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Entry version 162 (08 May 2019)
Sequence version 3 (06 Feb 2007)
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Protein

Calmodulin-binding transcription activator 2

Gene

CAMTA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription activator. May act as tumor suppressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi30 – 155CG-1PROSITE-ProRule annotationAdd BLAST126

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calmodulin-binding transcription activator 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAMTA2
Synonyms:KIAA0909
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18807 CAMTA2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611508 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O94983

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23125

Open Targets

More...
OpenTargetsi
ENSG00000108509

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38689

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CAMTA2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002358211 – 1202Calmodulin-binding transcription activator 2Add BLAST1202

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O94983

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94983

PeptideAtlas

More...
PeptideAtlasi
O94983

PRoteomics IDEntifications database

More...
PRIDEi
O94983

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50603
50604 [O94983-2]
50605 [O94983-3]
50606 [O94983-4]
50607 [O94983-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O94983

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O94983

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain. Expressed at constant levels throughout the cell cycle in neuroblastoma cell lines.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000108509 Expressed in 192 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O94983 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O94983 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051147

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with calmodulin.Curated

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116744, 8 interactors

Protein interaction database and analysis system

More...
IntActi
O94983, 11 interactors

Molecular INTeraction database

More...
MINTi
O94983

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000412886

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O94983

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini535 – 617IPT/TIGAdd BLAST83
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati712 – 745ANK 1Add BLAST34
Repeati757 – 787ANK 2Add BLAST31
Repeati791 – 821ANK 3Add BLAST31
Domaini1049 – 1078IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini1102 – 1131IQ 2PROSITE-ProRule annotationAdd BLAST30

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi79 – 86Nuclear localization signalPROSITE-ProRule annotation8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi289 – 300Ser-richAdd BLAST12

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAMTA family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0520 Eukaryota
ENOG410XS5M LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160105

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O94983

KEGG Orthology (KO)

More...
KOi
K21596

Identification of Orthologs from Complete Genome Data

More...
OMAi
ISFDSQF

Database of Orthologous Groups

More...
OrthoDBi
315169at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O94983

TreeFam database of animal gene trees

More...
TreeFami
TF323452

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005559 CG-1_dom
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR000048 IQ_motif_EF-hand-BS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03859 CG-1, 1 hit
PF01833 TIG, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01076 CG-1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF81296 SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS51437 CG_1, 1 hit
PS50096 IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94983-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNTKDTTEVA ENSHHLKIFL PKKLLECLPR CPLLPPERLR WNTNEEIASY
60 70 80 90 100
LITFEKHDEW LSCAPKTRPQ NGSIILYNRK KVKYRKDGYL WKKRKDGKTT
110 120 130 140 150
REDHMKLKVQ GMECLYGCYV HSSIVPTFHR RCYWLLQNPD IVLVHYLNVP
160 170 180 190 200
ALEDCGKGCS PIFCSISSDR REWLKWSREE LLGQLKPMFH GIKWSCGNGT
210 220 230 240 250
EEFSVEHLVQ QILDTHPTKP APRTHACLCS GGLGSGSLTH KCSSTKHRII
260 270 280 290 300
SPKVEPRALT LTSIPHAHPP EPPPLIAPLP PELPKAHTSP SSSSSSSSSG
310 320 330 340 350
FAEPLEIRPS PPTSRGGSSR GGTAILLLTG LEQRAGGLTP TRHLAPQADP
360 370 380 390 400
RPSMSLAVVV GTEPSAPPAP PSPAFDPDRF LNSPQRGQTY GGGQGVSPDF
410 420 430 440 450
PEAEAAHTPC SALEPAAALE PQAAARGPPP QSVAGGRRGN CFFIQDDDSG
460 470 480 490 500
EELKGHGAAP PIPSPPPSPP PSPAPLEPSS RVGRGEALFG GPVGASELEP
510 520 530 540 550
FSLSSFPDLM GELISDEAPS IPAPTPQLSP ALSTITDFSP EWSYPEGGVK
560 570 580 590 600
VLITGPWTEA AEHYSCVFDH IAVPASLVQP GVLRCYCPAH EVGLVSLQVA
610 620 630 640 650
GREGPLSASV LFEYRARRFL SLPSTQLDWL SLDDNQFRMS ILERLEQMEK
660 670 680 690 700
RMAEIAAAGQ VPCQGPDAPP VQDEGQGPGF EARVVVLVES MIPRSTWKGP
710 720 730 740 750
ERLAHGSPFR GMSLLHLAAA QGYARLIETL SQWRSVETGS LDLEQEVDPL
760 770 780 790 800
NVDHFSCTPL MWACALGHLE AAVLLFRWNR QALSIPDSLG RLPLSVAHSR
810 820 830 840 850
GHVRLARCLE ELQRQEPSVE PPFALSPPSS SPDTGLSSVS SPSELSDGTF
860 870 880 890 900
SVTSAYSSAP DGSPPPAPLP ASEMTMEDMA PGQLSSGVPE APLLLMDYEA
910 920 930 940 950
TNSKGPLSSL PALPPASDDG AAPEDADSPQ AVDVIPVDMI SLAKQIIEAT
960 970 980 990 1000
PERIKREDFV GLPEAGASMR ERTGAVGLSE TMSWLASYLE NVDHFPSSTP
1010 1020 1030 1040 1050
PSELPFERGR LAVPSAPSWA EFLSASTSGK MESDFALLTL SDHEQRELYE
1060 1070 1080 1090 1100
AARVIQTAFR KYKGRRLKEQ QEVAAAVIQR CYRKYKQLTW IALKFALYKK
1110 1120 1130 1140 1150
MTQAAILIQS KFRSYYEQKR FQQSRRAAVL IQQHYRSYRR RPGPPHRTSA
1160 1170 1180 1190 1200
TLPARNKGSF LTKKQDQAAR KIMRFLRRCR HRMRELKQNQ ELEGLPQPGL

AT
Length:1,202
Mass (Da):131,530
Last modified:February 6, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i09E17E4E240F4A58
GO
Isoform 2 (identifier: O94983-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1088-1094: Missing.

Show »
Length:1,195
Mass (Da):130,704
Checksum:iE172544E3C189739
GO
Isoform 3 (identifier: O94983-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MNTKDTTEVA → MAAAAVTRGTPG
     1088-1094: Missing.

Show »
Length:1,197
Mass (Da):130,697
Checksum:iA256178E19EC9555
GO
Isoform 4 (identifier: O94983-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGTDSPSPRPLRPGVTLPPGALTM
     114-137: Missing.

Show »
Length:1,201
Mass (Da):130,902
Checksum:iC3CB80558CE61B4E
GO
Isoform 5 (identifier: O94983-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-873: Missing.

Show »
Length:329
Mass (Da):37,129
Checksum:i69FDCB63AF1DD38F
GO
Isoform 6 (identifier: O94983-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGTDSPSPRPLRPGVTLPPGALTM
     1158-1202: GSFLTKKQDQ...EGLPQPGLAT → LLSHQEAGPG...SPPWGRLVQS

Note: No experimental confirmation available.
Show »
Length:1,241
Mass (Da):134,800
Checksum:i0E19A0F98947BB34
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L3W6I3L3W6_HUMAN
Calmodulin-binding transcription ac...
CAMTA2
1,207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2A1I3L2A1_HUMAN
Calmodulin-binding transcription ac...
CAMTA2
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3V0I3L3V0_HUMAN
Calmodulin-binding transcription ac...
CAMTA2
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L146I3L146_HUMAN
Calmodulin-binding transcription ac...
CAMTA2
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH16163 differs from that shown. Reason: Frameshift at position 865.Curated
The sequence BAA74932 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti140D → G in CAD38818 (PubMed:17974005).Curated1
Sequence conflicti682A → V in CAD38818 (PubMed:17974005).Curated1
Sequence conflicti688V → L in CAD38818 (PubMed:17974005).Curated1
Sequence conflicti788S → P in CAD38818 (PubMed:17974005).Curated1
Sequence conflicti1175F → S in CAD38818 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026417267A → P3 PublicationsCorresponds to variant dbSNP:rs238234Ensembl.1
Natural variantiVAR_026418903S → P2 PublicationsCorresponds to variant dbSNP:rs16942615Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0184891 – 873Missing in isoform 5. 1 PublicationAdd BLAST873
Alternative sequenceiVSP_0184901 – 10MNTKDTTEVA → MAAAAVTRGTPG in isoform 3. 1 Publication10
Alternative sequenceiVSP_0184911M → MGTDSPSPRPLRPGVTLPPG ALTM in isoform 4 and isoform 6. 2 Publications1
Alternative sequenceiVSP_018492114 – 137Missing in isoform 4. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_0184931088 – 1094Missing in isoform 2 and isoform 3. 2 Publications7
Alternative sequenceiVSP_0460591158 – 1202GSFLT…PGLAT → LLSHQEAGPGSPEDHEIPAA LPTQDEGTEAEPGAGRASPA GTGHMTWPPPFSPPWGRLVQ S in isoform 6. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB020716 mRNA Translation: BAA74932.1 Different initiation.
AL833974 mRNA Translation: CAD38818.2
AL831849 mRNA Translation: CAD38553.1
AC004771 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90372.1
CH471108 Genomic DNA Translation: EAW90373.1
BC010050 mRNA Translation: AAH10050.2
BC016163 mRNA Translation: AAH16163.1 Frameshift.
BC136534 mRNA Translation: AAI36535.1
BC142606 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS11063.1 [O94983-1]
CCDS54071.1 [O94983-4]
CCDS54072.1 [O94983-6]
CCDS54073.1 [O94983-3]

