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UniProtKB - O95067 (CCNB2_HUMAN)

Entry version 175 (07 Apr 2021)
Sequence version 1 (01 May 1999)
Previous versions | rss
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Protein

G2/mitotic-specific cyclin-B2

Gene

CCNB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O95067

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-156711, Polo-like kinase mediated events
R-HSA-162658, Golgi Cisternae Pericentriolar Stack Reorganization
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-2514853, Condensation of Prometaphase Chromosomes
R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-2980767, Activation of NIMA Kinases NEK9, NEK6, NEK7
R-HSA-2995383, Initiation of Nuclear Envelope (NE) Reformation
R-HSA-3301854, Nuclear Pore Complex (NPC) Disassembly
R-HSA-69273, Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-69478, G2/M DNA replication checkpoint
R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O95067

SIGNOR Signaling Network Open Resource

More...SIGNORi		O95067

Protein family/group databases

Transport Classification Database

More...TCDBi		1.I.1.1.3, the nuclear pore complex (npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCNB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1580, CCNB2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602755, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95067

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000157456.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9133

Open Targets

More...OpenTargetsi		ENSG00000157456

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26148

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O95067, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2094127

DrugCentral

More...DrugCentrali		O95067

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCNB2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000803611 – 398G2/mitotic-specific cyclin-B2Add BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei8PhosphothreonineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei94PhosphothreonineCombined sources1
Modified residuei99PhosphoserineCombined sources1
Modified residuei392PhosphoserineCombined sources1
Modified residuei398PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O95067

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O95067

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O95067

MaxQB - The MaxQuant DataBase

More...MaxQBi		O95067

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95067

PeptideAtlas

More...PeptideAtlasi		O95067

PRoteomics IDEntifications database

More...PRIDEi		O95067

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50636

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95067

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O95067

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95067

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Accumulates steadily during G2 and is abruptly destroyed at mitosis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000157456, Expressed in oocyte and 173 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O95067, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95067, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000157456, Tissue enhanced (lymphoid tissue, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114581, 45 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2008, Cyclin B2-CDK1 complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O95067

Database of interacting proteins

More...DIPi		DIP-31730N

Protein interaction database and analysis system

More...IntActi		O95067, 41 interactors

Molecular INTeraction database

More...MINTi		O95067

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000288207

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O95067

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O95067, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O95067

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0653, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155405

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95067

Identification of Orthologs from Complete Genome Data

More...OMAi		RYLQVQP

Database of Orthologous Groups

More...OrthoDBi		993640at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95067

TreeFam database of animal gene trees

More...TreeFami		TF101001

Family and domain databases

Conserved Domains Database

More...CDDi		cd00043, CYCLIN, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039361, Cyclin
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR004367, Cyclin_C-dom
IPR006671, Cyclin_N

The PANTHER Classification System

More...PANTHERi		PTHR10177, PTHR10177, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001771, Cyclin_A_B_D_E, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00385, CYCLIN, 2 hits
SM01332, Cyclin_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47954, SSF47954, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00292, CYCLINS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O95067-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLRRPTVS SDLENIDTGV NSKVKSHVTI RRTVLEEIGN RVTTRAAQVA 
        60         70         80         90        100
KKAQNTKVPV QPTKTTNVNK QLKPTASVKP VQMEKLAPKG PSPTPEDVSM 
       110        120        130        140        150
KEENLCQAFS DALLCKIEDI DNEDWENPQL CSDYVKDIYQ YLRQLEVLQS 
       160        170        180        190        200
INPHFLDGRD INGRMRAILV DWLVQVHSKF RLLQETLYMC VGIMDRFLQV 
       210        220        230        240        250
QPVSRKKLQL VGITALLLAS KYEEMFSPNI EDFVYITDNA YTSSQIREME 
       260        270        280        290        300
TLILKELKFE LGRPLPLHFL RRASKAGEVD VEQHTLAKYL MELTLIDYDM 
       310        320        330        340        350
VHYHPSKVAA AASCLSQKVL GQGKWNLKQQ YYTGYTENEV LEVMQHMAKN 
       360        370        380        390 
VVKVNENLTK FIAIKNKYAS SKLLKISMIP QLNSKAVKDL ASPLIGRS
Length:398
Mass (Da):45,282
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i874466E1DD68A4C4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H1UBN3H1UBN3_HUMAN
Cyclin B2
CCNB2 CCNB2V
374Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMP3H0YMP3_HUMAN
G2/mitotic-specific cyclin-B2
CCNB2
270Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022221100M → T1 PublicationCorresponds to variant dbSNP:rs16941036EnsemblClinVar.1
Natural variantiVAR_053052135V → I. Corresponds to variant dbSNP:rs2306785Ensembl.1
Natural variantiVAR_022222395I → T1 PublicationCorresponds to variant dbSNP:rs28383563EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF002822 mRNA Translation: AAD09309.1
AB020981 mRNA Translation: BAA78387.1
AL080146 mRNA Translation: CAB45739.1
CR533527 mRNA Translation: CAG38558.1
AY864066 Genomic DNA Translation: AAW34361.1
AK001404 mRNA Translation: BAG50905.1
CH471082 Genomic DNA Translation: EAW77563.1
BC105086 mRNA Translation: AAI05087.1
BC105112 mRNA Translation: AAI05113.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10170.1

