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Entry version 181 (29 Sep 2021)
Sequence version 3 (10 Jul 2007)
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Protein

Protein transport protein Sec31A

Gene

SEC31A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476).

The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
O94979

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-204005, COPII-mediated vesicle transport
R-HSA-2132295, MHC class II antigen presentation
R-HSA-381038, XBP1(S) activates chaperone genes
R-HSA-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O94979

Protein family/group databases

Transport Classification Database

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TCDBi
3.A.5.9.1, the general secretory pathway (sec) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein transport protein Sec31A
Alternative name(s):
ABP125
ABP130
SEC31-like protein 1
SEC31-related protein A
Web1-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEC31A
Synonyms:KIAA0905, SEC31L1
ORF Names:HSPC275, HSPC334
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:17052, SEC31A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610257, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O94979

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000138674

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neurodevelopmental disorder with spastic quadriplegia, optic atrophy, seizures, and structural brain anomalies (NEDSOSB)1 Publication
The disease may be caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, congenital neurodevelopmental disorder characterized by intrauterine growth retardation, microcephaly, marked developmental delay, spastic quadriplegia with profound contractures, pseudobulbar palsy with recurrent aspirations, epilepsy, dysmorphism, neurosensory deafness, optic nerve atrophy with no eye fixation, and death in early childhood. Brain imaging shows semilobar holoprosencephaly and agenesis of corpus callosum.
Related information in OMIM
A chromosomal aberration involving SEC31A is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;4)(p23;q21) with ALK.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi647K → R: Does not abolish monoubiquitination by the BCR(KLHL12) E3 ubiquitin ligase complex, revealing flexibility of ubiquitination sites; when associated with R-1217. 1 Publication1
Mutagenesisi1217K → R: Does not abolish monoubiquitination by the BCR(KLHL12) E3 ubiquitin ligase complex, revealing flexibility of ubiquitination sites; when associated with R-647. 1 Publication1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
22872

MalaCards human disease database

More...
MalaCardsi
SEC31A
MIMi618651, phenotype

Open Targets

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OpenTargetsi
ENSG00000138674

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162402737

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O94979, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SEC31A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002951471 – 1220Protein transport protein Sec31AAdd BLAST1220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei527PhosphoserineCombined sources1
Modified residuei532PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki647Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei799PhosphoserineCombined sources1
Modified residuei1161PhosphothreonineCombined sources1
Modified residuei1163PhosphoserineCombined sources1
Cross-linki1217Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats.2 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O94979

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O94979

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O94979

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O94979

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94979

PeptideAtlas

More...
PeptideAtlasi
O94979

PRoteomics IDEntifications database

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PRIDEi
O94979

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
45124
50595 [O94979-1]
50596 [O94979-2]
50597 [O94979-3]
50598 [O94979-4]
50599 [O94979-5]
50600 [O94979-6]
50601 [O94979-7]
50602 [O94979-8]
7204

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
O94979, 21 sites, 2 O-linked glycans (21 sites)

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O94979

MetOSite database of methionine sulfoxide sites

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MetOSitei
O94979

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O94979

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O94979

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundantly and ubiquitously expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000138674, Expressed in pituitary gland and 248 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O94979, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O94979, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000138674, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage.

Interacts (via WD 8) with SEC13 (By similarity).

Interacts with PDCD6; interaction takes place in response to cytosolic calcium increase and leads to bridge together the BCR(KLHL12) complex and SEC31A, leading to monoubiquitination (PubMed:27716508) (PubMed:16957052, PubMed:17196169, PubMed:27716508, PubMed:25667979).

Interacts with KLHL12.

