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UniProtKB - O94983 (CMTA2_HUMAN)

Entry version 177 (23 Feb 2022)
Sequence version 3 (06 Feb 2007)
Previous versions | rss
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Protein

Calmodulin-binding transcription activator 2

Gene

CAMTA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription activator. May act as tumor suppressor.

1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi30 – 155CG-1PROSITE-ProRule annotationAdd BLAST126

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O94983

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O94983

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calmodulin-binding transcription activator 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAMTA2
Synonyms:KIAA0909
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18807, CAMTA2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611508, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O94983

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000108509

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23125

Open Targets

More...OpenTargetsi		ENSG00000108509

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38689

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O94983, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CAMTA2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002358211 – 1202Calmodulin-binding transcription activator 2Add BLAST1202

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O94983

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O94983

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O94983

PeptideAtlas

More...PeptideAtlasi		O94983

PRoteomics IDEntifications database

More...PRIDEi		O94983

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		18913
50603 [O94983-1]
50604 [O94983-2]
50605 [O94983-3]
50606 [O94983-4]
50607 [O94983-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O94983

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O94983

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain. Expressed at constant levels throughout the cell cycle in neuroblastoma cell lines.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000108509, Expressed in frontal cortex and 205 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O94983, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O94983, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000108509, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with calmodulin.

Curated

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116744, 17 interactors

Protein interaction database and analysis system

More...IntActi		O94983, 18 interactors

Molecular INTeraction database

More...MINTi		O94983

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000412886

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O94983, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O94983

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini537 – 615IPT/TIGAdd BLAST79
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati712 – 745ANK 1Add BLAST34
Repeati757 – 787ANK 2Add BLAST31
Repeati791 – 821ANK 3Add BLAST31
Domaini1049 – 1078IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini1102 – 1131IQ 2PROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni263 – 322DisorderedSequence analysisAdd BLAST60
Regioni361 – 409DisorderedSequence analysisAdd BLAST49
Regioni421 – 491DisorderedSequence analysisAdd BLAST71
Regioni817 – 874DisorderedSequence analysisAdd BLAST58
Regioni906 – 929DisorderedSequence analysisAdd BLAST24

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi79 – 86Nuclear localization signalPROSITE-ProRule annotation8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi266 – 285Pro residuesSequence analysisAdd BLAST20
Compositional biasi286 – 303Polar residuesSequence analysisAdd BLAST18
Compositional biasi459 – 477Pro residuesSequence analysisAdd BLAST19
Compositional biasi829 – 860Polar residuesSequence analysisAdd BLAST32

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAMTA family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0520, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160105

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003170_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O94983

Identification of Orthologs from Complete Genome Data

More...OMAi		NPHLTQH

Database of Orthologous Groups

More...OrthoDBi		315169at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O94983

TreeFam database of animal gene trees

More...TreeFami		TF323452

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 1 hit
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036770, Ankyrin_rpt-contain_sf
IPR043661, Camta2
IPR005559, CG-1_dom
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR000048, IQ_motif_EF-hand-BS

