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UniProtKB - O94986 (CE152_HUMAN)

Protein

Centrosomal protein of 152 kDa

Gene

CEP152

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615).By similarity3 Publications

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 152 kDa
Short name:
Cep152
Gene namesi
Name:CEP152
Synonyms:KIAA0912
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000103995.13
HGNCiHGNC:29298 CEP152
MIMi613529 gene
neXtProtiNX_O94986

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Microcephaly 9, primary, autosomal recessive (MCPH9)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder.
See also OMIM:614852
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063813265Q → P in MCPH9. 1 PublicationCorresponds to variant dbSNP:rs267606717EnsemblClinVar.1
Seckel syndrome 5 (SCKL5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare autosomal recessive disorder characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and mental retardation.
See also OMIM:613823
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065258667K → R in SCKL5. 1 PublicationCorresponds to variant dbSNP:rs200879436EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi21E → K: Impairs interaction with PLK4; impaired procentriole assembly and chromosome segregation. 1 Publication1

Keywords - Diseasei

Disease mutation, Dwarfism, Mental retardation, Primary microcephaly

Organism-specific databases

DisGeNETi22995
GeneReviewsiCEP152
MalaCardsiCEP152
MIMi613823 phenotype
614852 phenotype
OpenTargetsiENSG00000103995
Orphaneti2512 Autosomal recessive primary microcephaly
808 Seckel syndrome
PharmGKBiPA142672126

Polymorphism and mutation databases

BioMutaiCEP152

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894621 – 1710Centrosomal protein of 152 kDaAdd BLAST1710

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1241PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO94986
PaxDbiO94986
PeptideAtlasiO94986
PRIDEiO94986
ProteomicsDBi50610
50611 [O94986-1]
50612 [O94986-2]

PTM databases

iPTMnetiO94986
PhosphoSitePlusiO94986

Expressioni

Gene expression databases

BgeeiENSG00000103995 Expressed in 172 organ(s), highest expression level in secondary oocyte
CleanExiHS_CEP152
ExpressionAtlasiO94986 baseline and differential
GenevisibleiO94986 HS

Organism-specific databases

HPAiHPA039408

Interactioni

Subunit structurei

Interacts (via N-terminus) with PLK4; the interaction is mutally exclusive with a PLK4:CEP192 interaction (PubMed:21059844, PubMed:20852615, PubMed:24997597). Interacts (via C-terminus) with CENPJ (via-N-terminus) (PubMed:20852615). Interacts with CINP (PubMed:21131973). Interacts with CDK5RAP2, WDR62, CEP63 and CEP131 (PubMed:21983783, PubMed:24613305, PubMed:26297806). CEP63, CDK5RAP2, CEP152, WDR62 are proposed to form a stepwise assembled complex at the centrosome forming a ring near parental centrioles (PubMed:26297806). Interacts with DEUP1; this interaction recruits CEP152 to the deuterosome. The interactions with CEP63 and DEUP1 are mutually exclusive (By similarity).By similarity6 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi116642, 124 interactors
ComplexPortaliCPX-1299 CEP152-PLK4 complex
DIPiDIP-31701N
IntActiO94986, 110 interactors
MINTiO94986
STRINGi9606.ENSP00000382271

Structurei

Secondary structure

11710
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO94986
SMRiO94986
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 60Interaction with PLK41 PublicationAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili234 – 490Sequence analysisAdd BLAST257
Coiled coili615 – 664Sequence analysisAdd BLAST50
Coiled coili700 – 772Sequence analysisAdd BLAST73
Coiled coili902 – 993Sequence analysisAdd BLAST92
Coiled coili1170 – 1241Sequence analysisAdd BLAST72

Sequence similaritiesi

Belongs to the CEP152 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGHC Eukaryota
ENOG410XQAW LUCA
GeneTreeiENSGT00630000089915
HOGENOMiHOG000111522
HOVERGENiHBG096403
InParanoidiO94986
KOiK16728
OMAiQSRREWT
OrthoDBiEOG091G0PGF
TreeFamiTF332017