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116539, 144 interactors

Database of interacting proteins

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DIPi
DIP-40438N

Protein interaction database and analysis system

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IntActi
O94979, 52 interactors

Molecular INTeraction database

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MINTi
O94979

STRING: functional protein association networks

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STRINGi
9606.ENSP00000378721

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
O94979, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11220
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O94979

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati4 – 47WD 1Add BLAST44
Repeati68 – 111WD 2Add BLAST44
Repeati120 – 160WD 3Add BLAST41
Repeati166 – 206WD 4Add BLAST41
Repeati209 – 254WD 5Add BLAST46
Repeati258 – 298WD 6Add BLAST41
Repeati301 – 342WD 7Add BLAST42
Repeati397 – 430WD 8; interaction with SEC13PROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni161 – 471Interaction with SEC131 PublicationAdd BLAST311
Regioni791 – 908DisorderedSequence analysisAdd BLAST118
Regioni800 – 1113Interaction with PDCD61 PublicationAdd BLAST314
Regioni924 – 1096DisorderedSequence analysisAdd BLAST173

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi842 – 848ALG-2-binding site motif-2 (ABS-2),7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi865 – 881Pro residuesSequence analysisAdd BLAST17
Compositional biasi924 – 938Polar residuesSequence analysisAdd BLAST15
Compositional biasi979 – 996Polar residuesSequence analysisAdd BLAST18
Compositional biasi1026 – 1056Polar residuesSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ALG-2-binding site motif-2 (ABS-2) contains a PXPGF sequence that binds hydrophobic pocket 3 of PDCD6.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat SEC31 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0307, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000003175

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_003033_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O94979

Identification of Orthologs from Complete Genome Data

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OMAi
FMIAICG

Database for complete collections of gene phylogenies

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PhylomeDBi
O94979

TreeFam database of animal gene trees

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TreeFami
TF313842

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR024298, ACE1_Sec16_Sec31
IPR040251, SEC31-like
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR036322, WD40_repeat_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR13923, PTHR13923, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12931, Sec16_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 6 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50082, WD_REPEATS_2, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 10 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 10 described isoforms and 19 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94979-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLKEVDRTA MQAWSPAQNH PIYLATGTSA QQLDATFSTN ASLEIFELDL
60 70 80 90 100
SDPSLDMKSC ATFSSSHRYH KLIWGPYKMD SKGDVSGVLI AGGENGNIIL
110 120 130 140 150
YDPSKIIAGD KEVVIAQNDK HTGPVRALDV NIFQTNLVAS GANESEIYIW
160 170 180 190 200
DLNNFATPMT PGAKTQPPED ISCIAWNRQV QHILASASPS GRATVWDLRK
210 220 230 240 250
NEPIIKVSDH SNRMHCSGLA WHPDVATQMV LASEDDRLPV IQMWDLRFAS
260 270 280 290 300
SPLRVLENHA RGILAIAWSM ADPELLLSCG KDAKILCSNP NTGEVLYELP
310 320 330 340 350
TNTQWCFDIQ WCPRNPAVLS AASFDGRISV YSIMGGSTDG LRQKQVDKLS
360 370 380 390 400
SSFGNLDPFG TGQPLPPLQI PQQTAQHSIV LPLKKPPKWI RRPVGASFSF
410 420 430 440 450
GGKLVTFENV RMPSHQGAEQ QQQQHHVFIS QVVTEKEFLS RSDQLQQAVQ
460 470 480 490 500
SQGFINYCQK KIDASQTEFE KNVWSFLKVN FEDDSRGKYL ELLGYRKEDL
510 520 530 540 550
GKKIALALNK VDGANVALKD SDQVAQSDGE ESPAAEEQLL GEHIKEEKEE
560 570 580 590 600
SEFLPSSGGT FNISVSGDID GLITQALLTG NFESAVDLCL HDNRMADAII
610 620 630 640 650
LAIAGGQELL ARTQKKYFAK SQSKITRLIT AVVMKNWKEI VESCDLKNWR
660 670 680 690 700
EALAAVLTYA KPDEFSALCD LLGTRLENEG DSLLQTQACL CYICAGNVEK
710 720 730 740 750
LVACWTKAQD GSHPLSLQDL IEKVVILRKA VQLTQAMDTS TVGVLLAAKM
760 770 780 790 800
SQYANLLAAQ GSIAAALAFL PDNTNQPNIM QLRDRLCRAQ GEPVAGHESP
810 820 830 840 850
KIPYEKQQLP KGRPGPVAGH HQMPRVQTQQ YYPHGENPPP PGFIMHGNVN
860 870 880 890 900
PNAAGQLPTS PGHMHTQVPP YPQPQPYQPA QPYPFGTGGS AMYRPQQPVA
910 920 930 940 950
PPTSNAYPNT PYISSASSYT GQSQLYAAQH QASSPTSSPA TSFPPPPSSG
960 970 980 990 1000
ASFQHGGPGA PPSSSAYALP PGTTGTLPAA SELPASQRTG PQNGWNDPPA
1010 1020 1030 1040 1050
LNRVPKKKKM PENFMPPVPI TSPIMNPLGD PQSQMLQQQP SAPVPLSSQS
1060 1070 1080 1090 1100
SFPQPHLPGG QPFHGVQQPL GQTGMPPSFS KPNIEGAPGA PIGNTFQHVQ
1110 1120 1130 1140 1150
SLPTKKITKK PIPDEHLILK TTFEDLIQRC LSSATDPQTK RKLDDASKRL
1160 1170 1180 1190 1200
EFLYDKLREQ TLSPTITSGL HNIARSIETR NYSEGLTMHT HIVSTSNFSE
1210 1220
TSAFMPVLKV VLTQANKLGV
Length:1,220
Mass (Da):133,015
Last modified:July 10, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A633B4436DB7482
GO
Isoform 2 (identifier: O94979-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     974-988: Missing.

Show »
Length:1,205
Mass (Da):131,534
Checksum:i245E11A9AD589F74
GO
Isoform 3 (identifier: O94979-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     876-876: P → R
     877-990: Missing.

Show »
Length:1,106
Mass (Da):121,651
Checksum:iD21AB6B647E1291B
GO
Isoform 4 (identifier: O94979-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     504-542: Missing.

Show »
Length:1,181
Mass (Da):129,036
Checksum:i6FCDB50DE1A19BF0
GO
Isoform 5 (identifier: O94979-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     504-509: IALALN → VNFWES
     510-1220: Missing.

Show »
Length:509
Mass (Da):56,731
Checksum:i883FD8815650FA25
GO
Isoform 6 (identifier: O94979-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     504-542: Missing.
     876-876: P → R
     877-990: Missing.

Show »
Length:1,067
Mass (Da):117,673
Checksum:iF2D05279DCE51522
GO
Isoform 7 (identifier: O94979-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-228: Missing.
     229-260: MVLASEDDRLPVIQMWDLRFASSPLRVLENHA → MVKLVLLSIVLLKVTVPKLSNYLLQLDFMPIH
     504-542: Missing.
     834-834: H → HVRIAPTVTTWSNKTPTALPSHPPAASPSDTQ
     974-988: Missing.

Show »
Length:969
Mass (Da):105,753
Checksum:iC968C7ACE341CCAB
GO
Isoform 8 (identifier: O94979-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     989-989: T → TENQSIQDQAPMLE

Show »
Length:1,233
Mass (Da):134,499
Checksum:i1D63F1DEA3EC45F4
GO
Isoform 9 (identifier: O94979-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MKLKEVDRTAMQAWSPAQNHPIYLAT → MLGESDERCTNAGSGCRRSSP
     974-988: Missing.

Show »
Length:1,200
Mass (Da):130,747
Checksum:iF2E4A99D905A6389
GO
Isoform 10 (identifier: O94979-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     504-542: Missing.
     974-988: Missing.

Show »
Length:1,166
Mass (Da):127,556
Checksum:iC780B386B096906E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BXG7H7BXG7_HUMAN
Protein transport protein Sec31A
SEC31A
969Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REX3D6REX3_HUMAN
Protein transport protein Sec31A
SEC31A
1,251Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHZ5D6RHZ5_HUMAN
Protein transport protein Sec31A
SEC31A
877Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAB3H0YAB3_HUMAN
Protein transport protein Sec31A
SEC31A
443Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9T9H0Y9T9_HUMAN
Protein transport protein Sec31A
SEC31A
235Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8W8H0Y8W8_HUMAN
Protein transport protein Sec31A
SEC31A
383Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCQ9D6RCQ9_HUMAN
Protein transport protein Sec31A
SEC31A
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RE64D6RE64_HUMAN
Protein transport protein Sec31A
SEC31A
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9V3H0Y9V3_HUMAN
Protein transport protein Sec31A
SEC31A
219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAF5H0YAF5_HUMAN
Protein transport protein Sec31A
SEC31A
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF28953 differs from that shown. Reason: Frameshift.Curated
The sequence AAF29012 differs from that shown. Reason: Frameshift.Curated
The sequence CAI45995 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti200K → E in BAA84923 (Ref. 2) Curated1
Sequence conflicti284K → R in BAC86336 (PubMed:14702039).Curated1
Sequence conflicti854A → S in BAA84923 (Ref. 2) Curated1
Sequence conflicti854A → S in BAA84924 (Ref. 2) Curated1
Sequence conflicti1007K → R in BAG58628 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033225263I → V. Corresponds to variant dbSNP:rs34554214EnsemblClinVar.1
Natural variantiVAR_053414456N → K. Corresponds to variant dbSNP:rs3797036Ensembl.1
Natural variantiVAR_033226841P → L. Corresponds to variant dbSNP:rs35579207EnsemblClinVar.1
Natural variantiVAR_0332271055P → T. Corresponds to variant dbSNP:rs35739017Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0267421 – 228Missing in isoform 7. 1 PublicationAdd BLAST228
Alternative sequenceiVSP_0446021 – 26MKLKE…IYLAT → MLGESDERCTNAGSGCRRSS P in isoform 9. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_026743229 – 260MVLAS…LENHA → MVKLVLLSIVLLKVTVPKLS NYLLQLDFMPIH in isoform 7. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_026744504 – 542Missing in isoform 4, isoform 6, isoform 7 and isoform 10. 4 PublicationsAdd BLAST39
Alternative sequenceiVSP_026745504 – 509IALALN → VNFWES in isoform 5. 1 Publication6
Alternative sequenceiVSP_026746510 – 1220Missing in isoform 5. 1 PublicationAdd BLAST711
Alternative sequenceiVSP_026747834H → HVRIAPTVTTWSNKTPTALP SHPPAASPSDTQ in isoform 7. 1 Publication1
Alternative sequenceiVSP_026748876P → R in isoform 3 and isoform 6. 2 Publications1
Alternative sequenceiVSP_026749877 – 990Missing in isoform 3 and isoform 6. 2 PublicationsAdd BLAST114
Alternative sequenceiVSP_026750974 – 988Missing in isoform 2, isoform 7, isoform 9 and isoform 10. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_026751989T → TENQSIQDQAPMLE in isoform 8. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF139184 mRNA Translation: AAF67836.1
AB018358 mRNA Translation: BAA84923.1
AB018359 mRNA Translation: BAA84924.1
AB020712 mRNA Translation: BAA74928.2
AK125897 mRNA Translation: BAC86336.1
AK295810 mRNA Translation: BAG58628.1
AL049463 mRNA Translation: CAH56418.1
CR933696 mRNA Translation: CAI45995.1 Sequence problems.
AC021105 Genomic DNA No translation available.
AC108469 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05908.1
BC047883 mRNA Translation: AAH47883.1
BC084583 mRNA Translation: AAH84583.1
BC117221 mRNA Translation: AAI17222.1
BC143489 mRNA Translation: AAI43490.1
BC143491 mRNA Translation: AAI43492.1
BC143492 mRNA Translation: AAI43493.1
AY137583 mRNA Translation: AAN15221.1
AF161393 mRNA Translation: AAF28953.1 Frameshift.
AF161452 mRNA Translation: AAF29012.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3596.1 [O94979-1]
CCDS3597.1 [O94979-4]
CCDS43244.1 [O94979-3]
CCDS47088.1 [O94979-2]
CCDS54773.1 [O94979-9]
CCDS75155.1 [O94979-6]
CCDS75156.1 [O94979-10]

