UniProtKB - O94986 (CE152_HUMAN)
Centrosomal protein of 152 kDa
CEP152
Functioni
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
GO - Biological processi
- centriole replication Source: UniProtKB
- centrosome duplication Source: UniProtKB
- ciliary basal body-plasma membrane docking Source: Reactome
- de novo centriole assembly involved in multi-ciliated epithelial cell differentiation Source: UniProtKB
- G2/M transition of mitotic cell cycle Source: Reactome
- regulation of G2/M transition of mitotic cell cycle Source: Reactome
Keywordsi
Biological process | Cilium biogenesis/degradation |
Enzyme and pathway databases
PathwayCommonsi | O94986 |
Reactomei | R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-8854518, AURKA Activation by TPX2 |
Names & Taxonomyi
Protein namesi | Recommended name: Centrosomal protein of 152 kDaCuratedShort name: Cep152 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29298, CEP152 |
MIMi | 613529, gene |
neXtProti | NX_O94986 |
VEuPathDBi | HostDB:ENSG00000103995.13 |
Subcellular locationi
Cytoskeleton
- centrosome 6 Publications
- centriole 5 Publications
Note: Colocalizes with CDK5RAP2, WDR62 and CEP63 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles (PubMed:21983783, PubMed:26297806). Localizes to the deuterosome (By similarity). Localizes to pericentriolar material (PCM) (PubMed:26337392).By similarity3 Publications
Cytoskeleton
- centriole Source: UniProtKB
- centrosome Source: UniProtKB
- pericentriolar material Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleoplasm Source: HPA
Other locations
- deuterosome Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Involvement in diseasei
Microcephaly 9, primary, autosomal recessive (MCPH9)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063813 | 265 | Q → P in MCPH9. 1 PublicationCorresponds to variant dbSNP:rs267606717Ensembl. | 1 |
Seckel syndrome 5 (SCKL5)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065258 | 667 | K → R in SCKL5. 1 PublicationCorresponds to variant dbSNP:rs200879436EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 21 | E → K: Impairs interaction with PLK4; impaired procentriole assembly and chromosome segregation. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, Dwarfism, Mental retardation, Primary microcephalyOrganism-specific databases
DisGeNETi | 22995 |
MalaCardsi | CEP152 |
MIMi | 613823, phenotype 614852, phenotype |
OpenTargetsi | ENSG00000103995 |
Orphaneti | 2512, Autosomal recessive primary microcephaly 808, Seckel syndrome |
PharmGKBi | PA142672126 |
Miscellaneous databases
Pharosi | O94986, Tbio |
Genetic variation databases
BioMutai | CEP152 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089462 | 1 – 1710 | Centrosomal protein of 152 kDaAdd BLAST | 1710 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1241 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O94986 |
jPOSTi | O94986 |
MassIVEi | O94986 |
PaxDbi | O94986 |
PeptideAtlasi | O94986 |
PRIDEi | O94986 |
ProteomicsDBi | 17727 50610 [O94986-4] 50611 [O94986-1] 50612 [O94986-2] |
PTM databases
iPTMneti | O94986 |
PhosphoSitePlusi | O94986 |
Expressioni
Gene expression databases
Bgeei | ENSG00000103995, Expressed in sural nerve and 187 other tissues |
ExpressionAtlasi | O94986, baseline and differential |
Genevisiblei | O94986, HS |
Organism-specific databases
HPAi | ENSG00000103995, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via N-terminus) with PLK4; the interaction is mutally exclusive with a PLK4:CEP192 interaction (PubMed:21059844, PubMed:20852615, PubMed:24997597).
Interacts (via C-terminus) with CENPJ (via-N-terminus) (PubMed:20852615).
Interacts with CINP (PubMed:21131973).
Interacts with CDK5RAP2, WDR62, CEP63 and CEP131 (PubMed:21983783, PubMed:24613305, PubMed:26297806). CEP63, CDK5RAP2, CEP152, WDR62 are proposed to form a stepwise assembled complex at the centrosome forming a ring near parental centrioles (PubMed:26297806).
Interacts with DEUP1; this interaction recruits CEP152 to the deuterosome. The interactions with CEP63 and DEUP1 are mutually exclusive (By similarity).