NCBI Reference Sequences

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RefSeqi
NP_001164637.1, NM_001171166.1 [O94983-3]
NP_001164638.1, NM_001171167.1 [O94983-6]
NP_001164639.1, NM_001171168.1 [O94983-4]
NP_055914.2, NM_015099.3 [O94983-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000348066; ENSP00000321813; ENSG00000108509 [O94983-1]
ENST00000361571; ENSP00000354828; ENSG00000108509 [O94983-4]
ENST00000381311; ENSP00000370712; ENSG00000108509 [O94983-3]
ENST00000414043; ENSP00000412886; ENSG00000108509 [O94983-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23125

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23125

UCSC genome browser

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UCSCi
uc002gag.3 human [O94983-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020716 mRNA Translation: BAA74932.1 Different initiation.
AL833974 mRNA Translation: CAD38818.2
AL831849 mRNA Translation: CAD38553.1
AC004771 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90372.1
CH471108 Genomic DNA Translation: EAW90373.1
BC010050 mRNA Translation: AAH10050.2
BC016163 mRNA Translation: AAH16163.1 Frameshift.
BC136534 mRNA Translation: AAI36535.1
BC142606 mRNA No translation available.
CCDSiCCDS11063.1 [O94983-1]
CCDS54071.1 [O94983-4]
CCDS54072.1 [O94983-6]
CCDS54073.1 [O94983-3]
RefSeqiNP_001164637.1, NM_001171166.1 [O94983-3]
NP_001164638.1, NM_001171167.1 [O94983-6]
NP_001164639.1, NM_001171168.1 [O94983-4]
NP_055914.2, NM_015099.3 [O94983-1]

3D structure databases

SMRiO94983
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116744, 8 interactors
IntActiO94983, 11 interactors
MINTiO94983
STRINGi9606.ENSP00000412886

PTM databases

iPTMnetiO94983
PhosphoSitePlusiO94983

Polymorphism and mutation databases

BioMutaiCAMTA2

Proteomic databases

jPOSTiO94983
PaxDbiO94983
PeptideAtlasiO94983
PRIDEiO94983
ProteomicsDBi50603
50604 [O94983-2]
50605 [O94983-3]
50606 [O94983-4]
50607 [O94983-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
23125
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348066; ENSP00000321813; ENSG00000108509 [O94983-1]
ENST00000361571; ENSP00000354828; ENSG00000108509 [O94983-4]
ENST00000381311; ENSP00000370712; ENSG00000108509 [O94983-3]
ENST00000414043; ENSP00000412886; ENSG00000108509 [O94983-6]
GeneIDi23125
KEGGihsa:23125
UCSCiuc002gag.3 human [O94983-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23125
DisGeNETi23125

GeneCards: human genes, protein and diseases

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GeneCardsi
CAMTA2
HGNCiHGNC:18807 CAMTA2
HPAiHPA051147
MIMi611508 gene
neXtProtiNX_O94983
OpenTargetsiENSG00000108509
PharmGKBiPA38689

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0520 Eukaryota
ENOG410XS5M LUCA
GeneTreeiENSGT00940000160105
InParanoidiO94983
KOiK21596
OMAiISFDSQF
OrthoDBi315169at2759
PhylomeDBiO94983
TreeFamiTF323452

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CAMTA2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23125

Protein Ontology

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PROi
PR:O94983

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000108509 Expressed in 192 organ(s), highest expression level in frontal cortex
ExpressionAtlasiO94983 baseline and differential
GenevisibleiO94983 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005559 CG-1_dom
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR000048 IQ_motif_EF-hand-BS
PfamiView protein in Pfam
PF03859 CG-1, 1 hit
PF01833 TIG, 1 hit
SMARTiView protein in SMART
SM01076 CG-1, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS51437 CG_1, 1 hit
PS50096 IQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCMTA2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94983
Secondary accession number(s): B9EGL0
, D3DTL5, E7EWU5, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: February 6, 2007
Last modified: May 8, 2019
This is version 162 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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