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UniProtKB - O95067 (CCNB2_HUMAN)
Protein
G2/mitotic-specific cyclin-B2
Gene
CCNB2
Organism
Homo sapiens (Human)
Status
Functioni
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
GO - Biological processi
- cell division Source: UniProtKB-KW
- G2/MI transition of meiotic cell cycle Source: Ensembl
- in utero embryonic development Source: Ensembl
- mitotic cell cycle phase transition Source: GO_Central
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- regulation of growth Source: Ensembl
- spindle assembly involved in female meiosis I Source: Ensembl
- T cell homeostasis Source: Ensembl
- thymus development Source: Ensembl
Keywordsi
Molecular function | Cyclin |
Biological process | Cell cycle, Cell division, Mitosis |
Enzyme and pathway databases
PathwayCommonsi | O95067 |
Reactomei | R-HSA-156711, Polo-like kinase mediated events R-HSA-162658, Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-2514853, Condensation of Prometaphase Chromosomes R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-2980767, Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2995383, Initiation of Nuclear Envelope (NE) Reformation R-HSA-3301854, Nuclear Pore Complex (NPC) Disassembly R-HSA-69273, Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69478, G2/M DNA replication checkpoint R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint |
SignaLinki | O95067 |
SIGNORi | O95067 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
Names & Taxonomyi
Protein namesi | Recommended name: G2/mitotic-specific cyclin-B2 |
Gene namesi | Name:CCNB2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1580, CCNB2 |
MIMi | 602755, gene |
neXtProti | NX_O95067 |
VEuPathDBi | HostDB:ENSG00000157456 |
Subcellular locationi
Cytoskeleton
- centrosome Source: UniProtKB
- microtubule cytoskeleton Source: LIFEdb
Cytosol
- cytosol Source: HPA
Nucleus
- nucleus Source: GO_Central
Other locations
- cyclin-dependent protein kinase holoenzyme complex Source: GO_Central
- cytoplasm Source: GO_Central
- membrane Source: Ensembl
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 9133 |
OpenTargetsi | ENSG00000157456 |
PharmGKBi | PA26148 |
Miscellaneous databases
Pharosi | O95067, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2094127 |
DrugCentrali | O95067 |
Genetic variation databases
BioMutai | CCNB2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080361 | 1 – 398 | G2/mitotic-specific cyclin-B2Add BLAST | 398 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 8 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 11 | PhosphoserineCombined sources | 1 | |
Modified residuei | 77 | PhosphoserineCombined sources | 1 | |
Modified residuei | 92 | PhosphoserineCombined sources | 1 | |
Modified residuei | 94 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 99 | PhosphoserineCombined sources | 1 | |
Modified residuei | 392 | PhosphoserineCombined sources | 1 | |
Modified residuei | 398 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O95067 |
jPOSTi | O95067 |
MassIVEi | O95067 |
MaxQBi | O95067 |
PaxDbi | O95067 |
PeptideAtlasi | O95067 |
PRIDEi | O95067 |
ProteomicsDBi | 50636 |
PTM databases
iPTMneti | O95067 |
MetOSitei | O95067 |
PhosphoSitePlusi | O95067 |
Expressioni
Developmental stagei
Accumulates steadily during G2 and is abruptly destroyed at mitosis.
Gene expression databases
Bgeei | ENSG00000157456, Expressed in oocyte and 174 other tissues |
ExpressionAtlasi | O95067, baseline and differential |
Genevisiblei | O95067, HS |
Organism-specific databases
HPAi | ENSG00000157456, Group enriched (bone marrow, lymphoid tissue, testis) |
Interactioni
Subunit structurei
Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.
Binary interactionsi
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 114581, 58 interactors |
ComplexPortali | CPX-2008, Cyclin B2-CDK1 complex |
CORUMi | O95067 |
DIPi | DIP-31730N |
IntActi | O95067, 47 interactors |
MINTi | O95067 |
STRINGi | 9606.ENSP00000288207 |
Chemistry databases
BindingDBi | O95067 |
Miscellaneous databases
RNActi | O95067, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0653, Eukaryota |
GeneTreei | ENSGT00940000155405 |
InParanoidi | O95067 |
OMAi | QPTKTNV |
OrthoDBi | 993640at2759 |
PhylomeDBi | O95067 |
TreeFami | TF101001 |
Family and domain databases
CDDi | cd00043, CYCLIN, 2 hits |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
PIRSFi | PIRSF001771, Cyclin_A_B_D_E, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
O95067-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALLRRPTVS SDLENIDTGV NSKVKSHVTI RRTVLEEIGN RVTTRAAQVA
60 70 80 90 100
KKAQNTKVPV QPTKTTNVNK QLKPTASVKP VQMEKLAPKG PSPTPEDVSM
110 120 130 140 150
KEENLCQAFS DALLCKIEDI DNEDWENPQL CSDYVKDIYQ YLRQLEVLQS
160 170 180 190 200
INPHFLDGRD INGRMRAILV DWLVQVHSKF RLLQETLYMC VGIMDRFLQV
210 220 230 240 250
QPVSRKKLQL VGITALLLAS KYEEMFSPNI EDFVYITDNA YTSSQIREME
260 270 280 290 300
TLILKELKFE LGRPLPLHFL RRASKAGEVD VEQHTLAKYL MELTLIDYDM
310 320 330 340 350