By similarity6 PublicationsBinary interactionsi
Hide detailsO94986
With | #Exp. | IntAct |
---|---|---|
CEP131 [Q9UPN4] | 3 | EBI-311012,EBI-2558372 |
PLK4 [O00444] | 7 | EBI-311012,EBI-746202 |
Isoform 3 [O94986-3]
With | #Exp. | IntAct |
---|---|---|
CEP135 [Q66GS9] | 2 | EBI-15878364,EBI-1046993 |
PLK4 [O00444] | 16 | EBI-15878364,EBI-746202 |
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 116642, 133 interactors |
ComplexPortali | CPX-1299, CEP152-PLK4 complex |
DIPi | DIP-31701N |
IntActi | O94986, 111 interactors |
MINTi | O94986 |
STRINGi | 9606.ENSP00000370337 |
Miscellaneous databases
RNActi | O94986, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O94986 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 60 | Interaction with PLK41 PublicationAdd BLAST | 60 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 234 – 490 | Sequence analysisAdd BLAST | 257 | |
Coiled coili | 615 – 664 | Sequence analysisAdd BLAST | 50 | |
Coiled coili | 700 – 772 | Sequence analysisAdd BLAST | 73 | |
Coiled coili | 902 – 993 | Sequence analysisAdd BLAST | 92 | |
Coiled coili | 1170 – 1241 | Sequence analysisAdd BLAST | 72 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QT0E, Eukaryota |
GeneTreei | ENSGT00950000182870 |
HOGENOMi | CLU_003346_0_0_1 |
InParanoidi | O94986 |
OMAi | NGPSCQG |
OrthoDBi | 1249457at2759 |
TreeFami | TF332017 |
Family and domain databases
InterProi | View protein in InterPro IPR029598, Cep152 |
PANTHERi | PTHR10337:SF6, PTHR10337:SF6, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLDFGSVAL PVQNEDEEYD EEDYEREKEL QQLLTDLPHD MLDDDLSSPE
60 70 80 90 100
LQYSDCSEDG TDGQPHHPEQ LEMSWNEQML PKSQSVNGYN EIQSLYAGEK
110 120 130 140 150
CGNVWEENRS KTEDRHPVYH PEEGGDEGGS GYSPPSKCEQ TDLYHLPENF
160 170 180 190 200
RPYTNGQKQE FNNQATNVIK FSDPQWNHFQ GPSCQGLEPY NKVTYKPYQS
210 220 230 240 250
SAQNNGSPAQ EITGSDTFEG LQQQFLGANE NSAENMQIIQ LQVLNKAKER
260 270 280 290 300
QLENLIEKLN ESERQIRYLN HQLVIIKDEK DGLTLSLRES QKLFQNGKER
310 320 330 340 350
EIQLEAQIKA LETQIQALKV NEEQMIKKSR TTEMALESLK QQLVDLHHSE
360 370 380 390 400
SLQRAREQHE SIVMGLTKKY EEQVLSLQKN LDATVTALKE QEDICSRLKD
410 420 430 440 450
HVKQLERNQE AIKLEKTEII NKLTRSLEES QKQCAHLLQS GSVQEVAQLQ
460 470 480 490 500
FQLQQAQKAH AMSANMNKAL QEELTELKDE ISLYESAAKL GIHPSDSEGE
510 520 530 540 550
LNIELTESYV DLGIKKVNWK KSKVTSIVQE EDPNEELSKD EFILKLKAEV
560 570 580 590 600
QRLLGSNSMK RHLVSQLQND LKDCHKKIED LHQVKKDEKS IEVETKTDTS
610 620 630 640 650
EKPKNQLWPE SSTSDVVRDD ILLLKNEIQV LQQQNQELKE TEGKLRNTNQ
660 670 680 690 700
DLCNQMRQMV QDFDHDKQEA VDRCERTYQQ HHEAMKTQIR ESLLAKHALE
710 720 730 740 750
KQQLFEAYER THLQLRSELD KLNKEVTAVQ ECYLEVCREK DNLELTLRKT
760 770 780 790 800
TEKEQQTQEK IKEKLIQQLE KEWQSKLDQT IKAMKKKTLD CGSQTDQVTT
810 820 830 840 850
SDVISKKEMA IMIEEQKCTI QQNLEQEKDI AIKGAMKKLE IELELKHCEN
860 870 880 890 900
ITKQVEIAVQ NAHQRWLGEL PELAEYQALV KAEQKKWEEQ HEVSVNKRIS
910 920 930 940 950
FAVSEAKEKW KSELENMRKN ILPGKELEEK IHSLQKELEL KNEEVPVVIR
960 970 980 990 1000
AELAKARSEW NKEKQEEIHR IQEQNEQDYR QFLDDHRNKI NEVLAAAKED
1010 1020 1030 1040 1050
FMKQKTELLL QKETELQTCL DQSRREWTMQ EAKRIQLEIY QYEEDILTVL
1060 1070 1080 1090 1100
GVLLSDTQKE HISDSEDKQL LEIMSTCSSK WMSVQYFEKL KGCIQKAFQD
1110 1120 1130 1140 1150
TLPLLVENAD PEWKKRNMAE LSKDSASQGT GQGDPGPAAG HHAQPLALQA
1160 1170 1180 1190 1200
TEAEADKKKV LEIKDLCCGH CFQELEKAKQ ECQDLKGKLE KCCRHLQHLE
