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Protein

Olfactory receptor 2F2

Gene

OR2F2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2F2
Alternative name(s):
Olfactory receptor 7-1
Short name:
OR7-1
Olfactory receptor OR7-6
Gene namesi
Name:OR2F2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000221910.2
HGNCiHGNC:8247 OR2F2
neXtProtiNX_O95006

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 317CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi135948
PharmGKBiPA32156

Polymorphism and mutation databases

BioMutaiOR2F2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504701 – 317Olfactory receptor 2F2Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95006
PeptideAtlasiO95006
PRIDEiO95006
ProteomicsDBi50623

PTM databases

iPTMnetiO95006
PhosphoSitePlusiO95006

Expressioni

Gene expression databases

BgeeiENSG00000221910 Expressed in 1 organ(s), highest expression level in muscle tissue
CleanExiHS_OR2F2
GenevisibleiO95006 HS

Interactioni

Protein-protein interaction databases

BioGridi126444, 1 interactor
STRINGi9606.ENSP00000386222

Structurei

3D structure databases

ProteinModelPortaliO95006
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9H7 Eukaryota
ENOG4111DQU LUCA
GeneTreeiENSGT00820000126998
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiO95006
KOiK04257
OMAiQTWAREF
OrthoDBiEOG091G0C0S
PhylomeDBiO95006
TreeFamiTF337251

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O95006-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEIDNQTWVR EFILLGLSSD WCTQISLFSL FLVTYLMTVL GNCLIVLLIR
60 70 80 90 100
LDSRLHTPMY FFLTNLSLVD VSYATSVVPQ LLAHFLAEHK AIPFQSCAAQ
110 120 130 140 150
LFFSLALGGI EFVLLAVMAY DRHVAVSDRL RYSAIMHGGL CARLAITSWV
160 170 180 190 200
SGSINSLVQT AITFQLPMCT NKFIDHISCE LLAVVRLACV DTSSNEAAIM
210 220 230 240 250
VSSIVLLMTP FCLVLLSYIR IISTILKIQS REGRKKAFHT CASHLTVVAL
260 270 280 290 300
CYGTTIFTYI QPHSGPSVLQ EKLISVFYAI VMPLLNPVIY SLRNKEVKGA
310
WHKLLEKFSG LTSKLGT
Length:317
Mass (Da):35,294
Last modified:May 1, 1999 - v1
Checksum:i031EA92D9A60720C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02204898A → V. Corresponds to variant dbSNP:rs2240359Ensembl.1
Natural variantiVAR_034172170T → A. Corresponds to variant dbSNP:rs13229174Ensembl.1
Natural variantiVAR_034173278Y → H. Corresponds to variant dbSNP:rs13235235Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236959 Genomic DNA Translation: EAL23794.1
AC004853 Genomic DNA No translation available.
BC136813 mRNA Translation: AAI36814.1
BK004214 Genomic DNA Translation: DAA04612.1
CCDSiCCDS43666.1
RefSeqiNP_001004685.1, NM_001004685.1
UniGeneiHs.553596

Genome annotation databases

EnsembliENST00000408955; ENSP00000386222; ENSG00000221910
ENST00000643492; ENSP00000495472; ENSG00000284965
GeneIDi135948
KEGGihsa:135948
UCSCiuc011ktv.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236959 Genomic DNA Translation: EAL23794.1
AC004853 Genomic DNA No translation available.
BC136813 mRNA Translation: AAI36814.1
BK004214 Genomic DNA Translation: DAA04612.1
CCDSiCCDS43666.1
RefSeqiNP_001004685.1, NM_001004685.1
UniGeneiHs.553596

3D structure databases

ProteinModelPortaliO95006
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126444, 1 interactor
STRINGi9606.ENSP00000386222

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO95006
PhosphoSitePlusiO95006

Polymorphism and mutation databases

BioMutaiOR2F2

Proteomic databases

PaxDbiO95006
PeptideAtlasiO95006
PRIDEiO95006
ProteomicsDBi50623

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408955; ENSP00000386222; ENSG00000221910
ENST00000643492; ENSP00000495472; ENSG00000284965
GeneIDi135948
KEGGihsa:135948
UCSCiuc011ktv.3 human

Organism-specific databases

CTDi135948
DisGeNETi135948
EuPathDBiHostDB:ENSG00000221910.2
GeneCardsiOR2F2
HGNCiHGNC:8247 OR2F2
neXtProtiNX_O95006
PharmGKBiPA32156
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9H7 Eukaryota
ENOG4111DQU LUCA
GeneTreeiENSGT00820000126998
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiO95006
KOiK04257
OMAiQTWAREF
OrthoDBiEOG091G0C0S
PhylomeDBiO95006
TreeFamiTF337251

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR2F2
GenomeRNAii135948
PROiPR:O95006

Gene expression databases

BgeeiENSG00000221910 Expressed in 1 organ(s), highest expression level in muscle tissue
CleanExiHS_OR2F2
GenevisibleiO95006 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR2F2_HUMAN
AccessioniPrimary (citable) accession number: O95006
Secondary accession number(s): A4D2G0, Q6IFP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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