The PANTHER Classification System

More...PANTHERi		PTHR23335:SF9, PTHR23335:SF9, 4 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03859, CG-1, 1 hit
PF01833, TIG, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01076, CG-1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS51437, CG_1, 1 hit
PS50096, IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94983-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNTKDTTEVA ENSHHLKIFL PKKLLECLPR CPLLPPERLR WNTNEEIASY 
        60         70         80         90        100
LITFEKHDEW LSCAPKTRPQ NGSIILYNRK KVKYRKDGYL WKKRKDGKTT 
       110        120        130        140        150
REDHMKLKVQ GMECLYGCYV HSSIVPTFHR RCYWLLQNPD IVLVHYLNVP 
       160        170        180        190        200
ALEDCGKGCS PIFCSISSDR REWLKWSREE LLGQLKPMFH GIKWSCGNGT 
       210        220        230        240        250
EEFSVEHLVQ QILDTHPTKP APRTHACLCS GGLGSGSLTH KCSSTKHRII 
       260        270        280        290        300
SPKVEPRALT LTSIPHAHPP EPPPLIAPLP PELPKAHTSP SSSSSSSSSG 
       310        320        330        340        350
FAEPLEIRPS PPTSRGGSSR GGTAILLLTG LEQRAGGLTP TRHLAPQADP 
       360        370        380        390        400
RPSMSLAVVV GTEPSAPPAP PSPAFDPDRF LNSPQRGQTY GGGQGVSPDF 
       410        420        430        440        450
PEAEAAHTPC SALEPAAALE PQAAARGPPP QSVAGGRRGN CFFIQDDDSG 
       460        470        480        490        500
EELKGHGAAP PIPSPPPSPP PSPAPLEPSS RVGRGEALFG GPVGASELEP 
       510        520        530        540        550
FSLSSFPDLM GELISDEAPS IPAPTPQLSP ALSTITDFSP EWSYPEGGVK 
       560        570        580        590        600
VLITGPWTEA AEHYSCVFDH IAVPASLVQP GVLRCYCPAH EVGLVSLQVA 
       610        620        630        640        650
GREGPLSASV LFEYRARRFL SLPSTQLDWL SLDDNQFRMS ILERLEQMEK 
       660        670        680        690        700
RMAEIAAAGQ VPCQGPDAPP VQDEGQGPGF EARVVVLVES MIPRSTWKGP 
       710        720        730        740        750
ERLAHGSPFR GMSLLHLAAA QGYARLIETL SQWRSVETGS LDLEQEVDPL 
       760        770        780        790        800
NVDHFSCTPL MWACALGHLE AAVLLFRWNR QALSIPDSLG RLPLSVAHSR 
       810        820        830        840        850
GHVRLARCLE ELQRQEPSVE PPFALSPPSS SPDTGLSSVS SPSELSDGTF 
       860        870        880        890        900
SVTSAYSSAP DGSPPPAPLP ASEMTMEDMA PGQLSSGVPE APLLLMDYEA 
       910        920        930        940        950
TNSKGPLSSL PALPPASDDG AAPEDADSPQ AVDVIPVDMI SLAKQIIEAT 
       960        970        980        990       1000
PERIKREDFV GLPEAGASMR ERTGAVGLSE TMSWLASYLE NVDHFPSSTP 
      1010       1020       1030       1040       1050
PSELPFERGR LAVPSAPSWA EFLSASTSGK MESDFALLTL SDHEQRELYE 
      1060       1070       1080       1090       1100
AARVIQTAFR KYKGRRLKEQ QEVAAAVIQR CYRKYKQLTW IALKFALYKK 
      1110       1120       1130       1140       1150
MTQAAILIQS KFRSYYEQKR FQQSRRAAVL IQQHYRSYRR RPGPPHRTSA 
      1160       1170       1180       1190       1200
TLPARNKGSF LTKKQDQAAR KIMRFLRRCR HRMRELKQNQ ELEGLPQPGL 

AT
Length:1,202
Mass (Da):131,530
Last modified:February 6, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i09E17E4E240F4A58
GO
Isoform 2 (identifier: O94983-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1088-1094: Missing.

Show »
Length:1,195
Mass (Da):130,704
Checksum:iE172544E3C189739
GO
Isoform 3 (identifier: O94983-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MNTKDTTEVA → MAAAAVTRGTPG
     1088-1094: Missing.

Show »
Length:1,197
Mass (Da):130,697
Checksum:iA256178E19EC9555
GO
Isoform 4 (identifier: O94983-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGTDSPSPRPLRPGVTLPPGALTM
     114-137: Missing.

Show »
Length:1,201
Mass (Da):130,902
Checksum:iC3CB80558CE61B4E
GO
Isoform 5 (identifier: O94983-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-873: Missing.

