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UniProtKB - O94919 (ENDD1_HUMAN)

Entry version 140 (08 May 2019)
Sequence version 2 (19 Jul 2004)
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Protein

Endonuclease domain-containing 1 protein

Gene

ENDOD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a DNase and a RNase.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608 Platelet degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endonuclease domain-containing 1 protein (EC:3.1.30.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ENDOD1
Synonyms:KIAA0830
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29129 ENDOD1

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O94919

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23052

Open Targets

More...OpenTargetsi		ENSG00000149218

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA143485454

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ENDOD1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001992422 – 500Endonuclease domain-containing 1 proteinAdd BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei407N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O94919

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O94919

MaxQB - The MaxQuant DataBase

More...MaxQBi		O94919

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O94919

PeptideAtlas

More...PeptideAtlasi		O94919

PRoteomics IDEntifications database

More...PRIDEi		O94919

ProteomicsDB human proteome resource

More...ProteomicsDBi		50555

2D gel databases

USC-OGP 2-DE database

More...OGPi		O94919

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O94919

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O94919

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O94919

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000149218 Expressed in 237 organ(s), highest expression level in corpus callosum

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O94919 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA008932
HPA010517

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		116689, 29 interactors

Protein interaction database and analysis system

More...IntActi		O94919, 11 interactors

Molecular INTeraction database

More...MINTi		O94919

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000278505

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA/RNA non-specific endonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410J1DZ Eukaryota
ENOG4111RBI LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182790

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000112371

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O94919

KEGG Orthology (KO)

More...KOi		K15049

Identification of Orthologs from Complete Genome Data

More...OMAi		IPWKVLK

Database of Orthologous Groups

More...OrthoDBi		858590at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O94919

TreeFam database of animal gene trees

More...TreeFami		TF333322

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001604 DNA/RNA_non-sp_Endonuclease
IPR039015 ENDOD1
IPR020821 Extracellular_endonuc_su_A

The PANTHER Classification System

More...PANTHERi		PTHR21472 PTHR21472, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01223 Endonuclease_NS, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00892 Endonuclease_NS, 1 hit
SM00477 NUC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O94919-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTARWLALG SLFALAGLLE GRLVGEEEAG FGECDKFFYA GTPPAGLAAD 
        60         70         80         90        100
SHVKICQRAE GAERFATLYS TRDRIPVYSA FRAPRPAPGG AEQRWLVEPQ 
       110        120        130        140        150
IDDPNSNLEE AINEAEAITS VNSLGSKQAL NTDYLDSDYQ RGQLYPFSLS 
       160        170        180        190        200
SDVQVATFTL TNSAPMTQSF QERWYVNLHS LMDRALTPQC GSGEDLYILT 
       210        220        230        240        250
GTVPSDYRVK DKVAVPEFVW LAACCAVPGG GWAMGFVKHT RDSDIIEDVM 
       260        270        280        290        300
VKDLQKLLPF NPQLFQNNCG ETEQDTEKMK KILEVVNQIQ DEERMVQSQK 
       310        320        330        340        350
SSSPLSSTRS KRSTLLPPEA SEGSSSFLGK LMGFIATPFI KLFQLIYYLV 
       360        370        380        390        400
VAILKNIVYF LWCVTKQVIN GIESCLYRLG SATISYFMAI GEELVSIPWK 
       410        420        430        440        450
VLKVVAKVIR ALLRILCCLL KAICRVLSIP VRVLVDVATF PVYTMGAIPI 
       460        470        480        490        500
VCKDIALGLG GTVSLLFDTA FGTLGGLFQV VFSVCKRIGY KVTFDNSGEL
Length:500
Mass (Da):55,017
Last modified:July 19, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B62754FE2E9AD9C
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA74853 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti113N → I in BAF84362 (PubMed:14702039).Curated1
Sequence conflicti189Q → R in BAF84362 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022044350V → M. Corresponds to variant dbSNP:rs3740862Ensembl.1
Natural variantiVAR_022045446G → V. Corresponds to variant dbSNP:rs3740861Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB020637 mRNA Translation: BAA74853.1 Different initiation.
AK291673 mRNA Translation: BAF84362.1
BC026191 mRNA Translation: AAH26191.1
BC071171 mRNA Translation: AAH71171.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41699.1

NCBI Reference Sequences

More...RefSeqi		NP_055851.1, NM_015036.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000278505; ENSP00000278505; ENSG00000149218

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23052

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23052

UCSC genome browser

More...UCSCi		uc001pfh.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020637 mRNA Translation: BAA74853.1 Different initiation.
AK291673 mRNA Translation: BAF84362.1
BC026191 mRNA Translation: AAH26191.1
BC071171 mRNA Translation: AAH71171.1
CCDSiCCDS41699.1
RefSeqiNP_055851.1, NM_015036.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi116689, 29 interactors
IntActiO94919, 11 interactors
MINTiO94919
STRINGi9606.ENSP00000278505

PTM databases

iPTMnetiO94919
PhosphoSitePlusiO94919
SwissPalmiO94919

Polymorphism and mutation databases

BioMutaiENDOD1

2D gel databases

OGPiO94919

Proteomic databases

EPDiO94919
jPOSTiO94919
MaxQBiO94919
PaxDbiO94919
PeptideAtlasiO94919
PRIDEiO94919
ProteomicsDBi50555

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278505; ENSP00000278505; ENSG00000149218
GeneIDi23052
KEGGihsa:23052
UCSCiuc001pfh.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23052
DisGeNETi23052

GeneCards: human genes, protein and diseases

More...GeneCardsi		ENDOD1
HGNCiHGNC:29129 ENDOD1
HPAiHPA008932
HPA010517
neXtProtiNX_O94919
OpenTargetsiENSG00000149218
PharmGKBiPA143485454

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410J1DZ Eukaryota
ENOG4111RBI LUCA
GeneTreeiENSGT00950000182790
HOGENOMiHOG000112371
InParanoidiO94919
KOiK15049
OMAiIPWKVLK
OrthoDBi858590at2759
PhylomeDBiO94919
TreeFamiTF333322

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23052

Protein Ontology

More...PROi		PR:O94919

Gene expression databases

BgeeiENSG00000149218 Expressed in 237 organ(s), highest expression level in corpus callosum
GenevisibleiO94919 HS

Family and domain databases

InterProiView protein in InterPro
IPR001604 DNA/RNA_non-sp_Endonuclease
IPR039015 ENDOD1
IPR020821 Extracellular_endonuc_su_A
PANTHERiPTHR21472 PTHR21472, 1 hit
PfamiView protein in Pfam
PF01223 Endonuclease_NS, 1 hit
SMARTiView protein in SMART
SM00892 Endonuclease_NS, 1 hit
SM00477 NUC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiENDD1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94919
Secondary accession number(s): A8K6K8, Q6GQY5, Q8TAQ8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: May 8, 2019
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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