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Protein

G2/mitotic-specific cyclin-B2

Gene

CCNB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-156711 Polo-like kinase mediated events
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2514853 Condensation of Prometaphase Chromosomes
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-69478 G2/M DNA replication checkpoint
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
SignaLinkiO95067
SIGNORiO95067

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B2
Gene namesi
Name:CCNB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000157456.7
HGNCiHGNC:1580 CCNB2
MIMi602755 gene
neXtProtiNX_O95067

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9133
OpenTargetsiENSG00000157456
PharmGKBiPA26148

Chemistry databases

ChEMBLiCHEMBL2094127

Polymorphism and mutation databases

BioMutaiCCNB2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000803611 – 398G2/mitotic-specific cyclin-B2Add BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphothreonineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei94PhosphothreonineCombined sources1
Modified residuei99PhosphoserineCombined sources1
Modified residuei392PhosphoserineCombined sources1
Modified residuei398PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95067
MaxQBiO95067
PaxDbiO95067
PeptideAtlasiO95067
PRIDEiO95067
ProteomicsDBi50636

PTM databases

iPTMnetiO95067
PhosphoSitePlusiO95067

Expressioni

Developmental stagei

Accumulates steadily during G2 and is abruptly destroyed at mitosis.

Gene expression databases

BgeeiENSG00000157456 Expressed in 152 organ(s), highest expression level in oocyte
CleanExiHS_CCNB2
ExpressionAtlasiO95067 baseline and differential
GenevisibleiO95067 HS

Organism-specific databases

HPAiCAB009575
HPA008873

Interactioni

Subunit structurei

Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114581, 38 interactors
ComplexPortaliCPX-2008 Cyclin B2-CDK1 complex
CORUMiO95067
DIPiDIP-31730N
IntActiO95067, 32 interactors
MINTiO95067
STRINGi9606.ENSP00000288207

Chemistry databases

BindingDBiO95067

Structurei

3D structure databases

ProteinModelPortaliO95067
SMRiO95067
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiKOG0653 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00760000118939
HOGENOMiHOG000167672
HOVERGENiHBG061650
InParanoidiO95067
KOiK21770
OMAiISMKEEN
OrthoDBiEOG091G0E9B
PhylomeDBiO95067
TreeFamiTF101001

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
PIRSFiPIRSF001771 Cyclin_A_B_D_E, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O95067-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLRRPTVS SDLENIDTGV NSKVKSHVTI RRTVLEEIGN RVTTRAAQVA
60 70 80 90 100
KKAQNTKVPV QPTKTTNVNK QLKPTASVKP VQMEKLAPKG PSPTPEDVSM
110 120 130 140 150
KEENLCQAFS DALLCKIEDI DNEDWENPQL CSDYVKDIYQ YLRQLEVLQS
160 170 180 190 200
INPHFLDGRD INGRMRAILV DWLVQVHSKF RLLQETLYMC VGIMDRFLQV
210 220 230 240 250
QPVSRKKLQL VGITALLLAS KYEEMFSPNI EDFVYITDNA YTSSQIREME
260 270 280 290 300
TLILKELKFE LGRPLPLHFL RRASKAGEVD VEQHTLAKYL MELTLIDYDM
310 320 330 340 350
VHYHPSKVAA AASCLSQKVL GQGKWNLKQQ YYTGYTENEV LEVMQHMAKN
360 370 380 390
VVKVNENLTK FIAIKNKYAS SKLLKISMIP QLNSKAVKDL ASPLIGRS
Length:398
Mass (Da):45,282
Last modified:May 1, 1999 - v1
Checksum:i874466E1DD68A4C4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H1UBN3H1UBN3_HUMAN
Cyclin B2
CCNB2 CCNB2V
374Annotation score:
H0YMP3H0YMP3_HUMAN
G2/mitotic-specific cyclin-B2
CCNB2
270Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022221100M → T1 PublicationCorresponds to variant dbSNP:rs16941036Ensembl.1
Natural variantiVAR_053052135V → I. Corresponds to variant dbSNP:rs2306785Ensembl.1
Natural variantiVAR_022222395I → T1 PublicationCorresponds to variant dbSNP:rs28383563Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002822 mRNA Translation: AAD09309.1
AB020981 mRNA Translation: BAA78387.1
AL080146 mRNA Translation: CAB45739.1
CR533527 mRNA Translation: CAG38558.1
AY864066 Genomic DNA Translation: AAW34361.1
AK001404 mRNA Translation: BAG50905.1
CH471082 Genomic DNA Translation: EAW77563.1
BC105086 mRNA Translation: AAI05087.1
BC105112 mRNA Translation: AAI05113.1
CCDSiCCDS10170.1
PIRiT12530
RefSeqiNP_004692.1, NM_004701.3
UniGeneiHs.194698