Protein sequence database of the Protein Information Resource

More...PIRi		T12530

NCBI Reference Sequences

More...RefSeqi		NP_004692.1, NM_004701.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000288207; ENSP00000288207; ENSG00000157456

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9133

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9133

UCSC genome browser

More...UCSCi		uc002afz.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002822 mRNA Translation: AAD09309.1
AB020981 mRNA Translation: BAA78387.1
AL080146 mRNA Translation: CAB45739.1
CR533527 mRNA Translation: CAG38558.1
AY864066 Genomic DNA Translation: AAW34361.1
AK001404 mRNA Translation: BAG50905.1
CH471082 Genomic DNA Translation: EAW77563.1
BC105086 mRNA Translation: AAI05087.1
BC105112 mRNA Translation: AAI05113.1
CCDSiCCDS10170.1
PIRiT12530
RefSeqiNP_004692.1, NM_004701.3

3D structure databases

SMRiO95067
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114581, 45 interactors
ComplexPortaliCPX-2008, Cyclin B2-CDK1 complex
CORUMiO95067
DIPiDIP-31730N
IntActiO95067, 41 interactors
MINTiO95067
STRINGi9606.ENSP00000288207

Chemistry databases

BindingDBiO95067
ChEMBLiCHEMBL2094127
DrugCentraliO95067

Protein family/group databases

TCDBi1.I.1.1.3, the nuclear pore complex (npc) family

PTM databases

iPTMnetiO95067
MetOSiteiO95067
PhosphoSitePlusiO95067

Genetic variation databases

BioMutaiCCNB2

Proteomic databases

EPDiO95067
jPOSTiO95067
MassIVEiO95067
MaxQBiO95067
PaxDbiO95067
PeptideAtlasiO95067
PRIDEiO95067
ProteomicsDBi50636

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1393, 605 antibodies

The DNASU plasmid repository

More...DNASUi		9133

Genome annotation databases

EnsembliENST00000288207; ENSP00000288207; ENSG00000157456
GeneIDi9133
KEGGihsa:9133
UCSCiuc002afz.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9133
DisGeNETi9133

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCNB2
HGNCiHGNC:1580, CCNB2
HPAiENSG00000157456, Tissue enhanced (lymphoid tissue, testis)
MIMi602755, gene
neXtProtiNX_O95067
OpenTargetsiENSG00000157456
PharmGKBiPA26148
VEuPathDBiHostDB:ENSG00000157456.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0653, Eukaryota
GeneTreeiENSGT00940000155405
InParanoidiO95067
OMAiRYLQVQP
OrthoDBi993640at2759
PhylomeDBiO95067
TreeFamiTF101001

Enzyme and pathway databases

PathwayCommonsiO95067
ReactomeiR-HSA-156711, Polo-like kinase mediated events
R-HSA-162658, Golgi Cisternae Pericentriolar Stack Reorganization
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-2514853, Condensation of Prometaphase Chromosomes
R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-2980767, Activation of NIMA Kinases NEK9, NEK6, NEK7
R-HSA-2995383, Initiation of Nuclear Envelope (NE) Reformation
R-HSA-3301854, Nuclear Pore Complex (NPC) Disassembly
R-HSA-69273, Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-69478, G2/M DNA replication checkpoint
R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
SignaLinkiO95067
SIGNORiO95067

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9133, 13 hits in 1011 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CCNB2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Cyclin_B2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9133
PharosiO95067, Tbio

Protein Ontology

More...PROi		PR:O95067
RNActiO95067, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000157456, Expressed in oocyte and 173 other tissues
ExpressionAtlasiO95067, baseline and differential
GenevisibleiO95067, HS

Family and domain databases

CDDicd00043, CYCLIN, 2 hits
InterProiView protein in InterPro
IPR039361, Cyclin
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR004367, Cyclin_C-dom
IPR006671, Cyclin_N
PANTHERiPTHR10177, PTHR10177, 1 hit
PfamiView protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit
PIRSFiPIRSF001771, Cyclin_A_B_D_E, 1 hit
SMARTiView protein in SMART
SM00385, CYCLIN, 2 hits
SM01332, Cyclin_C, 1 hit
SUPFAMiSSF47954, SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292, CYCLINS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCNB2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95067
Secondary accession number(s): B3KM93, Q6FI99
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1999
Last modified: April 7, 2021
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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