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Protein

F-box only protein 21

Gene

FBXO21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 21
Gene namesi
Name:FBXO21
Synonyms:FBX21, KIAA0875
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000135108.14
HGNCiHGNC:13592 FBXO21
MIMi609095 gene
neXtProtiNX_O94952

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi23014
OpenTargetsiENSG00000135108
PharmGKBiPA28034

Polymorphism and mutation databases

BioMutaiFBXO21

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199031 – 628F-box only protein 21Add BLAST628

Proteomic databases

EPDiO94952
PaxDbiO94952
PeptideAtlasiO94952
PRIDEiO94952
ProteomicsDBi50572
50573 [O94952-1]

PTM databases

iPTMnetiO94952
PhosphoSitePlusiO94952

Expressioni

Gene expression databases

BgeeiENSG00000135108 Expressed in 243 organ(s), highest expression level in peritoneum
CleanExiHS_FBXO21
ExpressionAtlasiO94952 baseline and differential
GenevisibleiO94952 HS

Organism-specific databases

HPAiHPA062411
HPA071452

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi116656, 39 interactors
IntActiO94952, 3 interactors
STRINGi9606.ENSP00000328187

Structurei

3D structure databases

ProteinModelPortaliO94952
SMRiO94952
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 84F-boxAdd BLAST57

Phylogenomic databases

eggNOGiENOG410II53 Eukaryota
COG2912 LUCA
GeneTreeiENSGT00390000005653
HOGENOMiHOG000065670
HOVERGENiHBG051569
InParanoidiO94952
KOiK10301
OMAiHEKHRDV
OrthoDBiEOG091G03G6
PhylomeDBiO94952
TreeFamiTF313177

Family and domain databases

Gene3Di2.30.30.390, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR011722 Hemimethylated_DNA-bd_dom
IPR036623 Hemimethylated_DNA-bd_sf
IPR032698 SirB1_N
PfamiView protein in Pfam
PF13369 Transglut_core2, 1 hit
PF08755 YccV-like, 1 hit
SMARTiView protein in SMART
SM00992 YccV-like, 1 hit
SUPFAMiSSF141255 SSF141255, 1 hit
SSF81383 SSF81383, 1 hit
TIGRFAMsiTIGR02097 yccV, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94952-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAVDSAM EVVPALAEEA APEVAGLSCL VNLPGEVLEY ILCCGSLTAA
60 70 80 90 100
DIGRVSSTCR RLRELCQSSG KVWKEQFRVR WPSLMKHYSP TDYVNWLEEY
110 120 130 140 150
KVRQKAGLEA RKIVASFSKR FFSEHVPCNG FSDIENLEGP EIFFEDELVC
160 170 180 190 200
ILNMEGRKAL TWKYYAKKIL YYLRQQKILN NLKAFLQQPD DYESYLEGAV
210 220 230 240 250
YIDQYCNPLS DISLKDIQAQ IDSIVELVCK TLRGINSRHP SLAFKAGESS
260 270 280 290 300
MIMEIELQSQ VLDAMNYVLY DQLKFKGNRM DYYNALNLYM HQVLIRRTGI
310 320 330 340 350
PISMSLLYLT IARQLGVPLE PVNFPSHFLL RWCQGAEGAT LDIFDYIYID
360 370 380 390 400
AFGKGKQLTV KECEYLIGQH VTAALYGVVN VKKVLQRMVG NLLSLGKREG
410 420 430 440 450
IDQSYQLLRD SLDLYLAMYP DQVQLLLLQA RLYFHLGIWP EKSFCLVLKV
460 470 480 490 500
LDILQHIQTL DPGQHGAVGY LVQHTLEHIE RKKEEVGVEV KLRSDEKHRD
510 520 530 540 550
VCYSIGLIMK HKRYGYNCVI YGWDPTCMMG HEWIRNMNVH SLPHGHHQPF
560 570 580 590 600
YNVLVEDGSC RYAAQENLEY NVEPQEISHP DVGRYFSEFT GTHYIPNAEL
610 620
EIRYPEDLEF VYETVQNIYS AKKENIDE
Note: May be due to a competing acceptor splice site. No experimental confirmation available.
Length:628
Mass (Da):72,270
Last modified:December 16, 2008 - v2
Checksum:i56144BB92D3CE446
GO
Isoform 2 (identifier: O94952-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     442-448: Missing.

