UniProtKB - O94991 (SLIK5_HUMAN)
Protein
SLIT and NTRK-like protein 5
Gene
SLITRK5
Organism
Homo sapiens (Human)
Status
Functioni
Suppresses neurite outgrowth.By similarity
GO - Biological processi
- adult behavior Source: Ensembl
- axonogenesis Source: GO_Central
- chemical synaptic transmission Source: Ensembl
- dendrite morphogenesis Source: Ensembl
- grooming behavior Source: Ensembl
- positive regulation of synapse assembly Source: Ensembl
- regulation of presynapse assembly Source: InterPro
- response to xenobiotic stimulus Source: Ensembl
- skin development Source: Ensembl
- striatum development Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | O94991 |
Reactomei | R-HSA-388844, Receptor-type tyrosine-protein phosphatases |
Names & Taxonomyi
Protein namesi | Recommended name: SLIT and NTRK-like protein 5Alternative name(s): Leucine-rich repeat-containing protein 11 |
Gene namesi | Name:SLITRK5 Synonyms:KIAA0918, LRRC11 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000165300.7 |
HGNCi | HGNC:20295, SLITRK5 |
MIMi | 609680, gene |
neXtProti | NX_O94991 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
- receptor complex Source: MGI
- synapse Source: GOC
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 41 – 664 | ExtracellularSequence analysisAdd BLAST | 624 | |
Transmembranei | 665 – 685 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 686 – 958 | CytoplasmicSequence analysisAdd BLAST | 273 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 26050 |
OpenTargetsi | ENSG00000165300 |
PharmGKBi | PA134885524 |
Miscellaneous databases
Pharosi | O94991, Tbio |
Polymorphism and mutation databases
BioMutai | SLITRK5 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 40 | Sequence analysisAdd BLAST | 40 | |
ChainiPRO_0000032681 | 41 – 958 | SLIT and NTRK-like protein 5Add BLAST | 918 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 103 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 644 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | O94991 |
jPOSTi | O94991 |
MassIVEi | O94991 |
MaxQBi | O94991 |
PaxDbi | O94991 |
PeptideAtlasi | O94991 |
PRIDEi | O94991 |
ProteomicsDBi | 5027 50619 [O94991-1] |
PTM databases
GlyGeni | O94991, 2 sites |
iPTMneti | O94991 |
PhosphoSitePlusi | O94991 |
Expressioni
Tissue specificityi
Expressed predominantly in the cerebral cortex of the brain but also at low levels in the spinal cord and medulla.1 Publication
Gene expression databases
Bgeei | ENSG00000165300, Expressed in neocortex and 155 other tissues |
Genevisiblei | O94991, HS |
Organism-specific databases
HPAi | ENSG00000165300, Tissue enhanced (brain, fallopian tube, salivary gland) |
Interactioni
Binary interactionsi
Hide detailsO94991
With | #Exp. | IntAct |
---|---|---|
BOLA2B [A0A087WZT3] | 3 | EBI-17240818,EBI-12006120 |
CLCNKA - isoform 3 [P51800-3] | 3 | EBI-17240818,EBI-11980535 |
Protein-protein interaction databases
BioGRIDi | 117513, 12 interactors |
IntActi | O94991, 6 interactors |
STRINGi | 9606.ENSP00000366283 |
Miscellaneous databases
RNActi | O94991, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 82 – 103 | LRR 1Add BLAST | 22 | |
Repeati | 106 – 127 | LRR 2Add BLAST | 22 | |
Repeati | 130 – 151 | LRR 3Add BLAST | 22 | |
Repeati | 154 – 175 | LRR 4Add BLAST | 22 | |
Repeati | 178 – 199 | LRR 5Add BLAST | 22 | |
Repeati | 201 – 222 | LRR 6Add BLAST | 22 | |
Domaini | 235 – 286 | LRRCT 1Add BLAST | 52 | |
Domaini | 365 – 407 | LRRNTAdd BLAST | 43 | |
Repeati | 410 – 431 | LRR 7Add BLAST | 22 | |
Repeati | 434 – 455 | LRR 8Add BLAST | 22 | |
Repeati | 458 – 479 | LRR 9Add BLAST | 22 | |
Repeati | 482 – 503 | LRR 10Add BLAST | 22 | |
Repeati | 506 – 527 | LRR 11Add BLAST | 22 | |
Repeati | 529 – 550 | LRR 12Add BLAST | 22 | |
Domaini | 563 – 614 | LRRCT 2Add BLAST | 52 |
Sequence similaritiesi
Belongs to the SLITRK family.Curated
Keywords - Domaini
Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QUVV, Eukaryota |
GeneTreei | ENSGT00940000158453 |
HOGENOMi | CLU_012706_1_0_1 |
InParanoidi | O94991 |
OMAi | INYTGVT |
OrthoDBi | 217854at2759 |
PhylomeDBi | O94991 |
TreeFami | TF326378 |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR043326, Slitrk |
PANTHERi | PTHR45773, PTHR45773, 1 hit |
Pfami | View protein in Pfam PF13855, LRR_8, 2 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 10 hits SM00082, LRRCT, 2 hits |
PROSITEi | View protein in PROSITE PS51450, LRR, 11 hits |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: O94991-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MHTCCPPVTL EQDLHRKMHS WMLQTLAFAV TSLVLSCAET IDYYGEICDN
60 70 80 90 100
ACPCEEKDGI LTVSCENRGI ISLSEISPPR FPIYHLLLSG NLLNRLYPNE
110 120 130 140 150
FVNYTGASIL HLGSNVIQDI ETGAFHGLRG LRRLHLNNNK LELLRDDTFL
160 170 180 190 200
GLENLEYLQV DYNYISVIEP NAFGKLHLLQ VLILNDNLLS SLPNNLFRFV
210 220 230 240 250
PLTHLDLRGN RLKLLPYVGL LQHMDKVVEL QLEENPWNCS CELISLKDWL
260 270 280 290 300
DSISYSALVG DVVCETPFRL HGRDLDEVSK QELCPRRLIS DYEMRPQTPL
310 320 330 340 350
STTGYLHTTP ASVNSVATSS SAVYKPPLKP PKGTRQPNKP RVRPTSRQPS
360 370 380 390 400
KDLGYSNYGP SIAYQTKSPV PLECPTACSC NLQISDLGLN VNCQERKIES
410 420 430 440 450
IAELQPKPYN PKKMYLTENY IAVVRRTDFL EATGLDLLHL GNNRISMIQD
460 470 480 490 500
RAFGDLTNLR RLYLNGNRIE RLSPELFYGL QSLQYLFLQY NLIREIQSGT
510 520 530 540 550
FDPVPNLQLL FLNNNLLQAM PSGVFSGLTL LRLNLRSNHF TSLPVSGVLD
560 570 580 590 600
QLKSLIQIDL HDNPWDCTCD IVGMKLWVEQ LKVGVLVDEV ICKAPKKFAE
610 620 630 640 650
TDMRSIKSEL LCPDYSDVVV STPTPSSIQV PARTSAVTPA VRLNSTGAPA
660 670 680 690 700
SLGAGGGASS VPLSVLILSL LLVFIMSVFV AAGLFVLVMK RRKKNQSDHT
710 720 730 740 750
STNNSDVSSF NMQYSVYGGG GGTGGHPHAH VHHRGPALPK VKTPAGHVYE
760 770 780 790 800
YIPHPLGHMC KNPIYRSREG NSVEDYKDLH ELKVTYSSNH HLQQQQQPPP
810 820 830 840 850
PPQQPQQQPP PQLQLQPGEE ERRESHHLRS PAYSVSTIEP REDLLSPVQD
860 870 880 890 900
ADRFYRGILE PDKHCSTTPA GNSLPEYPKF PCSPAAYTFS PNYDLRRPHQ
910 920 930 940 950
YLHPGAGDSR LREPVLYSPP SAVFVEPNRN EYLELKAKLN VEPDYLEVLE
KQTTFSQF
Sequence cautioni
The sequence BAA74941 differs from that shown. Reason: Erroneous initiation.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056676 | 1 – 31 | MHTCC…AFAVT → MGAGKHREGGGGDPTSLNGC ADLIQRRTEIS in isoform 2. 1 PublicationAdd BLAST | 31 | |
Alternative sequenceiVSP_056677 | 32 – 272 | Missing in isoform 2. 1 PublicationAdd BLAST | 241 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB020725 mRNA Translation: BAA74941.1 Different initiation. AK024251 mRNA Translation: BAG51280.1 AK299744 mRNA Translation: BAG61637.1 AL603883 Genomic DNA No translation available. CH471085 Genomic DNA Translation: EAX08917.1 BC098106 mRNA Translation: AAH98106.1 BC103509 mRNA Translation: AAI03510.1 |
