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Entry version 138 (16 Jan 2019)
Sequence version 2 (18 May 2010)
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Protein

Protein FAM13A

Gene

FAM13A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840 Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM13A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM13A
Synonyms:FAM13A1, KIAA0914
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000138640.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19367 FAM13A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613299 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O94988

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10144

MalaCards human disease database

More...
MalaCardsi
FAM13A

Open Targets

More...
OpenTargetsi
ENSG00000138640

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2032 Idiopathic pulmonary fibrosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164719541

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM13A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000589201 – 1023Protein FAM13AAdd BLAST1023

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei345PhosphoserineBy similarity1
Modified residuei597PhosphoserineBy similarity1
Modified residuei617PhosphoserineBy similarity1
Modified residuei727PhosphoserineBy similarity1
Modified residuei732PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O94988

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O94988

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O94988

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94988

PeptideAtlas

More...
PeptideAtlasi
O94988

PRoteomics IDEntifications database

More...
PRIDEi
O94988

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50613
50614 [O94988-1]
50615 [O94988-3]
50616 [O94988-5]
50617 [O94988-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O94988

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O94988

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is widely expressed, with highest expression in skeletal muscle, thymus, brain and lung. Isoform 3 is less abundant than isoform 1 and predominantly expressed in kidney, pancreas,liver, lung and thymus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138640 Expressed in 232 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O94988 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O94988 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038108
HPA038109

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115447, 11 interactors

Protein interaction database and analysis system

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IntActi
O94988, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264344

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O94988

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O94988

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 231Rho-GAPPROSITE-ProRule annotationAdd BLAST189

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili666 – 730Sequence analysisAdd BLAST65
Coiled coili946 – 978Sequence analysisAdd BLAST33

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM13 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4270 Eukaryota
ENOG410XRR2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153471

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112468

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051529

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O94988

Identification of Orthologs from Complete Genome Data

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OMAi
QEDERPM

Database of Orthologous Groups

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OrthoDBi
1026411at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O94988

TreeFam database of animal gene trees

More...
TreeFami
TF328895

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.555.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039102 FAM13
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom

The PANTHER Classification System

More...
PANTHERi
PTHR15904 PTHR15904, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00620 RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00324 RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50238 RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: O94988-4) [UniParc]FASTAAdd to basket
Also known as: FAM13A1_v2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGAGALAICQ SKAAVRLKED MKKIVAVPLN EQKDFTYQKL FGVSLQELER
60 70 80 90 100
QGLTENGIPA VVWNIVEYLT QHGLTQEGLF RVNGNVKVVE QLRLKFESGV
110 120 130 140 150
PVELGKDGDV CSAASLLKLF LRELPDSLIT SALQPRFIQL FQDGRNDVQE
160 170 180 190 200
SSLRDLIKEL PDTHYCLLKY LCQFLTKVAK HHVQNRMNVH NLATVFGPNC
210 220 230 240 250
FHVPPGLEGM KEQDLCNKIM AKILENYNTL FEVEYTENDH LRCENLARLI
260 270 280 290 300
IVKEVYYKNS LPILLTRGLE RDMPKPPPKT KIPKSRSEGS IQAHRVLQPE
310 320 330 340 350
LSDGIPQLSL RLSYRKACLE DMNSAEGAIS AKLVPSSQED ERPLSPFYLS
360 370 380 390 400
AHVPQVSNVS ATGELLERTI RSAVEQHLFD VNNSGGQSSE DSESGTLSAS
410 420 430 440 450
SATSARQRRR QSKEQDEVRH GRDKGLINKE NTPSGFNHLD DCILNTQEVE
460 470 480 490 500
KVHKNTFGCA GERSKPKRQK SSTKLSELHD NQDGLVNMES LNSTRSHERT
510 520 530 540 550
GPDDFEWMSD ERKGNEKDGG HTQHFESPTM KIQEHPSLSD TKQQRNQDAG
560 570 580 590 600
DQEESFVSEV PQSDLTALCD EKNWEEPIPA FSSWQRENSD SDEAHLSPQA
610 620 630 640 650
GRLIRQLLDE DSDPMLSPRF YAYGQSRQYL DDTEVPPSPP NSHSFMRRRS
660 670 680 690 700
SSLGSYDDEQ EDLTPAQLTR RIQSLKKKIR KFEDRFEEEK KYRPSHSDKA
710 720 730 740 750
ANPEVLKWTN DLAKFRRQLK ESKLKISEED LTPRMRQRSN TLPKSFGSQL
760 770 780 790 800
EKEDEKKQEL VDKAIKPSVE ATLESIQRKL QEKRAESSRP EDIKDMTKDQ
810 820 830 840 850
IANEKVALQK ALLYYESIHG RPVTKNERQV MKPLYDRYRL VKQILSRANT
860 870 880 890 900
IPIIGSPSSK RRSPLLQPII EGETASFFKE IKEEEEGSED DSNVKPDFMV
910 920 930 940 950
TLKTDFSARC FLDQFEDDAD GFISPMDDKI PSKCSQDTGL SNLHAASIPE
960 970 980 990 1000
LLEHLQEMRE EKKRIRKKLR DFEDNFFRQN GRNVQKEDRT PMAEEYSEYK
1010 1020
HIKAKLRLLE VLISKRDTDS KSM
Length:1,023
Mass (Da):116,932
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i767AC5A8EC862D68
GO
Isoform 1 (identifier: O94988-1) [UniParc]FASTAAdd to basket
Also known as: FAM13A1_v1