VHYHPSKVAA AASCLSQKVL GQGKWNLKQQ YYTGYTENEV LEVMQHMAKN
360 370 380 390
VVKVNENLTK FIAIKNKYAS SKLLKISMIP QLNSKAVKDL ASPLIGRS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH1UBN3 | H1UBN3_HUMAN | Cyclin B2 | CCNB2 CCNB2V | 374 | Annotation score: | ||
H0YMP3 | H0YMP3_HUMAN | G2/mitotic-specific cyclin-B2 | CCNB2 | 270 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022221 | 100 | M → T1 PublicationCorresponds to variant dbSNP:rs16941036EnsemblClinVar. | 1 | |
Natural variantiVAR_053052 | 135 | V → I. Corresponds to variant dbSNP:rs2306785Ensembl. | 1 | |
Natural variantiVAR_022222 | 395 | I → T1 PublicationCorresponds to variant dbSNP:rs28383563EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF002822 mRNA Translation: AAD09309.1 AB020981 mRNA Translation: BAA78387.1 AL080146 mRNA Translation: CAB45739.1 CR533527 mRNA Translation: CAG38558.1 AY864066 Genomic DNA Translation: AAW34361.1 AK001404 mRNA Translation: BAG50905.1 CH471082 Genomic DNA Translation: EAW77563.1 BC105086 mRNA Translation: AAI05087.1 BC105112 mRNA Translation: AAI05113.1 |
CCDSi | CCDS10170.1 |
PIRi | T12530 |
RefSeqi | NP_004692.1, NM_004701.3 |
Genome annotation databases
Ensembli | ENST00000288207.7; ENSP00000288207.2; ENSG00000157456.8 |
GeneIDi | 9133 |
KEGGi | hsa:9133 |
MANE-Selecti | ENST00000288207.7; ENSP00000288207.2; NM_004701.4; NP_004692.1 |
UCSCi | uc002afz.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF002822 mRNA Translation: AAD09309.1 AB020981 mRNA Translation: BAA78387.1 AL080146 mRNA Translation: CAB45739.1 CR533527 mRNA Translation: CAG38558.1 AY864066 Genomic DNA Translation: AAW34361.1 AK001404 mRNA Translation: BAG50905.1 CH471082 Genomic DNA Translation: EAW77563.1 BC105086 mRNA Translation: AAI05087.1 BC105112 mRNA Translation: AAI05113.1 |
CCDSi | CCDS10170.1 |
PIRi | T12530 |
RefSeqi | NP_004692.1, NM_004701.3 |
3D structure databases
AlphaFoldDBi | O95067 |
SMRi | O95067 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114581, 58 interactors |
ComplexPortali | CPX-2008, Cyclin B2-CDK1 complex |
CORUMi | O95067 |
DIPi | DIP-31730N |
IntActi | O95067, 47 interactors |
MINTi | O95067 |
STRINGi | 9606.ENSP00000288207 |
Chemistry databases
BindingDBi | O95067 |
ChEMBLi | CHEMBL2094127 |
DrugCentrali | O95067 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
PTM databases
iPTMneti | O95067 |
MetOSitei | O95067 |
PhosphoSitePlusi | O95067 |
Genetic variation databases
BioMutai | CCNB2 |
Proteomic databases
EPDi | O95067 |
jPOSTi | O95067 |
MassIVEi | O95067 |
MaxQBi | O95067 |
PaxDbi | O95067 |
PeptideAtlasi | O95067 |
PRIDEi | O95067 |
ProteomicsDBi | 50636 |
Protocols and materials databases
Antibodypediai | 1393, 618 antibodies from 37 providers |
DNASUi | 9133 |
Genome annotation databases
Ensembli | ENST00000288207.7; ENSP00000288207.2; ENSG00000157456.8 |
GeneIDi | 9133 |
KEGGi | hsa:9133 |
MANE-Selecti | ENST00000288207.7; ENSP00000288207.2; NM_004701.4; NP_004692.1 |
UCSCi | uc002afz.4, human |
Organism-specific databases
CTDi | 9133 |
DisGeNETi | 9133 |
GeneCardsi | CCNB2 |
HGNCi | HGNC:1580, CCNB2 |
HPAi | ENSG00000157456, Group enriched (bone marrow, lymphoid tissue, testis) |
MIMi | 602755, gene |
neXtProti | NX_O95067 |
OpenTargetsi | ENSG00000157456 |
PharmGKBi | PA26148 |
VEuPathDBi | HostDB:ENSG00000157456 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0653, Eukaryota |
GeneTreei | ENSGT00940000155405 |
InParanoidi | O95067 |
OMAi | QPTKTNV |
OrthoDBi | 993640at2759 |
PhylomeDBi | O95067 |
TreeFami | TF101001 |
Enzyme and pathway databases
PathwayCommonsi | O95067 |
Reactomei | R-HSA-156711, Polo-like kinase mediated events R-HSA-162658, Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-2514853, Condensation of Prometaphase Chromosomes R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-2980767, Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2995383, Initiation of Nuclear Envelope (NE) Reformation R-HSA-3301854, Nuclear Pore Complex (NPC) Disassembly R-HSA-69273, Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69478, G2/M DNA replication checkpoint R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint |
SignaLinki | O95067 |
SIGNORi | O95067 |
Miscellaneous databases
BioGRID-ORCSi | 9133, 18 hits in 1102 CRISPR screens |
ChiTaRSi | CCNB2, human |
GeneWikii | Cyclin_B2 |
GenomeRNAii | 9133 |
Pharosi | O95067, Tbio |
PROi | PR:O95067 |
RNActi | O95067, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000157456, Expressed in oocyte and 174 other tissues |
ExpressionAtlasi | O95067, baseline and differential |
Genevisiblei | O95067, HS |
Family and domain databases
CDDi | cd00043, CYCLIN, 2 hits |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
PIRSFi | PIRSF001771, Cyclin_A_B_D_E, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CCNB2_HUMAN | |
Accessioni | O95067Primary (citable) accession number: O95067 Secondary accession number(s): B3KM93, Q6FI99 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | May 1, 1999 | |
Last modified: | May 25, 2022 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families