UniProtKB - O94967 (WDR47_HUMAN)
Protein
WD repeat-containing protein 47
Gene
WDR47
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein |
Enzyme and pathway databases
PathwayCommonsi | O94967 |
SignaLinki | O94967 |
Names & Taxonomyi
Protein namesi | Recommended name: WD repeat-containing protein 47Alternative name(s): Neuronal enriched MAP-interacting protein Short name: Nemitin |
Gene namesi | Name:WDR47 Synonyms:KIAA0893 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000085433.15 |
HGNCi | HGNC:29141, WDR47 |
MIMi | 615734, gene |
neXtProti | NX_O94967 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Note: Localization along microtubules is mediated by MAP1S.By similarity
Cytoskeleton
- microtubule Source: UniProtKB-KW
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePathology & Biotechi
Organism-specific databases
DisGeNETi | 22911 |
OpenTargetsi | ENSG00000085433 |
PharmGKBi | PA134937302 |
Miscellaneous databases
Pharosi | O94967, Tdark |
Polymorphism and mutation databases
BioMutai | WDR47 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051397 | 1 – 919 | WD repeat-containing protein 47Add BLAST | 919 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 285 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 289 | PhosphoserineBy similarity | 1 | |
Modified residuei | 292 | PhosphoserineCombined sources | 1 | |
Modified residuei | 297 | PhosphoserineCombined sources | 1 | |
Modified residuei | 312 | PhosphoserineCombined sources | 1 | |
Modified residuei | 422 | PhosphoserineCombined sources | 1 | |
Modified residuei | 542 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O94967 |
jPOSTi | O94967 |
MassIVEi | O94967 |
MaxQBi | O94967 |
PaxDbi | O94967 |
PeptideAtlasi | O94967 |
PRIDEi | O94967 |
ProteomicsDBi | 2284 50587 [O94967-1] 50588 [O94967-2] 50589 [O94967-3] |
PTM databases
iPTMneti | O94967 |
PhosphoSitePlusi | O94967 |
Expressioni
Gene expression databases
Bgeei | ENSG00000085433, Expressed in Ammon's horn and 244 other tissues |
ExpressionAtlasi | O94967, baseline and differential |
Genevisiblei | O94967, HS |
Organism-specific databases
HPAi | ENSG00000085433, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts with MAP1S (via WD repeats).
By similarityBinary interactionsi
O94967
With | #Exp. | IntAct |
---|---|---|
TCL1A [P56279] | 3 | EBI-723239,EBI-749995 |
Protein-protein interaction databases
BioGRIDi | 116574, 21 interactors |
IntActi | O94967, 15 interactors |
MINTi | O94967 |
STRINGi | 9606.ENSP00000383599 |
Miscellaneous databases
RNActi | O94967, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 42 | LisHPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 45 – 102 | CTLHPROSITE-ProRule annotationAdd BLAST | 58 | |
Repeati | 604 – 643 | WD 1Add BLAST | 40 | |
Repeati | 659 – 698 | WD 2Add BLAST | 40 | |
Repeati | 706 – 748 | WD 3Add BLAST | 43 | |
Repeati | 753 – 791 | WD 4Add BLAST | 39 | |
Repeati | 798 – 837 | WD 5Add BLAST | 40 | |
Repeati | 840 – 879 | WD 6Add BLAST | 40 | |
Repeati | 886 – 918 | WD 7Add BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 425 – 474 | Gln-richAdd BLAST | 50 |
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0641, Eukaryota |
GeneTreei | ENSGT00940000155561 |
HOGENOMi | CLU_014985_0_0_1 |
InParanoidi | O94967 |
OMAi | ECHSIFE |
OrthoDBi | 245263at2759 |
PhylomeDBi | O94967 |
TreeFami | TF312810 |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR024977, Apc4_WD40_dom IPR006595, CTLH_C IPR006594, LisH IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf IPR040067, WDR47 |
PANTHERi | PTHR19863, PTHR19863, 1 hit |
