Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - O94983 (CMTA2_HUMAN)

Protein

Calmodulin-binding transcription activator 2

Gene

CAMTA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription activator. May act as tumor suppressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi30 – 155CG-1PROSITE-ProRule annotationAdd BLAST126

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
  • histone deacetylase binding Source: MGI
  • proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
  • sequence-specific DNA binding Source: GO_Central
  • transcription factor binding Source: MGI
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-binding transcription activator 2
Gene namesi
Name:CAMTA2
Synonyms:KIAA0909
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108509.20
HGNCiHGNC:18807 CAMTA2
MIMi611508 gene
neXtProtiNX_O94983

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23125
OpenTargetsiENSG00000108509
PharmGKBiPA38689

Polymorphism and mutation databases

BioMutaiCAMTA2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002358211 – 1202Calmodulin-binding transcription activator 2Add BLAST1202

Proteomic databases

PaxDbiO94983
PeptideAtlasiO94983
PRIDEiO94983
ProteomicsDBi50603
50604 [O94983-2]
50605 [O94983-3]
50606 [O94983-4]
50607 [O94983-5]

PTM databases

iPTMnetiO94983
PhosphoSitePlusiO94983

Expressioni

Tissue specificityi

Detected in brain. Expressed at constant levels throughout the cell cycle in neuroblastoma cell lines.2 Publications

Gene expression databases

BgeeiENSG00000108509 Expressed in 192 organ(s), highest expression level in frontal cortex
CleanExiHS_CAMTA2
ExpressionAtlasiO94983 baseline and differential
GenevisibleiO94983 HS

Organism-specific databases

HPAiHPA051147

Interactioni

Subunit structurei

May interact with calmodulin.Curated

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi116744, 8 interactors
IntActiO94983, 11 interactors
MINTiO94983
STRINGi9606.ENSP00000412886

Structurei

3D structure databases

ProteinModelPortaliO94983
SMRiO94983
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini535 – 617IPT/TIGAdd BLAST83
Repeati712 – 745ANK 1Add BLAST34
Repeati757 – 787ANK 2Add BLAST31
Repeati791 – 821ANK 3Add BLAST31
Domaini1049 – 1078IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini1102 – 1131IQ 2PROSITE-ProRule annotationAdd BLAST30

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi79 – 86Nuclear localization signalPROSITE-ProRule annotation8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi289 – 300Ser-richAdd BLAST12

Sequence similaritiesi

Belongs to the CAMTA family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0520 Eukaryota
ENOG410XS5M LUCA
GeneTreeiENSGT00390000001446
HOVERGENiHBG058078
InParanoidiO94983
KOiK21596
OMAiISFDSQF
OrthoDBiEOG091G01MB
PhylomeDBiO94983
TreeFamiTF323452

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005559 CG-1_dom
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR000048 IQ_motif_EF-hand-BS
PfamiView protein in Pfam
PF03859 CG-1, 1 hit
PF01833 TIG, 1 hit
SMARTiView protein in SMART
SM01076 CG-1, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS51437 CG_1, 1 hit
PS50096 IQ, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94983-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNTKDTTEVA ENSHHLKIFL PKKLLECLPR CPLLPPERLR WNTNEEIASY 
        60         70         80         90        100
LITFEKHDEW LSCAPKTRPQ NGSIILYNRK KVKYRKDGYL WKKRKDGKTT 
       110        120        130        140        150
REDHMKLKVQ GMECLYGCYV HSSIVPTFHR RCYWLLQNPD IVLVHYLNVP 
       160        170        180        190        200
ALEDCGKGCS PIFCSISSDR REWLKWSREE LLGQLKPMFH GIKWSCGNGT 
       210        220        230        240        250
EEFSVEHLVQ QILDTHPTKP APRTHACLCS GGLGSGSLTH KCSSTKHRII 
       260        270        280        290        300
SPKVEPRALT LTSIPHAHPP EPPPLIAPLP PELPKAHTSP SSSSSSSSSG 
       310        320        330        340        350
FAEPLEIRPS PPTSRGGSSR GGTAILLLTG LEQRAGGLTP TRHLAPQADP 
       360        370        380        390        400
RPSMSLAVVV GTEPSAPPAP PSPAFDPDRF LNSPQRGQTY GGGQGVSPDF 
       410        420        430        440        450
PEAEAAHTPC SALEPAAALE PQAAARGPPP QSVAGGRRGN CFFIQDDDSG 
       460        470        480        490        500
EELKGHGAAP PIPSPPPSPP PSPAPLEPSS RVGRGEALFG GPVGASELEP 
       510        520        530        540        550
FSLSSFPDLM GELISDEAPS IPAPTPQLSP ALSTITDFSP EWSYPEGGVK 
       560        570        580        590        600
VLITGPWTEA AEHYSCVFDH IAVPASLVQP GVLRCYCPAH EVGLVSLQVA 
       610        620        630        640        650
GREGPLSASV LFEYRARRFL SLPSTQLDWL SLDDNQFRMS ILERLEQMEK 
       660        670        680        690        700
RMAEIAAAGQ VPCQGPDAPP VQDEGQGPGF EARVVVLVES MIPRSTWKGP 
       710        720        730        740        750
ERLAHGSPFR GMSLLHLAAA QGYARLIETL SQWRSVETGS LDLEQEVDPL 
       760        770        780        790        800
NVDHFSCTPL MWACALGHLE AAVLLFRWNR QALSIPDSLG RLPLSVAHSR 
       810        820        830        840        850
GHVRLARCLE ELQRQEPSVE PPFALSPPSS SPDTGLSSVS SPSELSDGTF 
       860        870        880        890        900
SVTSAYSSAP DGSPPPAPLP ASEMTMEDMA PGQLSSGVPE APLLLMDYEA 
       910        920        930        940        950
TNSKGPLSSL PALPPASDDG AAPEDADSPQ AVDVIPVDMI SLAKQIIEAT 
       960        970        980        990       1000
PERIKREDFV GLPEAGASMR ERTGAVGLSE TMSWLASYLE NVDHFPSSTP 
      1010       1020       1030       1040       1050
PSELPFERGR LAVPSAPSWA EFLSASTSGK MESDFALLTL SDHEQRELYE 
      1060       1070       1080       1090       1100
AARVIQTAFR KYKGRRLKEQ QEVAAAVIQR CYRKYKQLTW IALKFALYKK 
      1110       1120       1130       1140       1150
MTQAAILIQS KFRSYYEQKR FQQSRRAAVL IQQHYRSYRR RPGPPHRTSA 
      1160       1170       1180       1190       1200
TLPARNKGSF LTKKQDQAAR KIMRFLRRCR HRMRELKQNQ ELEGLPQPGL 

