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Protein

Solute carrier organic anion transporter family member 2B1

Gene

SLCO2B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.By similarity

GO - Molecular functioni

  • bile acid transmembrane transporter activity Source: GO_Central
  • organic anion transmembrane transporter activity Source: UniProtKB
  • sodium-independent organic anion transmembrane transporter activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-879518 Transport of organic anions

Protein family/group databases

TCDBi2.A.60.1.20 the organo anion transporter (oat) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 2B1
Alternative name(s):
Organic anion transporter B
Short name:
OATP-B
Organic anion transporter polypeptide-related protein 2
Short name:
OATP-RP2
Short name:
OATPRP2
Solute carrier family 21 member 9
Gene namesi
Name:SLCO2B1
Synonyms:KIAA0880, OATP2B1, OATPB, SLC21A9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000137491.14
HGNCiHGNC:10962 SLCO2B1
MIMi604988 gene
neXtProtiNX_O94956

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49CytoplasmicSequence analysisAdd BLAST49
Transmembranei50 – 69Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini70 – 88ExtracellularSequence analysisAdd BLAST19
Transmembranei89 – 109Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini110 – 115CytoplasmicSequence analysis6
Transmembranei116 – 140Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini141 – 185ExtracellularSequence analysisAdd BLAST45
Transmembranei186 – 215Helical; Name=4Sequence analysisAdd BLAST30
Topological domaini216 – 234CytoplasmicSequence analysisAdd BLAST19
Transmembranei235 – 255Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini256 – 273ExtracellularSequence analysisAdd BLAST18
Transmembranei274 – 298Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini299 – 366CytoplasmicSequence analysisAdd BLAST68
Transmembranei367 – 388Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini389 – 408ExtracellularSequence analysisAdd BLAST20
Transmembranei409 – 432Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini433 – 436CytoplasmicSequence analysis4
Transmembranei437 – 460Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini461 – 564ExtracellularSequence analysisAdd BLAST104
Transmembranei565 – 587Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini588 – 596CytoplasmicSequence analysis9
Transmembranei597 – 622Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini623 – 655ExtracellularSequence analysisAdd BLAST33
Transmembranei656 – 673Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini674 – 709CytoplasmicSequence analysisAdd BLAST36

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11309
PharmGKBiPA35845

Chemistry databases

ChEMBLiCHEMBL1743124
DrugBankiDB03166 Acetic acid
DB00770 Alprostadil
DB01076 Atorvastatin
DB03793 Benzoic Acid
DB01053 Benzylpenicillin
DB04272 Citric Acid
DB00286 Conjugated Equine Estrogens
DB05804 dehydroepiandrosterone sulfate
DB00390 Digoxin
DB00917 Dinoprostone
DB01049 Ergoloid mesylate
DB00783 Estradiol
DB00655 Estrone
DB00950 Fexofenadine
DB01095 Fluvastatin
DB01016 Glyburide
DB01050 Ibuprofen
DB01088 Iloprost
DB04398 Lactic Acid
DB00654 Latanoprost
DB00471 Montelukast
DB03467 Naringenin
DB00627 Niacin
DB03902 Oxalic Acid
DB02746 Phthalic Acid
DB08860 Pitavastatin
DB00175 Pravastatin
DB04216 Quercetin
DB01045 Rifampicin
DB01098 Rosuvastatin
DB00936 Salicylic acid
DB04348 Taurocholic Acid
DB01124 Tolbutamide
GuidetoPHARMACOLOGYi1224

Polymorphism and mutation databases

BioMutaiSLCO2B1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910611 – 709Solute carrier organic anion transporter family member 2B1Add BLAST709