NCBI Reference Sequences

More...
RefSeqi
NP_001070674.1, NM_001077206.3 [O94979-3]
NP_001070675.1, NM_001077207.3 [O94979-1]
NP_001070676.1, NM_001077208.3 [O94979-2]
NP_001177978.1, NM_001191049.2 [O94979-9]
NP_001287673.1, NM_001300744.2 [O94979-6]
NP_001287674.1, NM_001300745.2 [O94979-10]
NP_001305048.1, NM_001318119.1 [O94979-2]
NP_001305049.1, NM_001318120.1 [O94979-1]
NP_057295.2, NM_016211.4 [O94979-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311785; ENSP00000309070; ENSG00000138674 [O94979-3]
ENST00000348405; ENSP00000337602; ENSG00000138674 [O94979-4]
ENST00000355196; ENSP00000347329; ENSG00000138674 [O94979-1]
ENST00000395310; ENSP00000378721; ENSG00000138674 [O94979-1]
ENST00000443462; ENSP00000408027; ENSG00000138674 [O94979-9]
ENST00000448323; ENSP00000400926; ENSG00000138674 [O94979-1]
ENST00000500777; ENSP00000421464; ENSG00000138674 [O94979-6]
ENST00000505984; ENSP00000424451; ENSG00000138674 [O94979-10]
ENST00000508502; ENSP00000424635; ENSG00000138674 [O94979-2]
ENST00000509142; ENSP00000426569; ENSG00000138674 [O94979-3]
ENST00000513858; ENSP00000426886; ENSG00000138674 [O94979-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22872

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22872

UCSC genome browser

More...
UCSCi
uc003hnf.3, human [O94979-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139184 mRNA Translation: AAF67836.1
AB018358 mRNA Translation: BAA84923.1
AB018359 mRNA Translation: BAA84924.1
AB020712 mRNA Translation: BAA74928.2
AK125897 mRNA Translation: BAC86336.1
AK295810 mRNA Translation: BAG58628.1
AL049463 mRNA Translation: CAH56418.1
CR933696 mRNA Translation: CAI45995.1 Sequence problems.
AC021105 Genomic DNA No translation available.
AC108469 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05908.1
BC047883 mRNA Translation: AAH47883.1
BC084583 mRNA Translation: AAH84583.1
BC117221 mRNA Translation: AAI17222.1
BC143489 mRNA Translation: AAI43490.1
BC143491 mRNA Translation: AAI43492.1
BC143492 mRNA Translation: AAI43493.1
AY137583 mRNA Translation: AAN15221.1
AF161393 mRNA Translation: AAF28953.1 Frameshift.
AF161452 mRNA Translation: AAF29012.1 Frameshift.
CCDSiCCDS3596.1 [O94979-1]
CCDS3597.1 [O94979-4]
CCDS43244.1 [O94979-3]
CCDS47088.1 [O94979-2]
CCDS54773.1 [O94979-9]
CCDS75155.1 [O94979-6]
CCDS75156.1 [O94979-10]
RefSeqiNP_001070674.1, NM_001077206.3 [O94979-3]
NP_001070675.1, NM_001077207.3 [O94979-1]
NP_001070676.1, NM_001077208.3 [O94979-2]
NP_001177978.1, NM_001191049.2 [O94979-9]
NP_001287673.1, NM_001300744.2 [O94979-6]
NP_001287674.1, NM_001300745.2 [O94979-10]
NP_001305048.1, NM_001318119.1 [O94979-2]
NP_001305049.1, NM_001318120.1 [O94979-1]
NP_057295.2, NM_016211.4 [O94979-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WXAX-ray2.36C/D837-848[»]
SMRiO94979
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116539, 144 interactors
DIPiDIP-40438N
IntActiO94979, 52 interactors
MINTiO94979
STRINGi9606.ENSP00000378721

