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UniProtKB - O94986 (CE152_HUMAN)

Protein

Centrosomal protein of 152 kDa

Gene

CEP152

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrosomal protein of 152 kDa
Short name:
Cep152
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEP152
Synonyms:KIAA0912
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000103995.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:29298 CEP152

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613529 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O94986

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Microcephaly 9, primary, autosomal recessive (MCPH9)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder.
See also OMIM:614852
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_063813265Q → P in MCPH9. 1 PublicationCorresponds to variant dbSNP:rs267606717EnsemblClinVar.1
Seckel syndrome 5 (SCKL5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare autosomal recessive disorder characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and mental retardation.
See also OMIM:613823
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065258667K → R in SCKL5. 1 PublicationCorresponds to variant dbSNP:rs200879436EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi21E → K: Impairs interaction with PLK4; impaired procentriole assembly and chromosome segregation. 1 Publication1

Keywords - Diseasei

Disease mutation, Dwarfism, Mental retardation, Primary microcephaly

Organism-specific databases

DisGeNET

More...DisGeNETi		22995

MalaCards human disease database

More...MalaCardsi		CEP152
MIMi613823 phenotype
614852 phenotype

Open Targets

More...OpenTargetsi		ENSG00000103995

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		2512 Autosomal recessive primary microcephaly
808 Seckel syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142672126

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CEP152

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000894621 – 1710Centrosomal protein of 152 kDaAdd BLAST1710

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1241PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O94986

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O94986

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O94986

PeptideAtlas

More...PeptideAtlasi		O94986

PRoteomics IDEntifications database

More...PRIDEi		O94986

ProteomicsDB human proteome resource

More...ProteomicsDBi		50610
50611 [O94986-1]
50612 [O94986-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O94986

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O94986

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000103995 Expressed in 172 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

More...CleanExi		HS_CEP152

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O94986 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O94986 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA039408

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminus) with PLK4; the interaction is mutally exclusive with a PLK4:CEP192 interaction (PubMed:21059844, PubMed:20852615, PubMed:24997597). Interacts (via C-terminus) with CENPJ (via-N-terminus) (PubMed:20852615). Interacts with CINP (PubMed:21131973). Interacts with CDK5RAP2, WDR62, CEP63 and CEP131 (PubMed:21983783, PubMed:24613305, PubMed:26297806). CEP63, CDK5RAP2, CEP152, WDR62 are proposed to form a stepwise assembled complex at the centrosome forming a ring near parental centrioles (PubMed:26297806). Interacts with DEUP1; this interaction recruits CEP152 to the deuterosome. The interactions with CEP63 and DEUP1 are mutually exclusive (By similarity).By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		116642, 124 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1299 CEP152-PLK4 complex

Database of interacting proteins

More...DIPi		DIP-31701N

Protein interaction database and analysis system

More...IntActi		O94986, 110 interactors

Molecular INTeraction database

More...MINTi		O94986

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000382271

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11710
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4N7VX-ray2.76C1-60[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		O94986

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O94986

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 60Interaction with PLK41 PublicationAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili234 – 490Sequence analysisAdd BLAST257
Coiled coili615 – 664Sequence analysisAdd BLAST50
Coiled coili700 – 772Sequence analysisAdd BLAST73
Coiled coili902 – 993Sequence analysisAdd BLAST92
Coiled coili1170 – 1241Sequence analysisAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CEP152 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IGHC Eukaryota
ENOG410XQAW LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153127

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000111522

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG096403

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O94986

KEGG Orthology (KO)

More...KOi		K16728

Identification of Orthologs from Complete Genome Data

More...OMAi		QSRREWT

Database of Orthologous Groups

More...OrthoDBi		243447at2759

TreeFam database of animal gene trees

More...TreeFami		TF332017

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029598 Cep152

The PANTHER Classification System

More...PANTHERi		PTHR10337:SF6 PTHR10337:SF6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: O94986-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLDFGSVAL PVQNEDEEYD EEDYEREKEL QQLLTDLPHD MLDDDLSSPE 
        60         70         80         90        100
LQYSDCSEDG TDGQPHHPEQ LEMSWNEQML PKSQSVNGYN EIQSLYAGEK 
       110        120        130        140        150
CGNVWEENRS KTEDRHPVYH PEEGGDEGGS GYSPPSKCEQ TDLYHLPENF 
       160        170        180        190        200
RPYTNGQKQE FNNQATNVIK FSDPQWNHFQ GPSCQGLEPY NKVTYKPYQS 
       210        220        230        240        250
SAQNNGSPAQ EITGSDTFEG LQQQFLGANE NSAENMQIIQ LQVLNKAKER 
       260        270        280        290        300
QLENLIEKLN ESERQIRYLN HQLVIIKDEK DGLTLSLRES QKLFQNGKER 
       310        320        330        340        350
EIQLEAQIKA LETQIQALKV NEEQMIKKSR TTEMALESLK QQLVDLHHSE 
       360        370        380        390        400
SLQRAREQHE SIVMGLTKKY EEQVLSLQKN LDATVTALKE QEDICSRLKD 
       410        420        430        440        450
HVKQLERNQE AIKLEKTEII NKLTRSLEES QKQCAHLLQS GSVQEVAQLQ 
       460        470        480        490        500
FQLQQAQKAH AMSANMNKAL QEELTELKDE ISLYESAAKL GIHPSDSEGE 
       510        520        530        540        550
LNIELTESYV DLGIKKVNWK KSKVTSIVQE EDPNEELSKD EFILKLKAEV 
       560        570        580        590        600
QRLLGSNSMK RHLVSQLQND LKDCHKKIED LHQVKKDEKS IEVETKTDTS 
       610        620        630        640        650
EKPKNQLWPE SSTSDVVRDD ILLLKNEIQV LQQQNQELKE TEGKLRNTNQ 
       660        670        680        690        700
DLCNQMRQMV QDFDHDKQEA VDRCERTYQQ HHEAMKTQIR ESLLAKHALE 
       710        720        730        740        750
KQQLFEAYER THLQLRSELD KLNKEVTAVQ ECYLEVCREK DNLELTLRKT 
       760        770        780        790        800
TEKEQQTQEK IKEKLIQQLE KEWQSKLDQT IKAMKKKTLD CGSQTDQVTT 
       810        820        830        840        850
SDVISKKEMA IMIEEQKCTI QQNLEQEKDI AIKGAMKKLE IELELKHCEN 
       860        870        880        890        900
ITKQVEIAVQ NAHQRWLGEL PELAEYQALV KAEQKKWEEQ HEVSVNKRIS 
       910        920        930        940        950
FAVSEAKEKW KSELENMRKN ILPGKELEEK IHSLQKELEL KNEEVPVVIR 
       960        970        980        990       1000
AELAKARSEW NKEKQEEIHR IQEQNEQDYR QFLDDHRNKI NEVLAAAKED 
      1010       1020       1030       1040       1050
FMKQKTELLL QKETELQTCL DQSRREWTMQ EAKRIQLEIY QYEEDILTVL 
      1060       1070       1080       1090       1100
GVLLSDTQKE HISDSEDKQL LEIMSTCSSK WMSVQYFEKL KGCIQKAFQD 
      1110       1120       1130       1140       1150
TLPLLVENAD PEWKKRNMAE LSKDSASQGT GQGDPGPAAG HHAQPLALQA 
      1160       1170       1180       1190       1200
TEAEADKKKV LEIKDLCCGH CFQELEKAKQ ECQDLKGKLE KCCRHLQHLE 
      1210       1220       1230       1240       1250
RKHKAVVEKI GEENNKVVEE LIEENNDMKN KLEELQTLCK TPPRSLSAGA 
      1260       1270       1280       1290       1300
IENACLPCSG GALEELRGQY IKAVKKIKCD MLRYIQESKE RAAEMVKAEV 
      1310       1320       1330       1340       1350
LRERQETARK MRKYYLICLQ QILQDDGKEG AEKKIMNAAS KLATMAKLLE 
      1360       1370       1380       1390       1400
TPISSKSQSK TTQSALPLTS EMLIAVKKSK RNDVNQKIPC CIESKSNSVN 
      1410       1420       1430       1440       1450
TITRTLCEQA PKRRAACNLQ RLLENSEHQS IKHVGSKETH LEFQFGDGSC 
      1460       1470       1480       1490       1500
KHLNSLPRNV SPEFVPCEGE GGFGLHKKKD LLSDNGSESL PHSAAYPFLG 
      1510       1520       1530       1540       1550
TLGNKPSPRC TPGPSESGCM HITFRDSNER LGLKVYKCNP LMESENAASE 
      1560       1570       1580       1590       1600
KSQGLDVQEP PVKDGGDLSD CLGWPSSSAT LSFDSREASF VHGRPQGTLE 
      1610       1620       1630       1640       1650
IPSESVKSKQ FSPSGYLSDT EESNMICQTM KCQRYQTPYL SEETTYLEPG 
      1660       1670       1680       1690       1700
KISVNCGHPS RHKADRLKSD FKKLSSTLPS SVCQQPSRKL IVPLSSQQDS 
      1710
GFDSPFVNLD
Note: Gene prediction based on EST data.
Length:1,710
Mass (Da):195,626
Last modified:June 26, 2013 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1727BDA921E1F6BD
GO
Isoform 1 (identifier: O94986-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-181: Missing.
     1365-1368: ALPL → GMSK
     1369-1710: Missing.

