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Entry version 208 (29 Sep 2021)
Sequence version 1 (01 May 1999)
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Protein

Glutaminase kidney isoform, mitochondrial

Gene

GLS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain (PubMed:30575854, PubMed:30239721, PubMed:30970188).

3 Publications

Lacks catalytic activity.

1 Publication

Caution

Isoform 3 is predicted to be expressed at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Contrary to expectations, it has been shown to be well expressed, and the encoded protein is detected in mitochondria (PubMed:11015561, PubMed:17940881, PubMed:22228304).1 Publication3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Isoform 1 and isoform 3 are activated by phosphate. Inhibited by BPTES. BPTES binds between subunits and favors dissociation of the tetramer into dimers (PubMed:22049910). Inhibited by 6-diazo-5-oxo-L-norleucine (DON) (PubMed:24451979). Enzyme activity is stimulated by phosphorylation (PubMed:22538822).3 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.9 mM for glutamine (isoform 1)1 Publication
  2. KM=1.4 mM for glutamine (isoform 3)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei286SubstrateCombined sources1 Publication2 Publications1
Binding sitei335SubstrateCombined sources1 Publication2 Publications1
Binding sitei381SubstrateCombined sources1 Publication2 Publications1
Binding sitei388SubstrateCombined sources1 Publication2 Publications1
Binding sitei414SubstrateCombined sources1 Publication2 Publications1
Binding sitei466SubstrateCombined sources1 Publication2 Publications1
Binding sitei484Substrate; via amide nitrogenCombined sources1 Publication2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • glutaminase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.5.1.2, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O94925

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-210500, Glutamate Neurotransmitter Release Cycle
R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-8964539, Glutamate and glutamine metabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
O94925

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O94925

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutaminase kidney isoform, mitochondrial (EC:3.5.1.26 Publications)
Short name:
GLS
Alternative name(s):
K-glutaminase
L-glutamine amidohydrolase
Cleaved into the following 2 chains:
Glutaminase kidney isoform, mitochondrial 68 kDa chainBy similarity
Glutaminase kidney isoform, mitochondrial 65 kDa chainBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GLS
Synonyms:GLS1, KIAA0838
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4331, GLS

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
138280, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O94925

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000115419

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Developmental and epileptic encephalopathy 71 (DEE71)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE71 is an autosomal recessive form with onset at birth. Death occurs in first weeks of life.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08197181 – 669Missing in DEE71. 1 PublicationAdd BLAST589
Natural variantiVAR_081972272R → K in DEE71. 1 PublicationCorresponds to variant dbSNP:rs1558972120EnsemblClinVar.1
Infantile cataract, skin abnormalities, glutamate excess, and impaired intellectual development (CASGID)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disease characterized by infantile-onset cataract, erythematic subcutaneous nodules, profound developmental delay, self-injurious behavior, and intracerebral glutamate excess. Histopathologic analysis of skin lesions show deep perivascular and periglandular lymphohistiocytic infiltrates and pronounced leukocytoclasia at the surface of the dermis, focal vacuolar alterations, hyperkeratosis, and parakeratosis of the epidermis.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_081974482S → C in CASGID; increased enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs1558986214EnsemblClinVar.1
Global developmental delay, progressive ataxia, and elevated glutamine (GDPAG)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disease characterized by early-onset delay in motor skills, delayed speech, progressive ataxia, and neurologic deterioration. Plasma glutamine is persistently elevated by a factor of 2.5 despite normal plasma ammonia levels.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_081973313P → L in GDPAG; loss of enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs1558973667EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi249Y → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi286S → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi289K → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi318F → Y: No effect on catalytic activity. Loss of inhibition by BPTES; when associated with S-322. 1 Publication1
Mutagenesisi321L → A: Decreased enzyme activity. 1 Publication1
Mutagenesisi322F → S: No effect on catalytic activity. Loss of inhibition by BPTES; when associated with Y-318. 1 Publication1
Mutagenesisi323L → A: Decreased enzyme activity. 1 Publication1
Mutagenesisi394Y → A: Decreased enzyme activity. 1 Publication1
Mutagenesisi394Y → L: No effect on catalytic activity. Loss of inhibition by BPTES. 1 Publication1
Mutagenesisi466Y → A: Loss of enzyme activity. 1 Publication1

Keywords - Diseasei

Cataract, Disease variant, Epilepsy

Organism-specific databases

DisGeNET

More...
DisGeNETi
2744

MalaCards human disease database

More...
MalaCardsi
GLS
MIMi618328, phenotype
618339, phenotype
618412, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000115419

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
557064, Neonatal epileptic encephalopathy due to glutaminase deficiency
557056, Spastic ataxia-dysarthria due to glutaminase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28734

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O94925, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2146302

Drug and drug target database

More...
DrugBanki
DB13155, Esculin
DB00142, Glutamic acid
DB09374, Indocyanine green acid form
DB00130, L-Glutamine

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2891

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GLS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 54MitochondrionCuratedAdd BLAST54
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001162255 – 669Glutaminase kidney isoform, mitochondrial 68 kDa chainAdd BLAST615
ChainiPRO_000044741273 – 669Glutaminase kidney isoform, mitochondrial 65 kDa chainBy similarityAdd BLAST597

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei130N6-succinyllysineBy similarity1
Modified residuei164N6-succinyllysineBy similarity1
Modified residuei311N6-acetyllysineCombined sources1
Modified residuei652PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Synthesized as a 74-kDa cytosolic precursor which is proteolytically processed by the mitochondrial-processing peptidase (MPP) via a 72-kDa intermediate to yield the mature mitochondrial 68- and 65-kDa subunits.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei72 – 73Cleavage; by MPPBy similarity2

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-516
CPTAC-517

Encyclopedia of Proteome Dynamics

More...
EPDi
O94925

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O94925

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O94925

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O94925

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94925

PeptideAtlas

More...
PeptideAtlasi
O94925

PRoteomics IDEntifications database

More...
PRIDEi
O94925

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
50560 [O94925-1]
50561 [O94925-2]
50562 [O94925-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
O94925-2 [O94925-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2043, 3 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
O94925, 2 sites, 7 N-linked glycans (1 site), 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O94925

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O94925

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O94925

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 3 are detected in brain cortex. Isoform 3 is highly expressed in astrocytoma, ganglioglioma and ependymoma. Isoform 1 is highly expressed in brain and kidney, but not detected in liver. Isoform 3 is highly expressed in heart and pancreas, detected at lower levels in placenta, lung, pancreas and kidney, but is not detected in liver. Isoform 2 is expressed in cardiac and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115419, Expressed in middle temporal gyrus and 238 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O94925, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O94925, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000115419, Tissue enhanced (kidney)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer, dimer of dimers (PubMed:22538822, PubMed:26988803, PubMed:28526749, PubMed:29317493). The tetramers can assemble into rod-like oligomers (in vitro), but the physiological significance of this is not clear (By similarity).

Interacts with RAF1 and MAP2K2 (PubMed:22538822).

Interacts with ATCAY; the interaction is direct and may control GLS localization, negatively regulating its activity.

By similarity6 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
109006, 148 interactors

Database of interacting proteins

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DIPi
DIP-50591N

Protein interaction database and analysis system

More...
IntActi
O94925, 51 interactors

Molecular INTeraction database

More...
MINTi
O94925

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000317379

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O94925

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O94925, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1669
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O94925

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O94925

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati585 – 614ANK 1Add BLAST30
Repeati619 – 648ANK 2Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni68 – 118DisorderedSequence analysisAdd BLAST51
Regioni315 – 322Highly mobile activation loopBy similarity8
Regioni647 – 669DisorderedSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal ANK repeats prevent the assembly of the supra-tetrameric filaments.1 Publication
A highly mobile activation loop at the dimer-dimer interface is important for enzyme activity.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glutaminase family.Curated

Keywords - Domaini

ANK repeat, Repeat, Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0506, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010463

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_016439_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O94925

Identification of Orthologs from Complete Genome Data

More...
OMAi
QCCSMEA

Database of Orthologous Groups

More...
OrthoDBi
349094at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O94925

TreeFam database of animal gene trees

More...
TreeFami
TF313359

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
3.40.710.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00313, Glutaminase, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR012338, Beta-lactam/transpept-like
IPR015868, Glutaminase
IPR041541, Glutaminase_EF-hand

