UniProtKB - O94972 (TRI37_HUMAN)
Protein
E3 ubiquitin-protein ligase TRIM37
Gene
TRIM37
Organism
Homo sapiens (Human)
Status
Functioni
E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724).4 Publications
Miscellaneous
Acts as a proto-oncogene via its ability to monoubiquinate 'Lys-119' of histone H2A (H2AK119Ub): overexpressed in a number of breast cancers and promotes transformation of cells by mediating silencing of tumor suppressor genes (PubMed:25470042).1 Publication
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication EC:2.3.2.27
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.2 PublicationsView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 15 – 55 | RING-type; degeneratePROSITE-ProRule annotationAdd BLAST | 41 | |
Zinc fingeri | 90 – 132 | B box-typePROSITE-ProRule annotationAdd BLAST | 43 |
GO - Molecular functioni
- chromatin binding Source: Ensembl
- protein homodimerization activity Source: UniProtKB
- tumor necrosis factor receptor binding Source: UniProtKB
- ubiquitin protein ligase activity Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
- ubiquitin-protein transferase activity Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- aggresome assembly Source: UniProtKB
- histone H2A-K119 monoubiquitination Source: UniProtKB
- histone H2A monoubiquitination Source: UniProtKB
- negative regulation of centriole replication Source: UniProtKB
- negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of DNA-binding transcription factor activity Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- protein autoubiquitination Source: UniProtKB
Keywordsi
Molecular function | Repressor, Transferase |
Biological process | Transcription, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | O94972 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase TRIM37Curated (EC:2.3.2.271 Publication)Alternative name(s): Mulibrey nanism protein1 Publication RING-type E3 ubiquitin transferase TRIM37Curated Tripartite motif-containing protein 37Curated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7523 TRIM37 |
MIMi | 605073 gene |
neXtProti | NX_O94972 |
Subcellular locationi
Peroxisome
- Peroxisome 1 Publication
Other locations
- perinuclear region 1 Publication
Note: Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation.1 Publication
Cytosol
- cytosol Source: UniProtKB
Peroxisome
- peroxisome Source: UniProtKB
Other locations
- aggresome Source: UniProtKB
- cytoplasm Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, PeroxisomePathology & Biotechi
Involvement in diseasei
Mulibrey nanism (MUL)8 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive growth disorder characterized by severe growth failure of prenatal onset, constrictive pericardium and progressive cardiomyopathy, facial dysmorphism, and failure of sexual maturation. Additional clinical features include hepatomegaly, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, hypoplasia of various endocrine glands, insulin resistance with type 2 diabetes, and an increased risk for Wilms' tumor.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060217 | 76 | L → P in MUL; decreased ubiquitination and abolishes the formation of perinuclear aggregates. 1 PublicationCorresponds to variant dbSNP:rs386834004EnsemblClinVar. | 1 | |
Natural variantiVAR_060219 | 109 | C → S in MUL; no effect on E3 ubiquitin-protein ligase activity. 1 PublicationCorresponds to variant dbSNP:rs121908391EnsemblClinVar. | 1 | |
Natural variantiVAR_060220 | 322 | G → V in MUL; no effect on ubiquitination but affects subcellular localization. 2 PublicationsCorresponds to variant dbSNP:rs386834009EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 18 | C → R: Abolishes ability to monoubiquitinate 'Lys-119' of histone H2A (H2AK119Ub). 1 Publication | 1 | |
Mutagenesisi | 35 – 36 | CC → SS: Reduces ubiquitination and abolishes the formation of perinuclear aggregates. 1 Publication | 2 |
Keywords - Diseasei
Dwarfism, Proto-oncogeneOrganism-specific databases
DisGeNETi | 4591 |
MalaCardsi | TRIM37 |
MIMi | 253250 phenotype |
OpenTargetsi | ENSG00000108395 |
Orphaneti | 2576 Mulibrey nanism |
PharmGKBi | PA35497 |
Miscellaneous databases
Pharosi | O94972 |
Polymorphism and mutation databases
BioMutai | TRIM37 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056254 | 1 – 964 | E3 ubiquitin-protein ligase TRIM37Add BLAST | 964 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 454 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Auto-ubiquitinated.1 Publication
Keywords - PTMi
Acetylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O94972 |
jPOSTi | O94972 |
MassIVEi | O94972 |
MaxQBi | O94972 |
PaxDbi | O94972 |
PeptideAtlasi | O94972 |
PRIDEi | O94972 |
ProteomicsDBi | 31814 50590 [O94972-1] 50591 [O94972-2] |
PTM databases
iPTMneti | O94972 |
PhosphoSitePlusi | O94972 |
Expressioni
Tissue specificityi
Ubiquitous (PubMed:10888877). Highly expressed in testis, while it is weakly expressed in other tissues (PubMed:16310976).2 Publications
Inductioni
Overexpressed in a number of breast cancer cell lines.1 Publication
Gene expression databases
Bgeei | ENSG00000108395 Expressed in 228 organ(s), highest expression level in endometrium epithelium |
ExpressionAtlasi | O94972 baseline and differential |
Genevisiblei | O94972 HS |
Organism-specific databases
HPAi | HPA021911 |
Interactioni
Subunit structurei
Associates with the PRC2/EED-EZH2 complex.
1 PublicationBinary interactionsi
GO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
- tumor necrosis factor receptor binding Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 110678, 111 interactors |
DIPi | DIP-34437N |
IntActi | O94972, 83 interactors |
STRINGi | 9606.ENSP00000262294 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O94972 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O94972 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 276 – 403 | MATHPROSITE-ProRule annotationAdd BLAST | 128 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 132 – 234 | Sequence analysisAdd BLAST | 103 | |
Coiled coili | 419 – 450 | Sequence analysisAdd BLAST | 32 | |
Coiled coili | 673 – 700 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 534 – 540 | Poly-Ser | 7 | |
Compositional biasi | 578 – 581 | Poly-Ala | 4 |
Sequence similaritiesi
Belongs to the TRIM/RBCC family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 15 – 55 | RING-type; degeneratePROSITE-ProRule annotationAdd BLAST | 41 | |
Zinc fingeri | 90 – 132 | B box-typePROSITE-ProRule annotationAdd BLAST | 43 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG410ITG1 Eukaryota ENOG410YSD5 LUCA |
GeneTreei | ENSGT00410000025800 |
HOGENOMi | HOG000013010 |
InParanoidi | O94972 |
KOi | K10608 |
OMAi | XYEYRVE |
OrthoDBi | 128089at2759 |
PhylomeDBi | O94972 |
TreeFami | TF351092 |
Family and domain databases
CDDi | cd00021 BBOX, 1 hit cd03773 MATH_TRIM37, 1 hit |
Gene3Di | 2.60.210.10, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR003649 Bbox_C IPR002083 MATH/TRAF_dom IPR008974 TRAF-like IPR037299 TRIM37_MATH IPR000315 Znf_B-box IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00917 MATH, 1 hit PF00643 zf-B_box, 1 hit |
SMARTi | View protein in SMART SM00502 BBC, 1 hit SM00336 BBOX, 1 hit SM00061 MATH, 1 hit |
SUPFAMi | SSF49599 SSF49599, 1 hit |
PROSITEi | View protein in PROSITE PS50144 MATH, 1 hit PS50119 ZF_BBOX, 1 hit PS50089 ZF_RING_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O94972-1) [UniParc]FASTAAdd to basket
Also known as: TRIM37a1 Publication, TRIM37b1 Publication
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDEQSVESIA EVFRCFICME KLRDARLCPH CSKLCCFSCI RRWLTEQRAQ
60 70 80 90 100
CPHCRAPLQL RELVNCRWAE EVTQQLDTLQ LCSLTKHEEN EKDKCENHHE
110 120 130 140 150
KLSVFCWTCK KCICHQCALW GGMHGGHTFK PLAEIYEQHV TKVNEEVAKL
160 170 180 190 200
RRRLMELISL VQEVERNVEA VRNAKDERVR EIRNAVEMMI ARLDTQLKNK
210 220 230 240 250
LITLMGQKTS LTQETELLES LLQEVEHQLR SCSKSELISK SSEILMMFQQ
260 270 280 290 300
VHRKPMASFV TTPVPPDFTS ELVPSYDSAT FVLENFSTLR QRADPVYSPP
310 320 330 340 350
LQVSGLCWRL KVYPDGNGVV RGYYLSVFLE LSAGLPETSK YEYRVEMVHQ
360 370 380 390 400
SCNDPTKNII REFASDFEVG ECWGYNRFFR LDLLANEGYL NPQNDTVILR
410 420 430 440 450
FQVRSPTFFQ KSRDQHWYIT QLEAAQTSYI QQINNLKERL TIELSRTQKS
460 470 480 490 500
RDLSPPDNHL SPQNDDALET RAKKSACSDM LLEGGPTTAS VREAKEDEED
510 520 530 540 550
EEKIQNEDYH HELSDGDLDL DLVYEDEVNQ LDGSSSSASS TATSNTEEND
560 570 580 590 600
IDEETMSGEN DVEYNNMELE EGELMEDAAA AGPAGSSHGY VGSSSRISRR
610 620 630 640 650
THLCSAATSS LLDIDPLILI HLLDLKDRSS IENLWGLQPR PPASLLQPTA
660 670 680 690 700
SYSRKDKDQR KQQAMWRVPS DLKMLKRLKT QMAEVRCMKT DVKNTLSEIK
710 720 730 740 750
SSSAASGDMQ TSLFSADQAA LAACGTENSG RLQDLGMELL AKSSVANCYI
760 770 780 790 800
RNSTNKKSNS PKPARSSVAG SLSLRRAVDP GENSRSKGDC QTLSEGSPGS
810 820 830 840 850
SQSGSRHSSP RALIHGSIGD ILPKTEDRQC KALDSDAVVV AVFSGLPAVE
860 870 880 890 900
KRRKMVTLGA NAKGGHLEGL QMTDLENNSE TGELQPVLPE GASAAPEEGM
910 920 930 940 950
SSDSDIECDT ENEEQEEHTS VGGFHDSFMV MTQPPDEDTH SSFPDGEQIG
960
PEDLSFNTDE NSGR
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KT90 | J3KT90_HUMAN | E3 ubiquitin-protein ligase TRIM37 | TRIM37 | 194 | Annotation score: | ||
J3KT32 | J3KT32_HUMAN | E3 ubiquitin-protein ligase TRIM37 | TRIM37 | 54 | Annotation score: | ||
J3QSF6 | J3QSF6_HUMAN | E3 ubiquitin-protein ligase TRIM37 | TRIM37 | 117 | Annotation score: | ||
J3KS72 | J3KS72_HUMAN | E3 ubiquitin-protein ligase TRIM37 | TRIM37 | 67 | Annotation score: | ||
J3QRK3 | J3QRK3_HUMAN | E3 ubiquitin-protein ligase TRIM37 | TRIM37 | 103 | Annotation score: | ||
J3QSA0 | J3QSA0_HUMAN | E3 ubiquitin-protein ligase TRIM37 | TRIM37 | 58 | Annotation score: | ||
J3QSH5 | J3QSH5_HUMAN | E3 ubiquitin-protein ligase TRIM37 | TRIM37 | 113 | Annotation score: |
Sequence cautioni
The sequence BAA74921 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 620 | I → M in BAF85148 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 624 | D → A in AAL36460 (Ref. 1) Curated | 1 | |
Sequence conflicti | 916 | E → G in BAG57954 (PubMed:10048485).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060217 | 76 | L → P in MUL; decreased ubiquitination and abolishes the formation of perinuclear aggregates. 1 PublicationCorresponds to variant dbSNP:rs386834004EnsemblClinVar. | 1 | |
Natural variantiVAR_060218 | 108 | T → A1 PublicationCorresponds to variant dbSNP:rs17853504Ensembl. | 1 | |
Natural variantiVAR_060219 | 109 | C → S in MUL; no effect on E3 ubiquitin-protein ligase activity. 1 PublicationCorresponds to variant dbSNP:rs121908391EnsemblClinVar. | 1 | |
Natural variantiVAR_060220 | 322 | G → V in MUL; no effect on ubiquitination but affects subcellular localization. 2 PublicationsCorresponds to variant dbSNP:rs386834009EnsemblClinVar. | 1 | |
Natural variantiVAR_075470 | 432 | Q → R1 PublicationCorresponds to variant dbSNP:rs1458302547Ensembl. | 1 | |
Natural variantiVAR_052142 | 838 | V → I. Corresponds to variant dbSNP:rs7222388EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011919 | 1 – 122 | Missing in isoform 2. 1 PublicationAdd BLAST | 122 | |
Alternative sequenceiVSP_057468 | 8 – 41 | Missing in isoform 3. Add BLAST | 34 | |
Alternative sequenceiVSP_011920 | 899 – 937 | Missing in isoform 2. 1 PublicationAdd BLAST | 39 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF213365 mRNA Translation: AAL36460.1 AB020705 mRNA Translation: BAA74921.1 Different initiation. AK289674 mRNA Translation: BAF82363.1 AK294850 mRNA Translation: BAG57954.1 AK292459 mRNA Translation: BAF85148.1 BX537955 mRNA Translation: CAD97922.1 AC005207 Genomic DNA No translation available. AC036154 Genomic DNA No translation available. AC099850 Genomic DNA No translation available. AC100832 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94425.1 CH471109 Genomic DNA Translation: EAW94426.1 BC036012 mRNA Translation: AAH36012.1 |
CCDSi | CCDS32694.1 [O94972-1] CCDS45746.1 [O94972-1] CCDS82174.1 [O94972-3] |
RefSeqi | NP_001005207.1, NM_001005207.3 [O94972-1] NP_001307916.1, NM_001320987.1 [O94972-3] NP_001307919.1, NM_001320990.1 [O94972-2] NP_056109.1, NM_015294.4 [O94972-1] |
Genome annotation databases
Ensembli | ENST00000262294; ENSP00000262294; ENSG00000108395 [O94972-1] ENST00000393065; ENSP00000376784; ENSG00000108395 [O94972-3] ENST00000393066; ENSP00000376785; ENSG00000108395 [O94972-1] |
GeneIDi | 4591 |
KEGGi | hsa:4591 |
UCSCi | uc002iwy.5 human [O94972-1] uc010woc.3 human |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF213365 mRNA Translation: AAL36460.1 AB020705 mRNA Translation: BAA74921.1 Different initiation. AK289674 mRNA Translation: BAF82363.1 AK294850 mRNA Translation: BAG57954.1 AK292459 mRNA Translation: BAF85148.1 BX537955 mRNA Translation: CAD97922.1 AC005207 Genomic DNA No translation available. AC036154 Genomic DNA No translation available. AC099850 Genomic DNA No translation available. AC100832 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94425.1 CH471109 Genomic DNA Translation: EAW94426.1 BC036012 mRNA Translation: AAH36012.1 |
CCDSi | CCDS32694.1 [O94972-1] CCDS45746.1 [O94972-1] CCDS82174.1 [O94972-3] |
RefSeqi | NP_001005207.1, NM_001005207.3 [O94972-1] NP_001307916.1, NM_001320987.1 [O94972-3] NP_001307919.1, NM_001320990.1 [O94972-2] NP_056109.1, NM_015294.4 [O94972-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3LRQ | X-ray | 2.29 | A/B/C/D | 1-90 | [»] | |
SMRi | O94972 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 110678, 111 interactors |
DIPi | DIP-34437N |
IntActi | O94972, 83 interactors |
STRINGi | 9606.ENSP00000262294 |
PTM databases
iPTMneti | O94972 |
PhosphoSitePlusi | O94972 |
Polymorphism and mutation databases
BioMutai | TRIM37 |
Proteomic databases
EPDi | O94972 |
jPOSTi | O94972 |
MassIVEi | O94972 |
MaxQBi | O94972 |
PaxDbi | O94972 |
PeptideAtlasi | O94972 |
PRIDEi | O94972 |
ProteomicsDBi | 31814 50590 [O94972-1] 50591 [O94972-2] |
Genome annotation databases
Ensembli | ENST00000262294; ENSP00000262294; ENSG00000108395 [O94972-1] ENST00000393065; ENSP00000376784; ENSG00000108395 [O94972-3] ENST00000393066; ENSP00000376785; ENSG00000108395 [O94972-1] |
GeneIDi | 4591 |
KEGGi | hsa:4591 |
UCSCi | uc002iwy.5 human [O94972-1] uc010woc.3 human |
Organism-specific databases
CTDi | 4591 |
DisGeNETi | 4591 |
GeneCardsi | TRIM37 |
HGNCi | HGNC:7523 TRIM37 |
HPAi | HPA021911 |
MalaCardsi | TRIM37 |
MIMi | 253250 phenotype 605073 gene |
neXtProti | NX_O94972 |
OpenTargetsi | ENSG00000108395 |
Orphaneti | 2576 Mulibrey nanism |
PharmGKBi | PA35497 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410ITG1 Eukaryota ENOG410YSD5 LUCA |
GeneTreei | ENSGT00410000025800 |
HOGENOMi | HOG000013010 |
InParanoidi | O94972 |
KOi | K10608 |
OMAi | XYEYRVE |
OrthoDBi | 128089at2759 |
PhylomeDBi | O94972 |
TreeFami | TF351092 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Reactomei | R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | O94972 |
Miscellaneous databases
ChiTaRSi | TRIM37 human |
EvolutionaryTracei | O94972 |
GeneWikii | TRIM37 |
GenomeRNAii | 4591 |
Pharosi | O94972 |
PROi | PR:O94972 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108395 Expressed in 228 organ(s), highest expression level in endometrium epithelium |
ExpressionAtlasi | O94972 baseline and differential |
Genevisiblei | O94972 HS |
Family and domain databases
CDDi | cd00021 BBOX, 1 hit cd03773 MATH_TRIM37, 1 hit |
Gene3Di | 2.60.210.10, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR003649 Bbox_C IPR002083 MATH/TRAF_dom IPR008974 TRAF-like IPR037299 TRIM37_MATH IPR000315 Znf_B-box IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00917 MATH, 1 hit PF00643 zf-B_box, 1 hit |
SMARTi | View protein in SMART SM00502 BBC, 1 hit SM00336 BBOX, 1 hit SM00061 MATH, 1 hit |
SUPFAMi | SSF49599 SSF49599, 1 hit |
PROSITEi | View protein in PROSITE PS50144 MATH, 1 hit PS50119 ZF_BBOX, 1 hit PS50089 ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRI37_HUMAN | |
Accessioni | O94972Primary (citable) accession number: O94972 Secondary accession number(s): A8K0V9 Q8WYF7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | November 23, 2004 | |
Last modified: | November 13, 2019 | |
This is version 183 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references