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Protein

Ribonuclease P protein subunit p14

Gene

RPP14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

Miscellaneous

This protein is produced by a bicistronic gene which also produces the HTD2 protein from an overlapping reading frame.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. EC:3.1.26.5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ribonuclease P activity Source: UniProtKB-EC
  • RNA binding Source: ProtInc

GO - Biological processi

  • tRNA 5'-leader removal Source: FlyBase

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processtRNA processing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribonuclease P protein subunit p14 (EC:3.1.26.5)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPP14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000163684.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30327 RPP14

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606112 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95059

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11102

Open Targets

More...
OpenTargetsi
ENSG00000163684

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134896894

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ABHD6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001400102 – 124Ribonuclease P protein subunit p14Add BLAST123

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O95059

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O95059

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95059

PeptideAtlas

More...
PeptideAtlasi
O95059

PRoteomics IDEntifications database

More...
PRIDEi
O95059

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50635

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
O95059

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95059

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95059

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163684 Expressed in 190 organ(s), highest expression level in quadriceps femoris

CleanEx database of gene expression profiles

More...
CleanExi
HS_RPP14

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95059 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036194

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116283, 23 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O95059

Protein interaction database and analysis system

More...
IntActi
O95059, 22 interactors

Molecular INTeraction database

More...
MINTi
O95059

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000295959

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O95059

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IXUB Eukaryota
ENOG4112ADM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000048121

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006985

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG079505

KEGG Orthology (KO)

More...
KOi
K14529

Identification of Orthologs from Complete Genome Data

More...
OMAi
RNPSEHH

Database of Orthologous Groups

More...
OrthoDBi
EOG091G10J1

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95059

TreeFam database of animal gene trees

More...
TreeFami
TF324711

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.3250, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002759 RNase_P/MRP_subunit
IPR038085 Rnp2-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01900 RNase_P_Rpp14, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF160350 SSF160350, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O95059-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAPAATYER VVYKNPSEYH YMKVCLEFQD CGVGLNAAQF KQLLISAVKD
60 70 80 90 100
LFGEVDAALP LDILTYEEKT LSAILRICSS GLVKLWSSLT LLGSYKGKKC
110 120
AFRVIQVSPF LLALSGNSRE LVLD
Length:124
Mass (Da):13,693
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i10AF6C947785DD90
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF001175 mRNA Translation: AAD00892.1
CR407611 mRNA Translation: CAG28539.1
AK311969 mRNA Translation: BAG34908.1
BC002441 mRNA Translation: AAH02441.1
BC007342 mRNA Translation: AAH07342.1
BC012017 mRNA Translation: AAH12017.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2888.1

NCBI Reference Sequences

More...
RefSeqi
NP_001092253.1, NM_001098783.2
NP_008973.1, NM_007042.4
XP_011531615.1, XM_011533313.2
XP_016861130.1, XM_017005641.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.446320
Hs.700016

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000295959; ENSP00000295959; ENSG00000163684
ENST00000445193; ENSP00000412894; ENSG00000163684
ENST00000466547; ENSP00000419909; ENSG00000163684

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11102

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11102

UCSC genome browser

More...
UCSCi
uc003dju.6 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001175 mRNA Translation: AAD00892.1
CR407611 mRNA Translation: CAG28539.1
AK311969 mRNA Translation: BAG34908.1
BC002441 mRNA Translation: AAH02441.1
BC007342 mRNA Translation: AAH07342.1
BC012017 mRNA Translation: AAH12017.1
CCDSiCCDS2888.1
RefSeqiNP_001092253.1, NM_001098783.2
NP_008973.1, NM_007042.4
XP_011531615.1, XM_011533313.2
XP_016861130.1, XM_017005641.1
UniGeneiHs.446320
Hs.700016

3D structure databases

ProteinModelPortaliO95059
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116283, 23 interactors
CORUMiO95059
IntActiO95059, 22 interactors
MINTiO95059
STRINGi9606.ENSP00000295959

PTM databases

iPTMnetiO95059
PhosphoSitePlusiO95059

Polymorphism and mutation databases

BioMutaiABHD6

Proteomic databases

EPDiO95059
MaxQBiO95059
PaxDbiO95059
PeptideAtlasiO95059
PRIDEiO95059
ProteomicsDBi50635
TopDownProteomicsiO95059

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
11102
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295959; ENSP00000295959; ENSG00000163684
ENST00000445193; ENSP00000412894; ENSG00000163684
ENST00000466547; ENSP00000419909; ENSG00000163684
GeneIDi11102
KEGGihsa:11102
UCSCiuc003dju.6 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11102
DisGeNETi11102
EuPathDBiHostDB:ENSG00000163684.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RPP14
HGNCiHGNC:30327 RPP14
HPAiHPA036194
MIMi606112 gene
neXtProtiNX_O95059
OpenTargetsiENSG00000163684
PharmGKBiPA134896894

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IXUB Eukaryota
ENOG4112ADM LUCA
GeneTreeiENSGT00510000048121
HOGENOMiHOG000006985
HOVERGENiHBG079505
KOiK14529
OMAiRNPSEHH
OrthoDBiEOG091G10J1
PhylomeDBiO95059
TreeFamiTF324711

Enzyme and pathway databases

ReactomeiR-HSA-6784531 tRNA processing in the nucleus
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RPP14 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RPP14

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11102

Protein Ontology

More...
PROi
PR:O95059

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163684 Expressed in 190 organ(s), highest expression level in quadriceps femoris
CleanExiHS_RPP14
GenevisibleiO95059 HS

Family and domain databases

Gene3Di3.30.70.3250, 1 hit
InterProiView protein in InterPro
IPR002759 RNase_P/MRP_subunit
IPR038085 Rnp2-like_sf
PfamiView protein in Pfam
PF01900 RNase_P_Rpp14, 1 hit
SUPFAMiSSF160350 SSF160350, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPP14_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95059
Secondary accession number(s): Q53X97
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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