UniProtKB - O94919 (ENDD1_HUMAN)
Protein
Endonuclease domain-containing 1 protein
Gene
ENDOD1
Organism
Homo sapiens (Human)
Status
Functioni
May act as a DNase and a RNase.Curated
GO - Molecular functioni
- endonuclease activity Source: UniProtKB-KW
- metal ion binding Source: InterPro
- nucleic acid binding Source: InterPro
GO - Biological processi
- platelet degranulation Source: Reactome
Keywordsi
Molecular function | Endonuclease, Hydrolase, Nuclease |
Enzyme and pathway databases
PathwayCommonsi | O94919 |
Reactomei | R-HSA-114608, Platelet degranulation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ENDOD1 Synonyms:KIAA0830 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29129, ENDOD1 |
neXtProti | NX_O94919 |
VEuPathDBi | HostDB:ENSG00000149218.4 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Other locations
- membrane Source: UniProtKB
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 23052 |
OpenTargetsi | ENSG00000149218 |
PharmGKBi | PA143485454 |
Miscellaneous databases
Pharosi | O94919, Tdark |
Genetic variation databases
BioMutai | ENDOD1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000019924 | 22 – 500 | Endonuclease domain-containing 1 proteinAdd BLAST | 479 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 407 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | O94919 |
jPOSTi | O94919 |
MassIVEi | O94919 |
MaxQBi | O94919 |
PaxDbi | O94919 |
PeptideAtlasi | O94919 |
PRIDEi | O94919 |
ProteomicsDBi | 50555 |
2D gel databases
OGPi | O94919 |
PTM databases
iPTMneti | O94919 |
MetOSitei | O94919 |
PhosphoSitePlusi | O94919 |
SwissPalmi | O94919 |
Expressioni
Gene expression databases
Bgeei | ENSG00000149218, Expressed in corpus callosum and 249 other tissues |
Genevisiblei | O94919, HS |
Organism-specific databases
HPAi | ENSG00000149218, Low tissue specificity |
Interactioni
Binary interactionsi
O94919
With | #Exp. | IntAct |
---|---|---|
VSNL1 [P62760] | 3 | EBI-6163734,EBI-740943 |
Protein-protein interaction databases
BioGRIDi | 116689, 36 interactors |
IntActi | O94919, 26 interactors |
MINTi | O94919 |
STRINGi | 9606.ENSP00000278505 |
Miscellaneous databases
RNActi | O94919, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the DNA/RNA non-specific endonuclease family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QQYK, Eukaryota |
GeneTreei | ENSGT01010000222309 |
HOGENOMi | CLU_035817_0_0_1 |
InParanoidi | O94919 |
OMAi | FQERWYM |
OrthoDBi | 858590at2759 |
PhylomeDBi | O94919 |
TreeFami | TF333322 |
Family and domain databases
InterProi | View protein in InterPro IPR001604, DNA/RNA_non-sp_Endonuclease IPR039015, ENDOD1 IPR020821, Extracellular_endonuc_su_A |
PANTHERi | PTHR21472, PTHR21472, 1 hit |
Pfami | View protein in Pfam PF01223, Endonuclease_NS, 1 hit |
SMARTi | View protein in SMART SM00892, Endonuclease_NS, 1 hit SM00477, NUC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O94919-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGTARWLALG SLFALAGLLE GRLVGEEEAG FGECDKFFYA GTPPAGLAAD
60 70 80 90 100
SHVKICQRAE GAERFATLYS TRDRIPVYSA FRAPRPAPGG AEQRWLVEPQ
110 120 130 140 150
IDDPNSNLEE AINEAEAITS VNSLGSKQAL NTDYLDSDYQ RGQLYPFSLS
160 170 180 190 200
SDVQVATFTL TNSAPMTQSF QERWYVNLHS LMDRALTPQC GSGEDLYILT
210 220 230 240 250
GTVPSDYRVK DKVAVPEFVW LAACCAVPGG GWAMGFVKHT RDSDIIEDVM
260 270 280 290 300
VKDLQKLLPF NPQLFQNNCG ETEQDTEKMK KILEVVNQIQ DEERMVQSQK
310 320 330 340 350
SSSPLSSTRS KRSTLLPPEA SEGSSSFLGK LMGFIATPFI KLFQLIYYLV
360 370 380 390 400
VAILKNIVYF LWCVTKQVIN GIESCLYRLG SATISYFMAI GEELVSIPWK
410 420 430 440 450
VLKVVAKVIR ALLRILCCLL KAICRVLSIP VRVLVDVATF PVYTMGAIPI