The PANTHER Classification System

More...
PANTHERi
PTHR12544, PTHR12544, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit
PF17959, EF-hand_14, 1 hit
PF04960, Glutaminase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF56601, SSF56601, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03814, Gln_ase, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94925-1) [UniParc]FASTAAdd to basket
Also known as: KGA3 Publications

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMRLRGSGML RDLLLRSPAG VSATLRRAQP LVTLCRRPRG GGRPAAGPAA
60 70 80 90 100
AARLHPWWGG GGWPAEPLAR GLSSSPSEIL QELGKGSTHP QPGVSPPAAP
110 120 130 140 150
AAPGPKDGPG ETDAFGNSEG KELVASGENK IKQGLLPSLE DLLFYTIAEG
160 170 180 190 200
QEKIPVHKFI TALKSTGLRT SDPRLKECMD MLRLTLQTTS DGVMLDKDLF
210 220 230 240 250
KKCVQSNIVL LTQAFRRKFV IPDFMSFTSH IDELYESAKK QSGGKVADYI
260 270 280 290 300
PQLAKFSPDL WGVSVCTVDG QRHSTGDTKV PFCLQSCVKP LKYAIAVNDL
310 320 330 340 350
GTEYVHRYVG KEPSGLRFNK LFLNEDDKPH NPMVNAGAIV VTSLIKQGVN
360 370 380 390 400
NAEKFDYVMQ FLNKMAGNEY VGFSNATFQS ERESGDRNFA IGYYLKEKKC
410 420 430 440 450
FPEGTDMVGI LDFYFQLCSI EVTCESASVM AATLANGGFC PITGERVLSP
460 470 480 490 500
EAVRNTLSLM HSCGMYDFSG QFAFHVGLPA KSGVAGGILL VVPNVMGMMC
510 520 530 540 550
WSPPLDKMGN SVKGIHFCHD LVSLCNFHNY DNLRHFAKKL DPRREGGDQR
560 570 580 590 600
VKSVINLLFA AYTGDVSALR RFALSAMDME QRDYDSRTAL HVAAAEGHVE
610 620 630 640 650
VVKFLLEACK VNPFPKDRWN NTPMDEALHF GHHDVFKILQ EYQVQYTPQG
660
DSDNGKENQT VHKNLDGLL
Length:669
Mass (Da):73,461
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E5E63505E84E0B7
GO
Isoform 2 (identifier: O94925-2) [UniParc]FASTAAdd to basket
Also known as: GAM

The sequence of this isoform differs from the canonical sequence as follows:
     162-169: ALKSTGLR → VSFYIFLS
     170-669: Missing.

Show »
Length:169
Mass (Da):17,738
Checksum:i869F0D4A9B2B3AEE
GO
Isoform 3 (identifier: O94925-3) [UniParc]FASTAAdd to basket
Also known as: Glutaminase C1 Publication, GAC2 Publications

The sequence of this isoform differs from the canonical sequence as follows:
     551-669: VKSVINLLFA...TVHKNLDGLL → HSFGPLDYES...YRMESLGEKS

Show »
Length:598
Mass (Da):65,460
Checksum:i3076ED034A79ABA5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z509B7Z509_HUMAN
Glutaminase
GLS
174Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C201H7C201_HUMAN
Glutaminase
GLS
182Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B8ZZA8B8ZZA8_HUMAN
Glutaminase
GLS
169Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JIJ6C9JIJ6_HUMAN
Glutaminase
GLS
164Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B8ZZC5B8ZZC5_HUMAN
Glutaminase
GLS
103Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZD1H7BZD1_HUMAN
Glutaminase
GLS
114Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA74861 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6G → S in AAF00090 (PubMed:11015561).Curated1
Sequence conflicti66E → D in AAF00090 (PubMed:11015561).Curated1
Sequence conflicti219F → L in AAG47842 (PubMed:10719215).Curated1
Sequence conflicti268V → A in AAD47056 (PubMed:11015561).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08197181 – 669Missing in DEE71. 1 PublicationAdd BLAST589
Natural variantiVAR_049188254A → P. Corresponds to variant dbSNP:rs16833035Ensembl.1
Natural variantiVAR_081972272R → K in DEE71. 1 PublicationCorresponds to variant dbSNP:rs1558972120EnsemblClinVar.1
Natural variantiVAR_081973313P → L in GDPAG; loss of enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs1558973667EnsemblClinVar.1
Natural variantiVAR_081974482S → C in CASGID; increased enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs1558986214EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001765162 – 169ALKSTGLR → VSFYIFLS in isoform 2. Curated8
Alternative sequenceiVSP_001766170 – 669Missing in isoform 2. CuratedAdd BLAST500
Alternative sequenceiVSP_001767551 – 669VKSVI…LDGLL → HSFGPLDYESLQQELALKET VWKKVSPESNEDISTTVVYR MESLGEKS in isoform 3. 1 PublicationAdd BLAST119

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF158555 mRNA Translation: AAD47056.1
AF097492 mRNA Translation: AAF00088.1
AF097493 mRNA Translation: AAF00089.1
AF097495 mRNA Translation: AAF00090.1
AB020645 mRNA Translation: BAA74861.2 Different initiation.
AF223943 mRNA Translation: AAF33825.1
AF327434 mRNA Translation: AAG47842.1
BC038507 mRNA Translation: AAH38507.2
AF279697 mRNA Translation: AAG17700.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2308.1 [O94925-1]
CCDS58744.1 [O94925-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001243239.1, NM_001256310.1 [O94925-3]
NP_055720.3, NM_014905.4 [O94925-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000320717; ENSP00000317379; ENSG00000115419 [O94925-1]
ENST00000338435; ENSP00000340689; ENSG00000115419 [O94925-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2744

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2744

UCSC genome browser

More...
UCSCi
uc002use.4, human [O94925-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF158555 mRNA Translation: AAD47056.1
AF097492 mRNA Translation: AAF00088.1
AF097493 mRNA Translation: AAF00089.1
AF097495 mRNA Translation: AAF00090.1
AB020645 mRNA Translation: BAA74861.2 Different initiation.
AF223943 mRNA Translation: AAF33825.1
AF327434 mRNA Translation: AAG47842.1
BC038507 mRNA Translation: AAH38507.2
AF279697 mRNA Translation: AAG17700.1
CCDSiCCDS2308.1 [O94925-1]
CCDS58744.1 [O94925-3]
RefSeqiNP_001243239.1, NM_001256310.1 [O94925-3]
NP_055720.3, NM_014905.4 [O94925-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CZDX-ray2.40A221-533[»]
3UNWX-ray2.56A/B/C/D71-597[»]
3UO9X-ray2.30A/B/C/D71-597[»]
3VOYX-ray2.20A221-533[»]
3VOZX-ray2.40A221-533[»]
3VP0X-ray2.40A221-533[»]
3VP1X-ray2.30A221-533[»]
3VP2X-ray2.70A221-533[»]
3VP3X-ray2.70A221-533[»]
3VP4X-ray2.45A221-533[»]
4O7DX-ray2.30A221-531[»]
5D3OX-ray2.79A/B72-597[»]
5FI2X-ray2.50A/B/C/D72-597[»]
5FI6X-ray2.52A/B/C/D72-597[»]
5FI7X-ray2.50A/B/C/D72-597[»]
5HL1X-ray2.40A/B/C/D72-597[»]
5I94X-ray2.98A/B/C/D72-597[»]
5JYOX-ray2.10A/B/C/D/E/F/G/H221-533[»]
5JYPX-ray2.74A221-533[»]
5U0IX-ray1.42A/B551-669[»]
5U0JX-ray1.72A/B/C/D551-669[»]
5UQEX-ray3.60A/B/C/D/F137-656[»]
5WJ6X-ray2.44A/B/C/D72-550[»]
6LOXX-ray3.20A/B/C/D71-600[»]
6UJGX-ray3.00A/B/C/D/E/F/G/H72-550[»]
6UJMX-ray2.50A/B/C/D72-550[»]
6UK6X-ray2.90A/B/C/D72-550[»]
6UKBX-ray3.00A/B/C/D72-550[»]
6UL9X-ray2.50A/B/C/D72-550[»]
6ULAX-ray2.95A/B/C/D/E/F/G/H72-550[»]
6ULJX-ray2.69A/B/C/D72-550[»]
6UMCX-ray2.75A/B/C/D72-550[»]
6UMDX-ray2.70A/B/C/D72-550[»]
6UMEX-ray2.90A/B/C/D72-550[»]
6UMFX-ray2.68A/B/C/D72-550[»]
SMRiO94925
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109006, 148 interactors
DIPiDIP-50591N
IntActiO94925, 51 interactors
MINTiO94925
STRINGi9606.ENSP00000317379