Pfami | View protein in Pfam PF12894, ANAPC4_WD40, 1 hit PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00668, CTLH, 1 hit SM00667, LisH, 1 hit SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50897, CTLH, 1 hit PS50896, LISH, 1 hit PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 5 hits PS50294, WD_REPEATS_REGION, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O94967-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTAEETVNVK EVEIIKLILD FLNSKKLHIS MLALEKESGV INGLFSDDML
60 70 80 90 100
FLRQLILDGQ WDEVLQFIQP LECMEKFDKK RFRYIILKQK FLEALCVNNA
110 120 130 140 150
MSAEDEPQHL EFTMQEAVQC LHALEEYCPS KDDYSKLCLL LTLPRLTNHA
160 170 180 190 200
EFKDWNPSTA RVHCFEEACV MVAEFIPADR KLSEAGFKAS NNRLFQLVMK
210 220 230 240 250
GLLYECCVEF CQSKATGEEI TESEVLLGID LLCGNGCDDL DLSLLSWLQN
260 270 280 290 300
LPSSVFSCAF EQKMLNIHVD KLLKPTKAAY ADLLTPLISK LSPYPSSPMR
310 320 330 340 350
RPQSADAYMT RSLNPALDGL TCGLTSHDKR ISDLGNKTSP MSHSFANFHY
360 370 380 390 400
PGVQNLSRSL MLENTECHSI YEESPERDTP VDAQRPIGSE ILGQSSVSEK
410 420 430 440 450
EPANGAQNPG PAKQEKNELR DSTEQFQEYY RQRLRYQQHL EQKEQQRQIY
460 470 480 490 500
QQMLLEGGVN QEDGPDQQQN LTEQFLNRSI QKLGELNIGM DGLGNEVSAL
510 520 530 540 550
NQQCNGSKGN GSNGSSVTSF TTPPQDSSQR LTHDASNIHT STPRNPGSTN
560 570 580 590 600
HIPFLEESPC GSQISSEHSV IKPPLGDSPG SLSRSKGEED DKSKKQFVCI
610 620 630 640 650
NILEDTQAVR AVAFHPAGGL YAVGSNSKTL RVCAYPDVID PSAHETPKQP
660 670 680 690 700
VVRFKRNKHH KGSIYCVAWS PCGQLLATGS NDKYVKVLPF NAETCNATGP
710 720 730 740 750
DLEFSMHDGT IRDLAFMEGP ESGGAILISA GAGDCNIYTT DCQRGQGLHA
760 770 780 790 800
LSGHTGHILA LYTWSGWMIA SGSQDKTVRF WDLRVPSCVR VVGTTFHGTG
810 820 830 840 850
SAVASVAVDP SGRLLATGQE DSSCMLYDIR GGRMVQSYHP HSSDVRSVRF
860 870 880 890 900
SPGAHYLLTG SYDMKIKVTD LQGDLTKQLP IMVVGEHKDK VIQCRWHTQD
910
LSFLSSSADR TVTLWTYNG
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MRE6 | A0A0A0MRE6_HUMAN | WD repeat-containing protein 47 | WDR47 | 893 | Annotation score: | ||
E9PR96 | E9PR96_HUMAN | WD repeat-containing protein 47 | WDR47 | 173 | Annotation score: | ||
E9PKZ6 | E9PKZ6_HUMAN | WD repeat-containing protein 47 | WDR47 | 106 | Annotation score: | ||
E9PN15 | E9PN15_HUMAN | WD repeat-containing protein 47 | WDR47 | 56 | Annotation score: | ||
E9PNF6 | E9PNF6_HUMAN | WD repeat-containing protein 47 | WDR47 | 93 | Annotation score: |
Sequence cautioni
The sequence AK225781 differs from that shown. Reason: Frameshift.Curated
The sequence BAA74916 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 298 | P → Q in AAH39254 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 369 | S → C in AAH39254 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 698 | T → TVS in AAH39254 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 779 | R → G in AAH34964 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 789 | V → A in AAH34964 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012093 | 54 – 81 | Missing in isoform 2. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_046727 | 109 | H → HVRFLFLK in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_035045 | 377 | R → RS in isoform 3 and isoform 4. 3 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB020700 mRNA Translation: BAA74916.2 Different initiation. AK289789 mRNA Translation: BAF82478.1 AK225781 mRNA No translation available. BX679664 Genomic DNA No translation available. AL449266 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56350.1 CH471122 Genomic DNA Translation: EAW56351.1 BC034964 mRNA Translation: AAH34964.1 BC039254 mRNA Translation: AAH39254.1 |
CCDSi | CCDS30787.1 [O94967-3] CCDS44186.1 [O94967-4] CCDS44187.1 [O94967-1] |
RefSeqi | NP_001136022.1, NM_001142550.1 [O94967-4] NP_001136023.1, NM_001142551.1 [O94967-1] NP_055784.3, NM_014969.5 [O94967-3] XP_016856186.1, XM_017000697.1 [O94967-1] |
Genome annotation databases