1210 1220 1230 1240 1250
RKHKAVVEKI GEENNKVVEE LIEENNDMKN KLEELQTLCK TPPRSLSAGA
1260 1270 1280 1290 1300
IENACLPCSG GALEELRGQY IKAVKKIKCD MLRYIQESKE RAAEMVKAEV
1310 1320 1330 1340 1350
LRERQETARK MRKYYLICLQ QILQDDGKEG AEKKIMNAAS KLATMAKLLE
1360 1370 1380 1390 1400
TPISSKSQSK TTQSALPLTS EMLIAVKKSK RNDVNQKIPC CIESKSNSVN
1410 1420 1430 1440 1450
TITRTLCEQA PKRRAACNLQ RLLENSEHQS IKHVGSKETH LEFQFGDGSC
1460 1470 1480 1490 1500
KHLNSLPRNV SPEFVPCEGE GGFGLHKKKD LLSDNGSESL PHSAAYPFLG
1510 1520 1530 1540 1550
TLGNKPSPRC TPGPSESGCM HITFRDSNER LGLKVYKCNP LMESENAASE
1560 1570 1580 1590 1600
KSQGLDVQEP PVKDGGDLSD CLGWPSSSAT LSFDSREASF VHGRPQGTLE
1610 1620 1630 1640 1650
IPSESVKSKQ FSPSGYLSDT EESNMICQTM KCQRYQTPYL SEETTYLEPG
1660 1670 1680 1690 1700
KISVNCGHPS RHKADRLKSD FKKLSSTLPS SVCQQPSRKL IVPLSSQQDS
1710
GFDSPFVNLD
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A075B719 | A0A075B719_HUMAN | Centrosomal protein of 152 kDa | CEP152 | 584 | Annotation score: | ||
H0YMG1 | H0YMG1_HUMAN | Centrosomal protein of 152 kDa | CEP152 | 64 | Annotation score: | ||
H0YN91 | H0YN91_HUMAN | Centrosomal protein of 152 kDa | CEP152 | 68 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 558 | S → P in AAH69186 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047932 | 54 | S → L. Corresponds to variant dbSNP:rs2289181EnsemblClinVar. | 1 | |
Natural variantiVAR_063813 | 265 | Q → P in MCPH9. 1 PublicationCorresponds to variant dbSNP:rs267606717Ensembl. | 1 | |
Natural variantiVAR_065258 | 667 | K → R in SCKL5. 1 PublicationCorresponds to variant dbSNP:rs200879436EnsemblClinVar. | 1 | |
Natural variantiVAR_050779 | 793 | S → I1 PublicationCorresponds to variant dbSNP:rs2289178EnsemblClinVar. | 1 | |
Natural variantiVAR_050780 | 914 | L → V. Corresponds to variant dbSNP:rs16961560EnsemblClinVar. | 1 | |
Natural variantiVAR_050781 | 1106 | V → A. Corresponds to variant dbSNP:rs16961557Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035981 | 89 – 181 | Missing in isoform 1. 1 PublicationAdd BLAST | 93 | |
Alternative sequenceiVSP_047002 | 1156 – 1211 | Missing in isoform 3. 1 PublicationAdd BLAST | 56 | |
Alternative sequenceiVSP_035983 | 1365 – 1368 | ALPL → GMSK in isoform 1 and isoform 2. 1 Publication | 4 | |
Alternative sequenceiVSP_035984 | 1369 – 1710 | Missing in isoform 1 and isoform 2. 1 PublicationAdd BLAST | 342 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB020719 mRNA Translation: BAA74935.1 Different initiation. AC012379 Genomic DNA No translation available. AC022084 Genomic DNA No translation available. AC084757 Genomic DNA No translation available. BC069186 mRNA Translation: AAH69186.1 Sequence problems. BC117182 mRNA Translation: AAI17183.1 |
CCDSi | CCDS42033.1 [O94986-3] CCDS58361.1 [O94986-4] |
RefSeqi | NP_001181927.1, NM_001194998.1 [O94986-4] NP_055800.2, NM_014985.3 [O94986-3] XP_006720500.1, XM_006720437.3 [O94986-4] |
Genome annotation databases
Ensembli | ENST00000325747; ENSP00000321000; ENSG00000103995 [O94986-1] ENST00000380950; ENSP00000370337; ENSG00000103995 [O94986-4] ENST00000399334; ENSP00000382271; ENSG00000103995 [O94986-3] |
GeneIDi | 22995 |
KEGGi | hsa:22995 |
