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Protein

RING finger protein 37

Gene

UBOX5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri483 – 528RING-typePROSITE-ProRule annotationAdd BLAST46

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • ubiquitin protein ligase activity Source: GO_Central
  • ubiquitin protein ligase binding Source: UniProtKB
  • ubiquitin-ubiquitin ligase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 37Curated (EC:2.3.2.27By similarity)
Alternative name(s):
RING-type E3 ubiquitin transferase RNF37Curated
U-box domain-containing protein 5Imported
UbcM4-interacting protein 51 Publication
Short name:
hUIP51 Publication
Ubiquitin-conjugating enzyme 7-interacting protein 5Imported
Gene namesi
Name:UBOX5Imported
Synonyms:KIAA0860Imported, RNF37Curated, UBCE7IP5Imported, UIP51 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000185019.16
HGNCiHGNC:17777 UBOX5
neXtProtiNX_O94941

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185019
PharmGKBiPA134991794

Polymorphism and mutation databases

BioMutaiUBOX5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000560761 – 541RING finger protein 37Add BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei451Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

EPDiO94941
MaxQBiO94941
PaxDbiO94941
PeptideAtlasiO94941
PRIDEiO94941
ProteomicsDBi50570
50571 [O94941-2]

PTM databases

iPTMnetiO94941
PhosphoSitePlusiO94941

Expressioni

Tissue specificityi

Expressed in liver, heart, brain, kidney and testis.1 Publication

Gene expression databases

BgeeiENSG00000185019 Expressed in 181 organ(s), highest expression level in gastrocnemius
CleanExiHS_UBOX5
ExpressionAtlasiO94941 baseline and differential
GenevisibleiO94941 HS

Organism-specific databases

HPAiHPA028871

Interactioni

Subunit structurei

Interacts with UBE2L3. Interacts with VCP.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116554, 22 interactors
IntActiO94941, 17 interactors
STRINGi9606.ENSP00000217173

Structurei

3D structure databases

ProteinModelPortaliO94941
SMRiO94941
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini258 – 338U-boxAdd BLAST81

Domaini

The U-box domain mediates interaction with E2 ubiquitin ligases and is required for the ubiquitin-protein ligase activity.1 Publication1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri483 – 528RING-typePROSITE-ProRule annotationAdd BLAST46

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2042 Eukaryota
COG5113 LUCA
GeneTreeiENSGT00510000049555
HOGENOMiHOG000132931
HOVERGENiHBG054212
InParanoidiO94941
KOiK10600
OMAiHMDCSTG
OrthoDBiEOG091G0L8V
PhylomeDBiO94941
TreeFamiTF329105

Family and domain databases

CDDicd16660 RING-Ubox_RNF37, 1 hit
Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR039925 RNF37_RING-Ubox
IPR039847 Ubox5
IPR003613 Ubox_domain
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR13492 PTHR13492, 1 hit
PfamiView protein in Pfam
PF04564 U-box, 1 hit
SMARTiView protein in SMART
SM00504 Ubox, 1 hit
PROSITEiView protein in PROSITE
PS51698 U_BOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O94941-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVINLCLPQF RPRIHCNKIS ADGYEVENLI SEDLTKRSHG FRTEYFIKPP
60 70 80 90 100
VYVTVSFPFN VEICRINIDL TAGGGQNVTG LEMYTSASSS RVSWNTPQCR
110 120 130 140 150
TLGPAEPSVP DKEAFTLVGK VLLKNQSQVV FSHRGFKARP PFGAMEATLP
160 170 180 190 200
SPAVVAQELW NKGALSLSHV AHLRICITHV TGGGIPCIKR LEVWGQPAKT
210 220 230 240 250
CSQEVIDSIL LVTSENLPQD VALQAPALPM ESDCDPGDQP ESQQAPSSLQ
260 270 280 290 300
KLAEIIQDVP EEFLDPITLE IMPCPMLLPS GKVIDQSTLE KCNRSEATWG
310 320 330 340 350
RVPSDPFTGV AFTPHSQPLP HPSLKARIDH FLLQHSIPGC HLLGRAQTAL
360 370 380 390 400
AVIPSSIVLP SQKRKIEQAE HVPDSNFGVN ASCFSATSPL VLPTTSEHTA
410 420 430 440 450
KKMKATNEPS LTHMDCSTGP LSHEQKLSQS LEIALASTLG SMPSFTARLT
460 470 480 490 500
RGQLQHLGTR GSNTSWRPGT GSEQPGSILG PECASCKRVF SPYFKKEPVY
510 520 530 540
QLPCGHLLCR PCLGEKQRSL PMTCTACQRP VASQDVLRVH F
Length:541
Mass (Da):58,966
Last modified:May 1, 1999 - v1
Checksum:i4AF1A0C5115FAF7B
GO
Isoform 2 (identifier: O94941-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     419-472: Missing.

Note: No experimental confirmation available.
Show »
Length:487
Mass (Da):53,276
Checksum:i82BE211EECCCFC05
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A2Q6A2A2Q6_HUMAN
RING finger protein 37
UBOX5
88Annotation score:

Sequence cautioni

The sequence BAA74883 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04640296T → M. Corresponds to variant dbSNP:rs999409Ensembl.1
Natural variantiVAR_046403479L → P. Corresponds to variant dbSNP:rs34205880Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042899419 – 472Missing in isoform 2. 2 PublicationsAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020667 mRNA Translation: BAA74883.2 Different initiation.
AK022444 mRNA Translation: BAG51073.1
CR457089 mRNA Translation: CAG33370.1
AL121891 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10550.1
CH471133 Genomic DNA Translation: EAX10551.1
BC000515 mRNA Translation: AAH00515.1
BC046122 mRNA Translation: AAH46122.1
CCDSiCCDS13046.1 [O94941-1]
CCDS13047.1 [O94941-2]
RefSeqiNP_055763.1, NM_014948.3 [O94941-1]
NP_955447.1, NM_199415.2 [O94941-2]
UniGeneiHs.654646

Genome annotation databases

EnsembliENST00000217173; ENSP00000217173; ENSG00000185019 [O94941-1]
ENST00000348031; ENSP00000311726; ENSG00000185019 [O94941-2]
GeneIDi22888
KEGGihsa:22888
UCSCiuc002whw.5 human [O94941-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020667 mRNA Translation: BAA74883.2 Different initiation.
AK022444 mRNA Translation: BAG51073.1
CR457089 mRNA Translation: CAG33370.1
AL121891 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10550.1
CH471133 Genomic DNA Translation: EAX10551.1
BC000515 mRNA Translation: AAH00515.1
BC046122 mRNA Translation: AAH46122.1
CCDSiCCDS13046.1 [O94941-1]
CCDS13047.1 [O94941-2]
RefSeqiNP_055763.1, NM_014948.3 [O94941-1]
NP_955447.1, NM_199415.2 [O94941-2]
UniGeneiHs.654646

3D structure databases

ProteinModelPortaliO94941
SMRiO94941
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116554, 22 interactors
IntActiO94941, 17 interactors
STRINGi9606.ENSP00000217173

PTM databases

iPTMnetiO94941
PhosphoSitePlusiO94941

Polymorphism and mutation databases

BioMutaiUBOX5

Proteomic databases

EPDiO94941
MaxQBiO94941
PaxDbiO94941
PeptideAtlasiO94941
PRIDEiO94941
ProteomicsDBi50570
50571 [O94941-2]

Protocols and materials databases

DNASUi22888
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217173; ENSP00000217173; ENSG00000185019 [O94941-1]
ENST00000348031; ENSP00000311726; ENSG00000185019 [O94941-2]
GeneIDi22888
KEGGihsa:22888
UCSCiuc002whw.5 human [O94941-1]

Organism-specific databases

CTDi22888
EuPathDBiHostDB:ENSG00000185019.16
GeneCardsiUBOX5
HGNCiHGNC:17777 UBOX5
HPAiHPA028871
neXtProtiNX_O94941
OpenTargetsiENSG00000185019
PharmGKBiPA134991794
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2042 Eukaryota
COG5113 LUCA
GeneTreeiENSGT00510000049555
HOGENOMiHOG000132931
HOVERGENiHBG054212
InParanoidiO94941
KOiK10600
OMAiHMDCSTG
OrthoDBiEOG091G0L8V
PhylomeDBiO94941
TreeFamiTF329105

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

GeneWikiiUBOX5
GenomeRNAii22888
PROiPR:O94941

Gene expression databases

BgeeiENSG00000185019 Expressed in 181 organ(s), highest expression level in gastrocnemius
CleanExiHS_UBOX5
ExpressionAtlasiO94941 baseline and differential
GenevisibleiO94941 HS

Family and domain databases

CDDicd16660 RING-Ubox_RNF37, 1 hit
Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR039925 RNF37_RING-Ubox
IPR039847 Ubox5
IPR003613 Ubox_domain
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR13492 PTHR13492, 1 hit
PfamiView protein in Pfam
PF04564 U-box, 1 hit
SMARTiView protein in SMART
SM00504 Ubox, 1 hit
PROSITEiView protein in PROSITE
PS51698 U_BOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRNF37_HUMAN
AccessioniPrimary (citable) accession number: O94941
Secondary accession number(s): Q6IAR5, Q86X87, Q9H4J2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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