Family and domain databases

InterProiView protein in InterPro
IPR029598 Cep152
PANTHERiPTHR10337:SF6 PTHR10337:SF6, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: O94986-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLDFGSVAL PVQNEDEEYD EEDYEREKEL QQLLTDLPHD MLDDDLSSPE 
        60         70         80         90        100
LQYSDCSEDG TDGQPHHPEQ LEMSWNEQML PKSQSVNGYN EIQSLYAGEK 
       110        120        130        140        150
CGNVWEENRS KTEDRHPVYH PEEGGDEGGS GYSPPSKCEQ TDLYHLPENF 
       160        170        180        190        200
RPYTNGQKQE FNNQATNVIK FSDPQWNHFQ GPSCQGLEPY NKVTYKPYQS 
       210        220        230        240        250
SAQNNGSPAQ EITGSDTFEG LQQQFLGANE NSAENMQIIQ LQVLNKAKER 
       260        270        280        290        300
QLENLIEKLN ESERQIRYLN HQLVIIKDEK DGLTLSLRES QKLFQNGKER 
       310        320        330        340        350
EIQLEAQIKA LETQIQALKV NEEQMIKKSR TTEMALESLK QQLVDLHHSE 
       360        370        380        390        400
SLQRAREQHE SIVMGLTKKY EEQVLSLQKN LDATVTALKE QEDICSRLKD 
       410        420        430        440        450
HVKQLERNQE AIKLEKTEII NKLTRSLEES QKQCAHLLQS GSVQEVAQLQ 
       460        470        480        490        500
FQLQQAQKAH AMSANMNKAL QEELTELKDE ISLYESAAKL GIHPSDSEGE 
       510        520        530        540        550
LNIELTESYV DLGIKKVNWK KSKVTSIVQE EDPNEELSKD EFILKLKAEV 
       560        570        580        590        600
QRLLGSNSMK RHLVSQLQND LKDCHKKIED LHQVKKDEKS IEVETKTDTS 
       610        620        630        640        650
EKPKNQLWPE SSTSDVVRDD ILLLKNEIQV LQQQNQELKE TEGKLRNTNQ 
       660        670        680        690        700
DLCNQMRQMV QDFDHDKQEA VDRCERTYQQ HHEAMKTQIR ESLLAKHALE 
       710        720        730        740        750
KQQLFEAYER THLQLRSELD KLNKEVTAVQ ECYLEVCREK DNLELTLRKT 
       760        770        780        790        800
TEKEQQTQEK IKEKLIQQLE KEWQSKLDQT IKAMKKKTLD CGSQTDQVTT 
       810        820        830        840        850
SDVISKKEMA IMIEEQKCTI QQNLEQEKDI AIKGAMKKLE IELELKHCEN 
       860        870        880        890        900
ITKQVEIAVQ NAHQRWLGEL PELAEYQALV KAEQKKWEEQ HEVSVNKRIS 
       910        920        930        940        950
FAVSEAKEKW KSELENMRKN ILPGKELEEK IHSLQKELEL KNEEVPVVIR 
       960        970        980        990       1000
AELAKARSEW NKEKQEEIHR IQEQNEQDYR QFLDDHRNKI NEVLAAAKED 
      1010       1020       1030       1040       1050
FMKQKTELLL QKETELQTCL DQSRREWTMQ EAKRIQLEIY QYEEDILTVL 
      1060       1070       1080       1090       1100
GVLLSDTQKE HISDSEDKQL LEIMSTCSSK WMSVQYFEKL KGCIQKAFQD 
      1110       1120       1130       1140       1150
TLPLLVENAD PEWKKRNMAE LSKDSASQGT GQGDPGPAAG HHAQPLALQA 
      1160       1170       1180       1190       1200
TEAEADKKKV LEIKDLCCGH CFQELEKAKQ ECQDLKGKLE KCCRHLQHLE 
      1210       1220       1230       1240       1250
RKHKAVVEKI GEENNKVVEE LIEENNDMKN KLEELQTLCK TPPRSLSAGA 
      1260       1270       1280       1290       1300
IENACLPCSG GALEELRGQY IKAVKKIKCD MLRYIQESKE RAAEMVKAEV 
      1310       1320       1330       1340       1350
LRERQETARK MRKYYLICLQ QILQDDGKEG AEKKIMNAAS KLATMAKLLE 
      1360       1370       1380       1390       1400
TPISSKSQSK TTQSALPLTS EMLIAVKKSK RNDVNQKIPC CIESKSNSVN 
      1410       1420       1430       1440       1450
TITRTLCEQA PKRRAACNLQ RLLENSEHQS IKHVGSKETH LEFQFGDGSC 
      1460       1470       1480       1490       1500
KHLNSLPRNV SPEFVPCEGE GGFGLHKKKD LLSDNGSESL PHSAAYPFLG 
      1510       1520       1530       1540       1550
TLGNKPSPRC TPGPSESGCM HITFRDSNER LGLKVYKCNP LMESENAASE 
      1560       1570       1580       1590       1600
KSQGLDVQEP PVKDGGDLSD CLGWPSSSAT LSFDSREASF VHGRPQGTLE 
      1610       1620       1630       1640       1650
IPSESVKSKQ FSPSGYLSDT EESNMICQTM KCQRYQTPYL SEETTYLEPG 
      1660       1670       1680       1690       1700
KISVNCGHPS RHKADRLKSD FKKLSSTLPS SVCQQPSRKL IVPLSSQQDS 
      1710
GFDSPFVNLD
Note: Gene prediction based on EST data.
Length:1,710
Mass (Da):195,626
Last modified:June 26, 2013 - v4
Checksum:i1727BDA921E1F6BD
GO
Isoform 1 (identifier: O94986-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-181: Missing.
     1365-1368: ALPL → GMSK
     1369-1710: Missing.

