CCNB2

Functionⁱ

Essential for the control of the cell cycle at the G2/M (mitosis) transition.

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
cyclin-dependent protein serine/threonine kinase activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell division Source: UniProtKB-KW
G2/M transition of mitotic cell cycle Source: Reactome
in utero embryonic development Source: Ensembl
mitotic nuclear envelope disassembly Source: Reactome
regulation of cell cycle Source: Reactome
regulation of growth Source: Ensembl
T cell homeostasis Source: Ensembl
thymus development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cyclin
Biological process	Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-156711 Polo-like kinase mediated events R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2514853 Condensation of Prometaphase Chromosomes R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69478 G2/M DNA replication checkpoint R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
SignaLinkⁱ	O95067
SIGNORⁱ	O95067

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: G2/mitotic-specific cyclin-B2
Gene namesⁱ	Name:CCNB2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000157456.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1580 CCNB2
MIMⁱ	602755 gene
neXtProtⁱ	NX_O95067

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9133
Open Targets More...OpenTargetsⁱ	ENSG00000157456
PharmGKBⁱ	PA26148

Chemistry databases

ChEMBLⁱ	CHEMBL2094127

ChEMBLⁱ

CHEMBL2094127

Polymorphism and mutation databases

BioMutaⁱ	CCNB2

BioMutaⁱ

CCNB2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080361	1 – 398	G2/mitotic-specific cyclin-B2Add BLAST		398

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	8	PhosphothreonineCombined sources	1
Modified residueⁱ	11	PhosphoserineCombined sources	1
Modified residueⁱ	77	PhosphoserineCombined sources	1
Modified residueⁱ	92	PhosphoserineCombined sources	1
Modified residueⁱ	94	PhosphothreonineCombined sources	1
Modified residueⁱ	99	PhosphoserineCombined sources	1
Modified residueⁱ	392	PhosphoserineCombined sources	1
Modified residueⁱ	398	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O95067
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O95067
PaxDbⁱ	O95067
PeptideAtlas More...PeptideAtlasⁱ	O95067
PRIDEⁱ	O95067
ProteomicsDBⁱ	50636

PTM databases

iPTMnetⁱ	O95067
PhosphoSitePlusⁱ	O95067

Expressionⁱ

Developmental stageⁱ

Accumulates steadily during G2 and is abruptly destroyed at mitosis.

Gene expression databases

Bgeeⁱ	ENSG00000157456
CleanExⁱ	HS_CCNB2
ExpressionAtlasⁱ	O95067 baseline and differential
Genevisibleⁱ	O95067 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB009575 HPA008873

HPAⁱ

CAB009575
HPA008873

Interactionⁱ

Subunit structureⁱ

Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CDK2	P24941	3	EBI-375024,EBI-375096
FLNA	P21333	8	EBI-375024,EBI-350432

Show more details

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114581, 38 interactors
ComplexPortalⁱ	CPX-2008 Cyclin B2-CDK1 complex
CORUMⁱ	O95067
Database of interacting proteins More...DIPⁱ	DIP-31730N
IntActⁱ	O95067, 32 interactors
Molecular INTeraction database More...MINTⁱ	O95067
STRINGⁱ	9606.ENSP00000288207

Chemistry databases

BindingDBⁱ

O95067

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O95067
SMRⁱ	O95067
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0653 Eukaryota COG5024 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118939
HOGENOMⁱ	HOG000167672
HOVERGENⁱ	HBG061650
InParanoidⁱ	O95067
KEGG Orthology (KO) More...KOⁱ	K21770
OMAⁱ	ISMKEEN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0E9B
PhylomeDBⁱ	O95067
TreeFamⁱ	TF101001

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00043 CYCLIN, 2 hits
InterProⁱ	View protein in InterPro IPR039361 Cyclin IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR004367 Cyclin_C-dom IPR006671 Cyclin_N
PANTHERⁱ	PTHR10177 PTHR10177, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02984 Cyclin_C, 1 hit PF00134 Cyclin_N, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 2 hits SM01332 Cyclin_C, 1 hit
SUPFAMⁱ	SSF47954 SSF47954, 2 hits
PROSITEⁱ	View protein in PROSITE PS00292 CYCLINS, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O95067-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALLRRPTVS SDLENIDTGV NSKVKSHVTI RRTVLEEIGN RVTTRAAQVA 
        60         70         80         90        100
KKAQNTKVPV QPTKTTNVNK QLKPTASVKP VQMEKLAPKG PSPTPEDVSM 
       110        120        130        140        150
KEENLCQAFS DALLCKIEDI DNEDWENPQL CSDYVKDIYQ YLRQLEVLQS 
       160        170        180        190        200
INPHFLDGRD INGRMRAILV DWLVQVHSKF RLLQETLYMC VGIMDRFLQV 
       210        220        230        240        250
QPVSRKKLQL VGITALLLAS KYEEMFSPNI EDFVYITDNA YTSSQIREME 
       260        270        280        290        300
TLILKELKFE LGRPLPLHFL RRASKAGEVD VEQHTLAKYL MELTLIDYDM 
       310        320        330        340        350
VHYHPSKVAA AASCLSQKVL GQGKWNLKQQ YYTGYTENEV LEVMQHMAKN 
       360        370        380        390 
VVKVNENLTK FIAIKNKYAS SKLLKISMIP QLNSKAVKDL ASPLIGRS

Length:398

Mass (Da):45,282

Last modified:May 1, 1999 - v1

Checksum:ⁱ874466E1DD68A4C4

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_022221	100	M → T1 PublicationCorresponds to variant dbSNP:rs16941036Ensembl.	1
Natural variantⁱVAR_053052	135	V → I. Corresponds to variant dbSNP:rs2306785Ensembl.	1
Natural variantⁱVAR_022222	395	I → T1 PublicationCorresponds to variant dbSNP:rs28383563Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF002822 mRNA Translation: AAD09309.1 AB020981 mRNA Translation: BAA78387.1 AL080146 mRNA Translation: CAB45739.1 CR533527 mRNA Translation: CAG38558.1 AY864066 Genomic DNA Translation: AAW34361.1 AK001404 mRNA Translation: BAG50905.1 CH471082 Genomic DNA Translation: EAW77563.1 BC105086 mRNA Translation: AAI05087.1 BC105112 mRNA Translation: AAI05113.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10170.1
PIRⁱ	T12530
NCBI Reference Sequences More...RefSeqⁱ	NP_004692.1, NM_004701.3
UniGeneⁱ	Hs.194698

Genome annotation databases

Ensemblⁱ	ENST00000288207; ENSP00000288207; ENSG00000157456
GeneIDⁱ	9133
KEGGⁱ	hsa:9133
UCSC genome browser More...UCSCⁱ	uc002afz.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length
O95067	UPI00057BAA63		CAMDR		476
UPI00057B4DF1		CAMBA		316
G2/mitotic-specific cyclin-B2		PTEAL		403
G2/mitotic-specific cyclin-B2		MYODS		403
UPI00027F8D79		SAIBB		400
+97

Protein	Similar proteins		Species	Score	Length
O95067	UPI00057BAA63		CAMDR		476
UPI00057B4DF1		CAMBA		316
G2/mitotic-specific cyclin-B2		PTEAL		403
G2/mitotic-specific cyclin-B2		MYODS		403
UPI00027F8D79		SAIBB		400
+166

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF002822 mRNA Translation: AAD09309.1 AB020981 mRNA Translation: BAA78387.1 AL080146 mRNA Translation: CAB45739.1 CR533527 mRNA Translation: CAG38558.1 AY864066 Genomic DNA Translation: AAW34361.1 AK001404 mRNA Translation: BAG50905.1 CH471082 Genomic DNA Translation: EAW77563.1 BC105086 mRNA Translation: AAI05087.1 BC105112 mRNA Translation: AAI05113.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10170.1
PIRⁱ	T12530
NCBI Reference Sequences More...RefSeqⁱ	NP_004692.1, NM_004701.3
UniGeneⁱ	Hs.194698

3D structure databases

ProteinModelPortalⁱ	O95067
SMRⁱ	O95067
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114581, 38 interactors
ComplexPortalⁱ	CPX-2008 Cyclin B2-CDK1 complex
CORUMⁱ	O95067
Database of interacting proteins More...DIPⁱ	DIP-31730N
IntActⁱ	O95067, 32 interactors
Molecular INTeraction database More...MINTⁱ	O95067
STRINGⁱ	9606.ENSP00000288207

Chemistry databases

BindingDBⁱ	O95067
ChEMBLⁱ	CHEMBL2094127

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetⁱ	O95067
PhosphoSitePlusⁱ	O95067

Polymorphism and mutation databases

BioMutaⁱ	CCNB2

BioMutaⁱ

CCNB2

Proteomic databases

EPDⁱ	O95067
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O95067
PaxDbⁱ	O95067
PeptideAtlas More...PeptideAtlasⁱ	O95067
PRIDEⁱ	O95067
ProteomicsDBⁱ	50636

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9133
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000288207; ENSP00000288207; ENSG00000157456
GeneIDⁱ	9133
KEGGⁱ	hsa:9133
UCSC genome browser More...UCSCⁱ	uc002afz.4 human

Organism-specific databases

CTDⁱ	9133
DisGeNET More...DisGeNETⁱ	9133
EuPathDBⁱ	HostDB:ENSG00000157456.7
GeneCardsⁱ	CCNB2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1580 CCNB2
Human Protein Atlas More...HPAⁱ	CAB009575 HPA008873
MIMⁱ	602755 gene
neXtProtⁱ	NX_O95067
Open Targets More...OpenTargetsⁱ	ENSG00000157456
PharmGKBⁱ	PA26148
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0653 Eukaryota COG5024 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118939
HOGENOMⁱ	HOG000167672
HOVERGENⁱ	HBG061650
InParanoidⁱ	O95067
KEGG Orthology (KO) More...KOⁱ	K21770
OMAⁱ	ISMKEEN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0E9B
PhylomeDBⁱ	O95067
TreeFamⁱ	TF101001

Enzyme and pathway databases

Reactomeⁱ	R-HSA-156711 Polo-like kinase mediated events R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2514853 Condensation of Prometaphase Chromosomes R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69478 G2/M DNA replication checkpoint R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
SignaLinkⁱ	O95067
SIGNORⁱ	O95067

Miscellaneous databases

GeneWikiⁱ	Cyclin_B2
GenomeRNAiⁱ	9133
Protein Ontology More...PROⁱ	PR:O95067
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000157456
CleanExⁱ	HS_CCNB2
ExpressionAtlasⁱ	O95067 baseline and differential
Genevisibleⁱ	O95067 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00043 CYCLIN, 2 hits
InterProⁱ	View protein in InterPro IPR039361 Cyclin IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR004367 Cyclin_C-dom IPR006671 Cyclin_N
PANTHERⁱ	PTHR10177 PTHR10177, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02984 Cyclin_C, 1 hit PF00134 Cyclin_N, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 2 hits SM01332 Cyclin_C, 1 hit
SUPFAMⁱ	SSF47954 SSF47954, 2 hits
PROSITEⁱ	View protein in PROSITE PS00292 CYCLINS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CCNB2_HUMAN
Accessionⁱ	O95067Primary (citable) accession number: O95067 Secondary accession number(s): B3KM93, Q6FI99
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	May 1, 1999
	Last modified:	July 18, 2018
	This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - O95067 (CCNB2_HUMAN)

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G2/mitotic-specific cyclin-B2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytosol

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