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UniProtKB - O94967 (WDR47_HUMAN)

Protein

WD repeat-containing protein 47

Gene

WDR47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

SignaLinkiO94967

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 47
Alternative name(s):
Neuronal enriched MAP-interacting protein
Short name:
Nemitin
Gene namesi
Name:WDR47
Synonyms:KIAA0893
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000085433.15
HGNCiHGNC:29141 WDR47
MIMi615734 gene
neXtProtiNX_O94967

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000085433
PharmGKBiPA134937302

Polymorphism and mutation databases

BioMutaiWDR47

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513971 – 919WD repeat-containing protein 47Add BLAST919

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei285PhosphothreonineCombined sources1
Modified residuei289PhosphoserineBy similarity1
Modified residuei292PhosphoserineCombined sources1
Modified residuei297PhosphoserineCombined sources1
Modified residuei312PhosphoserineCombined sources1
Modified residuei422PhosphoserineCombined sources1
Modified residuei542PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO94967
MaxQBiO94967
PaxDbiO94967
PeptideAtlasiO94967
PRIDEiO94967
ProteomicsDBi50587
50588 [O94967-2]
50589 [O94967-3]

PTM databases

iPTMnetiO94967
PhosphoSitePlusiO94967

Expressioni

Gene expression databases

BgeeiENSG00000085433 Expressed in 231 organ(s), highest expression level in Ammon's horn
CleanExiHS_WDR47
ExpressionAtlasiO94967 baseline and differential
GenevisibleiO94967 HS

Organism-specific databases

HPAiHPA027287
HPA027289

Interactioni

Subunit structurei

Interacts with MAP1S (via WD repeats).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TCL1AP562793EBI-723239,EBI-749995

Protein-protein interaction databases

BioGridi116574, 16 interactors
IntActiO94967, 5 interactors
MINTiO94967

Structurei

3D structure databases

ProteinModelPortaliO94967
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 42LisHPROSITE-ProRule annotationAdd BLAST33
Domaini45 – 102CTLHPROSITE-ProRule annotationAdd BLAST58
Repeati604 – 643WD 1Add BLAST40
Repeati659 – 698WD 2Add BLAST40
Repeati706 – 748WD 3Add BLAST43
Repeati753 – 791WD 4Add BLAST39
Repeati798 – 837WD 5Add BLAST40
Repeati840 – 879WD 6Add BLAST40
Repeati886 – 918WD 7Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi425 – 474Gln-richAdd BLAST50

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0641 Eukaryota
ENOG410YF9K LUCA
GeneTreeiENSGT00760000119239
HOGENOMiHOG000231412
HOVERGENiHBG058798
InParanoidiO94967
OMAiSQQCNGS
OrthoDBiEOG091G08TY
PhylomeDBiO94967
TreeFamiTF312810

