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Entry version 170 (12 Aug 2020)
Sequence version 2 (30 Nov 2010)
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Protein

Solute carrier organic anion transporter family member 2B1

Gene

SLCO2B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the Na+-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O94956

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-189483, Heme degradation [O94956-3]
R-HSA-879518, Transport of organic anions

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.60.1.20, the organo anion transporter (oat) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 2B1
Alternative name(s):
Organic anion transporter B
Short name:
OATP-B
Organic anion transporter polypeptide-related protein 2
Short name:
OATP-RP2
Short name:
OATPRP2
Solute carrier family 21 member 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLCO2B1
Synonyms:KIAA0880, OATP2B1, OATPB, SLC21A9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000137491.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10962, SLCO2B1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604988, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O94956

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 49CytoplasmicSequence analysisAdd BLAST49
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei50 – 69Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini70 – 88ExtracellularSequence analysisAdd BLAST19
Transmembranei89 – 109Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini110 – 115CytoplasmicSequence analysis6
Transmembranei116 – 140Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini141 – 185ExtracellularSequence analysisAdd BLAST45
Transmembranei186 – 215Helical; Name=4Sequence analysisAdd BLAST30
Topological domaini216 – 234CytoplasmicSequence analysisAdd BLAST19
Transmembranei235 – 255Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini256 – 273ExtracellularSequence analysisAdd BLAST18
Transmembranei274 – 298Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini299 – 366CytoplasmicSequence analysisAdd BLAST68
Transmembranei367 – 388Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini389 – 408ExtracellularSequence analysisAdd BLAST20
Transmembranei409 – 432Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini433 – 436CytoplasmicSequence analysis4
Transmembranei437 – 460Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini461 – 564ExtracellularSequence analysisAdd BLAST104
Transmembranei565 – 587Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini588 – 596CytoplasmicSequence analysis9
Transmembranei597 – 622Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini623 – 655ExtracellularSequence analysisAdd BLAST33
Transmembranei656 – 673Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini674 – 709CytoplasmicSequence analysisAdd BLAST36

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11309

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35845

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O94956, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1743124

Drug and drug target database

More...
DrugBanki
DB03166, Acetic acid
DB00770, Alprostadil
DB11586, Asunaprevir
DB01072, Atazanavir
DB01076, Atorvastatin
DB12319, Benzbromarone
DB03793, Benzoic acid
DB01053, Benzylpenicillin
DB11591, Bilastine
DB08862, Cholecystokinin
DB04272, Citric acid
DB00286, Conjugated estrogens
DB09213, Dexibuprofen
DB00255, Diethylstilbestrol
DB00917, Dinoprostone
DB00975, Dipyridamole
DB05928, Dovitinib
DB00530, Erlotinib
DB13952, Estradiol acetate
DB13953, Estradiol benzoate
DB13954, Estradiol cypionate
DB13955, Estradiol dienanthate
DB13956, Estradiol valerate
DB00655, Estrone
DB00950, Fexofenadine
DB01095, Fluvastatin
DB01241, Gemfibrozil
DB01645, Genistein
DB01016, Glyburide
DB01050, Ibuprofen
DB01088, Iloprost
DB00224, Indinavir
DB01167, Itraconazole
DB04398, Lactic acid
DB11660, Latanoprostene bunod
DB00451, Levothyroxine
DB11611, Lifitegrast
DB00227, Lovastatin
DB00471, Montelukast
DB03467, Naringenin
DB01149, Nefazodone
DB00220, Nelfinavir
DB00627, Niacin
DB01051, Novobiocin
DB03902, Oxalic Acid
DB12978, Pexidartinib
DB02746, Phthalic Acid
DB00554, Piroxicam
DB08860, Pitavastatin
DB01708, Prasterone
DB05804, Prasterone sulfate
DB00175, Pravastatin
DB04216, Quercetin
DB00206, Reserpine
DB01045, Rifampicin
DB11753, Rifamycin
DB00503, Ritonavir
DB01098, Rosuvastatin
DB00936, Salicylic acid
DB01232, Saquinavir
DB09298, Silibinin
DB06290, Simeprevir
DB00641, Simvastatin
DB00795, Sulfasalazine
DB04348, Taurocholic acid
DB05521, Telaprevir
DB00759, Tetracycline
DB00932, Tipranavir
DB01124, Tolbutamide
DB00313, Valproic acid
DB11613, Velpatasvir