The sequence of this isoform differs from the canonical sequence as follows:
     1-326: Missing.
     327-335: GAISAKLVP → MACEIMPLQ

Show »
Length:697
Mass (Da):80,190
Checksum:iA95CFCDA5C0EEB00
GO
Isoform 2 (identifier: O94988-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-326: Missing.
     327-335: GAISAKLVP → MACEIMPLQ
     855-882: Missing.

Note: No experimental confirmation available.
Show »
Length:669
Mass (Da):77,104
Checksum:i6F72E70FA972482F
GO
Isoform 4 (identifier: O94988-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-340: Missing.
     341-349: ERPLSPFYL → MACEIMPLQ

Note: No experimental confirmation available.
Show »
Length:683
Mass (Da):78,540
Checksum:i02F9B3C086F8FD80
GO
Isoform 5 (identifier: O94988-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-354: Missing.
     355-364: QVSNVSATGE → MACEIMPLQR

Note: No experimental confirmation available.
Show »
Length:669
Mass (Da):77,232
Checksum:i904972533846C861
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PGM7E9PGM7_HUMAN
Protein FAM13A
FAM13A
609Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCC1D6RCC1_HUMAN
Protein FAM13A
FAM13A
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RFM4D6RFM4_HUMAN
Protein FAM13A
FAM13A
277Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGE4D6RGE4_HUMAN
Protein FAM13A
FAM13A
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6P521Q6P521_HUMAN
FAM13A protein
FAM13A
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RD35D6RD35_HUMAN
Protein FAM13A
FAM13A
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIY4D6RIY4_HUMAN
Protein FAM13A
FAM13A
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA74937 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC03636 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti509S → T in AK027138 (PubMed:14702039).Curated1
Sequence conflicti740N → Y in BAG59483 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049019769V → I1 PublicationCorresponds to variant dbSNP:rs7657817Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0391521 – 354Missing in isoform 5. 1 PublicationAdd BLAST354
Alternative sequenceiVSP_0391531 – 340Missing in isoform 4. 1 PublicationAdd BLAST340
Alternative sequenceiVSP_0391541 – 326Missing in isoform 1 and isoform 2. 2 PublicationsAdd BLAST326
Alternative sequenceiVSP_039155327 – 335GAISAKLVP → MACEIMPLQ in isoform 1 and isoform 2. 2 Publications9
Alternative sequenceiVSP_039156341 – 349ERPLSPFYL → MACEIMPLQ in isoform 4. 1 Publication9
Alternative sequenceiVSP_039157355 – 364QVSNVSATGE → MACEIMPLQR in isoform 5. 1 Publication10
Alternative sequenceiVSP_039158855 – 882Missing in isoform 2. 2 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB020721 mRNA Translation: BAA74937.3 Different initiation.
AK027138 mRNA No translation available.
AK091328 mRNA Translation: BAC03636.1 Sequence problems.
AK296932 mRNA Translation: BAG59483.1
AC108065 Genomic DNA No translation available.
AC021183 Genomic DNA No translation available.
BC086875 mRNA Translation: AAH86875.1
BN000265 mRNA Translation: CAE18110.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34029.1 [O94988-4]
CCDS43251.1 [O94988-1]
CCDS58911.1 [O94988-6]
CCDS58912.1 [O94988-5]
CCDS58913.1 [O94988-3]