AT
Length:1,202
Mass (Da):131,530
Last modified:February 6, 2007 - v3
Checksum:i09E17E4E240F4A58
GO
Isoform 2 (identifier: O94983-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1088-1094: Missing.

Show »
Length:1,195
Mass (Da):130,704
Checksum:iE172544E3C189739
GO
Isoform 3 (identifier: O94983-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MNTKDTTEVA → MAAAAVTRGTPG
     1088-1094: Missing.

Show »
Length:1,197
Mass (Da):130,697
Checksum:iA256178E19EC9555
GO
Isoform 4 (identifier: O94983-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGTDSPSPRPLRPGVTLPPGALTM
     114-137: Missing.

Show »
Length:1,201
Mass (Da):130,902
Checksum:iC3CB80558CE61B4E
GO
Isoform 5 (identifier: O94983-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-873: Missing.

Show »
Length:329
Mass (Da):37,129
Checksum:i69FDCB63AF1DD38F
GO
Isoform 6 (identifier: O94983-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGTDSPSPRPLRPGVTLPPGALTM
     1158-1202: GSFLTKKQDQ...EGLPQPGLAT → LLSHQEAGPG...SPPWGRLVQS

Note: No experimental confirmation available.
Show »
Length:1,241
Mass (Da):134,800
Checksum:i0E19A0F98947BB34
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L3W6I3L3W6_HUMAN
Calmodulin-binding transcription ac...
CAMTA2
1,207Annotation score:
I3L3V0I3L3V0_HUMAN
Calmodulin-binding transcription ac...
CAMTA2
163Annotation score:
I3L146I3L146_HUMAN
Calmodulin-binding transcription ac...
CAMTA2
161Annotation score:
I3L2A1I3L2A1_HUMAN
Calmodulin-binding transcription ac...
CAMTA2
178Annotation score:

Sequence cautioni

The sequence AAH16163 differs from that shown. Reason: Frameshift at position 865.Curated
The sequence BAA74932 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140D → G in CAD38818 (PubMed:17974005).Curated1
Sequence conflicti682A → V in CAD38818 (PubMed:17974005).Curated1
Sequence conflicti688V → L in CAD38818 (PubMed:17974005).Curated1
Sequence conflicti788S → P in CAD38818 (PubMed:17974005).Curated1
Sequence conflicti1175F → S in CAD38818 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026417267A → P3 PublicationsCorresponds to variant dbSNP:rs238234Ensembl.1
Natural variantiVAR_026418903S → P2 PublicationsCorresponds to variant dbSNP:rs16942615Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0184891 – 873Missing in isoform 5. 1 PublicationAdd BLAST873
Alternative sequenceiVSP_0184901 – 10MNTKDTTEVA → MAAAAVTRGTPG in isoform 3. 1 Publication10
Alternative sequenceiVSP_0184911M → MGTDSPSPRPLRPGVTLPPG ALTM in isoform 4 and isoform 6. 2 Publications1
Alternative sequenceiVSP_018492114 – 137Missing in isoform 4. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_0184931088 – 1094Missing in isoform 2 and isoform 3. 2 Publications7
Alternative sequenceiVSP_0460591158 – 1202GSFLT…PGLAT → LLSHQEAGPGSPEDHEIPAA LPTQDEGTEAEPGAGRASPA GTGHMTWPPPFSPPWGRLVQ S in isoform 6. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020716 mRNA Translation: BAA74932.1 Different initiation.
AL833974 mRNA Translation: CAD38818.2
AL831849 mRNA Translation: CAD38553.1
AC004771 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90372.1
CH471108 Genomic DNA Translation: EAW90373.1
BC010050 mRNA Translation: AAH10050.2
BC016163 mRNA Translation: AAH16163.1 Frameshift.
BC136534 mRNA Translation: AAI36535.1
BC142606 mRNA No translation available.
CCDSiCCDS11063.1 [O94983-1]
CCDS54071.1 [O94983-4]
CCDS54072.1 [O94983-6]
CCDS54073.1 [O94983-3]
RefSeqiNP_001164637.1, NM_001171166.1 [O94983-3]
NP_001164638.1, NM_001171167.1 [O94983-6]
NP_001164639.1, NM_001171168.1 [O94983-4]
NP_055914.2, NM_015099.3 [O94983-1]
UniGeneiHs.632242

Genome annotation databases

EnsembliENST00000348066; ENSP00000321813; ENSG00000108509 [O94983-1]
ENST00000361571; ENSP00000354828; ENSG00000108509 [O94983-4]
ENST00000381311; ENSP00000370712; ENSG00000108509 [O94983-3]
ENST00000414043; ENSP00000412886; ENSG00000108509 [O94983-6]
GeneIDi23125
KEGGihsa:23125
UCSCiuc002gag.3 human [O94983-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020716 mRNA Translation: BAA74932.1 Different initiation.
AL833974 mRNA Translation: CAD38818.2
AL831849 mRNA Translation: CAD38553.1
AC004771 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90372.1
CH471108 Genomic DNA Translation: EAW90373.1
BC010050 mRNA Translation: AAH10050.2
BC016163 mRNA Translation: AAH16163.1 Frameshift.
BC136534 mRNA Translation: AAI36535.1
BC142606 mRNA No translation available.
CCDSiCCDS11063.1 [O94983-1]
CCDS54071.1 [O94983-4]
CCDS54072.1 [O94983-6]
CCDS54073.1 [O94983-3]
RefSeqiNP_001164637.1, NM_001171166.1 [O94983-3]
NP_001164638.1, NM_001171167.1 [O94983-6]
NP_001164639.1, NM_001171168.1 [O94983-4]
NP_055914.2, NM_015099.3 [O94983-1]
UniGeneiHs.632242

3D structure databases

ProteinModelPortaliO94983
SMRiO94983
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116744, 8 interactors
IntActiO94983, 11 interactors
MINTiO94983
STRINGi9606.ENSP00000412886

PTM databases

iPTMnetiO94983
PhosphoSitePlusiO94983

Polymorphism and mutation databases

BioMutaiCAMTA2

Proteomic databases

PaxDbiO94983
PeptideAtlasiO94983
PRIDEiO94983
ProteomicsDBi50603
50604 [O94983-2]
50605 [O94983-3]
50606 [O94983-4]
50607 [O94983-5]

Protocols and materials databases

DNASUi23125
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348066; ENSP00000321813; ENSG00000108509 [O94983-1]
ENST00000361571; ENSP00000354828; ENSG00000108509 [O94983-4]
ENST00000381311; ENSP00000370712; ENSG00000108509 [O94983-3]
ENST00000414043; ENSP00000412886; ENSG00000108509 [O94983-6]
GeneIDi23125
KEGGihsa:23125
UCSCiuc002gag.3 human [O94983-1]

Organism-specific databases

CTDi23125
DisGeNETi23125
EuPathDBiHostDB:ENSG00000108509.20
GeneCardsiCAMTA2
HGNCiHGNC:18807 CAMTA2
HPAiHPA051147
MIMi611508 gene
neXtProtiNX_O94983
OpenTargetsiENSG00000108509
PharmGKBiPA38689
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0520 Eukaryota
ENOG410XS5M LUCA
GeneTreeiENSGT00390000001446
HOVERGENiHBG058078
InParanoidiO94983
KOiK21596
OMAiISFDSQF
OrthoDBiEOG091G01MB
PhylomeDBiO94983
TreeFamiTF323452

Miscellaneous databases

ChiTaRSiCAMTA2 human
GenomeRNAii23125
PROiPR:O94983
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108509 Expressed in 192 organ(s), highest expression level in frontal cortex
CleanExiHS_CAMTA2
ExpressionAtlasiO94983 baseline and differential
GenevisibleiO94983 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005559 CG-1_dom
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR000048 IQ_motif_EF-hand-BS
PfamiView protein in Pfam
PF03859 CG-1, 1 hit
PF01833 TIG, 1 hit
SMARTiView protein in SMART
SM01076 CG-1, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS51437 CG_1, 1 hit
PS50096 IQ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCMTA2_HUMAN
AccessioniPrimary (citable) accession number: O94983
Secondary accession number(s): B9EGL0
, D3DTL5, E7EWU5, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: February 6, 2007
Last modified: November 7, 2018
This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again