Show »
Length:329
Mass (Da):37,129
Checksum:i69FDCB63AF1DD38F
GO
Isoform 6 (identifier: O94983-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGTDSPSPRPLRPGVTLPPGALTM
     1158-1202: GSFLTKKQDQ...EGLPQPGLAT → LLSHQEAGPG...SPPWGRLVQS

Show »
Length:1,241
Mass (Da):134,800
Checksum:i0E19A0F98947BB34
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L3W6I3L3W6_HUMAN
Calmodulin-binding transcription ac...
CAMTA2
1,207Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L146I3L146_HUMAN
Calmodulin-binding transcription ac...
CAMTA2
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2A1I3L2A1_HUMAN
Calmodulin-binding transcription ac...
CAMTA2
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3V0I3L3V0_HUMAN
Calmodulin-binding transcription ac...
CAMTA2
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH16163 differs from that shown. Reason: Frameshift.Curated
The sequence BAA74932 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti140D → G in CAD38818 (PubMed:17974005).Curated1
Sequence conflicti682A → V in CAD38818 (PubMed:17974005).Curated1
Sequence conflicti688V → L in CAD38818 (PubMed:17974005).Curated1
Sequence conflicti788S → P in CAD38818 (PubMed:17974005).Curated1
Sequence conflicti1175F → S in CAD38818 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026417267A → P3 PublicationsCorresponds to variant dbSNP:rs238234Ensembl.1
Natural variantiVAR_026418903S → P2 PublicationsCorresponds to variant dbSNP:rs16942615Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0184891 – 873Missing in isoform 5. 1 PublicationAdd BLAST873
Alternative sequenceiVSP_0184901 – 10MNTKDTTEVA → MAAAAVTRGTPG in isoform 3. 1 Publication10
Alternative sequenceiVSP_0184911M → MGTDSPSPRPLRPGVTLPPG ALTM in isoform 4 and isoform 6. 2 Publications1
Alternative sequenceiVSP_018492114 – 137Missing in isoform 4. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_0184931088 – 1094Missing in isoform 2 and isoform 3. 2 Publications7
Alternative sequenceiVSP_0460591158 – 1202GSFLT…PGLAT → LLSHQEAGPGSPEDHEIPAA LPTQDEGTEAEPGAGRASPA GTGHMTWPPPFSPPWGRLVQ S in isoform 6. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB020716 mRNA Translation: BAA74932.1 Different initiation.
AL833974 mRNA Translation: CAD38818.2
AL831849 mRNA Translation: CAD38553.1
AC004771 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90372.1
CH471108 Genomic DNA Translation: EAW90373.1
BC010050 mRNA Translation: AAH10050.2
BC016163 mRNA Translation: AAH16163.1 Frameshift.
BC136534 mRNA Translation: AAI36535.1
BC142606 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11063.1 [O94983-1]
CCDS54071.1 [O94983-4]
CCDS54072.1 [O94983-6]
CCDS54073.1 [O94983-3]

NCBI Reference Sequences

More...RefSeqi		NP_001164637.1, NM_001171166.1 [O94983-3]
NP_001164638.1, NM_001171167.1 [O94983-6]
NP_001164639.1, NM_001171168.1 [O94983-4]
NP_055914.2, NM_015099.3 [O94983-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000348066; ENSP00000321813; ENSG00000108509
ENST00000361571; ENSP00000354828; ENSG00000108509 [O94983-4]
ENST00000381311; ENSP00000370712; ENSG00000108509 [O94983-3]
ENST00000414043; ENSP00000412886; ENSG00000108509 [O94983-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23125

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23125

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000348066.8; ENSP00000321813.7; NM_015099.4; NP_055914.2

UCSC genome browser

More...UCSCi		uc002gag.3, human [O94983-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020716 mRNA Translation: BAA74932.1 Different initiation.
AL833974 mRNA Translation: CAD38818.2
AL831849 mRNA Translation: CAD38553.1
AC004771 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90372.1
CH471108 Genomic DNA Translation: EAW90373.1
BC010050 mRNA Translation: AAH10050.2
BC016163 mRNA Translation: AAH16163.1 Frameshift.
BC136534 mRNA Translation: AAI36535.1
BC142606 mRNA No translation available.
CCDSiCCDS11063.1 [O94983-1]
CCDS54071.1 [O94983-4]
CCDS54072.1 [O94983-6]
CCDS54073.1 [O94983-3]
RefSeqiNP_001164637.1, NM_001171166.1 [O94983-3]
NP_001164638.1, NM_001171167.1 [O94983-6]
NP_001164639.1, NM_001171168.1 [O94983-4]
NP_055914.2, NM_015099.3 [O94983-1]

3D structure databases

SMRiO94983
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116744, 17 interactors
IntActiO94983, 18 interactors
MINTiO94983
STRINGi9606.ENSP00000412886

PTM databases

iPTMnetiO94983
PhosphoSitePlusiO94983

Genetic variation databases

BioMutaiCAMTA2

Proteomic databases

jPOSTiO94983
MassIVEiO94983
PaxDbiO94983
PeptideAtlasiO94983
PRIDEiO94983
ProteomicsDBi18913
50603 [O94983-1]
50604 [O94983-2]
50605 [O94983-3]
50606 [O94983-4]
50607 [O94983-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		53152, 28 antibodies from 19 providers

The DNASU plasmid repository

More...DNASUi		23125

Genome annotation databases

EnsembliENST00000348066; ENSP00000321813; ENSG00000108509
ENST00000361571; ENSP00000354828; ENSG00000108509 [O94983-4]
ENST00000381311; ENSP00000370712; ENSG00000108509 [O94983-3]
ENST00000414043; ENSP00000412886; ENSG00000108509 [O94983-6]
GeneIDi23125
KEGGihsa:23125
MANE-SelectiENST00000348066.8; ENSP00000321813.7; NM_015099.4; NP_055914.2
UCSCiuc002gag.3, human [O94983-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23125
DisGeNETi23125

GeneCards: human genes, protein and diseases

More...GeneCardsi		CAMTA2
HGNCiHGNC:18807, CAMTA2
HPAiENSG00000108509, Low tissue specificity
MIMi611508, gene
neXtProtiNX_O94983
OpenTargetsiENSG00000108509
PharmGKBiPA38689
VEuPathDBiHostDB:ENSG00000108509

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0520, Eukaryota
GeneTreeiENSGT00940000160105
HOGENOMiCLU_003170_2_0_1
InParanoidiO94983
OMAiNPHLTQH
OrthoDBi315169at2759
PhylomeDBiO94983
TreeFamiTF323452

Enzyme and pathway databases

PathwayCommonsiO94983
SignaLinkiO94983

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23125, 8 hits in 1072 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CAMTA2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23125
PharosiO94983, Tbio

Protein Ontology

More...PROi		PR:O94983
RNActiO94983, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000108509, Expressed in frontal cortex and 205 other tissues
ExpressionAtlasiO94983, baseline and differential
GenevisibleiO94983, HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036770, Ankyrin_rpt-contain_sf
IPR043661, Camta2
IPR005559, CG-1_dom
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR000048, IQ_motif_EF-hand-BS
PANTHERiPTHR23335:SF9, PTHR23335:SF9, 4 hits
PfamiView protein in Pfam
PF03859, CG-1, 1 hit
PF01833, TIG, 1 hit
SMARTiView protein in SMART
SM01076, CG-1, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS51437, CG_1, 1 hit
PS50096, IQ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCMTA2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94983
Secondary accession number(s): B9EGL0
, D3DTL5, E7EWU5, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: February 6, 2007
Last modified: February 23, 2022
This is version 177 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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