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UniProtKB - O94972 (TRI37_HUMAN)

Entry version 177 (10 Apr 2019)
Sequence version 2 (23 Nov 2004)
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Protein

E3 ubiquitin-protein ligase TRIM37

Gene

TRIM37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724).4 Publications

Miscellaneous

Acts as a proto-oncogene via its ability to monoubiquinate 'Lys-119' of histone H2A (H2AK119Ub): overexpressed in a number of breast cancers and promotes transformation of cells by mediating silencing of tumor suppressor genes (PubMed:25470042).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.2 Publications
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri15 – 55RING-type; degeneratePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri90 – 132B box-typePROSITE-ProRule annotationAdd BLAST43

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor, Transferase
Biological processTranscription, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O94972

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM37Curated (EC:2.3.2.271 Publication)
Alternative name(s):
Mulibrey nanism protein1 Publication
RING-type E3 ubiquitin transferase TRIM37Curated
Tripartite motif-containing protein 37Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM37Imported
Synonyms:KIAA0898, MUL1 Publication, POB11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000108395.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:7523 TRIM37

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605073 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O94972

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mulibrey nanism (MUL)8 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive growth disorder characterized by severe growth failure of prenatal onset, constrictive pericardium and progressive cardiomyopathy, facial dysmorphism, and failure of sexual maturation. Additional clinical features include hepatomegaly, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, hypoplasia of various endocrine glands, insulin resistance with type 2 diabetes, and an increased risk for Wilms' tumor.
See also OMIM:253250
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06021776L → P in MUL; decreased ubiquitination and abolishes the formation of perinuclear aggregates. 1 PublicationCorresponds to variant dbSNP:rs386834004EnsemblClinVar.1
Natural variantiVAR_060219109C → S in MUL; no effect on E3 ubiquitin-protein ligase activity. 1 PublicationCorresponds to variant dbSNP:rs121908391EnsemblClinVar.1
Natural variantiVAR_060220322G → V in MUL; no effect on ubiquitination but affects subcellular localization. 2 PublicationsCorresponds to variant dbSNP:rs386834009EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi18C → R: Abolishes ability to monoubiquitinate 'Lys-119' of histone H2A (H2AK119Ub). 1 Publication1
Mutagenesisi35 – 36CC → SS: Reduces ubiquitination and abolishes the formation of perinuclear aggregates. 1 Publication2

Keywords - Diseasei

Dwarfism, Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		4591

MalaCards human disease database

More...MalaCardsi		TRIM37
MIMi253250 phenotype

Open Targets

More...OpenTargetsi		ENSG00000108395

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		2576 Mulibrey nanism

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35497

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRIM37

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000562541 – 964E3 ubiquitin-protein ligase TRIM37Add BLAST964

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei454PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Auto-ubiquitinated.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O94972

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O94972

MaxQB - The MaxQuant DataBase

More...MaxQBi		O94972

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O94972

PeptideAtlas

More...PeptideAtlasi		O94972

PRoteomics IDEntifications database

More...PRIDEi		O94972

ProteomicsDB human proteome resource

More...ProteomicsDBi		50590
50591 [O94972-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O94972

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O94972

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous (PubMed:10888877). Highly expressed in testis, while it is weakly expressed in other tissues (PubMed:16310976).2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Overexpressed in a number of breast cancer cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000108395 Expressed in 228 organ(s), highest expression level in endometrium epithelium

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O94972 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O94972 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA021911

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with the PRC2/EED-EZH2 complex.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		110678, 107 interactors

Database of interacting proteins

More...DIPi		DIP-34437N

Protein interaction database and analysis system

More...IntActi		O94972, 67 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000262294

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1964
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LRQX-ray2.29A/B/C/D1-90[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		O94972

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O94972

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O94972

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini276 – 403MATHPROSITE-ProRule annotationAdd BLAST128

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili132 – 234Sequence analysisAdd BLAST103
Coiled coili419 – 450Sequence analysisAdd BLAST32
Coiled coili673 – 700Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi534 – 540Poly-Ser7
Compositional biasi578 – 581Poly-Ala4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 55RING-type; degeneratePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri90 – 132B box-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410ITG1 Eukaryota
ENOG410YSD5 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00410000025800

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000013010

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG057591

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O94972

KEGG Orthology (KO)

More...KOi		K10608

Identification of Orthologs from Complete Genome Data

More...OMAi		MWRVPPD

Database of Orthologous Groups

More...OrthoDBi		128089at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O94972

TreeFam database of animal gene trees

More...TreeFami		TF351092

Family and domain databases

Conserved Domains Database

More...CDDi		cd00021 BBOX, 1 hit
cd03773 MATH_TRIM37, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.210.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003649 Bbox_C
IPR002083 MATH/TRAF_dom
IPR008974 TRAF-like
IPR037299 TRIM37_MATH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00917 MATH, 1 hit
PF00643 zf-B_box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00502 BBC, 1 hit
SM00336 BBOX, 1 hit
SM00061 MATH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49599 SSF49599, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50144 MATH, 1 hit
PS50119 ZF_BBOX, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94972-1) [UniParc]FASTAAdd to basket
Also known as: TRIM37a1 Publication, TRIM37b1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDEQSVESIA EVFRCFICME KLRDARLCPH CSKLCCFSCI RRWLTEQRAQ 
        60         70         80         90        100
CPHCRAPLQL RELVNCRWAE EVTQQLDTLQ LCSLTKHEEN EKDKCENHHE 
       110        120        130        140        150
KLSVFCWTCK KCICHQCALW GGMHGGHTFK PLAEIYEQHV TKVNEEVAKL 
       160        170        180        190        200
RRRLMELISL VQEVERNVEA VRNAKDERVR EIRNAVEMMI ARLDTQLKNK 
       210        220        230        240        250
LITLMGQKTS LTQETELLES LLQEVEHQLR SCSKSELISK SSEILMMFQQ 
       260        270        280        290        300
VHRKPMASFV TTPVPPDFTS ELVPSYDSAT FVLENFSTLR QRADPVYSPP 
       310        320        330        340        350
LQVSGLCWRL KVYPDGNGVV RGYYLSVFLE LSAGLPETSK YEYRVEMVHQ 
       360        370        380        390        400
SCNDPTKNII REFASDFEVG ECWGYNRFFR LDLLANEGYL NPQNDTVILR 
       410        420        430        440        450
FQVRSPTFFQ KSRDQHWYIT QLEAAQTSYI QQINNLKERL TIELSRTQKS 
       460        470        480        490        500
RDLSPPDNHL SPQNDDALET RAKKSACSDM LLEGGPTTAS VREAKEDEED 
       510        520        530        540        550
EEKIQNEDYH HELSDGDLDL DLVYEDEVNQ LDGSSSSASS TATSNTEEND 
       560        570        580        590        600
IDEETMSGEN DVEYNNMELE EGELMEDAAA AGPAGSSHGY VGSSSRISRR 
       610        620        630        640        650
THLCSAATSS LLDIDPLILI HLLDLKDRSS IENLWGLQPR PPASLLQPTA 
       660        670        680        690        700
SYSRKDKDQR KQQAMWRVPS DLKMLKRLKT QMAEVRCMKT DVKNTLSEIK 
       710        720        730        740        750
SSSAASGDMQ TSLFSADQAA LAACGTENSG RLQDLGMELL AKSSVANCYI 
       760        770        780        790        800
RNSTNKKSNS PKPARSSVAG SLSLRRAVDP GENSRSKGDC QTLSEGSPGS 
       810        820        830        840        850
SQSGSRHSSP RALIHGSIGD ILPKTEDRQC KALDSDAVVV AVFSGLPAVE 
       860        870        880        890        900
KRRKMVTLGA NAKGGHLEGL QMTDLENNSE TGELQPVLPE GASAAPEEGM 
       910        920        930        940        950
SSDSDIECDT ENEEQEEHTS VGGFHDSFMV MTQPPDEDTH SSFPDGEQIG 
       960 
PEDLSFNTDE NSGR
Length:964
Mass (Da):107,906
Last modified:November 23, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC0F08D5A5DC3B5AC
GO
Isoform 2 (identifier: O94972-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.
     899-937: Missing.

Note: No experimental confirmation available.
Show »
Length:803
Mass (Da):89,186
Checksum:i43486E1064478477
GO
Isoform 3 (identifier: O94972-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     8-41: Missing.

Show »
Length:930
Mass (Da):103,941
Checksum:i9AD3B427995A9961
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KT90J3KT90_HUMAN
E3 ubiquitin-protein ligase TRIM37
TRIM37
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QSA0J3QSA0_HUMAN
E3 ubiquitin-protein ligase TRIM37
TRIM37
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QSH5J3QSH5_HUMAN
E3 ubiquitin-protein ligase TRIM37
TRIM37
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRK3J3QRK3_HUMAN
E3 ubiquitin-protein ligase TRIM37
TRIM37
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS72J3KS72_HUMAN
E3 ubiquitin-protein ligase TRIM37
TRIM37
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KT32J3KT32_HUMAN
E3 ubiquitin-protein ligase TRIM37
TRIM37
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QSF6J3QSF6_HUMAN
E3 ubiquitin-protein ligase TRIM37
TRIM37
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA74921 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti620I → M in BAF85148 (PubMed:14702039).Curated1
Sequence conflicti624D → A in AAL36460 (Ref. 1) Curated1
Sequence conflicti916E → G in BAG57954 (PubMed:10048485).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06021776L → P in MUL; decreased ubiquitination and abolishes the formation of perinuclear aggregates. 1 PublicationCorresponds to variant dbSNP:rs386834004EnsemblClinVar.1
Natural variantiVAR_060218108T → A1 PublicationCorresponds to variant dbSNP:rs17853504Ensembl.1
Natural variantiVAR_060219109C → S in MUL; no effect on E3 ubiquitin-protein ligase activity. 1 PublicationCorresponds to variant dbSNP:rs121908391EnsemblClinVar.1
Natural variantiVAR_060220322G → V in MUL; no effect on ubiquitination but affects subcellular localization. 2 PublicationsCorresponds to variant dbSNP:rs386834009EnsemblClinVar.1
Natural variantiVAR_075470432Q → R1 PublicationCorresponds to variant dbSNP:rs1458302547Ensembl.1
Natural variantiVAR_052142838V → I. Corresponds to variant dbSNP:rs7222388EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0119191 – 122Missing in isoform 2. 1 PublicationAdd BLAST122
Alternative sequenceiVSP_0574688 – 41Missing in isoform 3. Add BLAST34
Alternative sequenceiVSP_011920899 – 937Missing in isoform 2. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF213365 mRNA Translation: AAL36460.1
AB020705 mRNA Translation: BAA74921.1 Different initiation.
AK289674 mRNA Translation: BAF82363.1
AK294850 mRNA Translation: BAG57954.1
AK292459 mRNA Translation: BAF85148.1
BX537955 mRNA Translation: CAD97922.1
AC005207 Genomic DNA No translation available.
AC036154 Genomic DNA No translation available.
AC099850 Genomic DNA No translation available.
AC100832 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94425.1
CH471109 Genomic DNA Translation: EAW94426.1
BC036012 mRNA Translation: AAH36012.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32694.1 [O94972-1]
CCDS45746.1 [O94972-1]
CCDS82174.1 [O94972-3]

NCBI Reference Sequences

More...RefSeqi		NP_001005207.1, NM_001005207.3 [O94972-1]
NP_001307916.1, NM_001320987.1 [O94972-3]
NP_001307919.1, NM_001320990.1 [O94972-2]
NP_056109.1, NM_015294.4 [O94972-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.579079
Hs.605697

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262294; ENSP00000262294; ENSG00000108395 [O94972-1]
ENST00000393065; ENSP00000376784; ENSG00000108395 [O94972-3]
ENST00000393066; ENSP00000376785; ENSG00000108395 [O94972-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4591

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4591

UCSC genome browser

More...UCSCi		uc002iwy.5 human [O94972-1]
uc010woc.3 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF213365 mRNA Translation: AAL36460.1
AB020705 mRNA Translation: BAA74921.1 Different initiation.
AK289674 mRNA Translation: BAF82363.1
AK294850 mRNA Translation: BAG57954.1
AK292459 mRNA Translation: BAF85148.1
BX537955 mRNA Translation: CAD97922.1
AC005207 Genomic DNA No translation available.
AC036154 Genomic DNA No translation available.
AC099850 Genomic DNA No translation available.
AC100832 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94425.1
CH471109 Genomic DNA Translation: EAW94426.1
BC036012 mRNA Translation: AAH36012.1
CCDSiCCDS32694.1 [O94972-1]
CCDS45746.1 [O94972-1]
CCDS82174.1 [O94972-3]
RefSeqiNP_001005207.1, NM_001005207.3 [O94972-1]
NP_001307916.1, NM_001320987.1 [O94972-3]
NP_001307919.1, NM_001320990.1 [O94972-2]
NP_056109.1, NM_015294.4 [O94972-1]
UniGeneiHs.579079
Hs.605697

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LRQX-ray2.29A/B/C/D1-90[»]
ProteinModelPortaliO94972
SMRiO94972
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110678, 107 interactors
DIPiDIP-34437N
IntActiO94972, 67 interactors
STRINGi9606.ENSP00000262294

PTM databases

iPTMnetiO94972
PhosphoSitePlusiO94972

Polymorphism and mutation databases

BioMutaiTRIM37

Proteomic databases

EPDiO94972
jPOSTiO94972
MaxQBiO94972
PaxDbiO94972
PeptideAtlasiO94972
PRIDEiO94972
ProteomicsDBi50590
50591 [O94972-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262294; ENSP00000262294; ENSG00000108395 [O94972-1]
ENST00000393065; ENSP00000376784; ENSG00000108395 [O94972-3]
ENST00000393066; ENSP00000376785; ENSG00000108395 [O94972-1]
GeneIDi4591
KEGGihsa:4591
UCSCiuc002iwy.5 human [O94972-1]
uc010woc.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4591
DisGeNETi4591
EuPathDBiHostDB:ENSG00000108395.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRIM37

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0014039
HGNCiHGNC:7523 TRIM37
HPAiHPA021911
MalaCardsiTRIM37
MIMi253250 phenotype
605073 gene
neXtProtiNX_O94972
OpenTargetsiENSG00000108395
Orphaneti2576 Mulibrey nanism
PharmGKBiPA35497

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410ITG1 Eukaryota
ENOG410YSD5 LUCA
GeneTreeiENSGT00410000025800
HOGENOMiHOG000013010
HOVERGENiHBG057591
InParanoidiO94972
KOiK10608
OMAiMWRVPPD
OrthoDBi128089at2759
PhylomeDBiO94972
TreeFamiTF351092

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiO94972

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRIM37 human
EvolutionaryTraceiO94972

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TRIM37

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4591

Protein Ontology

More...PROi		PR:O94972

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000108395 Expressed in 228 organ(s), highest expression level in endometrium epithelium
ExpressionAtlasiO94972 baseline and differential
GenevisibleiO94972 HS

Family and domain databases

CDDicd00021 BBOX, 1 hit
cd03773 MATH_TRIM37, 1 hit
Gene3Di2.60.210.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR003649 Bbox_C
IPR002083 MATH/TRAF_dom
IPR008974 TRAF-like
IPR037299 TRIM37_MATH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00917 MATH, 1 hit
PF00643 zf-B_box, 1 hit
SMARTiView protein in SMART
SM00502 BBC, 1 hit
SM00336 BBOX, 1 hit
SM00061 MATH, 1 hit
SUPFAMiSSF49599 SSF49599, 1 hit
PROSITEiView protein in PROSITE
PS50144 MATH, 1 hit
PS50119 ZF_BBOX, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRI37_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94972
Secondary accession number(s): A8K0V9
, A8K8U4, A8MZ79, B4DGZ3, F8WEE6, Q7Z3E6, Q8IYF7, Q8WYF7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: April 10, 2019
This is version 177 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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