Show »
Length:1,275
Mass (Da):147,345
Checksum:iD1E91CED05D5E054
GO
Isoform 2 (identifier: O94986-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1365-1368: ALPL → GMSK
     1369-1710: Missing.

Show »
Length:1,368
Mass (Da):158,079
Checksum:i03F71584CB87AB49
GO
Isoform 3 (identifier: O94986-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1156-1211: Missing.

Note: No experimental confirmation available.
Show »
Length:1,654
Mass (Da):189,071
Checksum:iC517B4CFBDAB87E9
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B719A0A075B719_HUMAN
Centrosomal protein of 152 kDa
CEP152
584Annotation score:
H0YMG1H0YMG1_HUMAN
Centrosomal protein of 152 kDa
CEP152
64Annotation score:
H0YN91H0YN91_HUMAN
Centrosomal protein of 152 kDa
CEP152
68Annotation score:

Sequence cautioni

The sequence AAH69186 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA74935 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti558S → P in AAH69186 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04793254S → L. Corresponds to variant dbSNP:rs2289181EnsemblClinVar.1
Natural variantiVAR_063813265Q → P in MCPH9. 1 PublicationCorresponds to variant dbSNP:rs267606717EnsemblClinVar.1
Natural variantiVAR_065258667K → R in SCKL5. 1 PublicationCorresponds to variant dbSNP:rs200879436EnsemblClinVar.1
Natural variantiVAR_050779793S → I1 PublicationCorresponds to variant dbSNP:rs2289178EnsemblClinVar.1
Natural variantiVAR_050780914L → V. Corresponds to variant dbSNP:rs16961560EnsemblClinVar.1
Natural variantiVAR_0507811106V → A. Corresponds to variant dbSNP:rs16961557EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03598189 – 181Missing in isoform 1. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_0470021156 – 1211Missing in isoform 3. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_0359831365 – 1368ALPL → GMSK in isoform 1 and isoform 2. 1 Publication4
Alternative sequenceiVSP_0359841369 – 1710Missing in isoform 1 and isoform 2. 1 PublicationAdd BLAST342