Protein family/group databases

TCDBi3.A.5.9.1, the general secretory pathway (sec) family

PTM databases

GlyGeniO94979, 21 sites, 2 O-linked glycans (21 sites)
iPTMnetiO94979
MetOSiteiO94979
PhosphoSitePlusiO94979
SwissPalmiO94979

Genetic variation databases

BioMutaiSEC31A

Proteomic databases

EPDiO94979
jPOSTiO94979
MassIVEiO94979
MaxQBiO94979
PaxDbiO94979
PeptideAtlasiO94979
PRIDEiO94979
ProteomicsDBi45124
50595 [O94979-1]
50596 [O94979-2]
50597 [O94979-3]
50598 [O94979-4]
50599 [O94979-5]
50600 [O94979-6]
50601 [O94979-7]
50602 [O94979-8]
7204

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1692, 144 antibodies

The DNASU plasmid repository

More...
DNASUi
22872

Genome annotation databases

EnsembliENST00000311785; ENSP00000309070; ENSG00000138674 [O94979-3]
ENST00000348405; ENSP00000337602; ENSG00000138674 [O94979-4]
ENST00000355196; ENSP00000347329; ENSG00000138674 [O94979-1]
ENST00000395310; ENSP00000378721; ENSG00000138674 [O94979-1]
ENST00000443462; ENSP00000408027; ENSG00000138674 [O94979-9]
ENST00000448323; ENSP00000400926; ENSG00000138674 [O94979-1]
ENST00000500777; ENSP00000421464; ENSG00000138674 [O94979-6]
ENST00000505984; ENSP00000424451; ENSG00000138674 [O94979-10]
ENST00000508502; ENSP00000424635; ENSG00000138674 [O94979-2]
ENST00000509142; ENSP00000426569; ENSG00000138674 [O94979-3]
ENST00000513858; ENSP00000426886; ENSG00000138674 [O94979-6]
GeneIDi22872
KEGGihsa:22872
UCSCiuc003hnf.3, human [O94979-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22872
DisGeNETi22872

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SEC31A
HGNCiHGNC:17052, SEC31A
HPAiENSG00000138674, Low tissue specificity
MalaCardsiSEC31A
MIMi610257, gene
618651, phenotype
neXtProtiNX_O94979
OpenTargetsiENSG00000138674
PharmGKBiPA162402737
VEuPathDBiHostDB:ENSG00000138674

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0307, Eukaryota
GeneTreeiENSGT00390000003175
HOGENOMiCLU_003033_1_0_1
InParanoidiO94979
OMAiFMIAICG
PhylomeDBiO94979
TreeFamiTF313842

Enzyme and pathway databases

PathwayCommonsiO94979
ReactomeiR-HSA-204005, COPII-mediated vesicle transport
R-HSA-2132295, MHC class II antigen presentation
R-HSA-381038, XBP1(S) activates chaperone genes
R-HSA-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC
SignaLinkiO94979

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
22872, 21 hits in 1015 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SEC31A, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SEC31A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22872
PharosiO94979, Tbio

Protein Ontology

More...
PROi
PR:O94979
RNActiO94979, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138674, Expressed in pituitary gland and 248 other tissues
ExpressionAtlasiO94979, baseline and differential
GenevisibleiO94979, HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR024298, ACE1_Sec16_Sec31
IPR040251, SEC31-like
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR036322, WD40_repeat_dom_sf
PANTHERiPTHR13923, PTHR13923, 1 hit
PfamiView protein in Pfam
PF12931, Sec16_C, 1 hit
SMARTiView protein in SMART
SM00320, WD40, 6 hits
SUPFAMiSSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082, WD_REPEATS_2, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSC31A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94979
Secondary accession number(s): B4DIW6
, B7ZKZ7, B7ZL00, H7C2W3, Q17RR5, Q5H9P6, Q5XG74, Q659G7, Q6ZU90, Q7LCX9, Q86TJ0, Q8IZH4, Q9P048, Q9P0A6, Q9UM05, Q9UM06
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: September 29, 2021
This is version 181 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

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  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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