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UniProtKB - O94983 (CMTA2_HUMAN)
Protein
Calmodulin-binding transcription activator 2
Gene
CAMTA2
Organism
Homo sapiens (Human)
Status
Functioni
Transcription activator. May act as tumor suppressor.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 30 – 155 | CG-1PROSITE-ProRule annotationAdd BLAST | 126 |
GO - Molecular functioni
- chromatin binding Source: MGI
- double-stranded DNA binding Source: GO_Central
- histone deacetylase binding Source: MGI
- sequence-specific DNA binding Source: Ensembl
- transcription coactivator activity Source: ARUK-UCL
- transcription coregulator activity Source: GO_Central
GO - Biological processi
- cardiac muscle hypertrophy in response to stress Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | O94983 |
SignaLinki | O94983 |
Names & Taxonomyi
Protein namesi | Recommended name: Calmodulin-binding transcription activator 2 |
Gene namesi | Name:CAMTA2 Synonyms:KIAA0909 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18807, CAMTA2 |
MIMi | 611508, gene |
neXtProti | NX_O94983 |
VEuPathDBi | HostDB:ENSG00000108509 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 23125 |
OpenTargetsi | ENSG00000108509 |
PharmGKBi | PA38689 |
Miscellaneous databases
Pharosi | O94983, Tbio |
Genetic variation databases
BioMutai | CAMTA2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000235821 | 1 – 1202 | Calmodulin-binding transcription activator 2Add BLAST | 1202 |
Proteomic databases
jPOSTi | O94983 |
MassIVEi | O94983 |
PaxDbi | O94983 |
PeptideAtlasi | O94983 |
PRIDEi | O94983 |
ProteomicsDBi | 18913 50603 [O94983-1] 50604 [O94983-2] 50605 [O94983-3] 50606 [O94983-4] 50607 [O94983-5] |
PTM databases
iPTMneti | O94983 |
PhosphoSitePlusi | O94983 |
Expressioni
Tissue specificityi
Detected in brain. Expressed at constant levels throughout the cell cycle in neuroblastoma cell lines.2 Publications
Gene expression databases
Bgeei | ENSG00000108509, Expressed in frontal cortex and 205 other tissues |
ExpressionAtlasi | O94983, baseline and differential |
Genevisiblei | O94983, HS |
Organism-specific databases
HPAi | ENSG00000108509, Low tissue specificity |
Interactioni
Subunit structurei
May interact with calmodulin.
CuratedBinary interactionsi
O94983
With | #Exp. | IntAct |
---|---|---|
Nkx2-5 [P42582] from Mus musculus. | 2 | EBI-936534,EBI-297021 |
Isoform 5 [O94983-5]
GO - Molecular functioni
- histone deacetylase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 116744, 17 interactors |
IntActi | O94983, 18 interactors |
MINTi | O94983 |
STRINGi | 9606.ENSP00000412886 |
Miscellaneous databases
RNActi | O94983, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 537 – 615 | IPT/TIGAdd BLAST | 79 | |
Repeati | 712 – 745 | ANK 1Add BLAST | 34 | |
Repeati | 757 – 787 | ANK 2Add BLAST | 31 | |
Repeati | 791 – 821 | ANK 3Add BLAST | 31 | |
Domaini | 1049 – 1078 | IQ 1PROSITE-ProRule annotationAdd BLAST | 30 | |
Domaini | 1102 – 1131 | IQ 2PROSITE-ProRule annotationAdd BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 263 – 322 | DisorderedSequence analysisAdd BLAST | 60 | |
Regioni | 361 – 409 | DisorderedSequence analysisAdd BLAST | 49 | |
Regioni | 421 – 491 | DisorderedSequence analysisAdd BLAST | 71 | |
Regioni | 817 – 874 | DisorderedSequence analysisAdd BLAST | 58 | |
