OR6B1

Functionⁱ

Odorant receptor.Curated

GO - Molecular functionⁱ

G protein-coupled receptor activity Source: UniProtKB-KW
olfactory receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Olfaction, Sensory transduction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Olfactory receptor 6B1 Alternative name(s): Olfactory receptor 7-3 Short name: OR7-3 Olfactory receptor OR7-9
Gene namesⁱ	Name:OR6B1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000221813.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8354 OR6B1
neXtProtⁱ	NX_O95007

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 25	ExtracellularSequence analysisAdd BLAST	25
Transmembraneⁱ	26 – 46	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	47 – 54	CytoplasmicSequence analysis	8
Transmembraneⁱ	55 – 75	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	76 – 99	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	100 – 120	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	121 – 139	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	140 – 160	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	161 – 196	ExtracellularSequence analysisAdd BLAST	36
Transmembraneⁱ	197 – 217	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	218 – 235	CytoplasmicSequence analysisAdd BLAST	18
Transmembraneⁱ	236 – 256	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	257 – 269	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	270 – 290	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	291 – 311	CytoplasmicSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA32576

PharmGKBⁱ

PA32576

Polymorphism and mutation databases

BioMutaⁱ	OR6B1

BioMutaⁱ

OR6B1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000150620	1 – 311	Olfactory receptor 6B1Add BLAST		311

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	5	N-linked (GlcNAc...) asparagineSequence analysis		1
Disulfide bondⁱ	97 ↔ 189	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	O95007
PeptideAtlas More...PeptideAtlasⁱ	O95007
PRIDEⁱ	O95007
ProteomicsDBⁱ	50624

PTM databases

iPTMnetⁱ	O95007
PhosphoSitePlusⁱ	O95007

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000221813 Expressed in 2 organ(s), highest expression level in left testis
CleanExⁱ	HS_OR6B1
Genevisibleⁱ	O95007 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA053164

HPAⁱ

HPA053164

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	126443, 2 interactors
IntActⁱ	O95007, 2 interactors
STRINGⁱ	9606.ENSP00000386151

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O95007
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IF9G Eukaryota ENOG410YB1I LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00800000124041
HOGENOMⁱ	HOG000041364
HOVERGENⁱ	HBG017625
InParanoidⁱ	O95007
KEGG Orthology (KO) More...KOⁱ	K04257
OMAⁱ	PTIMSHG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DAJ
PhylomeDBⁱ	O95007
TreeFamⁱ	TF337475

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O95007-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MELENQTRVT KFILVGFPGS LSMRAAMFLI FLVAYILTVA ENVIIILLVL 
        60         70         80         90        100
QNRPLHKPMY FFLANLSFLE TWYISVTVPK LLFSFWSVNN SISFTLCMIQ 
       110        120        130        140        150
LYFFIALMCT ECVLLAAMAY DRYVAICRPL HYPTIMSHGL CFRLALGSWA 
       160        170        180        190        200
IGFGISLAKI YFISCLSFCG PNVINHFFCD ISPVLNLSCT DMSITELVDF 
       210        220        230        240        250
ILALVIFLFP LFITVLSYGC ILATILCMPT GKQKAFSTCA SHLVVVTIFY 
       260        270        280        290        300
SAIIFMYARP RVIHAFNMNK IISIFYAIVT PSLNPFIYCL RNREVKEALK 
       310 
KLAYCQASRS D

Length:311

Mass (Da):35,299

Last modified:May 1, 1999 - v1

Checksum:ⁱ671FD19658FE0616

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_034238	143	R → C. Corresponds to variant dbSNP:rs7787378Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC004853 Genomic DNA No translation available. CH236959 Genomic DNA Translation: EAL23796.1 Sequence problems. BC137042 mRNA Translation: AAI37043.1 BC137047 mRNA Translation: AAI37048.1 AF399605 Genomic DNA Translation: AAK95090.1 BK004216 Genomic DNA Translation: DAA04614.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43667.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001005281.1, NM_001005281.1
UniGeneⁱ	Hs.632031

Genome annotation databases

Ensemblⁱ	ENST00000408922; ENSP00000386151; ENSG00000221813 ENST00000641698; ENSP00000492907; ENSG00000221813 ENST00000642360; ENSP00000496557; ENSG00000284939 ENST00000647270; ENSP00000494805; ENSG00000284939
GeneIDⁱ	135946
KEGGⁱ	hsa:135946
UCSC genome browser More...UCSCⁱ	uc003wdt.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95007	Olfactory receptor		NEOLE		327	UniRef90_O95007
Olfactory receptor		BOVIN		320
Olfactory receptor		SHEEP		320
Olfactory receptor		MYOLU		317
Olfactory receptor		PANPA		317
+53

Protein	Similar proteins		Species	Score	Length	Source
O95007	Olfactory receptor 226		RAT		327	UniRef50_O95007
Olfactory receptor		NEOLE		327
Olfactory receptor		SHEEP		320
Olfactory receptor		BOVIN		320
Olfactory receptor		CANLF		317
+206

Cross-referencesⁱ

Web resourcesⁱ

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC004853 Genomic DNA No translation available. CH236959 Genomic DNA Translation: EAL23796.1 Sequence problems. BC137042 mRNA Translation: AAI37043.1 BC137047 mRNA Translation: AAI37048.1 AF399605 Genomic DNA Translation: AAK95090.1 BK004216 Genomic DNA Translation: DAA04614.1
CCDSⁱ	CCDS43667.1
RefSeqⁱ	NP_001005281.1, NM_001005281.1
UniGeneⁱ	Hs.632031

3D structure databases

ProteinModelPortalⁱ	O95007
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126443, 2 interactors
IntActⁱ	O95007, 2 interactors
STRINGⁱ	9606.ENSP00000386151

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	O95007
PhosphoSitePlusⁱ	O95007

Polymorphism and mutation databases

BioMutaⁱ	OR6B1

BioMutaⁱ

OR6B1

Proteomic databases

PaxDbⁱ	O95007
PeptideAtlasⁱ	O95007
PRIDEⁱ	O95007
ProteomicsDBⁱ	50624

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000408922; ENSP00000386151; ENSG00000221813 ENST00000641698; ENSP00000492907; ENSG00000221813 ENST00000642360; ENSP00000496557; ENSG00000284939 ENST00000647270; ENSP00000494805; ENSG00000284939
GeneIDⁱ	135946
KEGGⁱ	hsa:135946
UCSCⁱ	uc003wdt.2 human

Organism-specific databases

CTDⁱ	135946
EuPathDBⁱ	HostDB:ENSG00000221813.3
GeneCardsⁱ	OR6B1
HGNCⁱ	HGNC:8354 OR6B1
HPAⁱ	HPA053164
neXtProtⁱ	NX_O95007
PharmGKBⁱ	PA32576
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IF9G Eukaryota ENOG410YB1I LUCA
GeneTreeⁱ	ENSGT00800000124041
HOGENOMⁱ	HOG000041364
HOVERGENⁱ	HBG017625
InParanoidⁱ	O95007
KOⁱ	K04257
OMAⁱ	PTIMSHG
OrthoDBⁱ	EOG091G0DAJ
PhylomeDBⁱ	O95007
TreeFamⁱ	TF337475

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiⁱ	OR6B1
GenomeRNAiⁱ	135946
Protein Ontology More...PROⁱ	PR:O95007

Gene expression databases

Bgeeⁱ	ENSG00000221813 Expressed in 2 organ(s), highest expression level in left testis
CleanExⁱ	HS_OR6B1
Genevisibleⁱ	O95007 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OR6B1_HUMAN
Accessionⁱ	O95007Primary (citable) accession number: O95007 Secondary accession number(s): A4D2G2 , B9EH47, Q6IFP6, Q96R38
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
	Last sequence update:	May 1, 1999
	Last modified:	November 7, 2018
	This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - O95007 (OR6B1_HUMAN)

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Olfactory receptor 6B1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