TRIM37

Functionⁱ

E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724).4 Publications

Miscellaneous

Acts as a proto-oncogene via its ability to monoubiquinate 'Lys-119' of histone H2A (H2AK119Ub): overexpressed in a number of breast cancers and promotes transformation of cells by mediating silencing of tumor suppressor genes (PubMed:25470042).1 Publication

Catalytic activityⁱ

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.2 Publications
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	15 – 55	RING-type; degeneratePROSITE-ProRule annotationAdd BLAST		41
Zinc fingerⁱ	90 – 132	B box-typePROSITE-ProRule annotationAdd BLAST		43

GO - Molecular functionⁱ

chromatin binding Source: Ensembl
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11279055
tumor necrosis factor receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11279055
ubiquitin protein ligase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 25470042
ubiquitin protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11279055
ubiquitin-protein transferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15885686
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aggresome assembly
Source: UniProtKB
Inferred from direct assayⁱ
- 15885686
histone H2A-K119 monoubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 25470042
histone H2A monoubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 25470042
negative regulation of centriole replication
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23769972
negative regulation of NF-kappaB transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11279055
negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 25470042
positive regulation of DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 23077300
positive regulation of NF-kappaB transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 23077300
protein autoubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 15885686

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Repressor, Transferase
Biological process	Transcription, Ubl conjugation pathway
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkⁱ	O94972
UniPathwayⁱ	UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: E3 ubiquitin-protein ligase TRIM37Curated (EC:2.3.2.271 Publication) Alternative name(s): Mulibrey nanism protein1 Publication RING-type E3 ubiquitin transferase TRIM37Curated Tripartite motif-containing protein 37Curated
Gene namesⁱ	Name:TRIM37Imported Synonyms:KIAA0898, MUL1 Publication, POB11 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000108395.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7523 TRIM37
MIMⁱ	605073 gene
neXtProtⁱ	NX_O94972

Keywords - Cellular componentⁱ

Cytoplasm, Peroxisome

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Mulibrey nanism (MUL)8 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive growth disorder characterized by severe growth failure of prenatal onset, constrictive pericardium and progressive cardiomyopathy, facial dysmorphism, and failure of sexual maturation. Additional clinical features include hepatomegaly, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, hypoplasia of various endocrine glands, insulin resistance with type 2 diabetes, and an increased risk for Wilms' tumor.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	18	C → R: Abolishes ability to monoubiquitinate 'Lys-119' of histone H2A (H2AK119Ub). 1 Publication		1
Mutagenesisⁱ	35 – 36	CC → SS: Reduces ubiquitination and abolishes the formation of perinuclear aggregates. 1 Publication		2

Keywords - Diseaseⁱ

Dwarfism, Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4591
MalaCards human disease database More...MalaCardsⁱ	TRIM37
MIMⁱ	253250 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000108395
Orphanetⁱ	2576 MULIBREY nanism
PharmGKBⁱ	PA35497

Polymorphism and mutation databases

BioMutaⁱ	TRIM37

BioMutaⁱ

TRIM37

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000056254	1 – 964	E3 ubiquitin-protein ligase TRIM37Add BLAST		964

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources		1
Modified residueⁱ	454	PhosphoserineCombined sources		1

Post-translational modificationⁱ

Auto-ubiquitinated.1 Publication

Keywords - PTMⁱ

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	O94972
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O94972
PaxDbⁱ	O94972
PeptideAtlas More...PeptideAtlasⁱ	O94972
PRIDEⁱ	O94972
ProteomicsDBⁱ	50590 50591 [O94972-2]

PTM databases

iPTMnetⁱ	O94972
PhosphoSitePlusⁱ	O94972

Expressionⁱ

Tissue specificityⁱ

Inductionⁱ

Overexpressed in a number of breast cancer cell lines.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000108395 Expressed in 228 organ(s), highest expression level in endometrium epithelium
CleanExⁱ	HS_TRIM37
ExpressionAtlasⁱ	O94972 baseline and differential
Genevisibleⁱ	O94972 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA021911

HPAⁱ

HPA021911

Interactionⁱ

Subunit structureⁱ

Associates with the PRC2/EED-EZH2 complex.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
	A8K932	3	EBI-741602,EBI-10174671
AXIN1	A0A0S2Z4M1	3	EBI-741602,EBI-16429430
AXIN1	O15169	3	EBI-741602,EBI-710484
BYSL	Q13895	8	EBI-741602,EBI-358049
CDC20B	Q86Y33	3	EBI-741602,EBI-10260504
COPB1	P53618	3	EBI-741602,EBI-359063
CWF19L2	Q2TBE0	5	EBI-741602,EBI-5453285
DDX6	P26196	3	EBI-741602,EBI-351257
FAM107A	O95990-3	3	EBI-741602,EBI-10192902
FAM161A	Q3B820	3	EBI-741602,EBI-719941
FAM50B	Q9Y247	3	EBI-741602,EBI-742802
KAT5	Q92993	3	EBI-741602,EBI-399080
MCRS1	Q96EZ8	4	EBI-741602,EBI-348259
PNKP	Q96T60	3	EBI-741602,EBI-1045072
PRC1	O43663	3	EBI-741602,EBI-741137
RASD1	Q9Y272	3	EBI-741602,EBI-740818
RNF6	A0A0S2Z4G9	3	EBI-741602,EBI-16428950
RPL9P9	P32969	3	EBI-741602,EBI-358122
RXRB	P28702-3	3	EBI-741602,EBI-16429492
SCNM1	Q9BWG6	3	EBI-741602,EBI-748391
SSX2IP	Q9Y2D8	4	EBI-741602,EBI-2212028
UBASH3A	P57075	3	EBI-741602,EBI-2105393
ZMAT2	Q96NC0	3	EBI-741602,EBI-2682299
ZNF329	Q86UD4	3	EBI-741602,EBI-7233259
ZNF417	Q8TAU3	4	EBI-741602,EBI-740727

GO - Molecular functionⁱ

protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11279055
tumor necrosis factor receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11279055
ubiquitin protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11279055

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110678, 100 interactors
Database of interacting proteins More...DIPⁱ	DIP-34437N
IntActⁱ	O94972, 66 interactors
STRINGⁱ	9606.ENSP00000262294

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	1 – 12	Combined sources	12
Turnⁱ	16 – 18	Combined sources	3
Beta strandⁱ	23 – 27	Combined sources	5
Turnⁱ	29 – 31	Combined sources	3
Beta strandⁱ	34 – 36	Combined sources	3
Helixⁱ	37 – 46	Combined sources	10
Turnⁱ	52 – 54	Combined sources	3
Helixⁱ	60 – 62	Combined sources	3
Helixⁱ	69 – 79	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	O94972
SMRⁱ	O94972
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O94972

EvolutionaryTraceⁱ

O94972

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	276 – 403	MATHPROSITE-ProRule annotationAdd BLAST		128

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	132 – 234	Sequence analysisAdd BLAST	103
Coiled coilⁱ	419 – 450	Sequence analysisAdd BLAST	32
Coiled coilⁱ	673 – 700	Sequence analysisAdd BLAST	28

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	534 – 540	Poly-Ser		7
Compositional biasⁱ	578 – 581	Poly-Ala		4

Sequence similaritiesⁱ

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	15 – 55	RING-type; degeneratePROSITE-ProRule annotationAdd BLAST		41
Zinc fingerⁱ	90 – 132	B box-typePROSITE-ProRule annotationAdd BLAST		43

Keywords - Domainⁱ

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410ITG1 Eukaryota ENOG410YSD5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00410000025800
HOGENOMⁱ	HOG000013010
HOVERGENⁱ	HBG057591
InParanoidⁱ	O94972
KEGG Orthology (KO) More...KOⁱ	K10608
OMAⁱ	MWRVPPD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01C1
PhylomeDBⁱ	O94972
TreeFamⁱ	TF351092

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00021 BBOX, 1 hit cd03773 MATH_TRIM37, 1 hit
Gene3Dⁱ	2.60.210.10, 1 hit 3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR003649 Bbox_C IPR002083 MATH/TRAF_dom IPR008974 TRAF-like IPR037299 TRIM37_MATH IPR000315 Znf_B-box IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00917 MATH, 1 hit PF00643 zf-B_box, 1 hit
SMARTⁱ	View protein in SMART SM00502 BBC, 1 hit SM00336 BBOX, 1 hit SM00061 MATH, 1 hit
SUPFAMⁱ	SSF49599 SSF49599, 1 hit
PROSITEⁱ	View protein in PROSITE PS50144 MATH, 1 hit PS50119 ZF_BBOX, 1 hit PS50089 ZF_RING_2, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O94972-1) [UniParc]FASTA Add to basket

Also known as: TRIM37a1 Publication, TRIM37b1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDEQSVESIA EVFRCFICME KLRDARLCPH CSKLCCFSCI RRWLTEQRAQ 
        60         70         80         90        100
CPHCRAPLQL RELVNCRWAE EVTQQLDTLQ LCSLTKHEEN EKDKCENHHE 
       110        120        130        140        150
KLSVFCWTCK KCICHQCALW GGMHGGHTFK PLAEIYEQHV TKVNEEVAKL 
       160        170        180        190        200
RRRLMELISL VQEVERNVEA VRNAKDERVR EIRNAVEMMI ARLDTQLKNK 
       210        220        230        240        250
LITLMGQKTS LTQETELLES LLQEVEHQLR SCSKSELISK SSEILMMFQQ 
       260        270        280        290        300
VHRKPMASFV TTPVPPDFTS ELVPSYDSAT FVLENFSTLR QRADPVYSPP 
       310        320        330        340        350
LQVSGLCWRL KVYPDGNGVV RGYYLSVFLE LSAGLPETSK YEYRVEMVHQ 
       360        370        380        390        400
SCNDPTKNII REFASDFEVG ECWGYNRFFR LDLLANEGYL NPQNDTVILR 
       410        420        430        440        450
FQVRSPTFFQ KSRDQHWYIT QLEAAQTSYI QQINNLKERL TIELSRTQKS 
       460        470        480        490        500
RDLSPPDNHL SPQNDDALET RAKKSACSDM LLEGGPTTAS VREAKEDEED 
       510        520        530        540        550
EEKIQNEDYH HELSDGDLDL DLVYEDEVNQ LDGSSSSASS TATSNTEEND 
       560        570        580        590        600
IDEETMSGEN DVEYNNMELE EGELMEDAAA AGPAGSSHGY VGSSSRISRR 
       610        620        630        640        650
THLCSAATSS LLDIDPLILI HLLDLKDRSS IENLWGLQPR PPASLLQPTA 
       660        670        680        690        700
SYSRKDKDQR KQQAMWRVPS DLKMLKRLKT QMAEVRCMKT DVKNTLSEIK 
       710        720        730        740        750
SSSAASGDMQ TSLFSADQAA LAACGTENSG RLQDLGMELL AKSSVANCYI 
       760        770        780        790        800
RNSTNKKSNS PKPARSSVAG SLSLRRAVDP GENSRSKGDC QTLSEGSPGS 
       810        820        830        840        850
SQSGSRHSSP RALIHGSIGD ILPKTEDRQC KALDSDAVVV AVFSGLPAVE 
       860        870        880        890        900
KRRKMVTLGA NAKGGHLEGL QMTDLENNSE TGELQPVLPE GASAAPEEGM 
       910        920        930        940        950
SSDSDIECDT ENEEQEEHTS VGGFHDSFMV MTQPPDEDTH SSFPDGEQIG 
       960 
PEDLSFNTDE NSGR

Length:964

Mass (Da):107,906

Last modified:November 23, 2004 - v2

Checksum:ⁱC0F08D5A5DC3B5AC

GO

Isoform 2 (identifier: O94972-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-122: Missing.
899-937: Missing.

« Hide

        10         20         30         40         50
MHGGHTFKPL AEIYEQHVTK VNEEVAKLRR RLMELISLVQ EVERNVEAVR 
        60         70         80         90        100
NAKDERVREI RNAVEMMIAR LDTQLKNKLI TLMGQKTSLT QETELLESLL 
       110        120        130        140        150
QEVEHQLRSC SKSELISKSS EILMMFQQVH RKPMASFVTT PVPPDFTSEL 
       160        170        180        190        200
VPSYDSATFV LENFSTLRQR ADPVYSPPLQ VSGLCWRLKV YPDGNGVVRG 
       210        220        230        240        250
YYLSVFLELS AGLPETSKYE YRVEMVHQSC NDPTKNIIRE FASDFEVGEC 
       260        270        280        290        300
WGYNRFFRLD LLANEGYLNP QNDTVILRFQ VRSPTFFQKS RDQHWYITQL 
       310        320        330        340        350
EAAQTSYIQQ INNLKERLTI ELSRTQKSRD LSPPDNHLSP QNDDALETRA 
       360        370        380        390        400
KKSACSDMLL EGGPTTASVR EAKEDEEDEE KIQNEDYHHE LSDGDLDLDL 
       410        420        430        440        450
VYEDEVNQLD GSSSSASSTA TSNTEENDID EETMSGENDV EYNNMELEEG 
       460        470        480        490        500
ELMEDAAAAG PAGSSHGYVG SSSRISRRTH LCSAATSSLL DIDPLILIHL 
       510        520        530        540        550
LDLKDRSSIE NLWGLQPRPP ASLLQPTASY SRKDKDQRKQ QAMWRVPSDL 
       560        570        580        590        600
KMLKRLKTQM AEVRCMKTDV KNTLSEIKSS SAASGDMQTS LFSADQAALA 
       610        620        630        640        650
ACGTENSGRL QDLGMELLAK SSVANCYIRN STNKKSNSPK PARSSVAGSL 
       660        670        680        690        700
SLRRAVDPGE NSRSKGDCQT LSEGSPGSSQ SGSRHSSPRA LIHGSIGDIL 
       710        720        730        740        750
PKTEDRQCKA LDSDAVVVAV FSGLPAVEKR RKMVTLGANA KGGHLEGLQM 
       760        770        780        790        800
TDLENNSETG ELQPVLPEGA SAAPEEDTHS SFPDGEQIGP EDLSFNTDEN 

SGR

Note: No experimental confirmation available.

Show »

Length:803

Mass (Da):89,186

Checksum:ⁱ43486E1064478477

GO

Isoform 3 (identifier: O94972-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
8-41: Missing.

« Hide

        10         20         30         40         50
MDEQSVERWL TEQRAQCPHC RAPLQLRELV NCRWAEEVTQ QLDTLQLCSL 
        60         70         80         90        100
TKHEENEKDK CENHHEKLSV FCWTCKKCIC HQCALWGGMH GGHTFKPLAE 
       110        120        130        140        150
IYEQHVTKVN EEVAKLRRRL MELISLVQEV ERNVEAVRNA KDERVREIRN 
       160        170        180        190        200
AVEMMIARLD TQLKNKLITL MGQKTSLTQE TELLESLLQE VEHQLRSCSK 
       210        220        230        240        250
SELISKSSEI LMMFQQVHRK PMASFVTTPV PPDFTSELVP SYDSATFVLE 
       260        270        280        290        300
NFSTLRQRAD PVYSPPLQVS GLCWRLKVYP DGNGVVRGYY LSVFLELSAG 
       310        320        330        340        350
LPETSKYEYR VEMVHQSCND PTKNIIREFA SDFEVGECWG YNRFFRLDLL 
       360        370        380        390        400
ANEGYLNPQN DTVILRFQVR SPTFFQKSRD QHWYITQLEA AQTSYIQQIN 
       410        420        430        440        450
NLKERLTIEL SRTQKSRDLS PPDNHLSPQN DDALETRAKK SACSDMLLEG 
       460        470        480        490        500
GPTTASVREA KEDEEDEEKI QNEDYHHELS DGDLDLDLVY EDEVNQLDGS 
       510        520        530        540        550
SSSASSTATS NTEENDIDEE TMSGENDVEY NNMELEEGEL MEDAAAAGPA 
       560        570        580        590        600
GSSHGYVGSS SRISRRTHLC SAATSSLLDI DPLILIHLLD LKDRSSIENL 
       610        620        630        640        650
WGLQPRPPAS LLQPTASYSR KDKDQRKQQA MWRVPSDLKM LKRLKTQMAE 
       660        670        680        690        700
VRCMKTDVKN TLSEIKSSSA ASGDMQTSLF SADQAALAAC GTENSGRLQD 
       710        720        730        740        750
LGMELLAKSS VANCYIRNST NKKSNSPKPA RSSVAGSLSL RRAVDPGENS 
       760        770        780        790        800
RSKGDCQTLS EGSPGSSQSG SRHSSPRALI HGSIGDILPK TEDRQCKALD 
       810        820        830        840        850
SDAVVVAVFS GLPAVEKRRK MVTLGANAKG GHLEGLQMTD LENNSETGEL 
       860        870        880        890        900
QPVLPEGASA APEEGMSSDS DIECDTENEE QEEHTSVGGF HDSFMVMTQP 
       910        920        930
PDEDTHSSFP DGEQIGPEDL SFNTDENSGR

Show »

Length:930

Mass (Da):103,941

Checksum:ⁱ9AD3B427995A9961

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3KT90	J3KT90_HUMAN	E3 ubiquitin-protein ligase TRIM37 E3 ubiquitin-protein ligase TRIM37	TRIM37	194	Annotation score:
J3QSH5	J3QSH5_HUMAN	E3 ubiquitin-protein ligase TRIM37 E3 ubiquitin-protein ligase TRIM37	TRIM37	113	Annotation score:
J3QSA0	J3QSA0_HUMAN	E3 ubiquitin-protein ligase TRIM37 E3 ubiquitin-protein ligase TRIM37	TRIM37	58	Annotation score:
J3QRK3	J3QRK3_HUMAN	E3 ubiquitin-protein ligase TRIM37 E3 ubiquitin-protein ligase TRIM37	TRIM37	103	Annotation score:
J3KS72	J3KS72_HUMAN	E3 ubiquitin-protein ligase TRIM37 E3 ubiquitin-protein ligase TRIM37	TRIM37	67	Annotation score:
J3KT32	J3KT32_HUMAN	E3 ubiquitin-protein ligase TRIM37 E3 ubiquitin-protein ligase TRIM37	TRIM37	54	Annotation score:
J3QSF6	J3QSF6_HUMAN	E3 ubiquitin-protein ligase TRIM37 E3 ubiquitin-protein ligase TRIM37	TRIM37	117	Annotation score:

Sequence cautionⁱ

The sequence BAA74921 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	620	I → M in BAF85148 (PubMed:14702039).Curated	1
Sequence conflictⁱ	624	D → A in AAL36460 (Ref. 1) Curated	1
Sequence conflictⁱ	916	E → G in BAG57954 (PubMed:10048485).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_060217	76	L → P in MUL; decreased ubiquitination and abolishes the formation of perinuclear aggregates. 1 PublicationCorresponds to variant dbSNP:rs386834004EnsemblClinVar.	1
Natural variantⁱVAR_060218	108	T → A1 PublicationCorresponds to variant dbSNP:rs17853504Ensembl.	1
Natural variantⁱVAR_060219	109	C → S in MUL; no effect on E3 ubiquitin-protein ligase activity. 1 PublicationCorresponds to variant dbSNP:rs121908391EnsemblClinVar.	1
Natural variantⁱVAR_060220	322	G → V in MUL; no effect on ubiquitination but affects subcellular localization. 2 PublicationsCorresponds to variant dbSNP:rs386834009EnsemblClinVar.	1
Natural variantⁱVAR_075470	432	Q → R1 Publication	1
Natural variantⁱVAR_052142	838	V → I. Corresponds to variant dbSNP:rs7222388EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_011919	1 – 122	Missing in isoform 2. 1 PublicationAdd BLAST	122
Alternative sequenceⁱVSP_057468	8 – 41	Missing in isoform 3. Add BLAST	34
Alternative sequenceⁱVSP_011920	899 – 937	Missing in isoform 2. 1 PublicationAdd BLAST	39