Ensembli | ENST00000361054; ENSP00000354339; ENSG00000085433 [O94967-2] ENST00000369962; ENSP00000358979; ENSG00000085433 [O94967-1] ENST00000369965; ENSP00000358982; ENSG00000085433 [O94967-3] ENST00000400794; ENSP00000383599; ENSG00000085433 [O94967-4] |
GeneIDi | 22911 |
KEGGi | hsa:22911 |
UCSCi | uc001dwi.4, human [O94967-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB020700 mRNA Translation: BAA74916.2 Different initiation. AK289789 mRNA Translation: BAF82478.1 AK225781 mRNA No translation available. BX679664 Genomic DNA No translation available. AL449266 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56350.1 CH471122 Genomic DNA Translation: EAW56351.1 BC034964 mRNA Translation: AAH34964.1 BC039254 mRNA Translation: AAH39254.1 |
CCDSi | CCDS30787.1 [O94967-3] CCDS44186.1 [O94967-4] CCDS44187.1 [O94967-1] |
RefSeqi | NP_001136022.1, NM_001142550.1 [O94967-4] NP_001136023.1, NM_001142551.1 [O94967-1] NP_055784.3, NM_014969.5 [O94967-3] XP_016856186.1, XM_017000697.1 [O94967-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 116574, 21 interactors |
IntActi | O94967, 15 interactors |
MINTi | O94967 |
STRINGi | 9606.ENSP00000383599 |
PTM databases
iPTMneti | O94967 |
PhosphoSitePlusi | O94967 |
Polymorphism and mutation databases
BioMutai | WDR47 |
Proteomic databases
EPDi | O94967 |
jPOSTi | O94967 |
MassIVEi | O94967 |
MaxQBi | O94967 |
PaxDbi | O94967 |
PeptideAtlasi | O94967 |
PRIDEi | O94967 |
ProteomicsDBi | 2284 50587 [O94967-1] 50588 [O94967-2] 50589 [O94967-3] |
Protocols and materials databases
Antibodypediai | 33741, 44 antibodies |
DNASUi | 22911 |
Genome annotation databases
Ensembli | ENST00000361054; ENSP00000354339; ENSG00000085433 [O94967-2] ENST00000369962; ENSP00000358979; ENSG00000085433 [O94967-1] ENST00000369965; ENSP00000358982; ENSG00000085433 [O94967-3] ENST00000400794; ENSP00000383599; ENSG00000085433 [O94967-4] |
GeneIDi | 22911 |
KEGGi | hsa:22911 |
UCSCi | uc001dwi.4, human [O94967-1] |
Organism-specific databases
CTDi | 22911 |
DisGeNETi | 22911 |
EuPathDBi | HostDB:ENSG00000085433.15 |
GeneCardsi | WDR47 |
HGNCi | HGNC:29141, WDR47 |
HPAi | ENSG00000085433, Tissue enhanced (brain) |
MIMi | 615734, gene |
neXtProti | NX_O94967 |
OpenTargetsi | ENSG00000085433 |
PharmGKBi | PA134937302 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0641, Eukaryota |
GeneTreei | ENSGT00940000155561 |
HOGENOMi | CLU_014985_0_0_1 |
InParanoidi | O94967 |
OMAi | ECHSIFE |
OrthoDBi | 245263at2759 |
PhylomeDBi | O94967 |
TreeFami | TF312810 |
Enzyme and pathway databases
PathwayCommonsi | O94967 |
SignaLinki | O94967 |
Miscellaneous databases
BioGRID-ORCSi | 22911, 3 hits in 847 CRISPR screens |
ChiTaRSi | WDR47, human |
GeneWikii | WDR47 |
GenomeRNAii | 22911 |
Pharosi | O94967, Tdark |
PROi | PR:O94967 |
RNActi | O94967, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000085433, Expressed in Ammon's horn and 244 other tissues |
ExpressionAtlasi | O94967, baseline and differential |
Genevisiblei | O94967, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR024977, Apc4_WD40_dom IPR006595, CTLH_C IPR006594, LisH IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf IPR040067, WDR47 |
PANTHERi | PTHR19863, PTHR19863, 1 hit |
Pfami | View protein in Pfam PF12894, ANAPC4_WD40, 1 hit PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00668, CTLH, 1 hit SM00667, LisH, 1 hit SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50897, CTLH, 1 hit PS50896, LISH, 1 hit PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 5 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | WDR47_HUMAN | |
Accessioni | O94967Primary (citable) accession number: O94967 Secondary accession number(s): A8MX09 Q8IYU9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2001 |
Last sequence update: | May 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM