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UniProtKB - O94967 (WDR47_HUMAN)

Protein

WD repeat-containing protein 47

Gene

WDR47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O94967

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat-containing protein 47
Alternative name(s):
Neuronal enriched MAP-interacting protein
Short name:
Nemitin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR47
Synonyms:KIAA0893
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000085433.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:29141 WDR47

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615734 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O94967

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000085433

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134937302

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		WDR47

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000513971 – 919WD repeat-containing protein 47Add BLAST919

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei285PhosphothreonineCombined sources1
Modified residuei289PhosphoserineBy similarity1
Modified residuei292PhosphoserineCombined sources1
Modified residuei297PhosphoserineCombined sources1
Modified residuei312PhosphoserineCombined sources1
Modified residuei422PhosphoserineCombined sources1
Modified residuei542PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O94967

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O94967

MaxQB - The MaxQuant DataBase

More...MaxQBi		O94967

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O94967

PeptideAtlas

More...PeptideAtlasi		O94967

PRoteomics IDEntifications database

More...PRIDEi		O94967

ProteomicsDB human proteome resource

More...ProteomicsDBi		50587
50588 [O94967-2]
50589 [O94967-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O94967

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O94967

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000085433 Expressed in 231 organ(s), highest expression level in Ammon's horn

CleanEx database of gene expression profiles

More...CleanExi		HS_WDR47

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O94967 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O94967 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA027287
HPA027289

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MAP1S (via WD repeats).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TCL1AP562793EBI-723239,EBI-749995

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		116574, 16 interactors

Protein interaction database and analysis system

More...IntActi		O94967, 5 interactors

Molecular INTeraction database

More...MINTi		O94967

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		O94967

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 42LisHPROSITE-ProRule annotationAdd BLAST33
Domaini45 – 102CTLHPROSITE-ProRule annotationAdd BLAST58
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati604 – 643WD 1Add BLAST40
Repeati659 – 698WD 2Add BLAST40
Repeati706 – 748WD 3Add BLAST43
Repeati753 – 791WD 4Add BLAST39
Repeati798 – 837WD 5Add BLAST40
Repeati840 – 879WD 6Add BLAST40
Repeati886 – 918WD 7Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi425 – 474Gln-richAdd BLAST50

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0641 Eukaryota
ENOG410YF9K LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155561

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231412

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG058798

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O94967

Identification of Orthologs from Complete Genome Data

More...OMAi		SQQCNGS

Database of Orthologous Groups

More...OrthoDBi		245263at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O94967

TreeFam database of animal gene trees

More...TreeFami		TF312810

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024977 Apc4_WD40_dom
IPR006595 CTLH_C
IPR006594 LisH
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR040067 WDR47

The PANTHER Classification System

More...PANTHERi		PTHR19863 PTHR19863, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF00400 WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00668 CTLH, 1 hit
SM00667 LisH, 1 hit
SM00320 WD40, 7 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50897 CTLH, 1 hit
PS50896 LISH, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94967-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAEETVNVK EVEIIKLILD FLNSKKLHIS MLALEKESGV INGLFSDDML 
        60         70         80         90        100
FLRQLILDGQ WDEVLQFIQP LECMEKFDKK RFRYIILKQK FLEALCVNNA 
       110        120        130        140        150
MSAEDEPQHL EFTMQEAVQC LHALEEYCPS KDDYSKLCLL LTLPRLTNHA 
       160        170        180        190        200
EFKDWNPSTA RVHCFEEACV MVAEFIPADR KLSEAGFKAS NNRLFQLVMK 
       210        220        230        240        250
GLLYECCVEF CQSKATGEEI TESEVLLGID LLCGNGCDDL DLSLLSWLQN 
       260        270        280        290        300
LPSSVFSCAF EQKMLNIHVD KLLKPTKAAY ADLLTPLISK LSPYPSSPMR 
       310        320        330        340        350
RPQSADAYMT RSLNPALDGL TCGLTSHDKR ISDLGNKTSP MSHSFANFHY 
       360        370        380        390        400
PGVQNLSRSL MLENTECHSI YEESPERDTP VDAQRPIGSE ILGQSSVSEK 
       410        420        430        440        450
EPANGAQNPG PAKQEKNELR DSTEQFQEYY RQRLRYQQHL EQKEQQRQIY 
       460        470        480        490        500
QQMLLEGGVN QEDGPDQQQN LTEQFLNRSI QKLGELNIGM DGLGNEVSAL 
       510        520        530        540        550
NQQCNGSKGN GSNGSSVTSF TTPPQDSSQR LTHDASNIHT STPRNPGSTN 
       560        570        580        590        600
HIPFLEESPC GSQISSEHSV IKPPLGDSPG SLSRSKGEED DKSKKQFVCI 
       610        620        630        640        650
NILEDTQAVR AVAFHPAGGL YAVGSNSKTL RVCAYPDVID PSAHETPKQP 
       660        670        680        690        700
VVRFKRNKHH KGSIYCVAWS PCGQLLATGS NDKYVKVLPF NAETCNATGP 
       710        720        730        740        750
DLEFSMHDGT IRDLAFMEGP ESGGAILISA GAGDCNIYTT DCQRGQGLHA 
       760        770        780        790        800
LSGHTGHILA LYTWSGWMIA SGSQDKTVRF WDLRVPSCVR VVGTTFHGTG 
       810        820        830        840        850
SAVASVAVDP SGRLLATGQE DSSCMLYDIR GGRMVQSYHP HSSDVRSVRF 
       860        870        880        890        900
SPGAHYLLTG SYDMKIKVTD LQGDLTKQLP IMVVGEHKDK VIQCRWHTQD 
       910 
LSFLSSSADR TVTLWTYNG
Length:919
Mass (Da):101,949
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2BC571E17DB67166
GO
Isoform 2 (identifier: O94967-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-81: Missing.

Note: No experimental confirmation available.
Show »
Length:891
Mass (Da):98,516
Checksum:i5BDD9AC951F800D1
GO
Isoform 3 (identifier: O94967-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     377-377: R → RS

Show »
Length:920
Mass (Da):102,036
Checksum:i4C68054216E3515C
GO
Isoform 4 (identifier: O94967-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-109: H → HVRFLFLK
     377-377: R → RS

Note: No experimental confirmation available.
Show »
Length:927
Mass (Da):102,940
Checksum:iC9B4FE4F4992A2EE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRE6A0A0A0MRE6_HUMAN
WD repeat-containing protein 47
WDR47
893Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PR96E9PR96_HUMAN
WD repeat-containing protein 47
WDR47
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKZ6E9PKZ6_HUMAN
WD repeat-containing protein 47
WDR47
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNF6E9PNF6_HUMAN
WD repeat-containing protein 47
WDR47
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PN15E9PN15_HUMAN
WD repeat-containing protein 47
WDR47
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AK225781 differs from that shown. Reason: Frameshift at position 416.Curated
The sequence BAA74916 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti298P → Q in AAH39254 (PubMed:15489334).Curated1
Sequence conflicti369S → C in AAH39254 (PubMed:15489334).Curated1
Sequence conflicti698T → TVS in AAH39254 (PubMed:15489334).Curated1
Sequence conflicti779R → G in AAH34964 (PubMed:15489334).Curated1
Sequence conflicti789V → A in AAH34964 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01209354 – 81Missing in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_046727109H → HVRFLFLK in isoform 4. 1 Publication1
Alternative sequenceiVSP_035045377R → RS in isoform 3 and isoform 4. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB020700 mRNA Translation: BAA74916.2 Different initiation.
AK289789 mRNA Translation: BAF82478.1
AK225781 mRNA No translation available.
BX679664 Genomic DNA No translation available.
AL449266 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56350.1
CH471122 Genomic DNA Translation: EAW56351.1
BC034964 mRNA Translation: AAH34964.1
BC039254 mRNA Translation: AAH39254.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30787.1 [O94967-3]
CCDS44186.1 [O94967-4]
CCDS44187.1 [O94967-1]

NCBI Reference Sequences

More...RefSeqi		NP_001136022.1, NM_001142550.1 [O94967-4]
NP_001136023.1, NM_001142551.1 [O94967-1]
NP_055784.3, NM_014969.5 [O94967-3]
XP_016856186.1, XM_017000697.1 [O94967-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.570055

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000361054; ENSP00000354339; ENSG00000085433 [O94967-2]
ENST00000369962; ENSP00000358979; ENSG00000085433 [O94967-1]
ENST00000369965; ENSP00000358982; ENSG00000085433 [O94967-3]
ENST00000400794; ENSP00000383599; ENSG00000085433 [O94967-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		22911

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:22911

UCSC genome browser

More...UCSCi		uc001dwi.4 human [O94967-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020700 mRNA Translation: BAA74916.2 Different initiation.
AK289789 mRNA Translation: BAF82478.1
AK225781 mRNA No translation available.
BX679664 Genomic DNA No translation available.
AL449266 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56350.1
CH471122 Genomic DNA Translation: EAW56351.1
BC034964 mRNA Translation: AAH34964.1
BC039254 mRNA Translation: AAH39254.1
CCDSiCCDS30787.1 [O94967-3]
CCDS44186.1 [O94967-4]
CCDS44187.1 [O94967-1]
RefSeqiNP_001136022.1, NM_001142550.1 [O94967-4]
NP_001136023.1, NM_001142551.1 [O94967-1]
NP_055784.3, NM_014969.5 [O94967-3]
XP_016856186.1, XM_017000697.1 [O94967-1]
UniGeneiHs.570055

3D structure databases

ProteinModelPortaliO94967
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116574, 16 interactors
IntActiO94967, 5 interactors
MINTiO94967

PTM databases

iPTMnetiO94967
PhosphoSitePlusiO94967

Polymorphism and mutation databases

BioMutaiWDR47

Proteomic databases

EPDiO94967
jPOSTiO94967
MaxQBiO94967
PaxDbiO94967
PeptideAtlasiO94967
PRIDEiO94967
ProteomicsDBi50587
50588 [O94967-2]
50589 [O94967-3]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		22911
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361054; ENSP00000354339; ENSG00000085433 [O94967-2]
ENST00000369962; ENSP00000358979; ENSG00000085433 [O94967-1]
ENST00000369965; ENSP00000358982; ENSG00000085433 [O94967-3]
ENST00000400794; ENSP00000383599; ENSG00000085433 [O94967-4]
GeneIDi22911
KEGGihsa:22911
UCSCiuc001dwi.4 human [O94967-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		22911
EuPathDBiHostDB:ENSG00000085433.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		WDR47
HGNCiHGNC:29141 WDR47
HPAiHPA027287
HPA027289
MIMi615734 gene
neXtProtiNX_O94967
OpenTargetsiENSG00000085433
PharmGKBiPA134937302

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0641 Eukaryota
ENOG410YF9K LUCA
GeneTreeiENSGT00940000155561
HOGENOMiHOG000231412
HOVERGENiHBG058798
InParanoidiO94967
OMAiSQQCNGS
OrthoDBi245263at2759
PhylomeDBiO94967
TreeFamiTF312810

Enzyme and pathway databases

SignaLinkiO94967

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		WDR47 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		WDR47

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		22911

Protein Ontology

More...PROi		PR:O94967

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000085433 Expressed in 231 organ(s), highest expression level in Ammon's horn
CleanExiHS_WDR47
ExpressionAtlasiO94967 baseline and differential
GenevisibleiO94967 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR006595 CTLH_C
IPR006594 LisH
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR040067 WDR47
PANTHERiPTHR19863 PTHR19863, 1 hit
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00668 CTLH, 1 hit
SM00667 LisH, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50897 CTLH, 1 hit
PS50896 LISH, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR47_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94967
Secondary accession number(s): A8MX09
, Q5TYV7, Q5TYV8, Q5TYV9, Q8IXT7, Q8IYU9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 1999
Last modified: January 16, 2019
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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