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphoserineBy similarity1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei318PhosphothreonineCombined sources1
Modified residuei320PhosphoserineCombined sources1
Disulfide bondi489 ↔ 516PROSITE-ProRule annotation
Disulfide bondi493 ↔ 504PROSITE-ProRule annotation
Disulfide bondi495 ↔ 520PROSITE-ProRule annotation
Glycosylationi538N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO94956
PaxDbiO94956
PeptideAtlasiO94956
PRIDEiO94956
ProteomicsDBi50577
50578 [O94956-2]

PTM databases

iPTMnetiO94956
PhosphoSitePlusiO94956

Expressioni

Tissue specificityi

Isoform 1 has it's highest expression in brain, it is the major form expressed in duodenum, kidney, placenta, and skeletal muscle. Isoform 3 predominates in liver.1 Publication

Gene expression databases

BgeeiENSG00000137491 Expressed in 204 organ(s), highest expression level in right lobe of liver
CleanExiHS_SLCO2B1
ExpressionAtlasiO94956 baseline and differential
GenevisibleiO94956 HS

Organism-specific databases

HPAiHPA020659

Interactioni

Protein-protein interaction databases

BioGridi116442, 1 interactor
STRINGi9606.ENSP00000289575

Chemistry databases

BindingDBiO94956

Structurei

3D structure databases

ProteinModelPortaliO94956
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini483 – 543Kazal-likePROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
HOGENOMiHOG000231269
HOVERGENiHBG108345
InParanoidiO94956
KOiK14352
PhylomeDBiO94956
TreeFamiTF317540

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
PANTHERiPTHR11388 PTHR11388, 1 hit
PfamiView protein in Pfam
PF03137 OATP, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94956-1) [UniParc]FASTAAdd to basket
Also known as: 1b, FL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPRIGPAGE VPQVPDKETK ATMGTENTPG GKASPDPQDV RPSVFHNIKL
60 70 80 90 100
FVLCHSLLQL AQLMISGYLK SSISTVEKRF GLSSQTSGLL ASFNEVGNTA
110 120 130 140 150
LIVFVSYFGS RVHRPRMIGY GAILVALAGL LMTLPHFISE PYRYDNTSPE
160 170 180 190 200
DMPQDFKASL CLPTTSAPAS APSNGNCSSY TETQHLSVVG IMFVAQTLLG
210 220 230 240 250
VGGVPIQPFG ISYIDDFAHN SNSPLYLGIL FAVTMMGPGL AFGLGSLMLR
260 270 280 290 300
LYVDINQMPE GGISLTIKDP RWVGAWWLGF LIAAGAVALA AIPYFFFPKE
310 320 330 340 350
MPKEKRELQF RRKVLAVTDS PARKGKDSPS KQSPGESTKK QDGLVQIAPN
360 370 380 390 400
LTVIQFIKVF PRVLLQTLRH PIFLLVVLSQ VCLSSMAAGM AIFLPKFLER
410 420 430 440 450
QFSITASYAN LLIGCLSFPS VIVGIVVGGV LVKRLHLGPV GCGALCLLGM
460 470 480 490 500
LLCLFFSLPL FFIGCSSHQI AGITHQTSAH PGLELSPSCM EACSCPLDGF
510 520 530 540 550
NPVCDPSTRV EYITPCHAGC SSWVVQDALD NSQVFYTNCS CVVEGNPVLA
560 570 580 590 600
GSCDSTCSHL VVPFLLLVSL GSALACLTHT PSFMLILRGV KKEDKTLAVG
610 620 630 640 650
IQFMFLRILA WMPSPVIHGS AIDTTCVHWA LSCGRRAVCR YYNNDLLRNR
660 670 680 690 700
FIGLQFFFKT GSVICFALVL AVLRQQDKEA RTKESRSSPA VEQQLLVSGP

GKKPEDSRV
Length:709
Mass (Da):76,711
Last modified:November 30, 2010 - v2
Checksum:i652DB4B70B2D9A2D
GO
Isoform 2 (identifier: O94956-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     150-260: Missing.

Note: No experimental confirmation available.
Show »
Length:482
Mass (Da):52,489
Checksum:iE436FE77E1355157
GO
Isoform 3 (identifier: O94956-3) [UniParc]FASTAAdd to basket
Also known as: 1e, Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.

Note: Functional transporter. Predominant isoform in liver, expression at promoter is regulated by HNF4alpha.
Show »
Length:687
Mass (Da):74,450
Checksum:i9696809B01FD241D
GO
Isoform 4 (identifier: O94956-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     6-149: Missing.

Note: No experimental confirmation available.
Show »
Length:565
Mass (Da):61,177
Checksum:iAFFFAD6CD486F466
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PRW4E9PRW4_HUMAN
Solute carrier organic anion transp...
SLCO2B1
593Annotation score:
A0A024R5I4A0A024R5I4_HUMAN
Solute carrier organic anion transp...
SLCO2B1 hCG_27402
709Annotation score:
A0A0A0MTF1A0A0A0MTF1_HUMAN
Solute carrier organic anion transp...
SLCO2B1
565Annotation score:
E9PI53E9PI53_HUMAN
Solute carrier organic anion transp...
SLCO2B1
150Annotation score:
H0YE11H0YE11_HUMAN
Solute carrier organic anion transp...
SLCO2B1
147Annotation score:
E9PIU9E9PIU9_HUMAN
Solute carrier organic anion transp...
SLCO2B1
127Annotation score:
E9PN87E9PN87_HUMAN
Solute carrier organic anion transp...
SLCO2B1
87Annotation score:
A0A1B0GX35A0A1B0GX35_HUMAN
Solute carrier organic anion transp...
SLCO2B1
43Annotation score:

Sequence cautioni

The sequence BAA74903 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94N → D in BAF82923 (PubMed:14702039).Curated1
Sequence conflicti215D → V in AAG42205 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03641277E → K in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_053675201V → M. Corresponds to variant dbSNP:rs35199625Ensembl.1
Natural variantiVAR_053676312R → Q. Corresponds to variant dbSNP:rs12422149Ensembl.1
Natural variantiVAR_053677392I → T6 PublicationsCorresponds to variant dbSNP:rs1621378Ensembl.1
Natural variantiVAR_020294486S → F1 PublicationCorresponds to variant dbSNP:rs2306168Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0061471 – 116Missing in isoform 2. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_0541091 – 22Missing in isoform 3. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_0541106 – 149Missing in isoform 4. 1 PublicationAdd BLAST144
Alternative sequenceiVSP_006148150 – 260Missing in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026256 mRNA Translation: BAA78638.1
AF205073 mRNA Translation: AAG42205.1
AB020687 mRNA Translation: BAA74903.2 Different initiation.
AK290234 mRNA Translation: BAF82923.1
AK294503 mRNA Translation: BAG57720.1
AK300134 mRNA Translation: BAG61922.1
AL117465 mRNA Translation: CAB55940.1
AP001972 Genomic DNA No translation available.
BC041095 mRNA Translation: AAH41095.1
CCDSiCCDS44683.1 [O94956-3]
CCDS53679.1 [O94956-4]
CCDS8235.1 [O94956-1]
PIRiT17250
RefSeqiNP_001138683.1, NM_001145211.2
NP_001138684.1, NM_001145212.2
NP_009187.1, NM_007256.4
UniGeneiHs.7884

Genome annotation databases

EnsembliENST00000428359; ENSP00000388912; ENSG00000137491
ENST00000454962; ENSP00000389653; ENSG00000137491
GeneIDi11309
KEGGihsa:11309
UCSCiuc001owc.4 human [O94956-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026256 mRNA Translation: BAA78638.1
AF205073 mRNA Translation: AAG42205.1
AB020687 mRNA Translation: BAA74903.2 Different initiation.
AK290234 mRNA Translation: BAF82923.1
AK294503 mRNA Translation: BAG57720.1
AK300134 mRNA Translation: BAG61922.1
AL117465 mRNA Translation: CAB55940.1
AP001972 Genomic DNA No translation available.
BC041095 mRNA Translation: AAH41095.1
CCDSiCCDS44683.1 [O94956-3]
CCDS53679.1 [O94956-4]
CCDS8235.1 [O94956-1]
PIRiT17250
RefSeqiNP_001138683.1, NM_001145211.2
NP_001138684.1, NM_001145212.2
NP_009187.1, NM_007256.4
UniGeneiHs.7884

3D structure databases

ProteinModelPortaliO94956
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116442, 1 interactor
STRINGi9606.ENSP00000289575

Chemistry databases

BindingDBiO94956
ChEMBLiCHEMBL1743124
DrugBankiDB03166 Acetic acid
DB00770 Alprostadil
DB01076 Atorvastatin
DB03793 Benzoic Acid
DB01053 Benzylpenicillin
DB04272 Citric Acid
DB00286 Conjugated Equine Estrogens
DB05804 dehydroepiandrosterone sulfate
DB00390 Digoxin
DB00917 Dinoprostone
DB01049 Ergoloid mesylate
DB00783 Estradiol
DB00655 Estrone
DB00950 Fexofenadine
DB01095 Fluvastatin
DB01016 Glyburide
DB01050 Ibuprofen
DB01088 Iloprost
DB04398 Lactic Acid
DB00654 Latanoprost
DB00471 Montelukast
DB03467 Naringenin
DB00627 Niacin
DB03902 Oxalic Acid
DB02746 Phthalic Acid
DB08860 Pitavastatin
DB00175 Pravastatin
DB04216 Quercetin
DB01045 Rifampicin
DB01098 Rosuvastatin
DB00936 Salicylic acid
DB04348 Taurocholic Acid
DB01124 Tolbutamide
GuidetoPHARMACOLOGYi1224

Protein family/group databases

TCDBi2.A.60.1.20 the organo anion transporter (oat) family

PTM databases

iPTMnetiO94956
PhosphoSitePlusiO94956

Polymorphism and mutation databases

BioMutaiSLCO2B1

Proteomic databases

MaxQBiO94956
PaxDbiO94956
PeptideAtlasiO94956
PRIDEiO94956
ProteomicsDBi50577
50578 [O94956-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000428359; ENSP00000388912; ENSG00000137491
ENST00000454962; ENSP00000389653; ENSG00000137491
GeneIDi11309
KEGGihsa:11309
UCSCiuc001owc.4 human [O94956-1]

Organism-specific databases

CTDi11309
DisGeNETi11309
EuPathDBiHostDB:ENSG00000137491.14
GeneCardsiSLCO2B1
HGNCiHGNC:10962 SLCO2B1
HPAiHPA020659
MIMi604988 gene
neXtProtiNX_O94956
PharmGKBiPA35845
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
HOGENOMiHOG000231269
HOVERGENiHBG108345
InParanoidiO94956
KOiK14352
PhylomeDBiO94956
TreeFamiTF317540

Enzyme and pathway databases

ReactomeiR-HSA-879518 Transport of organic anions

Miscellaneous databases

ChiTaRSiSLCO2B1 human
GeneWikiiSLCO2B1
GenomeRNAii11309
PROiPR:O94956
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137491 Expressed in 204 organ(s), highest expression level in right lobe of liver
CleanExiHS_SLCO2B1
ExpressionAtlasiO94956 baseline and differential
GenevisibleiO94956 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
PANTHERiPTHR11388 PTHR11388, 1 hit
PfamiView protein in Pfam
PF03137 OATP, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSO2B1_HUMAN
AccessioniPrimary (citable) accession number: O94956
Secondary accession number(s): A8K2G9
, B4DGA9, B4DTB0, E7ERN5, E9PPU8, Q9H2Z0, Q9UFU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 30, 2010
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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