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR006595 CTLH_C
IPR006594 LisH
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00668 CTLH, 1 hit
SM00667 LisH, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50897 CTLH, 1 hit
PS50896 LISH, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94967-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAEETVNVK EVEIIKLILD FLNSKKLHIS MLALEKESGV INGLFSDDML 
        60         70         80         90        100
FLRQLILDGQ WDEVLQFIQP LECMEKFDKK RFRYIILKQK FLEALCVNNA 
       110        120        130        140        150
MSAEDEPQHL EFTMQEAVQC LHALEEYCPS KDDYSKLCLL LTLPRLTNHA 
       160        170        180        190        200
EFKDWNPSTA RVHCFEEACV MVAEFIPADR KLSEAGFKAS NNRLFQLVMK 
       210        220        230        240        250
GLLYECCVEF CQSKATGEEI TESEVLLGID LLCGNGCDDL DLSLLSWLQN 
       260        270        280        290        300
LPSSVFSCAF EQKMLNIHVD KLLKPTKAAY ADLLTPLISK LSPYPSSPMR 
       310        320        330        340        350
RPQSADAYMT RSLNPALDGL TCGLTSHDKR ISDLGNKTSP MSHSFANFHY 
       360        370        380        390        400
PGVQNLSRSL MLENTECHSI YEESPERDTP VDAQRPIGSE ILGQSSVSEK 
       410        420        430        440        450
EPANGAQNPG PAKQEKNELR DSTEQFQEYY RQRLRYQQHL EQKEQQRQIY 
       460        470        480        490        500
QQMLLEGGVN QEDGPDQQQN LTEQFLNRSI QKLGELNIGM DGLGNEVSAL 
       510        520        530        540        550
NQQCNGSKGN GSNGSSVTSF TTPPQDSSQR LTHDASNIHT STPRNPGSTN 
       560        570        580        590        600
HIPFLEESPC GSQISSEHSV IKPPLGDSPG SLSRSKGEED DKSKKQFVCI 
       610        620        630        640        650
NILEDTQAVR AVAFHPAGGL YAVGSNSKTL RVCAYPDVID PSAHETPKQP 
       660        670        680        690        700
VVRFKRNKHH KGSIYCVAWS PCGQLLATGS NDKYVKVLPF NAETCNATGP 
       710        720        730        740        750
DLEFSMHDGT IRDLAFMEGP ESGGAILISA GAGDCNIYTT DCQRGQGLHA 
       760        770        780        790        800
LSGHTGHILA LYTWSGWMIA SGSQDKTVRF WDLRVPSCVR VVGTTFHGTG 
       810        820        830        840        850
SAVASVAVDP SGRLLATGQE DSSCMLYDIR GGRMVQSYHP HSSDVRSVRF 
       860        870        880        890        900
SPGAHYLLTG SYDMKIKVTD LQGDLTKQLP IMVVGEHKDK VIQCRWHTQD 
       910 
LSFLSSSADR TVTLWTYNG
Length:919
Mass (Da):101,949
Last modified:May 1, 1999 - v1
Checksum:i2BC571E17DB67166
GO
Isoform 2 (identifier: O94967-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-81: Missing.

Note: No experimental confirmation available.
Show »
Length:891
Mass (Da):98,516
Checksum:i5BDD9AC951F800D1
GO
Isoform 3 (identifier: O94967-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     377-377: R → RS

Show »
Length:920
Mass (Da):102,036
Checksum:i4C68054216E3515C
GO
Isoform 4 (identifier: O94967-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-109: H → HVRFLFLK
     377-377: R → RS

Note: No experimental confirmation available.
Show »
Length:927
Mass (Da):102,940
Checksum:iC9B4FE4F4992A2EE
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRE6A0A0A0MRE6_HUMAN
WD repeat-containing protein 47
WDR47
893Annotation score:
E9PKZ6E9PKZ6_HUMAN
WD repeat-containing protein 47
WDR47
106Annotation score:
E9PR96E9PR96_HUMAN
WD repeat-containing protein 47
WDR47
173Annotation score:
E9PNF6E9PNF6_HUMAN
WD repeat-containing protein 47
WDR47
93Annotation score:
E9PN15E9PN15_HUMAN
WD repeat-containing protein 47
WDR47
56Annotation score:

Sequence cautioni

The sequence AK225781 differs from that shown. Reason: Frameshift at position 416.Curated
The sequence BAA74916 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti298P → Q in AAH39254 (PubMed:15489334).Curated1
Sequence conflicti369S → C in AAH39254 (PubMed:15489334).Curated1
Sequence conflicti698T → TVS in AAH39254 (PubMed:15489334).Curated1
Sequence conflicti779R → G in AAH34964 (PubMed:15489334).Curated1
Sequence conflicti789V → A in AAH34964 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01209354 – 81Missing in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_046727109H → HVRFLFLK in isoform 4. 1 Publication1
Alternative sequenceiVSP_035045377R → RS in isoform 3 and isoform 4. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020700 mRNA Translation: BAA74916.2 Different initiation.
AK289789 mRNA Translation: BAF82478.1
AK225781 mRNA No translation available.
BX679664 Genomic DNA No translation available.
AL449266 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56350.1
CH471122 Genomic DNA Translation: EAW56351.1
BC034964 mRNA Translation: AAH34964.1
BC039254 mRNA Translation: AAH39254.1
CCDSiCCDS30787.1 [O94967-3]
CCDS44186.1 [O94967-4]
CCDS44187.1 [O94967-1]
RefSeqiNP_001136022.1, NM_001142550.1 [O94967-4]
NP_001136023.1, NM_001142551.1 [O94967-1]
NP_055784.3, NM_014969.5 [O94967-3]
XP_016856186.1, XM_017000697.1 [O94967-1]
UniGeneiHs.570055

