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Protein

Ribonuclease P protein subunit p14

Gene

RPP14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

Miscellaneous

This protein is produced by a bicistronic gene which also produces the HTD2 protein from an overlapping reading frame.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  • ribonuclease P activity Source: UniProtKB-EC
  • RNA binding Source: ProtInc

GO - Biological processi

  • tRNA 5'-leader removal Source: FlyBase

Keywordsi

Molecular functionHydrolase
Biological processtRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6784531 tRNA processing in the nucleus
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p14 (EC:3.1.26.5)
Gene namesi
Name:RPP14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163684.11
HGNCiHGNC:30327 RPP14
MIMi606112 gene
neXtProtiNX_O95059

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11102
OpenTargetsiENSG00000163684
PharmGKBiPA134896894

Polymorphism and mutation databases

BioMutaiABHD6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001400102 – 124Ribonuclease P protein subunit p14Add BLAST123

Proteomic databases

EPDiO95059
MaxQBiO95059
PaxDbiO95059
PeptideAtlasiO95059
PRIDEiO95059
ProteomicsDBi50635
TopDownProteomicsiO95059

PTM databases

iPTMnetiO95059
PhosphoSitePlusiO95059

Expressioni

Gene expression databases

BgeeiENSG00000163684 Expressed in 190 organ(s), highest expression level in quadriceps femoris
CleanExiHS_RPP14
GenevisibleiO95059 HS

Organism-specific databases

HPAiHPA036194

Interactioni

Subunit structurei

RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.

Protein-protein interaction databases

BioGridi116283, 23 interactors
CORUMiO95059
IntActiO95059, 21 interactors
MINTiO95059
STRINGi9606.ENSP00000295959

Structurei

3D structure databases

ProteinModelPortaliO95059
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IXUB Eukaryota
ENOG4112ADM LUCA
GeneTreeiENSGT00510000048121
HOGENOMiHOG000006985
HOVERGENiHBG079505
KOiK14529
OMAiRNPSEHH
OrthoDBiEOG091G10J1
PhylomeDBiO95059
TreeFamiTF324711

Family and domain databases

Gene3Di3.30.70.3250, 1 hit
InterProiView protein in InterPro
IPR002759 RNase_P/MRP_subunit
IPR038085 Rnp2-like_sf
PfamiView protein in Pfam
PF01900 RNase_P_Rpp14, 1 hit
SUPFAMiSSF160350 SSF160350, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95059-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAPAATYER VVYKNPSEYH YMKVCLEFQD CGVGLNAAQF KQLLISAVKD
60 70 80 90 100
LFGEVDAALP LDILTYEEKT LSAILRICSS GLVKLWSSLT LLGSYKGKKC
110 120
AFRVIQVSPF LLALSGNSRE LVLD
Length:124
Mass (Da):13,693
Last modified:January 23, 2007 - v3
Checksum:i10AF6C947785DD90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001175 mRNA Translation: AAD00892.1
CR407611 mRNA Translation: CAG28539.1
AK311969 mRNA Translation: BAG34908.1
BC002441 mRNA Translation: AAH02441.1
BC007342 mRNA Translation: AAH07342.1
BC012017 mRNA Translation: AAH12017.1
CCDSiCCDS2888.1
RefSeqiNP_001092253.1, NM_001098783.2
NP_008973.1, NM_007042.4
XP_011531615.1, XM_011533313.2
XP_016861130.1, XM_017005641.1
UniGeneiHs.446320
Hs.700016

Genome annotation databases

EnsembliENST00000295959; ENSP00000295959; ENSG00000163684
ENST00000445193; ENSP00000412894; ENSG00000163684
ENST00000466547; ENSP00000419909; ENSG00000163684
GeneIDi11102
KEGGihsa:11102
UCSCiuc003dju.6 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001175 mRNA Translation: AAD00892.1
CR407611 mRNA Translation: CAG28539.1
AK311969 mRNA Translation: BAG34908.1
BC002441 mRNA Translation: AAH02441.1
BC007342 mRNA Translation: AAH07342.1
BC012017 mRNA Translation: AAH12017.1
CCDSiCCDS2888.1
RefSeqiNP_001092253.1, NM_001098783.2
NP_008973.1, NM_007042.4
XP_011531615.1, XM_011533313.2
XP_016861130.1, XM_017005641.1
UniGeneiHs.446320
Hs.700016

3D structure databases

ProteinModelPortaliO95059
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116283, 23 interactors
CORUMiO95059
IntActiO95059, 21 interactors
MINTiO95059
STRINGi9606.ENSP00000295959

PTM databases

iPTMnetiO95059
PhosphoSitePlusiO95059

Polymorphism and mutation databases

BioMutaiABHD6

Proteomic databases

EPDiO95059
MaxQBiO95059
PaxDbiO95059
PeptideAtlasiO95059
PRIDEiO95059
ProteomicsDBi50635
TopDownProteomicsiO95059

Protocols and materials databases

DNASUi11102
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295959; ENSP00000295959; ENSG00000163684
ENST00000445193; ENSP00000412894; ENSG00000163684
ENST00000466547; ENSP00000419909; ENSG00000163684
GeneIDi11102
KEGGihsa:11102
UCSCiuc003dju.6 human

Organism-specific databases

CTDi11102
DisGeNETi11102
EuPathDBiHostDB:ENSG00000163684.11
GeneCardsiRPP14
HGNCiHGNC:30327 RPP14
HPAiHPA036194
MIMi606112 gene
neXtProtiNX_O95059
OpenTargetsiENSG00000163684
PharmGKBiPA134896894
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXUB Eukaryota
ENOG4112ADM LUCA
GeneTreeiENSGT00510000048121
HOGENOMiHOG000006985
HOVERGENiHBG079505
KOiK14529
OMAiRNPSEHH
OrthoDBiEOG091G10J1
PhylomeDBiO95059
TreeFamiTF324711

Enzyme and pathway databases

ReactomeiR-HSA-6784531 tRNA processing in the nucleus
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSiRPP14 human
GeneWikiiRPP14
GenomeRNAii11102
PROiPR:O95059
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163684 Expressed in 190 organ(s), highest expression level in quadriceps femoris
CleanExiHS_RPP14
GenevisibleiO95059 HS

Family and domain databases

Gene3Di3.30.70.3250, 1 hit
InterProiView protein in InterPro
IPR002759 RNase_P/MRP_subunit
IPR038085 Rnp2-like_sf
PfamiView protein in Pfam
PF01900 RNase_P_Rpp14, 1 hit
SUPFAMiSSF160350 SSF160350, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRPP14_HUMAN
AccessioniPrimary (citable) accession number: O95059
Secondary accession number(s): Q53X97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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