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020719 mRNA Translation: BAA74935.1 Different initiation.
AC012379 Genomic DNA No translation available.
AC022084 Genomic DNA No translation available.
AC084757 Genomic DNA No translation available.
BC069186 mRNA Translation: AAH69186.1 Sequence problems.
BC117182 mRNA Translation: AAI17183.1
CCDSiCCDS42033.1 [O94986-3]
CCDS58361.1 [O94986-4]
RefSeqiNP_001181927.1, NM_001194998.1 [O94986-4]
NP_055800.2, NM_014985.3 [O94986-3]
XP_006720500.1, XM_006720437.3 [O94986-4]
UniGeneiHs.443005
Hs.597323

Genome annotation databases

EnsembliENST00000325747; ENSP00000321000; ENSG00000103995 [O94986-1]
ENST00000380950; ENSP00000370337; ENSG00000103995 [O94986-4]
ENST00000399334; ENSP00000382271; ENSG00000103995 [O94986-3]
GeneIDi22995
KEGGihsa:22995
UCSCiuc001zwy.4 human [O94986-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020719 mRNA Translation: BAA74935.1 Different initiation.
AC012379 Genomic DNA No translation available.
AC022084 Genomic DNA No translation available.
AC084757 Genomic DNA No translation available.
BC069186 mRNA Translation: AAH69186.1 Sequence problems.
BC117182 mRNA Translation: AAI17183.1
CCDSiCCDS42033.1 [O94986-3]
CCDS58361.1 [O94986-4]
RefSeqiNP_001181927.1, NM_001194998.1 [O94986-4]
NP_055800.2, NM_014985.3 [O94986-3]
XP_006720500.1, XM_006720437.3 [O94986-4]
UniGeneiHs.443005
Hs.597323

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4N7VX-ray2.76C1-60[»]
ProteinModelPortaliO94986
SMRiO94986
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116642, 124 interactors
ComplexPortaliCPX-1299 CEP152-PLK4 complex
DIPiDIP-31701N
IntActiO94986, 110 interactors
MINTiO94986
STRINGi9606.ENSP00000382271

PTM databases

iPTMnetiO94986
PhosphoSitePlusiO94986

Polymorphism and mutation databases

BioMutaiCEP152

Proteomic databases

EPDiO94986
PaxDbiO94986
PeptideAtlasiO94986
PRIDEiO94986
ProteomicsDBi50610
50611 [O94986-1]
50612 [O94986-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325747; ENSP00000321000; ENSG00000103995 [O94986-1]
ENST00000380950; ENSP00000370337; ENSG00000103995 [O94986-4]
ENST00000399334; ENSP00000382271; ENSG00000103995 [O94986-3]
GeneIDi22995
KEGGihsa:22995
UCSCiuc001zwy.4 human [O94986-4]

Organism-specific databases

CTDi22995
DisGeNETi22995
EuPathDBiHostDB:ENSG00000103995.13
GeneCardsiCEP152
GeneReviewsiCEP152
HGNCiHGNC:29298 CEP152
HPAiHPA039408
MalaCardsiCEP152
MIMi613529 gene
613823 phenotype
614852 phenotype
neXtProtiNX_O94986
OpenTargetsiENSG00000103995
Orphaneti2512 Autosomal recessive primary microcephaly
808 Seckel syndrome
PharmGKBiPA142672126
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGHC Eukaryota
ENOG410XQAW LUCA
GeneTreeiENSGT00630000089915
HOGENOMiHOG000111522
HOVERGENiHBG096403
InParanoidiO94986
KOiK16728
OMAiQSRREWT
OrthoDBiEOG091G0PGF
TreeFamiTF332017

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

Miscellaneous databases

ChiTaRSiCEP152 human
GeneWikiiCEP152
GenomeRNAii22995
PROiPR:O94986
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103995 Expressed in 172 organ(s), highest expression level in secondary oocyte
CleanExiHS_CEP152
ExpressionAtlasiO94986 baseline and differential
GenevisibleiO94986 HS

Family and domain databases

InterProiView protein in InterPro
IPR029598 Cep152
PANTHERiPTHR10337:SF6 PTHR10337:SF6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCE152_HUMAN
AccessioniPrimary (citable) accession number: O94986
Secondary accession number(s): E7ER66, Q17RV1, Q6NTA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 26, 2013
Last modified: November 7, 2018
This is version 143 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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