Genome annotation databases

EnsembliENST00000361054; ENSP00000354339; ENSG00000085433 [O94967-2]
ENST00000369962; ENSP00000358979; ENSG00000085433 [O94967-1]
ENST00000369965; ENSP00000358982; ENSG00000085433 [O94967-3]
ENST00000400794; ENSP00000383599; ENSG00000085433 [O94967-4]
GeneIDi22911
KEGGihsa:22911
UCSCiuc001dwi.4 human [O94967-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020700 mRNA Translation: BAA74916.2 Different initiation.
AK289789 mRNA Translation: BAF82478.1
AK225781 mRNA No translation available.
BX679664 Genomic DNA No translation available.
AL449266 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56350.1
CH471122 Genomic DNA Translation: EAW56351.1
BC034964 mRNA Translation: AAH34964.1
BC039254 mRNA Translation: AAH39254.1
CCDSiCCDS30787.1 [O94967-3]
CCDS44186.1 [O94967-4]
CCDS44187.1 [O94967-1]
RefSeqiNP_001136022.1, NM_001142550.1 [O94967-4]
NP_001136023.1, NM_001142551.1 [O94967-1]
NP_055784.3, NM_014969.5 [O94967-3]
XP_016856186.1, XM_017000697.1 [O94967-1]
UniGeneiHs.570055

3D structure databases

ProteinModelPortaliO94967
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116574, 16 interactors
IntActiO94967, 5 interactors
MINTiO94967

PTM databases

iPTMnetiO94967
PhosphoSitePlusiO94967

Polymorphism and mutation databases

BioMutaiWDR47

Proteomic databases

EPDiO94967
MaxQBiO94967
PaxDbiO94967
PeptideAtlasiO94967
PRIDEiO94967
ProteomicsDBi50587
50588 [O94967-2]
50589 [O94967-3]

Protocols and materials databases

DNASUi22911
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361054; ENSP00000354339; ENSG00000085433 [O94967-2]
ENST00000369962; ENSP00000358979; ENSG00000085433 [O94967-1]
ENST00000369965; ENSP00000358982; ENSG00000085433 [O94967-3]
ENST00000400794; ENSP00000383599; ENSG00000085433 [O94967-4]
GeneIDi22911
KEGGihsa:22911
UCSCiuc001dwi.4 human [O94967-1]

Organism-specific databases

CTDi22911
EuPathDBiHostDB:ENSG00000085433.15
GeneCardsiWDR47
HGNCiHGNC:29141 WDR47
HPAiHPA027287
HPA027289
MIMi615734 gene
neXtProtiNX_O94967
OpenTargetsiENSG00000085433
PharmGKBiPA134937302
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0641 Eukaryota
ENOG410YF9K LUCA
GeneTreeiENSGT00760000119239
HOGENOMiHOG000231412
HOVERGENiHBG058798
InParanoidiO94967
OMAiSQQCNGS
OrthoDBiEOG091G08TY
PhylomeDBiO94967
TreeFamiTF312810

Enzyme and pathway databases

SignaLinkiO94967

Miscellaneous databases

ChiTaRSiWDR47 human
GeneWikiiWDR47
GenomeRNAii22911
PROiPR:O94967
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000085433 Expressed in 231 organ(s), highest expression level in Ammon's horn
CleanExiHS_WDR47
ExpressionAtlasiO94967 baseline and differential
GenevisibleiO94967 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR006595 CTLH_C
IPR006594 LisH
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00668 CTLH, 1 hit
SM00667 LisH, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50897 CTLH, 1 hit
PS50896 LISH, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWDR47_HUMAN
AccessioniPrimary (citable) accession number: O94967
Secondary accession number(s): A8MX09
, Q5TYV7, Q5TYV8, Q5TYV9, Q8IXT7, Q8IYU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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