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Protein

Endonuclease domain-containing 1 protein

Gene

ENDOD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a DNase and a RNase.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease domain-containing 1 protein (EC:3.1.30.-)
Gene namesi
Name:ENDOD1
Synonyms:KIAA0830
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149218.4
HGNCiHGNC:29129 ENDOD1
neXtProtiNX_O94919

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000149218
PharmGKBiPA143485454

Polymorphism and mutation databases

BioMutaiENDOD1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001992422 – 500Endonuclease domain-containing 1 proteinAdd BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei407N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO94919
MaxQBiO94919
PaxDbiO94919
PeptideAtlasiO94919
PRIDEiO94919
ProteomicsDBi50555

2D gel databases

OGPiO94919

PTM databases

iPTMnetiO94919
PhosphoSitePlusiO94919
SwissPalmiO94919

Expressioni

Gene expression databases

BgeeiENSG00000149218 Expressed in 237 organ(s), highest expression level in corpus callosum
CleanExiHS_ENDOD1
GenevisibleiO94919 HS

Organism-specific databases

HPAiHPA008932
HPA010517

Interactioni

Protein-protein interaction databases

BioGridi116689, 28 interactors
IntActiO94919, 11 interactors
MINTiO94919

Structurei

3D structure databases

ProteinModelPortaliO94919
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1DZ Eukaryota
ENOG4111RBI LUCA
GeneTreeiENSGT00530000063903
HOGENOMiHOG000112371
HOVERGENiHBG081477
InParanoidiO94919
KOiK15049
OMAiSIPWKVL
OrthoDBiEOG091G05HX
PhylomeDBiO94919
TreeFamiTF333322

Family and domain databases

InterProiView protein in InterPro
IPR001604 DNA/RNA_non-sp_Endonuclease
IPR039015 ENDOD1
IPR020821 Extracellular_endonuc_su_A
PANTHERiPTHR21472 PTHR21472, 1 hit
PfamiView protein in Pfam
PF01223 Endonuclease_NS, 1 hit
SMARTiView protein in SMART
SM00892 Endonuclease_NS, 1 hit
SM00477 NUC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94919-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTARWLALG SLFALAGLLE GRLVGEEEAG FGECDKFFYA GTPPAGLAAD
60 70 80 90 100
SHVKICQRAE GAERFATLYS TRDRIPVYSA FRAPRPAPGG AEQRWLVEPQ
110 120 130 140 150
IDDPNSNLEE AINEAEAITS VNSLGSKQAL NTDYLDSDYQ RGQLYPFSLS
160 170 180 190 200
SDVQVATFTL TNSAPMTQSF QERWYVNLHS LMDRALTPQC GSGEDLYILT
210 220 230 240 250
GTVPSDYRVK DKVAVPEFVW LAACCAVPGG GWAMGFVKHT RDSDIIEDVM
260 270 280 290 300
VKDLQKLLPF NPQLFQNNCG ETEQDTEKMK KILEVVNQIQ DEERMVQSQK
310 320 330 340 350
SSSPLSSTRS KRSTLLPPEA SEGSSSFLGK LMGFIATPFI KLFQLIYYLV
360 370 380 390 400
VAILKNIVYF LWCVTKQVIN GIESCLYRLG SATISYFMAI GEELVSIPWK
410 420 430 440 450
VLKVVAKVIR ALLRILCCLL KAICRVLSIP VRVLVDVATF PVYTMGAIPI
460 470 480 490 500
VCKDIALGLG GTVSLLFDTA FGTLGGLFQV VFSVCKRIGY KVTFDNSGEL
Length:500
Mass (Da):55,017
Last modified:July 19, 2004 - v2
Checksum:i5B62754FE2E9AD9C
GO

Sequence cautioni

The sequence BAA74853 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113N → I in BAF84362 (PubMed:14702039).Curated1
Sequence conflicti189Q → R in BAF84362 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022044350V → M. Corresponds to variant dbSNP:rs3740862Ensembl.1
Natural variantiVAR_022045446G → V. Corresponds to variant dbSNP:rs3740861Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020637 mRNA Translation: BAA74853.1 Different initiation.
AK291673 mRNA Translation: BAF84362.1
BC026191 mRNA Translation: AAH26191.1
BC071171 mRNA Translation: AAH71171.1
CCDSiCCDS41699.1
RefSeqiNP_055851.1, NM_015036.2
UniGeneiHs.167115

Genome annotation databases

EnsembliENST00000278505; ENSP00000278505; ENSG00000149218
GeneIDi23052
KEGGihsa:23052
UCSCiuc001pfh.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020637 mRNA Translation: BAA74853.1 Different initiation.
AK291673 mRNA Translation: BAF84362.1
BC026191 mRNA Translation: AAH26191.1
BC071171 mRNA Translation: AAH71171.1
CCDSiCCDS41699.1
RefSeqiNP_055851.1, NM_015036.2
UniGeneiHs.167115

3D structure databases

ProteinModelPortaliO94919
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116689, 28 interactors
IntActiO94919, 11 interactors
MINTiO94919

PTM databases

iPTMnetiO94919
PhosphoSitePlusiO94919
SwissPalmiO94919

Polymorphism and mutation databases

BioMutaiENDOD1

2D gel databases

OGPiO94919

Proteomic databases

EPDiO94919
MaxQBiO94919
PaxDbiO94919
PeptideAtlasiO94919
PRIDEiO94919
ProteomicsDBi50555

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278505; ENSP00000278505; ENSG00000149218
GeneIDi23052
KEGGihsa:23052
UCSCiuc001pfh.4 human

Organism-specific databases

CTDi23052
EuPathDBiHostDB:ENSG00000149218.4
GeneCardsiENDOD1
HGNCiHGNC:29129 ENDOD1
HPAiHPA008932
HPA010517
neXtProtiNX_O94919
OpenTargetsiENSG00000149218
PharmGKBiPA143485454
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1DZ Eukaryota
ENOG4111RBI LUCA
GeneTreeiENSGT00530000063903
HOGENOMiHOG000112371
HOVERGENiHBG081477
InParanoidiO94919
KOiK15049
OMAiSIPWKVL
OrthoDBiEOG091G05HX
PhylomeDBiO94919
TreeFamiTF333322

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Miscellaneous databases

GenomeRNAii23052
PROiPR:O94919

Gene expression databases

BgeeiENSG00000149218 Expressed in 237 organ(s), highest expression level in corpus callosum
CleanExiHS_ENDOD1
GenevisibleiO94919 HS

Family and domain databases

InterProiView protein in InterPro
IPR001604 DNA/RNA_non-sp_Endonuclease
IPR039015 ENDOD1
IPR020821 Extracellular_endonuc_su_A
PANTHERiPTHR21472 PTHR21472, 1 hit
PfamiView protein in Pfam
PF01223 Endonuclease_NS, 1 hit
SMARTiView protein in SMART
SM00892 Endonuclease_NS, 1 hit
SM00477 NUC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiENDD1_HUMAN
AccessioniPrimary (citable) accession number: O94919
Secondary accession number(s): A8K6K8, Q6GQY5, Q8TAQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: September 12, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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