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UniProtKB - O94923 (GLCE_HUMAN)

Entry version 162 (29 Sep 2021)
Sequence version 3 (16 Jun 2009)
Previous versions | rss
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Protein

D-glucuronyl C5-epimerase

Gene

GLCE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins.

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: heparan sulfate biosynthesis

This protein is involved in the pathway heparan sulfate biosynthesis, which is part of Glycan metabolism.2 Publications
View all proteins of this organism that are known to be involved in the pathway heparan sulfate biosynthesis and in Glycan metabolism.

Pathwayi: heparin biosynthesis

This protein is involved in the pathway heparin biosynthesis, which is part of Glycan metabolism.Curated
View all proteins of this organism that are known to be involved in the pathway heparin biosynthesis and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei180SubstrateCombined sources1 Publication1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei180Critical for catalysisBy similarity1
Sitei187Critical for catalysisBy similarity1
Binding sitei202SubstrateCombined sources1 Publication1
Binding sitei210SubstrateCombined sources1 Publication1
Binding sitei213SubstrateCombined sources1 Publication1
Binding sitei216SubstrateCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi238Calcium; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi240CalciumCombined sources1 Publication1
Metal bindingi268CalciumCombined sources1 Publication1
Metal bindingi269Calcium; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi392CalciumCombined sources1 Publication1
Binding sitei510SubstrateCombined sources1 Publication1
Binding sitei514SubstrateCombined sources1 Publication1
Binding sitei560SubstrateCombined sources1 Publication1
Sitei560Critical for catalysisBy similarity1
Binding sitei563SubstrateCombined sources1 Publication1
Sitei578Critical for catalysis1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		5.1.3.17, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O94923

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2022928, HS-GAG biosynthesis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00756
UPA00862

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
D-glucuronyl C5-epimerase (EC:5.1.3.173 Publications)
Alternative name(s):
Heparan sulfate C5-epimerase
Short name:
Hsepi
Heparin/heparan sulfate:glucuronic acid C5-epimerase
Heparosan-N-sulfate-glucuronate 5-epimerase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GLCE
Synonyms:KIAA0836Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17855, GLCE

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612134, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O94923

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000138604

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 28Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini29 – 617LumenalSequence analysisAdd BLAST589

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi146Y → A: Reduces enzyme activity by about 60%. 1 Publication1
Mutagenesisi162Y → A: Reduces enzyme activity by about 75%. 1 Publication1
Mutagenesisi168Y → A: Almost abolishes enzyme activity. 1 Publication1
Mutagenesisi210Y → A: Reduces enzyme activity by about 30%. 1 Publication1
Mutagenesisi222Y → A: Almost abolishes enzyme activity. 1 Publication1
Mutagenesisi499E → Q: Loss of enzyme activity. 1 Publication1
Mutagenesisi500Y → F: Mildly decreased enzyme activity. 1 Publication1
Mutagenesisi578Y → F: Loss of enzyme activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		26035

Open Targets

More...OpenTargetsi		ENSG00000138604

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA145148750

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O94923, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GLCE

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001926451 – 617D-glucuronyl C5-epimeraseAdd BLAST617

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi225N-linked (GlcNAc...) asparagineCombined sources2 Publications1
Glycosylationi303N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi393N-linked (GlcNAc...) asparagineCombined sources1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O94923

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O94923

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O94923

MaxQB - The MaxQuant DataBase

More...MaxQBi		O94923

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O94923

PeptideAtlas

More...PeptideAtlasi		O94923

PRoteomics IDEntifications database

More...PRIDEi		O94923

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50559

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O94923, 4 sites, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O94923

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O94923

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O94923

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000138604, Expressed in testis and 207 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O94923, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O94923, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000138604, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:30872481).

Interacts with HS2ST1.

By similarity1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117501, 27 interactors

Protein interaction database and analysis system

More...IntActi		O94923, 20 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000261858

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O94923, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1617
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O94923

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni185 – 187Substrate bindingCombined sources1 Publication3
Regioni429 – 432Substrate bindingBy similarity4
Regioni499 – 500Substrate bindingCombined sources1 Publication2
Regioni572 – 581Substrate bindingCombined sources1 Publication10

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the D-glucuronyl C5-epimerase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3760, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006043

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O94923

Identification of Orthologs from Complete Genome Data

More...OMAi		RGVFMYF

Database of Orthologous Groups

More...OrthoDBi		561819at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O94923

TreeFam database of animal gene trees

More...TreeFami		TF105869

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010598, C5-epim_C
IPR039721, C5-epimerase