Show »
Length:621
Mass (Da):71,479
Checksum:iD302DD46F3ABB5A3
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q4G104Q4G104_HUMAN
F-box only protein 21
FBXO21
537Annotation score:
H0YHF6H0YHF6_HUMAN
F-box only protein 21
FBXO21
225Annotation score:
H0YIE9H0YIE9_HUMAN
F-box only protein 21
FBXO21
505Annotation score:

Sequence cautioni

The sequence CAB66833 differs from that shown. Reason: Erroneous termination at position 81. Translated as Trp.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047919180N → T. Corresponds to variant dbSNP:rs11556202Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035975442 – 448Missing in isoform 2. 4 Publications7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174601 mRNA Translation: AAF04522.1
AB020682 mRNA Translation: BAA74898.1
AK001699 mRNA Translation: BAG50962.1
AC026364 Genomic DNA No translation available.
AC026368 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW98105.1
BC091496 mRNA Translation: AAH91496.1
AL136899 mRNA Translation: CAB66833.2 Sequence problems.
CCDSiCCDS44989.1 [O94952-1]
CCDS9184.1 [O94952-2]
RefSeqiNP_055817.1, NM_015002.2 [O94952-1]
NP_296373.1, NM_033624.2 [O94952-2]
UniGeneiHs.740376

Genome annotation databases

EnsembliENST00000330622; ENSP00000328187; ENSG00000135108 [O94952-2]
ENST00000622495; ENSP00000483508; ENSG00000135108 [O94952-1]
GeneIDi23014
KEGGihsa:23014
UCSCiuc001twj.4 human [O94952-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174601 mRNA Translation: AAF04522.1
AB020682 mRNA Translation: BAA74898.1
AK001699 mRNA Translation: BAG50962.1
AC026364 Genomic DNA No translation available.
AC026368 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW98105.1
BC091496 mRNA Translation: AAH91496.1
AL136899 mRNA Translation: CAB66833.2 Sequence problems.
CCDSiCCDS44989.1 [O94952-1]
CCDS9184.1 [O94952-2]
RefSeqiNP_055817.1, NM_015002.2 [O94952-1]
NP_296373.1, NM_033624.2 [O94952-2]
UniGeneiHs.740376

3D structure databases

ProteinModelPortaliO94952
SMRiO94952
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116656, 39 interactors
IntActiO94952, 3 interactors
STRINGi9606.ENSP00000328187

PTM databases

iPTMnetiO94952
PhosphoSitePlusiO94952

Polymorphism and mutation databases

BioMutaiFBXO21

Proteomic databases

EPDiO94952
PaxDbiO94952
PeptideAtlasiO94952
PRIDEiO94952
ProteomicsDBi50572
50573 [O94952-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330622; ENSP00000328187; ENSG00000135108 [O94952-2]
ENST00000622495; ENSP00000483508; ENSG00000135108 [O94952-1]
GeneIDi23014
KEGGihsa:23014
UCSCiuc001twj.4 human [O94952-2]

Organism-specific databases

CTDi23014
DisGeNETi23014
EuPathDBiHostDB:ENSG00000135108.14
GeneCardsiFBXO21
HGNCiHGNC:13592 FBXO21
HPAiHPA062411
HPA071452
MIMi609095 gene
neXtProtiNX_O94952
OpenTargetsiENSG00000135108
PharmGKBiPA28034
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II53 Eukaryota
COG2912 LUCA
GeneTreeiENSGT00390000005653
HOGENOMiHOG000065670
HOVERGENiHBG051569
InParanoidiO94952
KOiK10301
OMAiHEKHRDV
OrthoDBiEOG091G03G6
PhylomeDBiO94952
TreeFamiTF313177

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiFBXO21 human
GenomeRNAii23014
PROiPR:O94952
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135108 Expressed in 243 organ(s), highest expression level in peritoneum
CleanExiHS_FBXO21
ExpressionAtlasiO94952 baseline and differential
GenevisibleiO94952 HS

Family and domain databases

Gene3Di2.30.30.390, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR011722 Hemimethylated_DNA-bd_dom
IPR036623 Hemimethylated_DNA-bd_sf
IPR032698 SirB1_N
PfamiView protein in Pfam
PF13369 Transglut_core2, 1 hit
PF08755 YccV-like, 1 hit
SMARTiView protein in SMART
SM00992 YccV-like, 1 hit
SUPFAMiSSF141255 SSF141255, 1 hit
SSF81383 SSF81383, 1 hit
TIGRFAMsiTIGR02097 yccV, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFBX21_HUMAN
AccessioniPrimary (citable) accession number: O94952
Secondary accession number(s): B3KMF0, Q5BJG0, Q9H087
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: December 16, 2008
Last modified: November 7, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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