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Protein

Olfactory receptor 6B1

Gene

OR6B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6B1
Alternative name(s):
Olfactory receptor 7-3
Short name:
OR7-3
Olfactory receptor OR7-9
Gene namesi
Name:OR6B1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000221813.3
HGNCiHGNC:8354 OR6B1
neXtProtiNX_O95007

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 196ExtracellularSequence analysisAdd BLAST36
Transmembranei197 – 217Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini218 – 235CytoplasmicSequence analysisAdd BLAST18
Transmembranei236 – 256Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini257 – 269ExtracellularSequence analysisAdd BLAST13
Transmembranei270 – 290Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini291 – 311CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32576

Polymorphism and mutation databases

BioMutaiOR6B1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506201 – 311Olfactory receptor 6B1Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95007
PeptideAtlasiO95007
PRIDEiO95007
ProteomicsDBi50624

PTM databases

iPTMnetiO95007
PhosphoSitePlusiO95007

Expressioni

Gene expression databases

BgeeiENSG00000221813 Expressed in 2 organ(s), highest expression level in left testis
CleanExiHS_OR6B1
GenevisibleiO95007 HS

Organism-specific databases

HPAiHPA053164

Interactioni

Protein-protein interaction databases

BioGridi126443, 2 interactors
IntActiO95007, 2 interactors
STRINGi9606.ENSP00000386151

Structurei

3D structure databases

ProteinModelPortaliO95007
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF9G Eukaryota
ENOG410YB1I LUCA
GeneTreeiENSGT00800000124041
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiO95007
KOiK04257
OMAiPTIMSHG
OrthoDBiEOG091G0DAJ
PhylomeDBiO95007
TreeFamiTF337475

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O95007-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELENQTRVT KFILVGFPGS LSMRAAMFLI FLVAYILTVA ENVIIILLVL
60 70 80 90 100
QNRPLHKPMY FFLANLSFLE TWYISVTVPK LLFSFWSVNN SISFTLCMIQ
110 120 130 140 150
LYFFIALMCT ECVLLAAMAY DRYVAICRPL HYPTIMSHGL CFRLALGSWA
160 170 180 190 200
IGFGISLAKI YFISCLSFCG PNVINHFFCD ISPVLNLSCT DMSITELVDF
210 220 230 240 250
ILALVIFLFP LFITVLSYGC ILATILCMPT GKQKAFSTCA SHLVVVTIFY
260 270 280 290 300
SAIIFMYARP RVIHAFNMNK IISIFYAIVT PSLNPFIYCL RNREVKEALK
310
KLAYCQASRS D
Length:311
Mass (Da):35,299
Last modified:May 1, 1999 - v1
Checksum:i671FD19658FE0616
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034238143R → C. Corresponds to variant dbSNP:rs7787378Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004853 Genomic DNA No translation available.
CH236959 Genomic DNA Translation: EAL23796.1 Sequence problems.
BC137042 mRNA Translation: AAI37043.1
BC137047 mRNA Translation: AAI37048.1
AF399605 Genomic DNA Translation: AAK95090.1
BK004216 Genomic DNA Translation: DAA04614.1
CCDSiCCDS43667.1
RefSeqiNP_001005281.1, NM_001005281.1
UniGeneiHs.632031

Genome annotation databases

EnsembliENST00000408922; ENSP00000386151; ENSG00000221813
ENST00000641698; ENSP00000492907; ENSG00000221813
ENST00000642360; ENSP00000496557; ENSG00000284939
ENST00000647270; ENSP00000494805; ENSG00000284939
GeneIDi135946
KEGGihsa:135946
UCSCiuc003wdt.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004853 Genomic DNA No translation available.
CH236959 Genomic DNA Translation: EAL23796.1 Sequence problems.
BC137042 mRNA Translation: AAI37043.1
BC137047 mRNA Translation: AAI37048.1
AF399605 Genomic DNA Translation: AAK95090.1
BK004216 Genomic DNA Translation: DAA04614.1
CCDSiCCDS43667.1
RefSeqiNP_001005281.1, NM_001005281.1
UniGeneiHs.632031

3D structure databases

ProteinModelPortaliO95007
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126443, 2 interactors
IntActiO95007, 2 interactors
STRINGi9606.ENSP00000386151

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO95007
PhosphoSitePlusiO95007

Polymorphism and mutation databases

BioMutaiOR6B1

Proteomic databases

PaxDbiO95007
PeptideAtlasiO95007
PRIDEiO95007
ProteomicsDBi50624

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408922; ENSP00000386151; ENSG00000221813
ENST00000641698; ENSP00000492907; ENSG00000221813
ENST00000642360; ENSP00000496557; ENSG00000284939
ENST00000647270; ENSP00000494805; ENSG00000284939
GeneIDi135946
KEGGihsa:135946
UCSCiuc003wdt.2 human

Organism-specific databases

CTDi135946
EuPathDBiHostDB:ENSG00000221813.3
GeneCardsiOR6B1
HGNCiHGNC:8354 OR6B1
HPAiHPA053164
neXtProtiNX_O95007
PharmGKBiPA32576
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF9G Eukaryota
ENOG410YB1I LUCA
GeneTreeiENSGT00800000124041
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiO95007
KOiK04257
OMAiPTIMSHG
OrthoDBiEOG091G0DAJ
PhylomeDBiO95007
TreeFamiTF337475

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR6B1
GenomeRNAii135946
PROiPR:O95007

Gene expression databases

BgeeiENSG00000221813 Expressed in 2 organ(s), highest expression level in left testis
CleanExiHS_OR6B1
GenevisibleiO95007 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR6B1_HUMAN
AccessioniPrimary (citable) accession number: O95007
Secondary accession number(s): A4D2G2
, B9EH47, Q6IFP6, Q96R38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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