Genome annotation databases

EnsembliENST00000288207; ENSP00000288207; ENSG00000157456
GeneIDi9133
KEGGihsa:9133
UCSCiuc002afz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002822 mRNA Translation: AAD09309.1
AB020981 mRNA Translation: BAA78387.1
AL080146 mRNA Translation: CAB45739.1
CR533527 mRNA Translation: CAG38558.1
AY864066 Genomic DNA Translation: AAW34361.1
AK001404 mRNA Translation: BAG50905.1
CH471082 Genomic DNA Translation: EAW77563.1
BC105086 mRNA Translation: AAI05087.1
BC105112 mRNA Translation: AAI05113.1
CCDSiCCDS10170.1
PIRiT12530
RefSeqiNP_004692.1, NM_004701.3
UniGeneiHs.194698

3D structure databases

ProteinModelPortaliO95067
SMRiO95067
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114581, 38 interactors
ComplexPortaliCPX-2008 Cyclin B2-CDK1 complex
CORUMiO95067
DIPiDIP-31730N
IntActiO95067, 32 interactors
MINTiO95067
STRINGi9606.ENSP00000288207

Chemistry databases

BindingDBiO95067
ChEMBLiCHEMBL2094127

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiO95067
PhosphoSitePlusiO95067

Polymorphism and mutation databases

BioMutaiCCNB2

Proteomic databases

EPDiO95067
MaxQBiO95067
PaxDbiO95067
PeptideAtlasiO95067
PRIDEiO95067
ProteomicsDBi50636

Protocols and materials databases

DNASUi9133
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288207; ENSP00000288207; ENSG00000157456
GeneIDi9133
KEGGihsa:9133
UCSCiuc002afz.4 human

Organism-specific databases

CTDi9133
DisGeNETi9133
EuPathDBiHostDB:ENSG00000157456.7
GeneCardsiCCNB2
HGNCiHGNC:1580 CCNB2
HPAiCAB009575
HPA008873
MIMi602755 gene
neXtProtiNX_O95067
OpenTargetsiENSG00000157456
PharmGKBiPA26148
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0653 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00760000118939
HOGENOMiHOG000167672
HOVERGENiHBG061650
InParanoidiO95067
KOiK21770
OMAiISMKEEN
OrthoDBiEOG091G0E9B
PhylomeDBiO95067
TreeFamiTF101001

Enzyme and pathway databases

ReactomeiR-HSA-156711 Polo-like kinase mediated events
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2514853 Condensation of Prometaphase Chromosomes
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-69478 G2/M DNA replication checkpoint
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
SignaLinkiO95067
SIGNORiO95067

Miscellaneous databases

GeneWikiiCyclin_B2
GenomeRNAii9133
PROiPR:O95067
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157456 Expressed in 152 organ(s), highest expression level in oocyte
CleanExiHS_CCNB2
ExpressionAtlasiO95067 baseline and differential
GenevisibleiO95067 HS

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
PIRSFiPIRSF001771 Cyclin_A_B_D_E, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCNB2_HUMAN
AccessioniPrimary (citable) accession number: O95067
Secondary accession number(s): B3KM93, Q6FI99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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