysisAdd BLAST20
Topological domaini250 – 271CytoplasmicCuratedAdd BLAST22
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10897
OpenTargetsiENSG00000174851
PharmGKBiPA134985105

Polymorphism and mutation databases

BioMutaiYIF1A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002332752 – 293Protein YIF1AAdd BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei12PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95070
MaxQBiO95070
PaxDbiO95070
PeptideAtlasiO95070
PRIDEiO95070
ProteomicsDBi50640
TopDownProteomicsiO95070

PTM databases

iPTMnetiO95070
PhosphoSitePlusiO95070

Expressioni

Gene expression databases

BgeeiENSG00000174851 Expressed in 201 organ(s), highest expression level in right lobe of liver
CleanExiHS_YIF1A
ExpressionAtlasiO95070 baseline and differential
GenevisibleiO95070 HS

Organism-specific databases

HPAiHPA014840

Interactioni

Subunit structurei

Interacts with YIPF5.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi116103, 28 interactors
IntActiO95070, 69 interactors
MINTiO95070
STRINGi9606.ENSP00000366098

Structurei

3D structure databases

ProteinModelPortaliO95070
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the YIF1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3094 Eukaryota
COG5197 LUCA
GeneTreeiENSGT00390000009423
HOGENOMiHOG000234333
HOVERGENiHBG053252
InParanoidiO95070
KOiK20362
OMAiANMAMAY
OrthoDBiEOG091G0H35
PhylomeDBiO95070
TreeFamiTF314528

Family and domain databases

InterProiView protein in InterPro
IPR005578 Yif1_fam
PANTHERiPTHR14083 PTHR14083, 1 hit
PfamiView protein in Pfam
PF03878 YIF1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

O95070-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYHSGYGAH GSKHRARAAP DPPPLFDDTS GGYSSQPGGY PATGADVAFS
60 70 80 90 100
VNHLLGDPMA NVAMAYGSSI ASHGKDMVHK ELHRFVSVSK LKYFFAVDTA
110 120 130 140 150
YVAKKLGLLV FPYTHQNWEV QYSRDAPLPP RQDLNAPDLY IPTMAFITYV
160 170 180 190 200
LLAGMALGIQ KRFSPEVLGL CASTALVWVV MEVLALLLGL YLATVRSDLS
210 220 230 240 250
TFHLLAYSGY KYVGMILSVL TGLLFGSDGY YVALAWTSSA LMYFIVRSLR
260 270 280 290
TAALGPDSMG GPVPRQRLQL YLTLGAAAFQ PLIIYWLTFH LVR
Length:293
Mass (Da):32,011
Last modified:May 2, 2006 - v2
Checksum:iAFD61379A56085EA
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NGW1A6NGW1_HUMAN
Protein YIF1A
YIF1A
241Annotation score:
E9PS11E9PS11_HUMAN
Protein YIF1A
YIF1A
79Annotation score:
C9JST7C9JST7_HUMAN
Protein YIF1A
YIF1A
199Annotation score:
E9PP02E9PP02_HUMAN
Protein YIF1A
YIF1A
158Annotation score:
E9PIZ0E9PIZ0_HUMAN
Protein YIF1A
YIF1A
160Annotation score:
E9PK42E9PK42_HUMAN
Protein YIF1A
YIF1A
53Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144M → K in CAG32991 (Ref. 2) Curated1
Sequence conflicti144M → K in AAH01299 (Ref. 4) Curated1
Sequence conflicti144M → K in AAH09892 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004876 mRNA Translation: AAD01206.1
CR456710 mRNA Translation: CAG32991.1
AP001107 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74509.1
BC001299 mRNA Translation: AAH01299.1
BC009892 mRNA Translation: AAH09892.2
CCDSiCCDS8132.1
RefSeqiNP_065203.2, NM_020470.2
UniGeneiHs.446445

Genome annotation databases

EnsembliENST00000376901; ENSP00000366098; ENSG00000174851
GeneIDi10897
KEGGihsa:10897
UCSCiuc001ohk.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004876 mRNA Translation: AAD01206.1
CR456710 mRNA Translation: CAG32991.1
AP001107 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74509.1
BC001299 mRNA Translation: AAH01299.1
BC009892 mRNA Translation: AAH09892.2
CCDSiCCDS8132.1
RefSeqiNP_065203.2, NM_020470.2
UniGeneiHs.446445

3D structure databases

ProteinModelPortaliO95070
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116103, 28 interactors
IntActiO95070, 69 interactors
MINTiO95070
STRINGi9606.ENSP00000366098

PTM databases

iPTMnetiO95070
PhosphoSitePlusiO95070

Polymorphism and mutation databases

BioMutaiYIF1A

Proteomic databases

EPDiO95070
MaxQBiO95070
PaxDbiO95070
PeptideAtlasiO95070
PRIDEiO95070
ProteomicsDBi50640
TopDownProteomicsiO95070

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376901; ENSP00000366098; ENSG00000174851
GeneIDi10897
KEGGihsa:10897
UCSCiuc001ohk.5 human

Organism-specific databases

CTDi10897
DisGeNETi10897
EuPathDBiHostDB:ENSG00000174851.14
GeneCardsiYIF1A
HGNCiHGNC:16688 YIF1A
HPAiHPA014840
MIMi611484 gene
neXtProtiNX_O95070
OpenTargetsiENSG00000174851
PharmGKBiPA134985105
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3094 Eukaryota
COG5197 LUCA
GeneTreeiENSGT00390000009423
HOGENOMiHOG000234333
HOVERGENiHBG053252
InParanoidiO95070
KOiK20362
OMAiANMAMAY
OrthoDBiEOG091G0H35
PhylomeDBiO95070
TreeFamiTF314528

Enzyme and pathway databases

ReactomeiR-HSA-381038 XBP1(S) activates chaperone genes

Miscellaneous databases

GeneWikiiYIF1A
GenomeRNAii10897
PROiPR:O95070
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174851 Expressed in 201 organ(s), highest expression level in right lobe of liver
CleanExiHS_YIF1A
ExpressionAtlasiO95070 baseline and differential
GenevisibleiO95070 HS

Family and domain databases

InterProiView protein in InterPro
IPR005578 Yif1_fam
PANTHERiPTHR14083 PTHR14083, 1 hit
PfamiView protein in Pfam
PF03878 YIF1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiYIF1A_HUMAN
AccessioniPrimary (citable) accession number: O95070
Secondary accession number(s): A6NM00, Q96G83, Q9BVD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: November 7, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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