DrugCentral

More...
DrugCentrali
O94956

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1224

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLCO2B1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001910611 – 709Solute carrier organic anion transporter family member 2B1Add BLAST709

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei34PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei318PhosphothreonineCombined sources1
Modified residuei320PhosphoserineCombined sources1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi489 ↔ 516PROSITE-ProRule annotation
Disulfide bondi493 ↔ 504PROSITE-ProRule annotation
Disulfide bondi495 ↔ 520PROSITE-ProRule annotation
Glycosylationi538N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O94956

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O94956

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O94956

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94956

PeptideAtlas

More...
PeptideAtlasi
O94956

PRoteomics IDEntifications database

More...
PRIDEi
O94956

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
17820
22826
50577 [O94956-1]
50578 [O94956-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
O94956, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O94956

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O94956

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 has it's highest expression in brain, it is the major form expressed in duodenum, kidney, placenta, and skeletal muscle. Isoform 3 predominates in liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137491, Expressed in right lobe of liver and 212 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O94956, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O94956, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000137491, Tissue enhanced (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116442, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000289575

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O94956

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O94956, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini483 – 543Kazal-likePROSITE-ProRule annotationAdd BLAST61

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3626, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008954_4_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O94956

KEGG Orthology (KO)

More...
KOi
K14352

Database of Orthologous Groups

More...
OrthoDBi
1029129at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O94956

TreeFam database of animal gene trees

More...
TreeFami
TF317540

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002350, Kazal_dom
IPR036259, MFS_trans_sf
IPR004156, OATP

The PANTHER Classification System

More...
PANTHERi
PTHR11388, PTHR11388, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03137, OATP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00805, oat, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51465, KAZAL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94956-1) [UniParc]FASTAAdd to basket
Also known as: 1b, FL

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPRIGPAGE VPQVPDKETK ATMGTENTPG GKASPDPQDV RPSVFHNIKL
60 70 80 90 100
FVLCHSLLQL AQLMISGYLK SSISTVEKRF GLSSQTSGLL ASFNEVGNTA
110 120 130 140 150
LIVFVSYFGS RVHRPRMIGY GAILVALAGL LMTLPHFISE PYRYDNTSPE
160 170 180 190 200
DMPQDFKASL CLPTTSAPAS APSNGNCSSY TETQHLSVVG IMFVAQTLLG
210 220 230 240 250
VGGVPIQPFG ISYIDDFAHN SNSPLYLGIL FAVTMMGPGL AFGLGSLMLR
260 270 280 290 300
LYVDINQMPE GGISLTIKDP RWVGAWWLGF LIAAGAVALA AIPYFFFPKE
310 320 330 340 350
MPKEKRELQF RRKVLAVTDS PARKGKDSPS KQSPGESTKK QDGLVQIAPN
360 370 380 390 400
LTVIQFIKVF PRVLLQTLRH PIFLLVVLSQ VCLSSMAAGM AIFLPKFLER
410 420 430 440 450
QFSITASYAN LLIGCLSFPS VIVGIVVGGV LVKRLHLGPV GCGALCLLGM
460 470 480 490 500
LLCLFFSLPL FFIGCSSHQI AGITHQTSAH PGLELSPSCM EACSCPLDGF
510 520 530 540 550
NPVCDPSTRV EYITPCHAGC SSWVVQDALD NSQVFYTNCS CVVEGNPVLA
560 570 580 590 600
GSCDSTCSHL VVPFLLLVSL GSALACLTHT PSFMLILRGV KKEDKTLAVG
610 620 630 640 650
IQFMFLRILA WMPSPVIHGS AIDTTCVHWA LSCGRRAVCR YYNNDLLRNR
660 670 680 690 700
FIGLQFFFKT GSVICFALVL AVLRQQDKEA RTKESRSSPA VEQQLLVSGP

GKKPEDSRV
Length:709
Mass (Da):76,711
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i652DB4B70B2D9A2D
GO
Isoform 2 (identifier: O94956-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     150-260: Missing.

Show »
Length:482
Mass (Da):52,489
Checksum:iE436FE77E1355157
GO
Isoform 3 (identifier: O94956-3) [UniParc]FASTAAdd to basket
Also known as: 1e, Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.

Note: Functional transporter. Predominant isoform in liver, expression at promoter is regulated by HNF4alpha.Curated
Show »
Length:687
Mass (Da):74,450
Checksum:i9696809B01FD241D
GO
Isoform 4 (identifier: O94956-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     6-149: Missing.