The PANTHER Classification System

More...PANTHERi		PTHR13174, PTHR13174, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06662, C5-epim_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O94923-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRCLAARVNY KTLIIICALF TLVTVLLWNK CSSDKAIQFP RRSSSGFRVD 
        60         70         80         90        100
GFEKRAAASE SNNYMNHVAK QQSEEAFPQE QQKAPPVVGG FNSNVGSKVL 
       110        120        130        140        150
GLKYEEIDCL INDEHTIKGR REGNEVFLPF TWVEKYFDVY GKVVQYDGYD 
       160        170        180        190        200
RFEFSHSYSK VYAQRAPYHP DGVFMSFEGY NVEVRDRVKC ISGVEGVPLS 
       210        220        230        240        250
TQWGPQGYFY PIQIAQYGLS HYSKNLTEKP PHIEVYETAE DRDKNKPNDW 
       260        270        280        290        300
TVPKGCFMAN VADKSRFTNV KQFIAPETSE GVSLQLGNTK DFIISFDLKF 
       310        320        330        340        350
LTNGSVSVVL ETTEKNQLFT IHYVSNAQLI AFKERDIYYG IGPRTSWSTV 
       360        370        380        390        400
TRDLVTDLRK GVGLSNTKAV KPTKIMPKKV VRLIAKGKGF LDNITISTTA 
       410        420        430        440        450
HMAAFFAASD WLVRNQDEKG GWPIMVTRKL GEGFKSLEPG WYSAMAQGQA 
       460        470        480        490        500
ISTLVRAYLL TKDHIFLNSA LRATAPYKFL SEQHGVKAVF MNKHDWYEEY 
       510        520        530        540        550
PTTPSSFVLN GFMYSLIGLY DLKETAGEKL GKEARSLYER GMESLKAMLP 
       560        570        580        590        600
LYDTGSGTIY DLRHFMLGIA PNLARWDYHT THINQLQLLS TIDESPVFKE 
       610 
FVKRWKSYLK GSRAKHN
Length:617
Mass (Da):70,101
Last modified:June 16, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F909A15FEA6DA05
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YNP1H0YNP1_HUMAN
Heparosan-N-sulfate-glucuronate 5-e...
GLCE
553Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05583765M → V. Corresponds to variant dbSNP:rs12440300Ensembl.1
Natural variantiVAR_057958597V → I1 PublicationCorresponds to variant dbSNP:rs3865014Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY635582 mRNA Translation: AAT48654.1
AC026992 mRNA No translation available.
AB020643 mRNA Translation: BAA74859.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32277.1

NCBI Reference Sequences

More...RefSeqi		NP_001311022.1, NM_001324093.1
NP_001311023.1, NM_001324094.1
NP_056369.1, NM_015554.2
XP_005254355.1, XM_005254298.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000261858; ENSP00000261858; ENSG00000138604

Database of genes from NCBI RefSeq genomes

More...GeneIDi		26035

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:26035

UCSC genome browser

More...UCSCi		uc002ary.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY635582 mRNA Translation: AAT48654.1
AC026992 mRNA No translation available.
AB020643 mRNA Translation: BAA74859.1
CCDSiCCDS32277.1
RefSeqiNP_001311022.1, NM_001324093.1
NP_001311023.1, NM_001324094.1
NP_056369.1, NM_015554.2
XP_005254355.1, XM_005254298.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6HZZX-ray2.52A/B98-617[»]
6I01X-ray2.10A/B98-617[»]
6I02X-ray2.45A/B98-617[»]
SMRiO94923
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi117501, 27 interactors
IntActiO94923, 20 interactors
STRINGi9606.ENSP00000261858

PTM databases

GlyGeniO94923, 4 sites, 1 O-linked glycan (1 site)
iPTMnetiO94923
PhosphoSitePlusiO94923
SwissPalmiO94923

Genetic variation databases

BioMutaiGLCE

Proteomic databases

EPDiO94923
jPOSTiO94923
MassIVEiO94923
MaxQBiO94923
PaxDbiO94923
PeptideAtlasiO94923
PRIDEiO94923
ProteomicsDBi50559

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26368, 67 antibodies

The DNASU plasmid repository

More...DNASUi		26035

Genome annotation databases

EnsembliENST00000261858; ENSP00000261858; ENSG00000138604
GeneIDi26035
KEGGihsa:26035
UCSCiuc002ary.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		26035
DisGeNETi26035

GeneCards: human genes, protein and diseases

More...GeneCardsi		GLCE
HGNCiHGNC:17855, GLCE
HPAiENSG00000138604, Tissue enhanced (brain)
MIMi612134, gene
neXtProtiNX_O94923
OpenTargetsiENSG00000138604
PharmGKBiPA145148750
VEuPathDBiHostDB:ENSG00000138604

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3760, Eukaryota
GeneTreeiENSGT00390000006043
InParanoidiO94923
OMAiRGVFMYF
OrthoDBi561819at2759
PhylomeDBiO94923
TreeFamiTF105869

Enzyme and pathway databases

UniPathwayiUPA00756
UPA00862
BRENDAi5.1.3.17, 2681
PathwayCommonsiO94923
ReactomeiR-HSA-2022928, HS-GAG biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		26035, 10 hits in 983 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GLCE, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GLCE

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		26035
PharosiO94923, Tbio

Protein Ontology

More...PROi		PR:O94923
RNActiO94923, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000138604, Expressed in testis and 207 other tissues
ExpressionAtlasiO94923, baseline and differential
GenevisibleiO94923, HS

Family and domain databases

InterProiView protein in InterPro
IPR010598, C5-epim_C
IPR039721, C5-epimerase
PANTHERiPTHR13174, PTHR13174, 1 hit
PfamiView protein in Pfam
PF06662, C5-epim_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLCE_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94923
Secondary accession number(s): Q6GUQ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: June 16, 2009
Last modified: September 29, 2021
This is version 162 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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