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF213365 mRNA Translation: AAL36460.1 AB020705 mRNA Translation: BAA74921.1 Different initiation. AK289674 mRNA Translation: BAF82363.1 AK294850 mRNA Translation: BAG57954.1 AK292459 mRNA Translation: BAF85148.1 BX537955 mRNA Translation: CAD97922.1 AC005207 Genomic DNA No translation available. AC036154 Genomic DNA No translation available. AC099850 Genomic DNA No translation available. AC100832 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94425.1 CH471109 Genomic DNA Translation: EAW94426.1 BC036012 mRNA Translation: AAH36012.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32694.1 [O94972-1] CCDS45746.1 [O94972-1] CCDS82174.1 [O94972-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001005207.1, NM_001005207.3 [O94972-1] NP_001307916.1, NM_001320987.1 [O94972-3] NP_001307919.1, NM_001320990.1 [O94972-2] NP_056109.1, NM_015294.4 [O94972-1]
UniGeneⁱ	Hs.579079 Hs.605697

Genome annotation databases

Ensemblⁱ	ENST00000262294; ENSP00000262294; ENSG00000108395 [O94972-1] ENST00000393065; ENSP00000376784; ENSG00000108395 [O94972-3] ENST00000393066; ENSP00000376785; ENSG00000108395 [O94972-1]
GeneIDⁱ	4591
KEGGⁱ	hsa:4591
UCSC genome browser More...UCSCⁱ	uc002iwy.5 human [O94972-1] uc010woc.3 human

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O94972	cDNA FLJ12639 fis, clone NT2RM4001938, highly similar to Tripartite motif-containing protein 37		HUMAN		300	UniRef100_O94972
UPI0005D038F4		HUMAN		989
UPI0003E67567		HUMAN		719
UPI000D0C8C5E		HUMAN		835
UPI0007DC564B		HUMAN		810

Protein	Similar proteins		Species	Score	Length	Source
O94972	cDNA FLJ12639 fis, clone NT2RM4001938, highly similar to Tripartite motif-containing protein 37		HUMAN		300	UniRef90_O94972
E3 ubiquitin-protein ligase TRIM37 isoform X3		TURTR		997
Uncharacterized protein		PIG		992
Uncharacterized protein		AOTNA		991
Uncharacterized protein		MACMU		989
+277
O94972-3	E3 ubiquitin-protein ligase TRIM37		PTEAL		1040	UniRef90_O94972-3
Putative e3 ubiquitin-protein ligase trim37 (Fragment)		DESRO		958
Uncharacterized protein		PIG		948
E3 ubiquitin-protein ligase TRIM37		HETGA		944
E3 ubiquitin-protein ligase TRIM37 isoform X4		DELLE		931
+23

Protein	Similar proteins		Species	Score	Length	Source
O94972	E3 ubiquitin-protein ligase TRIM37		MOUSE		961	UniRef50_O94972
cDNA FLJ12639 fis, clone NT2RM4001938, highly similar to Tripartite motif-containing protein 37		HUMAN		300
E3 ubiquitin-protein ligase TRIM37 isoform X3		TURTR		997
Uncharacterized protein		PIG		992
Uncharacterized protein		AOTNA		991
+755

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF213365 mRNA Translation: AAL36460.1 AB020705 mRNA Translation: BAA74921.1 Different initiation. AK289674 mRNA Translation: BAF82363.1 AK294850 mRNA Translation: BAG57954.1 AK292459 mRNA Translation: BAF85148.1 BX537955 mRNA Translation: CAD97922.1 AC005207 Genomic DNA No translation available. AC036154 Genomic DNA No translation available. AC099850 Genomic DNA No translation available. AC100832 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94425.1 CH471109 Genomic DNA Translation: EAW94426.1 BC036012 mRNA Translation: AAH36012.1
CCDSⁱ	CCDS32694.1 [O94972-1] CCDS45746.1 [O94972-1] CCDS82174.1 [O94972-3]
RefSeqⁱ	NP_001005207.1, NM_001005207.3 [O94972-1] NP_001307916.1, NM_001320987.1 [O94972-3] NP_001307919.1, NM_001320990.1 [O94972-2] NP_056109.1, NM_015294.4 [O94972-1]
UniGeneⁱ	Hs.579079 Hs.605697

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3LRQ	X-ray	2.29	A/B/C/D	1-90	[»]
ProteinModelPortalⁱ	O94972
SMRⁱ	O94972
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110678, 100 interactors
DIPⁱ	DIP-34437N
IntActⁱ	O94972, 66 interactors
STRINGⁱ	9606.ENSP00000262294

PTM databases

iPTMnetⁱ	O94972
PhosphoSitePlusⁱ	O94972

Polymorphism and mutation databases

BioMutaⁱ	TRIM37

BioMutaⁱ

TRIM37

Proteomic databases

EPDⁱ	O94972
MaxQBⁱ	O94972
PaxDbⁱ	O94972
PeptideAtlasⁱ	O94972
PRIDEⁱ	O94972
ProteomicsDBⁱ	50590 50591 [O94972-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000262294; ENSP00000262294; ENSG00000108395 [O94972-1] ENST00000393065; ENSP00000376784; ENSG00000108395 [O94972-3] ENST00000393066; ENSP00000376785; ENSG00000108395 [O94972-1]
GeneIDⁱ	4591
KEGGⁱ	hsa:4591
UCSCⁱ	uc002iwy.5 human [O94972-1] uc010woc.3 human

Organism-specific databases

CTDⁱ	4591
DisGeNETⁱ	4591
EuPathDBⁱ	HostDB:ENSG00000108395.13
GeneCardsⁱ	TRIM37
H-InvDBⁱ	HIX0014039
HGNCⁱ	HGNC:7523 TRIM37
HPAⁱ	HPA021911
MalaCardsⁱ	TRIM37
MIMⁱ	253250 phenotype 605073 gene
neXtProtⁱ	NX_O94972
OpenTargetsⁱ	ENSG00000108395
Orphanetⁱ	2576 MULIBREY nanism
PharmGKBⁱ	PA35497
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410ITG1 Eukaryota ENOG410YSD5 LUCA
GeneTreeⁱ	ENSGT00410000025800
HOGENOMⁱ	HOG000013010
HOVERGENⁱ	HBG057591
InParanoidⁱ	O94972
KOⁱ	K10608
OMAⁱ	MWRVPPD
OrthoDBⁱ	EOG091G01C1
PhylomeDBⁱ	O94972
TreeFamⁱ	TF351092

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
Reactomeⁱ	R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkⁱ	O94972

Miscellaneous databases

ChiTaRSⁱ	TRIM37 human
EvolutionaryTraceⁱ	O94972
GeneWikiⁱ	TRIM37
GenomeRNAiⁱ	4591
Protein Ontology More...PROⁱ	PR:O94972
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000108395 Expressed in 228 organ(s), highest expression level in endometrium epithelium
CleanExⁱ	HS_TRIM37
ExpressionAtlasⁱ	O94972 baseline and differential
Genevisibleⁱ	O94972 HS

Family and domain databases

CDDⁱ	cd00021 BBOX, 1 hit cd03773 MATH_TRIM37, 1 hit
Gene3Dⁱ	2.60.210.10, 1 hit 3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR003649 Bbox_C IPR002083 MATH/TRAF_dom IPR008974 TRAF-like IPR037299 TRIM37_MATH IPR000315 Znf_B-box IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD
Pfamⁱ	View protein in Pfam PF00917 MATH, 1 hit PF00643 zf-B_box, 1 hit
SMARTⁱ	View protein in SMART SM00502 BBC, 1 hit SM00336 BBOX, 1 hit SM00061 MATH, 1 hit
SUPFAMⁱ	SSF49599 SSF49599, 1 hit
PROSITEⁱ	View protein in PROSITE PS50144 MATH, 1 hit PS50119 ZF_BBOX, 1 hit PS50089 ZF_RING_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TRI37_HUMAN
Accessionⁱ	O94972Primary (citable) accession number: O94972 Secondary accession number(s): A8K0V9 Q8WYF7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
	Last sequence update:	November 23, 2004
	Last modified:	November 7, 2018
	This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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Help

UniRef

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Supporting data

UniProtKB - O94972 (TRI37_HUMAN)

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E3 ubiquitin-protein ligase TRIM37

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Peroxisome

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Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

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Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

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Miscellaneous databases

Gene expression databases

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