Show »
Length:565
Mass (Da):61,177
Checksum:iAFFFAD6CD486F466
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A024R5I4A0A024R5I4_HUMAN
Solute carrier organic anion transp...
SLCO2B1 hCG_27402
709Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRW4E9PRW4_HUMAN
Solute carrier organic anion transp...
SLCO2B1
593Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTF1A0A0A0MTF1_HUMAN
Solute carrier organic anion transp...
SLCO2B1
565Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PI53E9PI53_HUMAN
Solute carrier organic anion transp...
SLCO2B1
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YE11H0YE11_HUMAN
Solute carrier organic anion transp...
SLCO2B1
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIU9E9PIU9_HUMAN
Solute carrier organic anion transp...
SLCO2B1
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PN87E9PN87_HUMAN
Solute carrier organic anion transp...
SLCO2B1
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GX35A0A1B0GX35_HUMAN
Solute carrier organic anion transp...
SLCO2B1
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA74903 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti94N → D in BAF82923 (PubMed:14702039).Curated1
Sequence conflicti215D → V in AAG42205 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03641277E → K in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs865987804Ensembl.1
Natural variantiVAR_053675201V → M. Corresponds to variant dbSNP:rs35199625Ensembl.1
Natural variantiVAR_053676312R → Q. Corresponds to variant dbSNP:rs12422149Ensembl.1
Natural variantiVAR_053677392I → T6 PublicationsCorresponds to variant dbSNP:rs1621378Ensembl.1
Natural variantiVAR_020294486S → F1 PublicationCorresponds to variant dbSNP:rs2306168Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0061471 – 116Missing in isoform 2. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_0541091 – 22Missing in isoform 3. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_0541106 – 149Missing in isoform 4. 1 PublicationAdd BLAST144
Alternative sequenceiVSP_006148150 – 260Missing in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB026256 mRNA Translation: BAA78638.1
AF205073 mRNA Translation: AAG42205.1
AB020687 mRNA Translation: BAA74903.2 Different initiation.
AK290234 mRNA Translation: BAF82923.1
AK294503 mRNA Translation: BAG57720.1
AK300134 mRNA Translation: BAG61922.1
AL117465 mRNA Translation: CAB55940.1
AP001972 Genomic DNA No translation available.
BC041095 mRNA Translation: AAH41095.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44683.1 [O94956-3]
CCDS53679.1 [O94956-4]
CCDS8235.1 [O94956-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T17250

NCBI Reference Sequences

More...
RefSeqi
NP_001138683.1, NM_001145211.2
NP_001138684.1, NM_001145212.2
NP_009187.1, NM_007256.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000428359; ENSP00000388912; ENSG00000137491
ENST00000454962; ENSP00000389653; ENSG00000137491

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11309

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11309

UCSC genome browser

More...
UCSCi
uc001owc.4, human [O94956-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026256 mRNA Translation: BAA78638.1
AF205073 mRNA Translation: AAG42205.1
AB020687 mRNA Translation: BAA74903.2 Different initiation.
AK290234 mRNA Translation: BAF82923.1
AK294503 mRNA Translation: BAG57720.1
AK300134 mRNA Translation: BAG61922.1
AL117465 mRNA Translation: CAB55940.1
AP001972 Genomic DNA No translation available.
BC041095 mRNA Translation: AAH41095.1
CCDSiCCDS44683.1 [O94956-3]
CCDS53679.1 [O94956-4]
CCDS8235.1 [O94956-1]
PIRiT17250
RefSeqiNP_001138683.1, NM_001145211.2
NP_001138684.1, NM_001145212.2
NP_009187.1, NM_007256.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi116442, 2 interactors
STRINGi9606.ENSP00000289575