Chemistry databases

BindingDBiO94925
ChEMBLiCHEMBL2146302
DrugBankiDB13155, Esculin
DB00142, Glutamic acid
DB09374, Indocyanine green acid form
DB00130, L-Glutamine
GuidetoPHARMACOLOGYi2891

PTM databases

GlyConnecti2043, 3 N-Linked glycans (1 site)
GlyGeniO94925, 2 sites, 7 N-linked glycans (1 site), 1 O-linked glycan (1 site)
iPTMnetiO94925
PhosphoSitePlusiO94925
SwissPalmiO94925

Genetic variation databases

BioMutaiGLS

Proteomic databases

CPTACiCPTAC-516
CPTAC-517
EPDiO94925
jPOSTiO94925
MassIVEiO94925
MaxQBiO94925
PaxDbiO94925
PeptideAtlasiO94925
PRIDEiO94925
ProteomicsDBi50560 [O94925-1]
50561 [O94925-2]
50562 [O94925-3]
TopDownProteomicsiO94925-2 [O94925-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34041, 443 antibodies

The DNASU plasmid repository

More...
DNASUi
2744

Genome annotation databases

EnsembliENST00000320717; ENSP00000317379; ENSG00000115419 [O94925-1]
ENST00000338435; ENSP00000340689; ENSG00000115419 [O94925-3]
GeneIDi2744
KEGGihsa:2744
UCSCiuc002use.4, human [O94925-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2744
DisGeNETi2744

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GLS
HGNCiHGNC:4331, GLS
HPAiENSG00000115419, Tissue enhanced (kidney)
MalaCardsiGLS
MIMi138280, gene
618328, phenotype
618339, phenotype
618412, phenotype
neXtProtiNX_O94925
OpenTargetsiENSG00000115419
Orphaneti557064, Neonatal epileptic encephalopathy due to glutaminase deficiency
557056, Spastic ataxia-dysarthria due to glutaminase deficiency
PharmGKBiPA28734
VEuPathDBiHostDB:ENSG00000115419

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0506, Eukaryota
GeneTreeiENSGT00390000010463
HOGENOMiCLU_016439_1_0_1
InParanoidiO94925
OMAiQCCSMEA
OrthoDBi349094at2759
PhylomeDBiO94925
TreeFamiTF313359

Enzyme and pathway databases

BRENDAi3.5.1.2, 2681
PathwayCommonsiO94925
ReactomeiR-HSA-210500, Glutamate Neurotransmitter Release Cycle
R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-8964539, Glutamate and glutamine metabolism
SABIO-RKiO94925
SIGNORiO94925

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
2744, 34 hits in 1015 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GLS, human
EvolutionaryTraceiO94925

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2744
PharosiO94925, Tchem

Protein Ontology

More...
PROi
PR:O94925
RNActiO94925, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115419, Expressed in middle temporal gyrus and 238 other tissues
ExpressionAtlasiO94925, baseline and differential
GenevisibleiO94925, HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
3.40.710.10, 1 hit
HAMAPiMF_00313, Glutaminase, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR012338, Beta-lactam/transpept-like
IPR015868, Glutaminase
IPR041541, Glutaminase_EF-hand
PANTHERiPTHR12544, PTHR12544, 1 hit
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF17959, EF-hand_14, 1 hit
PF04960, Glutaminase, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 2 hits
SUPFAMiSSF48403, SSF48403, 1 hit
SSF56601, SSF56601, 1 hit
TIGRFAMsiTIGR03814, Gln_ase, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLSK_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94925
Secondary accession number(s): Q9UL05
, Q9UL06, Q9UL07, Q9UN40
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 1999
Last modified: September 29, 2021
This is version 208 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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