CCDSi | CCDS9465.1 [O94991-1] |
RefSeqi | NP_056382.1, NM_015567.1 [O94991-1] XP_005254095.1, XM_005254038.4 XP_005254096.1, XM_005254039.2 |
Genome annotation databases
Ensembli | ENST00000325089; ENSP00000366283; ENSG00000165300 [O94991-1] |
GeneIDi | 26050 |
KEGGi | hsa:26050 |
UCSCi | uc001vln.4, human [O94991-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB020725 mRNA Translation: BAA74941.1 Different initiation. AK024251 mRNA Translation: BAG51280.1 AK299744 mRNA Translation: BAG61637.1 AL603883 Genomic DNA No translation available. CH471085 Genomic DNA Translation: EAX08917.1 BC098106 mRNA Translation: AAH98106.1 BC103509 mRNA Translation: AAI03510.1 |
CCDSi | CCDS9465.1 [O94991-1] |
RefSeqi | NP_056382.1, NM_015567.1 [O94991-1] XP_005254095.1, XM_005254038.4 XP_005254096.1, XM_005254039.2 |
3D structure databases
SMRi | O94991 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117513, 12 interactors |
IntActi | O94991, 6 interactors |
STRINGi | 9606.ENSP00000366283 |
PTM databases
GlyGeni | O94991, 2 sites |
iPTMneti | O94991 |
PhosphoSitePlusi | O94991 |
Polymorphism and mutation databases
BioMutai | SLITRK5 |
Proteomic databases
EPDi | O94991 |
jPOSTi | O94991 |
MassIVEi | O94991 |
MaxQBi | O94991 |
PaxDbi | O94991 |
PeptideAtlasi | O94991 |
PRIDEi | O94991 |
ProteomicsDBi | 5027 50619 [O94991-1] |
Protocols and materials databases
Antibodypediai | 2571, 132 antibodies |
Genome annotation databases
Ensembli | ENST00000325089; ENSP00000366283; ENSG00000165300 [O94991-1] |
GeneIDi | 26050 |
KEGGi | hsa:26050 |
UCSCi | uc001vln.4, human [O94991-1] |
Organism-specific databases
CTDi | 26050 |
DisGeNETi | 26050 |
EuPathDBi | HostDB:ENSG00000165300.7 |
GeneCardsi | SLITRK5 |
HGNCi | HGNC:20295, SLITRK5 |
HPAi | ENSG00000165300, Tissue enhanced (brain, fallopian tube, salivary gland) |
MIMi | 609680, gene |
neXtProti | NX_O94991 |
OpenTargetsi | ENSG00000165300 |
PharmGKBi | PA134885524 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUVV, Eukaryota |
GeneTreei | ENSGT00940000158453 |
HOGENOMi | CLU_012706_1_0_1 |
InParanoidi | O94991 |
OMAi | INYTGVT |
OrthoDBi | 217854at2759 |
PhylomeDBi | O94991 |
TreeFami | TF326378 |
Enzyme and pathway databases
PathwayCommonsi | O94991 |
Reactomei | R-HSA-388844, Receptor-type tyrosine-protein phosphatases |
Miscellaneous databases
BioGRID-ORCSi | 26050, 5 hits in 845 CRISPR screens |
ChiTaRSi | SLITRK5, human |
GeneWikii | SLITRK5 |
GenomeRNAii | 26050 |
Pharosi | O94991, Tbio |
PROi | PR:O94991 |
RNActi | O94991, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165300, Expressed in neocortex and 155 other tissues |
Genevisiblei | O94991, HS |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR043326, Slitrk |
PANTHERi | PTHR45773, PTHR45773, 1 hit |
Pfami | View protein in Pfam PF13855, LRR_8, 2 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 10 hits SM00082, LRRCT, 2 hits |
PROSITEi | View protein in PROSITE PS51450, LRR, 11 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SLIK5_HUMAN | |
Accessioni | O94991Primary (citable) accession number: O94991 Secondary accession number(s): B3KNB8, B4DSH5, Q5VT81 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2001 |
Last sequence update: | April 13, 2004 | |
Last modified: | December 2, 2020 | |
This is version 170 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM