UniProtKB - O94933 (SLIK3_HUMAN)
Protein
SLIT and NTRK-like protein 3
Gene
SLITRK3
Organism
Homo sapiens (Human)
Status
Functioni
Suppresses neurite outgrowth.By similarity
GO - Biological processi
- axonogenesis Source: GO_Central
- positive regulation of synapse assembly Source: Ensembl
- regulation of presynapse assembly Source: SynGO
- synaptic membrane adhesion Source: SynGO
Enzyme and pathway databases
Reactomei | R-HSA-388844 Receptor-type tyrosine-protein phosphatases |
Names & Taxonomyi
Protein namesi | Recommended name: SLIT and NTRK-like protein 3 |
Gene namesi | Name:SLITRK3 Synonyms:KIAA0848 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23501 SLITRK3 |
MIMi | 609679 gene |
neXtProti | NX_O94933 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Plasma Membrane
- integral component of postsynaptic density membrane Source: Ensembl
- integral component of postsynaptic specialization membrane Source: SynGO
- plasma membrane Source: Reactome
Other locations
- GABA-ergic synapse Source: SynGO
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 29 – 654 | ExtracellularSequence analysisAdd BLAST | 626 | |
Transmembranei | 655 – 675 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 676 – 977 | CytoplasmicSequence analysisAdd BLAST | 302 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 22865 |
OpenTargetsi | ENSG00000121871 |
PharmGKBi | PA134958002 |
Miscellaneous databases
Pharosi | O94933 |
Polymorphism and mutation databases
BioMutai | SLITRK3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000032677 | 27 – 977 | SLIT and NTRK-like protein 3Add BLAST | 951 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 68 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 596 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | O94933 |
jPOSTi | O94933 |
MassIVEi | O94933 |
PaxDbi | O94933 |
PeptideAtlasi | O94933 |
PRIDEi | O94933 |
ProteomicsDBi | 50569 |
PTM databases
iPTMneti | O94933 |
PhosphoSitePlusi | O94933 |
Expressioni
Tissue specificityi
Expressed in the occipital lobe of the cerebral cortex of the brain. Expressed at higher levels in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors.1 Publication
Gene expression databases
Bgeei | ENSG00000121871 Expressed in 98 organ(s), highest expression level in left uterine tube |
ExpressionAtlasi | O94933 baseline and differential |
Genevisiblei | O94933 HS |
Organism-specific databases
HPAi | HPA017636 HPA048042 |
Interactioni
Protein-protein interaction databases
BioGridi | 116533, 5 interactors |
IntActi | O94933, 4 interactors |
STRINGi | 9606.ENSP00000420091 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 78 – 99 | LRR 1Add BLAST | 22 | |
Repeati | 102 – 123 | LRR 2Add BLAST | 22 | |
Repeati | 126 – 147 | LRR 3Add BLAST | 22 | |
Repeati | 150 – 171 | LRR 4Add BLAST | 22 | |
Repeati | 174 – 195 | LRR 5Add BLAST | 22 | |
Repeati | 197 – 218 | LRR 6Add BLAST | 22 | |
Domaini | 232 – 283 | LRRCT 1Add BLAST | 52 | |
Domaini | 364 – 406 | LRRNTAdd BLAST | 43 | |
Repeati | 409 – 430 | LRR 7Add BLAST | 22 | |
Repeati | 433 – 454 | LRR 8Add BLAST | 22 | |
Repeati | 457 – 478 | LRR 9Add BLAST | 22 | |
Repeati | 481 – 502 | LRR 10Add BLAST | 22 | |
Repeati | 505 – 526 | LRR 11Add BLAST | 22 | |
Repeati | 528 – 549 | LRR 12Add BLAST | 22 | |
Domaini | 562 – 613 | LRRCT 2Add BLAST | 52 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 712 – 723 | Poly-GlyAdd BLAST | 12 |
Sequence similaritiesi
Belongs to the SLITRK family.Curated
Keywords - Domaini
Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410JR1Z Eukaryota ENOG410Y1DK LUCA |
GeneTreei | ENSGT00940000158681 |
HOGENOMi | HOG000290667 |
InParanoidi | O94933 |
OMAi | YDYIPHP |
OrthoDBi | 217854at2759 |
PhylomeDBi | O94933 |
TreeFami | TF351826 |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR000483 Cys-rich_flank_reg_C IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR032675 LRR_dom_sf |
Pfami | View protein in Pfam PF13855 LRR_8, 2 hits |
SMARTi | View protein in SMART SM00369 LRR_TYP, 9 hits SM00082 LRRCT, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O94933-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKPSIAEMLH RGRMLWIILL STIALGWTTP IPLIEDSEEI DEPCFDPCYC
60 70 80 90 100
EVKESLFHIH CDSKGFTNIS QITEFWSRPF KLYLQRNSMR KLYTNSFLHL
110 120 130 140 150
NNAVSINLGN NALQDIQTGA FNGLKILKRL YLHENKLDVF RNDTFLGLES
160 170 180 190 200
LEYLQADYNV IKRIESGAFR NLSKLRVLIL NDNLIPMLPT NLFKAVSLTH
210 220 230 240 250
LDLRGNRLKV LFYRGMLDHI GRSLMELQLE ENPWNCTCEI VQLKSWLERI
260 270 280 290 300
PYTALVGDIT CETPFHFHGK DLREIRKTEL CPLLSDSEVE ASLGIPHSSS
310 320 330 340 350
SKENAWPTKP SSMLSSVHFT ASSVEYKSSN KQPKPTKQPR TPRPPSTSQA
360 370 380 390 400
LYPGPNQPPI APYQTRPPIP IICPTGCTCN LHINDLGLTV NCKERGFNNI
410 420 430 440 450
SELLPRPLNA KKLYLSSNLI QKIYRSDFWN FSSLDLLHLG NNRISYVQDG
460 470 480 490 500
AFINLPNLKS LFLNGNDIEK LTPGMFRGLQ SLHYLYFEFN VIREIQPAAF
510 520 530 540 550
SLMPNLKLLF LNNNLLRTLP TDAFAGTSLA RLNLRKNYFL YLPVAGVLEH
560 570 580 590 600
LNAIVQIDLN ENPWDCTCDL VPFKQWIETI SSVSVVGDVL CRSPENLTHR
610 620 630 640 650
DVRTIELEVL CPEMLHVAPA GESPAQPGDS HLIGAPTSAS PYEFSPPGGP
660 670 680 690 700
VPLSVLILSL LVLFFSAVFV AAGLFAYVLR RRRKKLPFRS KRQEGVDLTG
710 720 730 740 750
IQMQCHRLFE DGGGGGGGSG GGGRPTLSSP EKAPPVGHVY EYIPHPVTQM
760 770 780 790 800
CNNPIYKPRE EEEVAVSSAQ EAGSAERGGP GTQPPGMGEA LLGSEQFAET
810 820 830 840 850
PKENHSNYRT LLEKEKEWAL AVSSSQLNTI VTVNHHHPHH PAVGGVSGVV
860 870 880 890 900
GGTGGDLAGF RHHEKNGGVV LFPPGGGCGS GSMLLDRERP QPAPCTVGFV
910 920 930 940 950
DCLYGTVPKL KELHVHPPGM QYPDLQQDAR LKETLLFSAG KGFTDHQTQK
960 970
SDYLELRAKL QTKPDYLEVL EKTTYRF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9K0R4 | C9K0R4_HUMAN | SLIT and NTRK-like protein 3 | SLITRK3 | 162 | Annotation score: |
Sequence cautioni
The sequence BAA74871 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 940 | G → E in BAA74871 (PubMed:10048485).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027757 | 605 | I → V. Corresponds to variant dbSNP:rs3828419Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB020655 mRNA Translation: BAA74871.2 Different initiation. AK290024 mRNA Translation: BAF82713.1 CH471052 Genomic DNA Translation: EAW78599.1 BC114621 mRNA Translation: AAI14622.1 |
CCDSi | CCDS3197.1 |
RefSeqi | NP_001305739.1, NM_001318810.1 NP_001305740.1, NM_001318811.1 NP_055741.2, NM_014926.3 |
Genome annotation databases
Ensembli | ENST00000241274; ENSP00000241274; ENSG00000121871 ENST00000475390; ENSP00000420091; ENSG00000121871 |
GeneIDi | 22865 |
KEGGi | hsa:22865 |
UCSCi | uc003fej.4 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB020655 mRNA Translation: BAA74871.2 Different initiation. AK290024 mRNA Translation: BAF82713.1 CH471052 Genomic DNA Translation: EAW78599.1 BC114621 mRNA Translation: AAI14622.1 |
CCDSi | CCDS3197.1 |
RefSeqi | NP_001305739.1, NM_001318810.1 NP_001305740.1, NM_001318811.1 NP_055741.2, NM_014926.3 |
3D structure databases
SMRi | O94933 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 116533, 5 interactors |
IntActi | O94933, 4 interactors |
STRINGi | 9606.ENSP00000420091 |
PTM databases
iPTMneti | O94933 |
PhosphoSitePlusi | O94933 |
Polymorphism and mutation databases
BioMutai | SLITRK3 |
Proteomic databases
EPDi | O94933 |
jPOSTi | O94933 |
MassIVEi | O94933 |
PaxDbi | O94933 |
PeptideAtlasi | O94933 |
PRIDEi | O94933 |
ProteomicsDBi | 50569 |
Genome annotation databases
Ensembli | ENST00000241274; ENSP00000241274; ENSG00000121871 ENST00000475390; ENSP00000420091; ENSG00000121871 |
GeneIDi | 22865 |
KEGGi | hsa:22865 |
UCSCi | uc003fej.4 human |
Organism-specific databases
CTDi | 22865 |
DisGeNETi | 22865 |
GeneCardsi | SLITRK3 |
HGNCi | HGNC:23501 SLITRK3 |
HPAi | HPA017636 HPA048042 |
MIMi | 609679 gene |
neXtProti | NX_O94933 |
OpenTargetsi | ENSG00000121871 |
PharmGKBi | PA134958002 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410JR1Z Eukaryota ENOG410Y1DK LUCA |
GeneTreei | ENSGT00940000158681 |
HOGENOMi | HOG000290667 |
InParanoidi | O94933 |
OMAi | YDYIPHP |
OrthoDBi | 217854at2759 |
PhylomeDBi | O94933 |
TreeFami | TF351826 |
Enzyme and pathway databases
Reactomei | R-HSA-388844 Receptor-type tyrosine-protein phosphatases |
Miscellaneous databases
GenomeRNAii | 22865 |
Pharosi | O94933 |
PROi | PR:O94933 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000121871 Expressed in 98 organ(s), highest expression level in left uterine tube |
ExpressionAtlasi | O94933 baseline and differential |
Genevisiblei | O94933 HS |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR000483 Cys-rich_flank_reg_C IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR032675 LRR_dom_sf |
Pfami | View protein in Pfam PF13855 LRR_8, 2 hits |
SMARTi | View protein in SMART SM00369 LRR_TYP, 9 hits SM00082 LRRCT, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SLIK3_HUMAN | |
Accessioni | O94933Primary (citable) accession number: O94933 Secondary accession number(s): Q1RMY6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2001 |
Last sequence update: | November 25, 2008 | |
Last modified: | November 13, 2019 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot