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UniProtKB - O95057 (DIRA1_HUMAN)
Protein
GTP-binding protein Di-Ras1
Gene
DIRAS1
Organism
Homo sapiens (Human)
Status
Functioni
Displays low GTPase activity and exists predominantly in the GTP-bound form.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 151 | GTP; via amide nitrogenCombined sources1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 17 – 22 | GTPCombined sources1 Publication | 6 | |
Nucleotide bindingi | 33 – 39 | GTPBy similarity | 7 | |
Nucleotide bindingi | 61 – 65 | GTPBy similarity | 5 | |
Nucleotide bindingi | 121 – 125 | GTPCombined sources1 Publication | 5 | |
Nucleotide bindingi | 151 – 152 | GTPBy similarity | 2 |
GO - Molecular functioni
- GDP binding Source: GO_Central
- GTPase activity Source: UniProtKB
- GTP binding Source: UniProtKB
GO - Biological processi
- signal transduction Source: InterPro
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | O95057 |
SignaLinki | O95057 |
Names & Taxonomyi
Protein namesi | Recommended name: GTP-binding protein Di-Ras1Alternative name(s): Distinct subgroup of the Ras family member 1 Ras-related inhibitor of cell growth Short name: Rig Small GTP-binding tumor suppressor 1 |
Gene namesi | Name:DIRAS1 Synonyms:GBTS1, RIG |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19127, DIRAS1 |
MIMi | 607862, gene |
neXtProti | NX_O95057 |
VEuPathDBi | HostDB:ENSG00000176490 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
Plasma Membrane
- plasma membrane Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 148252 |
OpenTargetsi | ENSG00000176490 |
PharmGKBi | PA134951835 |
Miscellaneous databases
Pharosi | O95057, Tbio |
Genetic variation databases
BioMutai | DIRAS1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191648 | 1 – 195 | GTP-binding protein Di-Ras1Add BLAST | 195 | |
PropeptideiPRO_0000370775 | 196 – 198 | Removed in mature formSequence analysis | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 195 | Cysteine methyl esterSequence analysis | 1 | |
Lipidationi | 195 | S-geranylgeranyl cysteineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, Methylation, PrenylationProteomic databases
EPDi | O95057 |
jPOSTi | O95057 |
MassIVEi | O95057 |
MaxQBi | O95057 |
PaxDbi | O95057 |
PeptideAtlasi | O95057 |
PRIDEi | O95057 |
ProteomicsDBi | 50634 |
PTM databases
iPTMneti | O95057 |
PhosphoSitePlusi | O95057 |
Expressioni
Tissue specificityi
Highly expressed in heart and brain.2 Publications
Gene expression databases
Bgeei | ENSG00000176490, Expressed in left ventricle myocardium and 166 other tissues |
ExpressionAtlasi | O95057, baseline and differential |
Genevisiblei | O95057, HS |
Organism-specific databases
HPAi | ENSG00000176490, Tissue enhanced (brain, heart muscle, tongue) |
Interactioni
Binary interactionsi
O95057
With | #Exp. | IntAct |
---|---|---|
PPP1R13B [Q96KQ4] | 3 | EBI-11993172,EBI-1105153 |
RAP1GDS1 - isoform 5 [P52306-5] | 5 | EBI-11993172,EBI-12832744 |
TP53BP2 [Q05BL1] | 3 | EBI-11993172,EBI-11952721 |
Protein-protein interaction databases
BioGRIDi | 127135, 24 interactors |
IntActi | O95057, 8 interactors |
STRINGi | 9606.ENSP00000325836 |
Miscellaneous databases
RNActi | O95057, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O95057 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O95057 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 178 – 198 | DisorderedSequence analysisAdd BLAST | 21 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 36 – 44 | Effector regionSequence analysis | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000159915 |
HOGENOMi | CLU_041217_9_8_1 |
InParanoidi | O95057 |
OMAi | QAWKCAF |
OrthoDBi | 1218505at2759 |
PhylomeDBi | O95057 |
TreeFami | TF313014 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SMARTi | View protein in SMART SM00174, RHO, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O95057-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPEQSNDYRV VVFGAGGVGK SSLVLRFVKG TFRDTYIPTI EDTYRQVISC
60 70 80 90 100
DKSVCTLQIT DTTGSHQFPA MQRLSISKGH AFILVFSVTS KQSLEELGPI
110 120 130 140 150
YKLIVQIKGS VEDIPVMLVG NKCDETQREV DTREAQAVAQ EWKCAFMETS
160 170 180 190
AKMNYNVKEL FQELLTLETR RNMSLNIDGK RSGKQKRTDR VKGKCTLM
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketK7EN06 | K7EN06_HUMAN | GTP-binding protein Di-Ras1 | DIRAS1 | 136 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB076888 mRNA Translation: BAC01115.1 AY056037 mRNA Translation: AAL23715.1 AY059641 mRNA Translation: AAL17968.1 AY180973 mRNA Translation: AAO22153.1 AC006538 Genomic DNA Translation: AAD13119.1 BC030660 mRNA Translation: AAH30660.1 |
CCDSi | CCDS12092.1 |
RefSeqi | NP_660156.1, NM_145173.3 |
Genome annotation databases
Ensembli | ENST00000323469; ENSP00000325836; ENSG00000176490 ENST00000585334; ENSP00000468417; ENSG00000176490 |
GeneIDi | 148252 |
KEGGi | hsa:148252 |
MANE-Selecti | ENST00000323469.5; ENSP00000325836.3; NM_145173.4; NP_660156.1 |
UCSCi | uc002lwf.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB076888 mRNA Translation: BAC01115.1 AY056037 mRNA Translation: AAL23715.1 AY059641 mRNA Translation: AAL17968.1 AY180973 mRNA Translation: AAO22153.1 AC006538 Genomic DNA Translation: AAD13119.1 BC030660 mRNA Translation: AAH30660.1 |
CCDSi | CCDS12092.1 |
RefSeqi | NP_660156.1, NM_145173.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2GF0 | X-ray | 1.90 | A/B/C/D | 1-198 | [»] | |
SMRi | O95057 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 127135, 24 interactors |
IntActi | O95057, 8 interactors |
STRINGi | 9606.ENSP00000325836 |
PTM databases
iPTMneti | O95057 |
PhosphoSitePlusi | O95057 |
Genetic variation databases
BioMutai | DIRAS1 |
Proteomic databases
EPDi | O95057 |
jPOSTi | O95057 |
MassIVEi | O95057 |
MaxQBi | O95057 |
PaxDbi | O95057 |
PeptideAtlasi | O95057 |
PRIDEi | O95057 |
ProteomicsDBi | 50634 |
Protocols and materials databases
Antibodypediai | 23037, 241 antibodies from 27 providers |
DNASUi | 148252 |
Genome annotation databases
Ensembli | ENST00000323469; ENSP00000325836; ENSG00000176490 ENST00000585334; ENSP00000468417; ENSG00000176490 |
GeneIDi | 148252 |
KEGGi | hsa:148252 |
MANE-Selecti | ENST00000323469.5; ENSP00000325836.3; NM_145173.4; NP_660156.1 |
UCSCi | uc002lwf.4, human |
Organism-specific databases
CTDi | 148252 |
DisGeNETi | 148252 |
GeneCardsi | DIRAS1 |
HGNCi | HGNC:19127, DIRAS1 |
HPAi | ENSG00000176490, Tissue enhanced (brain, heart muscle, tongue) |
MIMi | 607862, gene |
neXtProti | NX_O95057 |
OpenTargetsi | ENSG00000176490 |
PharmGKBi | PA134951835 |
VEuPathDBi | HostDB:ENSG00000176490 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000159915 |
HOGENOMi | CLU_041217_9_8_1 |
InParanoidi | O95057 |
OMAi | QAWKCAF |
OrthoDBi | 1218505at2759 |
PhylomeDBi | O95057 |
TreeFami | TF313014 |
Enzyme and pathway databases
PathwayCommonsi | O95057 |
SignaLinki | O95057 |
Miscellaneous databases
BioGRID-ORCSi | 148252, 5 hits in 1040 CRISPR screens |
EvolutionaryTracei | O95057 |
GenomeRNAii | 148252 |
Pharosi | O95057, Tbio |
PROi | PR:O95057 |
RNActi | O95057, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000176490, Expressed in left ventricle myocardium and 166 other tissues |
ExpressionAtlasi | O95057, baseline and differential |
Genevisiblei | O95057, HS |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SMARTi | View protein in SMART SM00174, RHO, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DIRA1_HUMAN | |
Accessioni | O95057Primary (citable) accession number: O95057 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2005 |
Last sequence update: | May 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families