Show »
Length:1,275
Mass (Da):147,345
Checksum:iD1E91CED05D5E054
GO
Isoform 2 (identifier: O94986-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1365-1368: ALPL → GMSK
     1369-1710: Missing.

Show »
Length:1,368
Mass (Da):158,079
Checksum:i03F71584CB87AB49
GO
Isoform 3 (identifier: O94986-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1156-1211: Missing.

Note: No experimental confirmation available.
Show »
Length:1,654
Mass (Da):189,071
Checksum:iC517B4CFBDAB87E9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B719A0A075B719_HUMAN
Centrosomal protein of 152 kDa
CEP152
584Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMG1H0YMG1_HUMAN
Centrosomal protein of 152 kDa
CEP152
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YN91H0YN91_HUMAN
Centrosomal protein of 152 kDa
CEP152
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH69186 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA74935 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti558S → P in AAH69186 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04793254S → L. Corresponds to variant dbSNP:rs2289181EnsemblClinVar.1
Natural variantiVAR_063813265Q → P in MCPH9. 1 PublicationCorresponds to variant dbSNP:rs267606717EnsemblClinVar.1
Natural variantiVAR_065258667K → R in SCKL5. 1 PublicationCorresponds to variant dbSNP:rs200879436EnsemblClinVar.1
Natural variantiVAR_050779793S → I1 PublicationCorresponds to variant dbSNP:rs2289178EnsemblClinVar.1
Natural variantiVAR_050780914L → V. Corresponds to variant dbSNP:rs16961560EnsemblClinVar.1
Natural variantiVAR_0507811106V → A. Corresponds to variant dbSNP:rs16961557EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03598189 – 181Missing in isoform 1. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_0470021156 – 1211Missing in isoform 3. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_0359831365 – 1368ALPL → GMSK in isoform 1 and isoform 2. 1 Publication4
Alternative sequenceiVSP_0359841369 – 1710Missing in isoform 1 and isoform 2. 1 PublicationAdd BLAST342

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB020719 mRNA Translation: BAA74935.1 Different initiation.
AC012379 Genomic DNA No translation available.
AC022084 Genomic DNA No translation available.
AC084757 Genomic DNA No translation available.
BC069186 mRNA Translation: AAH69186.1 Sequence problems.
BC117182 mRNA Translation: AAI17183.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42033.1 [O94986-3]
CCDS58361.1 [O94986-4]

NCBI Reference Sequences

More...RefSeqi		NP_001181927.1, NM_001194998.1 [O94986-4]
NP_055800.2, NM_014985.3 [O94986-3]
XP_006720500.1, XM_006720437.3 [O94986-4]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.443005
Hs.597323

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000325747; ENSP00000321000; ENSG00000103995 [O94986-1]
ENST00000380950; ENSP00000370337; ENSG00000103995 [O94986-4]
ENST00000399334; ENSP00000382271; ENSG00000103995 [O94986-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		22995

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:22995

UCSC genome browser

More...UCSCi		uc001zwy.4 human [O94986-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020719 mRNA Translation: BAA74935.1 Different initiation.
AC012379 Genomic DNA No translation available.
AC022084 Genomic DNA No translation available.
AC084757 Genomic DNA No translation available.
BC069186 mRNA Translation: AAH69186.1 Sequence problems.
BC117182 mRNA Translation: AAI17183.1
CCDSiCCDS42033.1 [O94986-3]
CCDS58361.1 [O94986-4]
RefSeqiNP_001181927.1, NM_001194998.1 [O94986-4]
NP_055800.2, NM_014985.3 [O94986-3]
XP_006720500.1, XM_006720437.3 [O94986-4]
UniGeneiHs.443005
Hs.597323

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4N7VX-ray2.76C1-60[»]
ProteinModelPortaliO94986
SMRiO94986
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116642, 124 interactors
ComplexPortaliCPX-1299 CEP152-PLK4 complex
DIPiDIP-31701N
IntActiO94986, 110 interactors
MINTiO94986
STRINGi9606.ENSP00000382271

PTM databases

iPTMnetiO94986
PhosphoSitePlusiO94986

Polymorphism and mutation databases

BioMutaiCEP152

Proteomic databases

EPDiO94986
jPOSTiO94986
PaxDbiO94986
PeptideAtlasiO94986
PRIDEiO94986
ProteomicsDBi50610
50611 [O94986-1]
50612 [O94986-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325747; ENSP00000321000; ENSG00000103995 [O94986-1]
ENST00000380950; ENSP00000370337; ENSG00000103995 [O94986-4]
ENST00000399334; ENSP00000382271; ENSG00000103995 [O94986-3]
GeneIDi22995
KEGGihsa:22995
UCSCiuc001zwy.4 human [O94986-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		22995
DisGeNETi22995
EuPathDBiHostDB:ENSG00000103995.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		CEP152
HGNCiHGNC:29298 CEP152
HPAiHPA039408
MalaCardsiCEP152
MIMi613529 gene
613823 phenotype
614852 phenotype
neXtProtiNX_O94986
OpenTargetsiENSG00000103995
Orphaneti2512 Autosomal recessive primary microcephaly
808 Seckel syndrome
PharmGKBiPA142672126

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IGHC Eukaryota
ENOG410XQAW LUCA
GeneTreeiENSGT00940000153127
HOGENOMiHOG000111522
HOVERGENiHBG096403
InParanoidiO94986
KOiK16728
OMAiQSRREWT
OrthoDBi243447at2759
TreeFamiTF332017

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CEP152 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CEP152

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		22995

Protein Ontology

More...PROi		PR:O94986

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000103995 Expressed in 172 organ(s), highest expression level in secondary oocyte
CleanExiHS_CEP152
ExpressionAtlasiO94986 baseline and differential
GenevisibleiO94986 HS

Family and domain databases

InterProiView protein in InterPro
IPR029598 Cep152
PANTHERiPTHR10337:SF6 PTHR10337:SF6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCE152_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94986
Secondary accession number(s): E7ER66, Q17RV1, Q6NTA0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 26, 2013
Last modified: January 16, 2019
This is version 145 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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