NCBI Reference Sequences

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RefSeqi
NP_001015045.1, NM_001015045.2 [O94988-1]
NP_001252507.1, NM_001265578.1 [O94988-5]
NP_001252508.1, NM_001265579.1 [O94988-3]
NP_001252509.1, NM_001265580.1 [O94988-6]
NP_055698.2, NM_014883.3 [O94988-4]
XP_011529818.1, XM_011531516.1 [O94988-4]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.714536
Hs.97270

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000264344; ENSP00000264344; ENSG00000138640 [O94988-4]
ENST00000395002; ENSP00000378450; ENSG00000138640 [O94988-3]
ENST00000503556; ENSP00000427189; ENSG00000138640 [O94988-5]
ENST00000508369; ENSP00000421562; ENSG00000138640 [O94988-1]
ENST00000513837; ENSP00000423252; ENSG00000138640 [O94988-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10144

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10144

UCSC genome browser

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UCSCi
uc003hsb.3 human [O94988-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020721 mRNA Translation: BAA74937.3 Different initiation.
AK027138 mRNA No translation available.
AK091328 mRNA Translation: BAC03636.1 Sequence problems.
AK296932 mRNA Translation: BAG59483.1
AC108065 Genomic DNA No translation available.
AC021183 Genomic DNA No translation available.
BC086875 mRNA Translation: AAH86875.1
BN000265 mRNA Translation: CAE18110.1
CCDSiCCDS34029.1 [O94988-4]
CCDS43251.1 [O94988-1]
CCDS58911.1 [O94988-6]
CCDS58912.1 [O94988-5]
CCDS58913.1 [O94988-3]
RefSeqiNP_001015045.1, NM_001015045.2 [O94988-1]
NP_001252507.1, NM_001265578.1 [O94988-5]
NP_001252508.1, NM_001265579.1 [O94988-3]
NP_001252509.1, NM_001265580.1 [O94988-6]
NP_055698.2, NM_014883.3 [O94988-4]
XP_011529818.1, XM_011531516.1 [O94988-4]
UniGeneiHs.714536
Hs.97270

3D structure databases

ProteinModelPortaliO94988
SMRiO94988
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115447, 11 interactors
IntActiO94988, 7 interactors
STRINGi9606.ENSP00000264344

PTM databases

iPTMnetiO94988
PhosphoSitePlusiO94988

Polymorphism and mutation databases

BioMutaiFAM13A

Proteomic databases

EPDiO94988
jPOSTiO94988
MaxQBiO94988
PaxDbiO94988
PeptideAtlasiO94988
PRIDEiO94988
ProteomicsDBi50613
50614 [O94988-1]
50615 [O94988-3]
50616 [O94988-5]
50617 [O94988-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264344; ENSP00000264344; ENSG00000138640 [O94988-4]
ENST00000395002; ENSP00000378450; ENSG00000138640 [O94988-3]
ENST00000503556; ENSP00000427189; ENSG00000138640 [O94988-5]
ENST00000508369; ENSP00000421562; ENSG00000138640 [O94988-1]
ENST00000513837; ENSP00000423252; ENSG00000138640 [O94988-6]
GeneIDi10144
KEGGihsa:10144
UCSCiuc003hsb.3 human [O94988-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10144
DisGeNETi10144
EuPathDBiHostDB:ENSG00000138640.14

GeneCards: human genes, protein and diseases

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GeneCardsi
FAM13A

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0004368
HGNCiHGNC:19367 FAM13A
HPAiHPA038108
HPA038109
MalaCardsiFAM13A
MIMi613299 gene
neXtProtiNX_O94988
OpenTargetsiENSG00000138640
Orphaneti2032 Idiopathic pulmonary fibrosis
PharmGKBiPA164719541

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4270 Eukaryota
ENOG410XRR2 LUCA
GeneTreeiENSGT00940000153471
HOGENOMiHOG000112468
HOVERGENiHBG051529
InParanoidiO94988
OMAiQEDERPM
OrthoDBi1026411at2759
PhylomeDBiO94988
TreeFamiTF328895

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FAM13A human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Family_with_sequence_similarity_13,_member_A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10144

Protein Ontology

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PROi
PR:O94988

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138640 Expressed in 232 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiO94988 baseline and differential
GenevisibleiO94988 HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR039102 FAM13
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PANTHERiPTHR15904 PTHR15904, 1 hit
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFA13A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94988
Secondary accession number(s): B4DLC1
, Q24JP0, Q5PR21, Q8NBA3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: May 18, 2010
Last modified: January 16, 2019
This is version 138 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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