ENDOD1

Protein namesⁱ	Recommended name: Endonuclease domain-containing 1 protein (EC:3.1.30.-)
Gene namesⁱ	Name:ENDOD1 Synonyms:KIAA0830
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000149218.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29129 ENDOD1
neXtProtⁱ	NX_O94919

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000149218
PharmGKBⁱ	PA143485454

Polymorphism and mutation databases

BioMutaⁱ	ENDOD1

BioMutaⁱ

ENDOD1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	Sequence analysisAdd BLAST		21
ChainⁱPRO_0000019924	22 – 500	Endonuclease domain-containing 1 proteinAdd BLAST		479

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	407	N6-acetyllysineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	O94919
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O94919
PaxDbⁱ	O94919
PeptideAtlas More...PeptideAtlasⁱ	O94919
PRIDEⁱ	O94919
ProteomicsDBⁱ	50555

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	O94919

OGPⁱ

O94919

PTM databases

iPTMnetⁱ	O94919
PhosphoSitePlusⁱ	O94919
SwissPalmⁱ	O94919

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000149218 Expressed in 237 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_ENDOD1
Genevisibleⁱ	O94919 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA008932 HPA010517

HPAⁱ

HPA008932
HPA010517

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	116689, 28 interactors
IntActⁱ	O94919, 11 interactors
Molecular INTeraction database More...MINTⁱ	O94919

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O94919
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the DNA/RNA non-specific endonuclease family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J1DZ Eukaryota ENOG4111RBI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063903
HOGENOMⁱ	HOG000112371
HOVERGENⁱ	HBG081477
InParanoidⁱ	O94919
KEGG Orthology (KO) More...KOⁱ	K15049
OMAⁱ	SIPWKVL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05HX
PhylomeDBⁱ	O94919
TreeFamⁱ	TF333322

Family and domain databases

InterProⁱ	View protein in InterPro IPR001604 DNA/RNA_non-sp_Endonuclease IPR039015 ENDOD1 IPR020821 Extracellular_endonuc_su_A
PANTHERⁱ	PTHR21472 PTHR21472, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01223 Endonuclease_NS, 1 hit
SMARTⁱ	View protein in SMART SM00892 Endonuclease_NS, 1 hit SM00477 NUC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

O94919-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGTARWLALG SLFALAGLLE GRLVGEEEAG FGECDKFFYA GTPPAGLAAD 
        60         70         80         90        100
SHVKICQRAE GAERFATLYS TRDRIPVYSA FRAPRPAPGG AEQRWLVEPQ 
       110        120        130        140        150
IDDPNSNLEE AINEAEAITS VNSLGSKQAL NTDYLDSDYQ RGQLYPFSLS 
       160        170        180        190        200
SDVQVATFTL TNSAPMTQSF QERWYVNLHS LMDRALTPQC GSGEDLYILT 
       210        220        230        240        250
GTVPSDYRVK DKVAVPEFVW LAACCAVPGG GWAMGFVKHT RDSDIIEDVM 
       260        270        280        290        300
VKDLQKLLPF NPQLFQNNCG ETEQDTEKMK KILEVVNQIQ DEERMVQSQK 
       310        320        330        340        350
SSSPLSSTRS KRSTLLPPEA SEGSSSFLGK LMGFIATPFI KLFQLIYYLV 
       360        370        380        390        400
VAILKNIVYF LWCVTKQVIN GIESCLYRLG SATISYFMAI GEELVSIPWK 
       410        420        430        440        450
VLKVVAKVIR ALLRILCCLL KAICRVLSIP VRVLVDVATF PVYTMGAIPI 
       460        470        480        490        500
VCKDIALGLG GTVSLLFDTA FGTLGGLFQV VFSVCKRIGY KVTFDNSGEL

Length:500

Mass (Da):55,017

Last modified:July 19, 2004 - v2

Checksum:ⁱ5B62754FE2E9AD9C

GO

Sequence cautionⁱ

The sequence BAA74853 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	113	N → I in BAF84362 (PubMed:14702039).Curated		1
Sequence conflictⁱ	189	Q → R in BAF84362 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_022044	350	V → M. Corresponds to variant dbSNP:rs3740862Ensembl.		1
Natural variantⁱVAR_022045	446	G → V. Corresponds to variant dbSNP:rs3740861Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB020637 mRNA Translation: BAA74853.1 Different initiation. AK291673 mRNA Translation: BAF84362.1 BC026191 mRNA Translation: AAH26191.1 BC071171 mRNA Translation: AAH71171.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41699.1
NCBI Reference Sequences More...RefSeqⁱ	NP_055851.1, NM_015036.2
UniGeneⁱ	Hs.167115

Genome annotation databases

Ensemblⁱ	ENST00000278505; ENSP00000278505; ENSG00000149218
GeneIDⁱ	23052
KEGGⁱ	hsa:23052
UCSC genome browser More...UCSCⁱ	uc001pfh.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O94919	Endonuclease domain containing 1		MACMU		500	UniRef90_O94919
Uncharacterized protein		MACNE		500
ENDOD1 isoform 1		PANTR		500
Endonuclease domain containing 1		CALJA		500
ENDOD1 isoform 1		PONAB		500
+23

Protein	Similar proteins		Species	Score	Length	Source
O94919	Uncharacterized protein		CHLSB		500	UniRef50_O94919
Endonuclease domain containing 1		MACMU		500
Uncharacterized protein		MACNE		500
Uncharacterized protein		COLAP		500
Uncharacterized protein		CERAT		500
+142

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB020637 mRNA Translation: BAA74853.1 Different initiation. AK291673 mRNA Translation: BAF84362.1 BC026191 mRNA Translation: AAH26191.1 BC071171 mRNA Translation: AAH71171.1
CCDSⁱ	CCDS41699.1
RefSeqⁱ	NP_055851.1, NM_015036.2
UniGeneⁱ	Hs.167115

3D structure databases

ProteinModelPortalⁱ	O94919
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116689, 28 interactors
IntActⁱ	O94919, 11 interactors
MINTⁱ	O94919

PTM databases

iPTMnetⁱ	O94919
PhosphoSitePlusⁱ	O94919
SwissPalmⁱ	O94919

Polymorphism and mutation databases

BioMutaⁱ	ENDOD1

BioMutaⁱ

ENDOD1

2D gel databases

OGPⁱ	O94919

OGPⁱ

O94919

Proteomic databases

EPDⁱ	O94919
MaxQBⁱ	O94919
PaxDbⁱ	O94919
PeptideAtlasⁱ	O94919
PRIDEⁱ	O94919
ProteomicsDBⁱ	50555

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000278505; ENSP00000278505; ENSG00000149218
GeneIDⁱ	23052
KEGGⁱ	hsa:23052
UCSCⁱ	uc001pfh.4 human

Organism-specific databases

CTDⁱ	23052
EuPathDBⁱ	HostDB:ENSG00000149218.4
GeneCardsⁱ	ENDOD1
HGNCⁱ	HGNC:29129 ENDOD1
HPAⁱ	HPA008932 HPA010517
neXtProtⁱ	NX_O94919
OpenTargetsⁱ	ENSG00000149218
PharmGKBⁱ	PA143485454
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J1DZ Eukaryota ENOG4111RBI LUCA
GeneTreeⁱ	ENSGT00530000063903
HOGENOMⁱ	HOG000112371
HOVERGENⁱ	HBG081477
InParanoidⁱ	O94919
KOⁱ	K15049
OMAⁱ	SIPWKVL
OrthoDBⁱ	EOG091G05HX
PhylomeDBⁱ	O94919
TreeFamⁱ	TF333322

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114608 Platelet degranulation

Reactomeⁱ

R-HSA-114608 Platelet degranulation

Miscellaneous databases

GenomeRNAiⁱ	23052
Protein Ontology More...PROⁱ	PR:O94919

Gene expression databases

Bgeeⁱ	ENSG00000149218 Expressed in 237 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_ENDOD1
Genevisibleⁱ	O94919 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001604 DNA/RNA_non-sp_Endonuclease IPR039015 ENDOD1 IPR020821 Extracellular_endonuc_su_A
PANTHERⁱ	PTHR21472 PTHR21472, 1 hit
Pfamⁱ	View protein in Pfam PF01223 Endonuclease_NS, 1 hit
SMARTⁱ	View protein in SMART SM00892 Endonuclease_NS, 1 hit SM00477 NUC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ENDD1_HUMAN
Accessionⁱ	O94919Primary (citable) accession number: O94919 Secondary accession number(s): A8K6K8, Q6GQY5, Q8TAQ8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
	Last sequence update:	July 19, 2004
	Last modified:	September 12, 2018
	This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O94919 (ENDD1_HUMAN)

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Endonuclease domain-containing 1 protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Cytosol

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