UCSCi | uc001zwy.4, human [O94986-4] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB020719 mRNA Translation: BAA74935.1 Different initiation. AC012379 Genomic DNA No translation available. AC022084 Genomic DNA No translation available. AC084757 Genomic DNA No translation available. BC069186 mRNA Translation: AAH69186.1 Sequence problems. BC117182 mRNA Translation: AAI17183.1 |
CCDSi | CCDS42033.1 [O94986-3] CCDS58361.1 [O94986-4] |
RefSeqi | NP_001181927.1, NM_001194998.1 [O94986-4] NP_055800.2, NM_014985.3 [O94986-3] XP_006720500.1, XM_006720437.3 [O94986-4] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4N7V | X-ray | 2.76 | C | 1-60 | [»] | |
6CSU | X-ray | 2.50 | B/D | 1261-1313 | [»] | |
6CSV | X-ray | 2.50 | A/B/C/D | 1261-1306 | [»] | |
SMRi | O94986 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116642, 133 interactors |
ComplexPortali | CPX-1299, CEP152-PLK4 complex |
DIPi | DIP-31701N |
IntActi | O94986, 111 interactors |
MINTi | O94986 |
STRINGi | 9606.ENSP00000370337 |
PTM databases
iPTMneti | O94986 |
PhosphoSitePlusi | O94986 |
Genetic variation databases
BioMutai | CEP152 |
Proteomic databases
EPDi | O94986 |
jPOSTi | O94986 |
MassIVEi | O94986 |
PaxDbi | O94986 |
PeptideAtlasi | O94986 |
PRIDEi | O94986 |
ProteomicsDBi | 17727 50610 [O94986-4] 50611 [O94986-1] 50612 [O94986-2] |
Protocols and materials databases
Antibodypediai | 50528, 172 antibodies |
Genome annotation databases
Ensembli | ENST00000325747; ENSP00000321000; ENSG00000103995 [O94986-1] ENST00000380950; ENSP00000370337; ENSG00000103995 [O94986-4] ENST00000399334; ENSP00000382271; ENSG00000103995 [O94986-3] |
GeneIDi | 22995 |
KEGGi | hsa:22995 |
UCSCi | uc001zwy.4, human [O94986-4] |
Organism-specific databases
CTDi | 22995 |
DisGeNETi | 22995 |
GeneCardsi | CEP152 |
HGNCi | HGNC:29298, CEP152 |
HPAi | ENSG00000103995, Low tissue specificity |
MalaCardsi | CEP152 |
MIMi | 613529, gene 613823, phenotype 614852, phenotype |
neXtProti | NX_O94986 |
OpenTargetsi | ENSG00000103995 |
Orphaneti | 2512, Autosomal recessive primary microcephaly 808, Seckel syndrome |
PharmGKBi | PA142672126 |
VEuPathDBi | HostDB:ENSG00000103995.13 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QT0E, Eukaryota |
GeneTreei | ENSGT00950000182870 |
HOGENOMi | CLU_003346_0_0_1 |
InParanoidi | O94986 |
OMAi | NGPSCQG |
OrthoDBi | 1249457at2759 |
TreeFami | TF332017 |
Enzyme and pathway databases
PathwayCommonsi | O94986 |
Reactomei | R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-8854518, AURKA Activation by TPX2 |
Miscellaneous databases
BioGRID-ORCSi | 22995, 156 hits in 877 CRISPR screens |
ChiTaRSi | CEP152, human |
GeneWikii | CEP152 |
GenomeRNAii | 22995 |
Pharosi | O94986, Tbio |
PROi | PR:O94986 |
RNActi | O94986, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000103995, Expressed in sural nerve and 187 other tissues |
ExpressionAtlasi | O94986, baseline and differential |
Genevisiblei | O94986, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029598, Cep152 |
PANTHERi | PTHR10337:SF6, PTHR10337:SF6, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CE152_HUMAN | |
Accessioni | O94986Primary (citable) accession number: O94986 Secondary accession number(s): E7ER66, Q17RV1, Q6NTA0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2005 |
Last sequence update: | June 26, 2013 | |
Last modified: | February 10, 2021 | |
This is version 160 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families