Regioni | 906 – 929 | DisorderedSequence analysisAdd BLAST | 24 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 79 – 86 | Nuclear localization signalPROSITE-ProRule annotation | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 266 – 285 | Pro residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 286 – 303 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 459 – 477 | Pro residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 829 – 860 | Polar residuesSequence analysisAdd BLAST | 32 |
Sequence similaritiesi
Belongs to the CAMTA family.Curated
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG0520, Eukaryota |
GeneTreei | ENSGT00940000160105 |
HOGENOMi | CLU_003170_2_0_1 |
InParanoidi | O94983 |
OMAi | NPHLTQH |
OrthoDBi | 315169at2759 |
PhylomeDBi | O94983 |
TreeFami | TF323452 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR036770, Ankyrin_rpt-contain_sf IPR043661, Camta2 IPR005559, CG-1_dom IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR000048, IQ_motif_EF-hand-BS |
PANTHERi | PTHR23335:SF9, PTHR23335:SF9, 4 hits |
Pfami | View protein in Pfam PF03859, CG-1, 1 hit PF01833, TIG, 1 hit |
SMARTi | View protein in SMART SM01076, CG-1, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS51437, CG_1, 1 hit PS50096, IQ, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O94983-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNTKDTTEVA ENSHHLKIFL PKKLLECLPR CPLLPPERLR WNTNEEIASY
60 70 80 90 100
LITFEKHDEW LSCAPKTRPQ NGSIILYNRK KVKYRKDGYL WKKRKDGKTT
110 120 130 140 150
REDHMKLKVQ GMECLYGCYV HSSIVPTFHR RCYWLLQNPD IVLVHYLNVP
160 170 180 190 200
ALEDCGKGCS PIFCSISSDR REWLKWSREE LLGQLKPMFH GIKWSCGNGT
210 220 230 240 250
EEFSVEHLVQ QILDTHPTKP APRTHACLCS GGLGSGSLTH KCSSTKHRII
260 270 280 290 300
SPKVEPRALT LTSIPHAHPP EPPPLIAPLP PELPKAHTSP SSSSSSSSSG
310 320 330 340 350
FAEPLEIRPS PPTSRGGSSR GGTAILLLTG LEQRAGGLTP TRHLAPQADP
360 370 380 390 400
RPSMSLAVVV GTEPSAPPAP PSPAFDPDRF LNSPQRGQTY GGGQGVSPDF
410 420 430 440 450
PEAEAAHTPC SALEPAAALE PQAAARGPPP QSVAGGRRGN CFFIQDDDSG
460 470 480 490 500
EELKGHGAAP PIPSPPPSPP PSPAPLEPSS RVGRGEALFG GPVGASELEP
510 520 530 540 550
FSLSSFPDLM GELISDEAPS IPAPTPQLSP ALSTITDFSP EWSYPEGGVK
560 570 580 590 600
VLITGPWTEA AEHYSCVFDH IAVPASLVQP GVLRCYCPAH EVGLVSLQVA
610 620 630 640 650
GREGPLSASV LFEYRARRFL SLPSTQLDWL SLDDNQFRMS ILERLEQMEK
660 670 680 690 700
RMAEIAAAGQ VPCQGPDAPP VQDEGQGPGF EARVVVLVES MIPRSTWKGP
710 720 730 740 750
ERLAHGSPFR GMSLLHLAAA QGYARLIETL SQWRSVETGS LDLEQEVDPL
760 770 780 790 800
NVDHFSCTPL MWACALGHLE AAVLLFRWNR QALSIPDSLG RLPLSVAHSR
810 820 830 840 850
GHVRLARCLE ELQRQEPSVE PPFALSPPSS SPDTGLSSVS SPSELSDGTF
860 870 880 890 900
SVTSAYSSAP DGSPPPAPLP ASEMTMEDMA PGQLSSGVPE APLLLMDYEA
910 920 930 940 950
TNSKGPLSSL PALPPASDDG AAPEDADSPQ AVDVIPVDMI SLAKQIIEAT
960 970 980 990 1000
PERIKREDFV GLPEAGASMR ERTGAVGLSE TMSWLASYLE NVDHFPSSTP
1010 1020 1030 1040 1050
PSELPFERGR LAVPSAPSWA EFLSASTSGK MESDFALLTL SDHEQRELYE
1060 1070 1080 1090 1100
AARVIQTAFR KYKGRRLKEQ QEVAAAVIQR CYRKYKQLTW IALKFALYKK
1110 1120 1130 1140 1150
MTQAAILIQS KFRSYYEQKR FQQSRRAAVL IQQHYRSYRR RPGPPHRTSA
1160 1170 1180 1190 1200
TLPARNKGSF LTKKQDQAAR KIMRFLRRCR HRMRELKQNQ ELEGLPQPGL
AT
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L3W6 | I3L3W6_HUMAN | Calmodulin-binding transcription ac... | CAMTA2 | 1,207 | Annotation score: | ||
I3L146 | I3L146_HUMAN | Calmodulin-binding transcription ac... | CAMTA2 | 161 | Annotation score: | ||
I3L2A1 | I3L2A1_HUMAN | Calmodulin-binding transcription ac... | CAMTA2 | 178 | Annotation score: | ||
I3L3V0 | I3L3V0_HUMAN | Calmodulin-binding transcription ac... | CAMTA2 | 163 | Annotation score: |
Sequence cautioni
The sequence AAH16163 differs from that shown. Reason: Frameshift.Curated
The sequence BAA74932 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 140 | D → G in CAD38818 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 682 | A → V in CAD38818 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 688 | V → L in CAD38818 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 788 | S → P in CAD38818 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1175 | F → S in CAD38818 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026417 | 267 | A → P3 PublicationsCorresponds to variant dbSNP:rs238234Ensembl. | 1 | |
Natural variantiVAR_026418 | 903 | S → P2 PublicationsCorresponds to variant dbSNP:rs16942615Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018489 | 1 – 873 | Missing in isoform 5. 1 PublicationAdd BLAST | 873 | |
Alternative sequenceiVSP_018490 | 1 – 10 | MNTKDTTEVA → MAAAAVTRGTPG in isoform 3. 1 Publication | 10 | |
Alternative sequenceiVSP_018491 | 1 | M → MGTDSPSPRPLRPGVTLPPG ALTM in isoform 4 and isoform 6. 2 Publications | 1 | |
Alternative sequenceiVSP_018492 | 114 – 137 | Missing in isoform 4. 1 PublicationAdd BLAST | 24 | |
Alternative sequenceiVSP_018493 | 1088 – 1094 | Missing in isoform 2 and isoform 3. 2 Publications | 7 | |
Alternative sequenceiVSP_046059 | 1158 – 1202 | GSFLT…PGLAT → LLSHQEAGPGSPEDHEIPAA LPTQDEGTEAEPGAGRASPA GTGHMTWPPPFSPPWGRLVQ S in isoform 6. 1 PublicationAdd BLAST | 45 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB020716 mRNA Translation: BAA74932.1 Different initiation. AL833974 mRNA Translation: CAD38818.2 AL831849 mRNA Translation: CAD38553.1 AC004771 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90372.1 CH471108 Genomic DNA Translation: EAW90373.1 BC010050 mRNA Translation: AAH10050.2 BC016163 mRNA Translation: AAH16163.1 Frameshift. BC136534 mRNA Translation: AAI36535.1 BC142606 mRNA No translation available. |
CCDSi | CCDS11063.1 [O94983-1] CCDS54071.1 [O94983-4] CCDS54072.1 [O94983-6] CCDS54073.1 [O94983-3] |
RefSeqi | NP_001164637.1, NM_001171166.1 [O94983-3] NP_001164638.1, NM_001171167.1 [O94983-6] NP_001164639.1, NM_001171168.1 [O94983-4] NP_055914.2, NM_015099.3 [O94983-1] |
Genome annotation databases
Ensembli | ENST00000348066; ENSP00000321813; ENSG00000108509 ENST00000361571; ENSP00000354828; ENSG00000108509 [O94983-4] ENST00000381311; ENSP00000370712; ENSG00000108509 [O94983-3] ENST00000414043; ENSP00000412886; ENSG00000108509 [O94983-6] |
GeneIDi | 23125 |
KEGGi | hsa:23125 |
MANE-Selecti | ENST00000348066.8; ENSP00000321813.7; NM_015099.4; NP_055914.2 |
UCSCi | uc002gag.3, human [O94983-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB020716 mRNA Translation: BAA74932.1 Different initiation. AL833974 mRNA Translation: CAD38818.2 AL831849 mRNA Translation: CAD38553.1 AC004771 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90372.1 CH471108 Genomic DNA Translation: EAW90373.1 BC010050 mRNA Translation: AAH10050.2 BC016163 mRNA Translation: AAH16163.1 Frameshift. BC136534 mRNA Translation: AAI36535.1 BC142606 mRNA No translation available. |
CCDSi | CCDS11063.1 [O94983-1] CCDS54071.1 [O94983-4] CCDS54072.1 [O94983-6] CCDS54073.1 [O94983-3] |
RefSeqi | NP_001164637.1, NM_001171166.1 [O94983-3] NP_001164638.1, NM_001171167.1 [O94983-6] NP_001164639.1, NM_001171168.1 [O94983-4] NP_055914.2, NM_015099.3 [O94983-1] |
3D structure databases
SMRi | O94983 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116744, 17 interactors |
IntActi | O94983, 18 interactors |
MINTi | O94983 |
STRINGi | 9606.ENSP00000412886 |
PTM databases
iPTMneti | O94983 |
PhosphoSitePlusi | O94983 |
Genetic variation databases
BioMutai | CAMTA2 |
Proteomic databases
jPOSTi | O94983 |
MassIVEi | O94983 |
PaxDbi | O94983 |
PeptideAtlasi | O94983 |
PRIDEi | O94983 |
ProteomicsDBi | 18913 50603 [O94983-1] 50604 [O94983-2] 50605 [O94983-3] 50606 [O94983-4] 50607 [O94983-5] |
Protocols and materials databases
Antibodypediai | 53152, 28 antibodies from 19 providers |
DNASUi | 23125 |
Genome annotation databases
Ensembli | ENST00000348066; ENSP00000321813; ENSG00000108509 ENST00000361571; ENSP00000354828; ENSG00000108509 [O94983-4] ENST00000381311; ENSP00000370712; ENSG00000108509 [O94983-3] ENST00000414043; ENSP00000412886; ENSG00000108509 [O94983-6] |
GeneIDi | 23125 |
KEGGi | hsa:23125 |
MANE-Selecti | ENST00000348066.8; ENSP00000321813.7; NM_015099.4; NP_055914.2 |
UCSCi | uc002gag.3, human [O94983-1] |
Organism-specific databases
CTDi | 23125 |
DisGeNETi | 23125 |
GeneCardsi | CAMTA2 |
HGNCi | HGNC:18807, CAMTA2 |
HPAi | ENSG00000108509, Low tissue specificity |
MIMi | 611508, gene |
neXtProti | NX_O94983 |
OpenTargetsi | ENSG00000108509 |
PharmGKBi | PA38689 |
VEuPathDBi | HostDB:ENSG00000108509 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0520, Eukaryota |
GeneTreei | ENSGT00940000160105 |
HOGENOMi | CLU_003170_2_0_1 |
InParanoidi | O94983 |
OMAi | NPHLTQH |
OrthoDBi | 315169at2759 |
PhylomeDBi | O94983 |
TreeFami | TF323452 |
Enzyme and pathway databases
PathwayCommonsi | O94983 |
SignaLinki | O94983 |
Miscellaneous databases
BioGRID-ORCSi | 23125, 8 hits in 1072 CRISPR screens |
ChiTaRSi | CAMTA2, human |
GenomeRNAii | 23125 |
Pharosi | O94983, Tbio |
PROi | PR:O94983 |
RNActi | O94983, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108509, Expressed in frontal cortex and 205 other tissues |
ExpressionAtlasi | O94983, baseline and differential |
Genevisiblei | O94983, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR036770, Ankyrin_rpt-contain_sf IPR043661, Camta2 IPR005559, CG-1_dom IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR000048, IQ_motif_EF-hand-BS |
PANTHERi | PTHR23335:SF9, PTHR23335:SF9, 4 hits |
Pfami | View protein in Pfam PF03859, CG-1, 1 hit PF01833, TIG, 1 hit |
SMARTi | View protein in SMART SM01076, CG-1, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS51437, CG_1, 1 hit PS50096, IQ, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CMTA2_HUMAN | |
Accessioni | O94983Primary (citable) accession number: O94983 Secondary accession number(s): B9EGL0 Q96G17 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | February 6, 2007 | |
Last modified: | February 23, 2022 | |
This is version 177 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families