460 470 480 490 500
VCKDIALGLG GTVSLLFDTA FGTLGGLFQV VFSVCKRIGY KVTFDNSGEL
Sequence cautioni
The sequence BAA74853 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 113 | N → I in BAF84362 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 189 | Q → R in BAF84362 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022044 | 350 | V → M. Corresponds to variant dbSNP:rs3740862Ensembl. | 1 | |
Natural variantiVAR_022045 | 446 | G → V. Corresponds to variant dbSNP:rs3740861Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB020637 mRNA Translation: BAA74853.1 Different initiation. AK291673 mRNA Translation: BAF84362.1 BC026191 mRNA Translation: AAH26191.1 BC071171 mRNA Translation: AAH71171.1 |
CCDSi | CCDS41699.1 |
RefSeqi | NP_055851.1, NM_015036.2 |
Genome annotation databases
Ensembli | ENST00000278505; ENSP00000278505; ENSG00000149218 |
GeneIDi | 23052 |
KEGGi | hsa:23052 |
UCSCi | uc001pfh.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB020637 mRNA Translation: BAA74853.1 Different initiation. AK291673 mRNA Translation: BAF84362.1 BC026191 mRNA Translation: AAH26191.1 BC071171 mRNA Translation: AAH71171.1 |
CCDSi | CCDS41699.1 |
RefSeqi | NP_055851.1, NM_015036.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 116689, 36 interactors |
IntActi | O94919, 26 interactors |
MINTi | O94919 |
STRINGi | 9606.ENSP00000278505 |
PTM databases
iPTMneti | O94919 |
MetOSitei | O94919 |
PhosphoSitePlusi | O94919 |
SwissPalmi | O94919 |
Genetic variation databases
BioMutai | ENDOD1 |
2D gel databases
OGPi | O94919 |
Proteomic databases
EPDi | O94919 |
jPOSTi | O94919 |
MassIVEi | O94919 |
MaxQBi | O94919 |
PaxDbi | O94919 |
PeptideAtlasi | O94919 |
PRIDEi | O94919 |
ProteomicsDBi | 50555 |
Protocols and materials databases
Antibodypediai | 2196, 95 antibodies |
Genome annotation databases
Ensembli | ENST00000278505; ENSP00000278505; ENSG00000149218 |
GeneIDi | 23052 |
KEGGi | hsa:23052 |
UCSCi | uc001pfh.4, human |
Organism-specific databases
CTDi | 23052 |
DisGeNETi | 23052 |
GeneCardsi | ENDOD1 |
HGNCi | HGNC:29129, ENDOD1 |
HPAi | ENSG00000149218, Low tissue specificity |
neXtProti | NX_O94919 |
OpenTargetsi | ENSG00000149218 |
PharmGKBi | PA143485454 |
VEuPathDBi | HostDB:ENSG00000149218.4 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQYK, Eukaryota |
GeneTreei | ENSGT01010000222309 |
HOGENOMi | CLU_035817_0_0_1 |
InParanoidi | O94919 |
OMAi | FQERWYM |
OrthoDBi | 858590at2759 |
PhylomeDBi | O94919 |
TreeFami | TF333322 |
Enzyme and pathway databases
PathwayCommonsi | O94919 |
Reactomei | R-HSA-114608, Platelet degranulation |
Miscellaneous databases
BioGRID-ORCSi | 23052, 4 hits in 872 CRISPR screens |
ChiTaRSi | ENDOD1, human |
GenomeRNAii | 23052 |
Pharosi | O94919, Tdark |
PROi | PR:O94919 |
RNActi | O94919, protein |
Gene expression databases
Bgeei | ENSG00000149218, Expressed in corpus callosum and 249 other tissues |
Genevisiblei | O94919, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001604, DNA/RNA_non-sp_Endonuclease IPR039015, ENDOD1 IPR020821, Extracellular_endonuc_su_A |
PANTHERi | PTHR21472, PTHR21472, 1 hit |
Pfami | View protein in Pfam PF01223, Endonuclease_NS, 1 hit |
SMARTi | View protein in SMART SM00892, Endonuclease_NS, 1 hit SM00477, NUC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ENDD1_HUMAN | |
Accessioni | O94919Primary (citable) accession number: O94919 Secondary accession number(s): A8K6K8, Q6GQY5, Q8TAQ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | July 19, 2004 | |
Last modified: | February 10, 2021 | |
This is version 151 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families