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Entry version 147 (22 Apr 2020)
Sequence version 1 (01 May 1999)
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Protein

Protein HEXIM1

Gene

HEXIM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).9 Publications

Miscellaneous

Inhibits Tat activity which is required for HIV-1 transcription.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processImmunity, Innate immunity, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein HEXIM1
Alternative name(s):
Cardiac lineage protein 1
Estrogen down-regulated gene 1 protein
Hexamethylene bis-acetamide-inducible protein 1
Menage a quatre protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HEXIM1
Synonyms:CLP1, EDG1, HIS1, MAQ1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24953 HEXIM1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607328 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O94992

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi152 – 155KHRR → ILAA: Abolishes interaction with 7SK snRNA. 1 Publication4
Mutagenesisi154 – 156RRR → AAA: Abolishes interaction with 7SK snRNA. 1 Publication3
Mutagenesisi203Y → D: Abolishes interaction with P-TEFb; when associated with D-205. 1 Publication1
Mutagenesisi205T → D: Abolishes interaction with P-TEFb. Same effect; when associated with D-203. 1 Publication1
Mutagenesisi208F → A, D or K: Partial loss of function. 1 Publication1
Mutagenesisi271Y → A or E: Loss of function. 1 Publication1
Mutagenesisi287L → A: Loss of oligomerization; when associated with A-294; A-332 and A-339. Loss of function and interaction with P-TEFb; when associated with A-294. 1 Publication1
Mutagenesisi294L → A: Loss of oligomerization; when associated with A-287; A-332 and A-339. Loss of function and interaction with P-TEFb; when associated with A-287. 1 Publication1
Mutagenesisi332L → A: Loss of oligomerization; when associated with A-287; A-294 and A-339. 1 Publication1
Mutagenesisi339L → A: Loss of oligomerization; when associated with A-287; A-294 and A-332. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
10614

Open Targets

More...
OpenTargetsi
ENSG00000186834

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671694

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O94992 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3120044

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HEXIM1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003052631 – 359Protein HEXIM1Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei97PhosphoserineCombined sources1
Modified residuei98PhosphoserineCombined sources1
Modified residuei233PhosphoserineCombined sources1
Modified residuei236PhosphothreonineCombined sources1
Modified residuei237PhosphoserineCombined sources1
Modified residuei252PhosphoserineCombined sources1
Modified residuei260PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O94992

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O94992

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O94992

MaxQB - The MaxQuant DataBase

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MaxQBi
O94992

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O94992

PeptideAtlas

More...
PeptideAtlasi
O94992

PRoteomics IDEntifications database

More...
PRIDEi
O94992

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
50620

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O94992

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O94992

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level). Down-regulated by estrogen.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186834 Expressed in placenta and 228 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O94992 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000186834 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer and heterooligomer with HEXIM2; probably dimeric (PubMed:15713661, PubMed:15965233, PubMed:16377779).

Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs (PubMed:12832472, PubMed:15201869, PubMed:15169877, PubMed:16362050, PubMed:15713661, PubMed:15855166, PubMed:16377779, PubMed:17643375, PubMed:17724342).

Interacts with the N-CoR complex through NCOR1 (PubMed:17452463).

Interacts with ESR1 and NR3C1 (PubMed:15940264, PubMed:15941832). May interact with NF-kappa-B through RELA (PubMed:12581153).

Interacts with CCNT2; mediates formation of a tripartite complex with KPNA2 (PubMed:19883659). Part of the HDP-RNP complex composed of at least HEXIM1, PRKDC, XRCC5, XRCC6, paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATR3) and NEAT1 non-coding RNA (PubMed:28712728).

16 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

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GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115860, 861 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O94992

Database of interacting proteins

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DIPi
DIP-46463N

Protein interaction database and analysis system

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IntActi
O94992, 33 interactors

Molecular INTeraction database

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MINTi
O94992

STRING: functional protein association networks

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STRINGi
9606.ENSP00000328773

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
O94992 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O94992

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O94992

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni150 – 177Basic region; mediates nuclear localization and interaction with 7SK snRNA and NR3C11 PublicationAdd BLAST28
Regioni202 – 205Interaction with P-TEFb4
Regioni210 – 250Autoinhibitory acidic region; in absence of 7SK snRNA interacts with the basic region preventing interaction with P-TEFb and modulating subcellular localizationAdd BLAST41
Regioni286 – 314Mediates interaction with CCNT1Add BLAST29
Regioni310 – 355Required for inhibition of ESR1-dependent transcriptionAdd BLAST46

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili283 – 349Sequence analysisAdd BLAST67

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The coiled-coil domain mediates oligomerization.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HEXIM family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IH8I Eukaryota
ENOG4111K9Z LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000002808

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_066028_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O94992

KEGG Orthology (KO)

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KOi
K15189

Identification of Orthologs from Complete Genome Data

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OMAi
VHEERNP

Database of Orthologous Groups

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OrthoDBi
1055089at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O94992

TreeFam database of animal gene trees

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TreeFami
TF336851

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR024872 HEXIM

The PANTHER Classification System

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PANTHERi
PTHR13469 PTHR13469, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF15313 HEXIM, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR02094 HEXIMFAMILY

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O94992-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEPFLSEYQ HQPQTSNCTG AAAVQEELNP ERPPGAEERV PEEDSRWQSR
60 70 80 90 100
AFPQLGGRPG PEGEGSLESQ PPPLQTQACP ESSCLREGEK GQNGDDSSAG
110 120 130 140 150
GDFPPPAEVE PTPEAELLAQ PCHDSEASKL GAPAAGGEEE WGQQQRQLGK
160 170 180 190 200
KKHRRRPSKK KRHWKPYYKL TWEEKKKFDE KQSLRASRIR AEMFAKGQPV
210 220 230 240 250
APYNTTQFLM DDHDQEEPDL KTGLYSKRAA AKSDDTSDDD FMEEGGEEDG
260 270 280 290 300
GSDGMGGDGS EFLQRDFSET YERYHTESLQ NMSKQELIKE YLELEKCLSR
310 320 330 340 350
MEDENNRLRL ESKRLGGDDA RVRELELELD RLRAENLQLL TENELHRQQE

RAPLSKFGD
Length:359
Mass (Da):40,623
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB12845C4E2595FF0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB021179 mRNA Translation: BAA36166.1
AK313557 mRNA Translation: BAG36332.1
BC006460 mRNA Translation: AAH06460.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11495.1

NCBI Reference Sequences

More...
RefSeqi
NP_006451.1, NM_006460.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000332499; ENSP00000328773; ENSG00000186834

Database of genes from NCBI RefSeq genomes

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GeneIDi
10614

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10614

UCSC genome browser

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UCSCi
uc002iig.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021179 mRNA Translation: BAA36166.1
AK313557 mRNA Translation: BAG36332.1
BC006460 mRNA Translation: AAH06460.1
CCDSiCCDS11495.1
RefSeqiNP_006451.1, NM_006460.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GD7NMR-A/B255-359[»]
3S9GX-ray2.10A/B255-359[»]
SMRiO94992
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi115860, 861 interactors
CORUMiO94992
DIPiDIP-46463N
IntActiO94992, 33 interactors
MINTiO94992
STRINGi9606.ENSP00000328773

Chemistry databases

ChEMBLiCHEMBL3120044

PTM databases

iPTMnetiO94992
PhosphoSitePlusiO94992

Polymorphism and mutation databases

BioMutaiHEXIM1

Proteomic databases

EPDiO94992
jPOSTiO94992
MassIVEiO94992
MaxQBiO94992
PaxDbiO94992
PeptideAtlasiO94992
PRIDEiO94992
ProteomicsDBi50620

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1837 432 antibodies

The DNASU plasmid repository

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DNASUi
10614

Genome annotation databases

EnsembliENST00000332499; ENSP00000328773; ENSG00000186834
GeneIDi10614
KEGGihsa:10614
UCSCiuc002iig.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10614
DisGeNETi10614

GeneCards: human genes, protein and diseases

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GeneCardsi
HEXIM1
HGNCiHGNC:24953 HEXIM1
HPAiENSG00000186834 Low tissue specificity
MIMi607328 gene
neXtProtiNX_O94992
OpenTargetsiENSG00000186834
PharmGKBiPA142671694

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IH8I Eukaryota
ENOG4111K9Z LUCA
GeneTreeiENSGT00390000002808
HOGENOMiCLU_066028_0_0_1
InParanoidiO94992
KOiK15189
OMAiVHEERNP
OrthoDBi1055089at2759
PhylomeDBiO94992
TreeFamiTF336851

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HEXIM1 human
EvolutionaryTraceiO94992

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HEXIM1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10614
PharosiO94992 Tbio

Protein Ontology

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PROi
PR:O94992
RNActiO94992 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000186834 Expressed in placenta and 228 other tissues
GenevisibleiO94992 HS

Family and domain databases

InterProiView protein in InterPro
IPR024872 HEXIM
PANTHERiPTHR13469 PTHR13469, 1 hit
PfamiView protein in Pfam
PF15313 HEXIM, 1 hit
PRINTSiPR02094 HEXIMFAMILY

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHEXI1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94992
Secondary accession number(s): B2R8Y5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 1, 1999
Last modified: April 22, 2020
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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