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UniProtKB - O94933 (SLIK3_HUMAN)

Entry version 157 (12 Aug 2020)
Sequence version 2 (25 Nov 2008)
Previous versions | rss
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Protein

SLIT and NTRK-like protein 3

Gene

SLITRK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Suppresses neurite outgrowth.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O94933

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-388844, Receptor-type tyrosine-protein phosphatases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SLIT and NTRK-like protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLITRK3
Synonyms:KIAA0848
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000121871.3

Human Gene Nomenclature Database

More...HGNCi		HGNC:23501, SLITRK3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609679, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O94933

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 654ExtracellularSequence analysisAdd BLAST626
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei655 – 675HelicalSequence analysisAdd BLAST21
Topological domaini676 – 977CytoplasmicSequence analysisAdd BLAST302

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		22865

Open Targets

More...OpenTargetsi		ENSG00000121871

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134958002

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O94933, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLITRK3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003267727 – 977SLIT and NTRK-like protein 3Add BLAST951

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi596N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O94933

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O94933

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O94933

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O94933

PeptideAtlas

More...PeptideAtlasi		O94933

PRoteomics IDEntifications database

More...PRIDEi		O94933

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50569

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O94933, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O94933

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O94933

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the occipital lobe of the cerebral cortex of the brain. Expressed at higher levels in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000121871, Expressed in left uterine tube and 123 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O94933, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O94933, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000121871, Tissue enhanced (brain, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116533, 6 interactors

Protein interaction database and analysis system

More...IntActi		O94933, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000420091

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O94933, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O94933

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati78 – 99LRR 1Add BLAST22
Repeati102 – 123LRR 2Add BLAST22
Repeati126 – 147LRR 3Add BLAST22
Repeati150 – 171LRR 4Add BLAST22
Repeati174 – 195LRR 5Add BLAST22
Repeati197 – 218LRR 6Add BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini232 – 283LRRCT 1Add BLAST52
Domaini364 – 406LRRNTAdd BLAST43
Repeati409 – 430LRR 7Add BLAST22
Repeati433 – 454LRR 8Add BLAST22
Repeati457 – 478LRR 9Add BLAST22
Repeati481 – 502LRR 10Add BLAST22
Repeati505 – 526LRR 11Add BLAST22
Repeati528 – 549LRR 12Add BLAST22
Domaini562 – 613LRRCT 2Add BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi712 – 723Poly-GlyAdd BLAST12

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLITRK family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QYY5, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158681

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012706_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O94933

Identification of Orthologs from Complete Genome Data

More...OMAi		IVQLKTW

Database of Orthologous Groups

More...OrthoDBi		217854at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O94933

TreeFam database of animal gene trees

More...TreeFami		TF351826

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000483, Cys-rich_flank_reg_C
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR043326, Slitrk

The PANTHER Classification System

More...PANTHERi		PTHR45773, PTHR45773, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13855, LRR_8, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00369, LRR_TYP, 9 hits
SM00082, LRRCT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O94933-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPSIAEMLH RGRMLWIILL STIALGWTTP IPLIEDSEEI DEPCFDPCYC 
        60         70         80         90        100
EVKESLFHIH CDSKGFTNIS QITEFWSRPF KLYLQRNSMR KLYTNSFLHL 
       110        120        130        140        150
NNAVSINLGN NALQDIQTGA FNGLKILKRL YLHENKLDVF RNDTFLGLES 
       160        170        180        190        200
LEYLQADYNV IKRIESGAFR NLSKLRVLIL NDNLIPMLPT NLFKAVSLTH 
       210        220        230        240        250
LDLRGNRLKV LFYRGMLDHI GRSLMELQLE ENPWNCTCEI VQLKSWLERI 
       260        270        280        290        300
PYTALVGDIT CETPFHFHGK DLREIRKTEL CPLLSDSEVE ASLGIPHSSS 
       310        320        330        340        350
SKENAWPTKP SSMLSSVHFT ASSVEYKSSN KQPKPTKQPR TPRPPSTSQA 
       360        370        380        390        400
LYPGPNQPPI APYQTRPPIP IICPTGCTCN LHINDLGLTV NCKERGFNNI 
       410        420        430        440        450
SELLPRPLNA KKLYLSSNLI QKIYRSDFWN FSSLDLLHLG NNRISYVQDG 
       460        470        480        490        500
AFINLPNLKS LFLNGNDIEK LTPGMFRGLQ SLHYLYFEFN VIREIQPAAF 
       510        520        530        540        550
SLMPNLKLLF LNNNLLRTLP TDAFAGTSLA RLNLRKNYFL YLPVAGVLEH 
       560        570        580        590        600
LNAIVQIDLN ENPWDCTCDL VPFKQWIETI SSVSVVGDVL CRSPENLTHR 
       610        620        630        640        650
DVRTIELEVL CPEMLHVAPA GESPAQPGDS HLIGAPTSAS PYEFSPPGGP 
       660        670        680        690        700
VPLSVLILSL LVLFFSAVFV AAGLFAYVLR RRRKKLPFRS KRQEGVDLTG 
       710        720        730        740        750
IQMQCHRLFE DGGGGGGGSG GGGRPTLSSP EKAPPVGHVY EYIPHPVTQM 
       760        770        780        790        800
CNNPIYKPRE EEEVAVSSAQ EAGSAERGGP GTQPPGMGEA LLGSEQFAET 
       810        820        830        840        850
PKENHSNYRT LLEKEKEWAL AVSSSQLNTI VTVNHHHPHH PAVGGVSGVV 
       860        870        880        890        900
GGTGGDLAGF RHHEKNGGVV LFPPGGGCGS GSMLLDRERP QPAPCTVGFV 
       910        920        930        940        950
DCLYGTVPKL KELHVHPPGM QYPDLQQDAR LKETLLFSAG KGFTDHQTQK 
       960        970 
SDYLELRAKL QTKPDYLEVL EKTTYRF
Length:977
Mass (Da):108,934
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i66936B7E00008961
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9K0R4C9K0R4_HUMAN
SLIT and NTRK-like protein 3
SLITRK3
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA74871 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti940G → E in BAA74871 (PubMed:10048485).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027757605I → V. Corresponds to variant dbSNP:rs3828419Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB020655 mRNA Translation: BAA74871.2 Different initiation.
AK290024 mRNA Translation: BAF82713.1
CH471052 Genomic DNA Translation: EAW78599.1
BC114621 mRNA Translation: AAI14622.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3197.1

NCBI Reference Sequences

More...RefSeqi		NP_001305739.1, NM_001318810.1
NP_001305740.1, NM_001318811.1
NP_055741.2, NM_014926.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000241274; ENSP00000241274; ENSG00000121871
ENST00000475390; ENSP00000420091; ENSG00000121871

Database of genes from NCBI RefSeq genomes

More...GeneIDi		22865

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:22865

UCSC genome browser

More...UCSCi		uc003fej.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020655 mRNA Translation: BAA74871.2 Different initiation.
AK290024 mRNA Translation: BAF82713.1
CH471052 Genomic DNA Translation: EAW78599.1
BC114621 mRNA Translation: AAI14622.1
CCDSiCCDS3197.1
RefSeqiNP_001305739.1, NM_001318810.1
NP_001305740.1, NM_001318811.1
NP_055741.2, NM_014926.3

3D structure databases

SMRiO94933
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116533, 6 interactors
IntActiO94933, 4 interactors
STRINGi9606.ENSP00000420091

PTM databases

GlyGeniO94933, 2 sites
iPTMnetiO94933
PhosphoSitePlusiO94933

Polymorphism and mutation databases

BioMutaiSLITRK3

Proteomic databases

EPDiO94933
jPOSTiO94933
MassIVEiO94933
PaxDbiO94933
PeptideAtlasiO94933
PRIDEiO94933
ProteomicsDBi50569

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2998, 105 antibodies

Genome annotation databases

EnsembliENST00000241274; ENSP00000241274; ENSG00000121871
ENST00000475390; ENSP00000420091; ENSG00000121871
GeneIDi22865
KEGGihsa:22865
UCSCiuc003fej.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		22865
DisGeNETi22865
EuPathDBiHostDB:ENSG00000121871.3

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLITRK3
HGNCiHGNC:23501, SLITRK3
HPAiENSG00000121871, Tissue enhanced (brain, liver)
MIMi609679, gene
neXtProtiNX_O94933
OpenTargetsiENSG00000121871
PharmGKBiPA134958002

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QYY5, Eukaryota
GeneTreeiENSGT00940000158681
HOGENOMiCLU_012706_0_0_1
InParanoidiO94933
OMAiIVQLKTW
OrthoDBi217854at2759
PhylomeDBiO94933
TreeFamiTF351826

Enzyme and pathway databases

PathwayCommonsiO94933
ReactomeiR-HSA-388844, Receptor-type tyrosine-protein phosphatases

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		22865, 5 hits in 865 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		22865
PharosiO94933, Tbio

Protein Ontology

More...PROi		PR:O94933
RNActiO94933, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000121871, Expressed in left uterine tube and 123 other tissues
ExpressionAtlasiO94933, baseline and differential
GenevisibleiO94933, HS

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483, Cys-rich_flank_reg_C
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR043326, Slitrk
PANTHERiPTHR45773, PTHR45773, 1 hit
PfamiView protein in Pfam
PF13855, LRR_8, 2 hits
SMARTiView protein in SMART
SM00369, LRR_TYP, 9 hits
SM00082, LRRCT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLIK3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94933
Secondary accession number(s): Q1RMY6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 25, 2008
Last modified: August 12, 2020
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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