Chemistry databases

BindingDBiO94956
ChEMBLiCHEMBL1743124
DrugBankiDB03166, Acetic acid
DB00770, Alprostadil
DB11586, Asunaprevir
DB01072, Atazanavir
DB01076, Atorvastatin
DB12319, Benzbromarone
DB03793, Benzoic acid
DB01053, Benzylpenicillin
DB11591, Bilastine
DB08862, Cholecystokinin
DB04272, Citric acid
DB00286, Conjugated estrogens
DB09213, Dexibuprofen
DB00255, Diethylstilbestrol
DB00917, Dinoprostone
DB00975, Dipyridamole
DB05928, Dovitinib
DB00530, Erlotinib
DB13952, Estradiol acetate
DB13953, Estradiol benzoate
DB13954, Estradiol cypionate
DB13955, Estradiol dienanthate
DB13956, Estradiol valerate
DB00655, Estrone
DB00950, Fexofenadine
DB01095, Fluvastatin
DB01241, Gemfibrozil
DB01645, Genistein
DB01016, Glyburide
DB01050, Ibuprofen
DB01088, Iloprost
DB00224, Indinavir
DB01167, Itraconazole
DB04398, Lactic acid
DB11660, Latanoprostene bunod
DB00451, Levothyroxine
DB11611, Lifitegrast
DB00227, Lovastatin
DB00471, Montelukast
DB03467, Naringenin
DB01149, Nefazodone
DB00220, Nelfinavir
DB00627, Niacin
DB01051, Novobiocin
DB03902, Oxalic Acid
DB12978, Pexidartinib
DB02746, Phthalic Acid
DB00554, Piroxicam
DB08860, Pitavastatin
DB01708, Prasterone
DB05804, Prasterone sulfate
DB00175, Pravastatin
DB04216, Quercetin
DB00206, Reserpine
DB01045, Rifampicin
DB11753, Rifamycin
DB00503, Ritonavir
DB01098, Rosuvastatin
DB00936, Salicylic acid
DB01232, Saquinavir
DB09298, Silibinin
DB06290, Simeprevir
DB00641, Simvastatin
DB00795, Sulfasalazine
DB04348, Taurocholic acid
DB05521, Telaprevir
DB00759, Tetracycline
DB00932, Tipranavir
DB01124, Tolbutamide
DB00313, Valproic acid
DB11613, Velpatasvir
DrugCentraliO94956
GuidetoPHARMACOLOGYi1224

Protein family/group databases

TCDBi2.A.60.1.20, the organo anion transporter (oat) family

PTM databases

GlyGeniO94956, 2 sites
iPTMnetiO94956
PhosphoSitePlusiO94956

Polymorphism and mutation databases

BioMutaiSLCO2B1

Proteomic databases

jPOSTiO94956
MassIVEiO94956
MaxQBiO94956
PaxDbiO94956
PeptideAtlasiO94956
PRIDEiO94956
ProteomicsDBi17820
22826
50577 [O94956-1]
50578 [O94956-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
17309, 104 antibodies

Genome annotation databases

EnsembliENST00000428359; ENSP00000388912; ENSG00000137491
ENST00000454962; ENSP00000389653; ENSG00000137491
GeneIDi11309
KEGGihsa:11309
UCSCiuc001owc.4, human [O94956-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11309
DisGeNETi11309
EuPathDBiHostDB:ENSG00000137491.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLCO2B1
HGNCiHGNC:10962, SLCO2B1
HPAiENSG00000137491, Tissue enhanced (liver)
MIMi604988, gene
neXtProtiNX_O94956
PharmGKBiPA35845

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3626, Eukaryota
HOGENOMiCLU_008954_4_2_1
InParanoidiO94956
KOiK14352
OrthoDBi1029129at2759
PhylomeDBiO94956
TreeFamiTF317540

Enzyme and pathway databases

PathwayCommonsiO94956
ReactomeiR-HSA-189483, Heme degradation [O94956-3]
R-HSA-879518, Transport of organic anions

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
11309, 2 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLCO2B1, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLCO2B1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11309
PharosiO94956, Tchem

Protein Ontology

More...
PROi
PR:O94956
RNActiO94956, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137491, Expressed in right lobe of liver and 212 other tissues
ExpressionAtlasiO94956, baseline and differential
GenevisibleiO94956, HS

Family and domain databases

InterProiView protein in InterPro
IPR002350, Kazal_dom
IPR036259, MFS_trans_sf
IPR004156, OATP
PANTHERiPTHR11388, PTHR11388, 1 hit
PfamiView protein in Pfam
PF03137, OATP, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit
TIGRFAMsiTIGR00805, oat, 1 hit
PROSITEiView protein in PROSITE
PS51465, KAZAL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSO2B1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94956
Secondary accession number(s): A8K2G9
, B4DGA9, B4DTB0, E7ERN5, E9PPU8, Q9H2Z0, Q9UFU1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 30, 2010
Last modified: August 12, 2020
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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