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Entry version 197 (16 Oct 2019)
Sequence version 1 (01 May 1999)
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Protein

Nuclear factor of activated T-cells 5

Gene

NFAT5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi293 – 3008

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O94916

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear factor of activated T-cells 5
Short name:
NF-AT5
Alternative name(s):
T-cell transcription factor NFAT5
Tonicity-responsive enhancer-binding protein1 Publication
Short name:
TonE-binding protein1 Publication
Short name:
TonEBP1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NFAT5
Synonyms:KIAA0827, TONEBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7774 NFAT5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604708 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O94916

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi120S → A: Normal nuclear localization. 1 Publication1
Mutagenesisi134S → A: Reduced nuclear localization. 1 Publication1
Mutagenesisi135T → A: Reduced nuclear localization. 1 Publication1
Mutagenesisi155S → A: Increased nuclear localization. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
10725

MalaCards human disease database

More...
MalaCardsi
NFAT5

Open Targets

More...
OpenTargetsi
ENSG00000102908

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
529980 Inflammatory bowel disease-recurrent sinopulmonary infections syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31581

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O94916

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NFAT5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002051831 – 1531Nuclear factor of activated T-cells 5Add BLAST1531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei120Phosphoserine1 Publication1
Modified residuei122N6-acetyllysineBy similarity1
Modified residuei134Phosphoserine1 Publication1
Modified residuei135Phosphothreonine; by CDK5Combined sources1 Publication1
Modified residuei155Phosphoserine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki556Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki556Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei561PhosphoserineCombined sources1
Cross-linki603Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform D (identifier: O94916-4)
Cross-linki573Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated (PubMed:10377394). Phosphorylated at Thr-135 by CDK5 in response to osmotic stress; this phosphorylation mediates its rapid nuclear localization (PubMed:21209322).2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O94916

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O94916

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O94916

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O94916

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94916

PeptideAtlas

More...
PeptideAtlasi
O94916

PRoteomics IDEntifications database

More...
PRIDEi
O94916

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
20588
50551 [O94916-1]
50552 [O94916-2]
50553 [O94916-3]
50554 [O94916-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O94916

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O94916

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O94916

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest levels in skeletal muscle, brain, heart and peripheral blood leukocytes.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000102908 Expressed in 215 organ(s), highest expression level in kidney

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O94916 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O94916 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA057304
HPA069711

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer when bound to DNA, completely encircles its DNA target.

Interacts with CIDEC; this interaction is direct and retains NFAT5 in the cytoplasm (By similarity). Does not bind with Fos and Jun transcription factors.

Interacts with DDX5 and DDX17; this interaction leads to DDX5/DDX17 recruitment to LNC2 and S100A4 promoters and NFAT5-mediated DDX5/DDX17-enhanced transactivation (PubMed:22266867).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115949, 10 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O94916

Database of interacting proteins

More...
DIPi
DIP-58524N

Protein interaction database and analysis system

More...
IntActi
O94916, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000457593

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11531
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O94916

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O94916

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini264 – 443RHDPROSITE-ProRule annotationAdd BLAST180

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi69 – 100Ser-richAdd BLAST32
Compositional biasi739 – 743Poly-Gln5
Compositional biasi879 – 888Poly-Gln10
Compositional biasi966 – 971Poly-Thr6
Compositional biasi1248 – 1266Poly-GlnAdd BLAST19

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGY4 Eukaryota
ENOG41118Z9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155213

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000236245

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O94916

KEGG Orthology (KO)

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KOi
K17335

Identification of Orthologs from Complete Genome Data

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OMAi
NADIFQQ

Database of Orthologous Groups

More...
OrthoDBi
95502at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O94916

TreeFam database of animal gene trees

More...
TreeFami
TF326480

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
2.60.40.340, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR008366 NFAT
IPR015646 NFAT5
IPR008967 p53-like_TF_DNA-bd
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12533 PTHR12533, 1 hit
PTHR12533:SF10 PTHR12533:SF10, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01789 NUCFACTORATC

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00429 IPT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50254 REL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform C (identifier: O94916-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSDFISLLS ADLDLESPKS LYSRESVYDL LPKELQLPPS RETSVASMSQ
60 70 80 90 100
TSGGEAGSPP PAVVAADASS APSSSSMGGA CSSFTTSSSP TIYSTSVTDS
110 120 130 140 150
KAMQVESCSS AVGVSNRGVS EKQLTSNTVQ QHPSTPKRHT VLYISPPPED
160 170 180 190 200
LLDNSRMSCQ DEGCGLESEQ SCSMWMEDSP SNFSNMSTSS YNDNTEVPRK
210 220 230 240 250
SRKRNPKQRP GVKRRDCEES NMDIFDADSA KAPHYVLSQL TTDNKGNSKA
260 270 280 290 300
GNGTLENQKG TGVKKSPMLC GQYPVKSEGK ELKIVVQPET QHRARYLTEG
310 320 330 340 350
SRGSVKDRTQ QGFPTVKLEG HNEPVVLQVF VGNDSGRVKP HGFYQACRVT
360 370 380 390 400
GRNTTPCKEV DIEGTTVIEV GLDPSNNMTL AVDCVGILKL RNADVEARIG
410 420 430 440 450
IAGSKKKSTR ARLVFRVNIM RKDGSTLTLQ TPSSPILCTQ PAGVPEILKK
460 470 480 490 500
SLHSCSVKGE EEVFLIGKNF LKGTKVIFQE NVSDENSWKS EAEIDMELFH
510 520 530 540 550
QNHLIVKVPP YHDQHITLPV SVGIYVVTNA GRSHDVQPFT YTPDPAAAGA
560 570 580 590 600
LNVNVKKEIS SPARPCSFEE AMKAMKTTGC NLDKVNIIPN ALMTPLIPSS
610 620 630 640 650
MIKSEDVTPM EVTAEKRSST IFKTTKSVGS TQQTLENISN IAGNGSFSSP
660 670 680 690 700
SSSHLPSENE KQQQIQPKAY NPETLTTIQT QDISQPGTFP AVSASSQLPN
710 720 730 740 750
SDALLQQATQ FQTRETQSRE ILQSDGTVVN LSQLTEASQQ QQQSPLQEQA
760 770 780 790 800
QTLQQQISSN IFPSPNSVSQ LQNTIQQLQA GSFTGSTASG SSGSVDLVQQ
810 820 830 840 850
VLEAQQQLSS VLFSAPDGNE NVQEQLSADI FQQVSQIQSG VSPGMFSSTE
860 870 880 890 900
PTVHTRPDNL LPGRAESVHP QSENTLSNQQ QQQQQQQQVM ESSAAMVMEM
910 920 930 940 950
QQSICQAAAQ IQSELFPSTA SANGNLQQSP VYQQTSHMMS ALSTNEDMQM
960 970 980 990 1000
QCELFSSPPA VSGNETSTTT TQQVATPGTT MFQTSSSGDG EETGTQAKQI
1010 1020 1030 1040 1050
QNSVFQTMVQ MQHSGDNQPQ VNLFSSTKSM MSVQNSGTQQ QGNGLFQQGN
1060 1070 1080 1090 1100
EMMSLQSGNF LQQSSHSQAQ LFHPQNPIAD AQNLSQETQG SLFHSPNPIV
1110 1120 1130 1140 1150
HSQTSTTSSE QMQPPMFHSQ STIAVLQGSS VPQDQQSTNI FLSQSPMNNL
1160 1170 1180 1190 1200
QTNTVAQEAF FAAPNSISPL QSTSNSEQQA AFQQQAPISH IQTPMLSQEQ
1210 1220 1230 1240 1250
AQPPQQGLFQ PQVALGSLPP NPMPQSQQGT MFQSQHSIVA MQSNSPSQEQ
1260 1270 1280 1290 1300
QQQQQQQQQQ QQQQQQSILF SNQNTMATMA SPKQPPPNMI FNPNQNPMAN
1310 1320 1330 1340 1350
QEQQNQSIFH QQSNMAPMNQ EQQPMQFQSQ STVSSLQNPG PTQSESSQTP
1360 1370 1380 1390 1400
LFHSSPQIQL VQGSPSSQEQ QVTLFLSPAS MSALQTSINQ QDMQQSPLYS
1410 1420 1430 1440 1450
PQNNMPGIQG ATSSPQPQAT LFHNTAGGTM NQLQNSPGSS QQTSGMFLFG
1460 1470 1480 1490 1500
IQNNCSQLLT SGPATLPDQL MAISQPGQPQ NEGQPPVTTL LSQQMPENSP
1510 1520 1530
LASSINTNQN IEKIDLLVSL QNQGNNLTGS F
Length:1,531
Mass (Da):165,763
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA68C68088DABF69E
GO
Isoform A (identifier: O94916-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Note: The transcript encoding this isoform contains an alternative coding exon 4 which contains 2 stop codons and could target the transcript to nonsense-mediated mRNA decay after the pioneer round of translation, as suggested by the decreased NFAT5 protein levels when the number of exon 4-containing transcripts increases. The insertion of exon 4 is stimulated in the presence of DDX5 and DDX17. Isoform A sequence described in this entry starts at the first methionine downstream of exon 4 last stop codon. An alternative protein sequence can be predicted from this transcript starting at Met-1. This isoform encodes an 81 amino acid-long protein.Curated1 Publication
Show »
Length:1,455
Mass (Da):157,983
Checksum:i4FA637348EAC0041
GO
Isoform B (identifier: O94916-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: R → RDSLKLHPSQNFHRAGLLE
     67-81: DASSAPSSSSMGGAC → GFASEAGSVCIKNDL
     82-1531: Missing.

Note: The transcript encoding this isoform contains an alternative coding exon 4 which contains 2 stop codons and could target the transcript to nonsense-mediated mRNA decay after the pioneer round of translation, as suggested by the decreased NFAT5 protein levels when the number of exon 4-containing transcripts increases. The insertion of exon 4 is stimulated in the presence of DDX5 and DDX17.Curated1 Publication
Show »
Length:99
Mass (Da):10,459
Checksum:i3E2BB95953579EE8
GO
Isoform D (identifier: O94916-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: R → RDSLKLHPSQNFHRAGLLE
     546-546: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:1,548
Mass (Da):167,737
Checksum:i48E5072E004F9C09
GO
Isoform E (identifier: O94916-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: R → RDSLKLHPSQNFHRAGLLE

Show »
Length:1,549
Mass (Da):167,808
Checksum:i12DBBD89C630E445
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BP21H3BP21_HUMAN
Nuclear factor of-activated T-cells...
NFAT5
119Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKS5J3QKS5_HUMAN
Nuclear factor of-activated T-cells...
NFAT5
228Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C020A0A494C020_HUMAN
Nuclear factor of-activated T-cells...
NFAT5
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A499FJX5A0A499FJX5_HUMAN
Nuclear factor of-activated T-cells...
NFAT5
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRL6J3KRL6_HUMAN
Nuclear factor of-activated T-cells...
NFAT5
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A499FIS8A0A499FIS8_HUMAN
Nuclear factor of-activated T-cells...
NFAT5
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK91166 differs from that shown. Reason: Frameshift.Curated
The sequence AAK91166 differs from that shown. Reason: Erroneous translation.Curated
The sequence BAA74850 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAB09693 differs from that shown. Reason: Frameshift.Curated
The sequence CAC42765 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti666 – 667QP → HA in CAC42764 (PubMed:11528118).Curated2
Sequence conflicti666 – 667QP → HA in CAC42765 (PubMed:11528118).Curated2
Sequence conflicti1369E → D in CAB09693 (PubMed:10565538).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0587841 – 76Missing in isoform A. 3 PublicationsAdd BLAST76
Alternative sequenceiVSP_05878524R → RDSLKLHPSQNFHRAGLLE in isoform B, isoform D and isoform E. 2 Publications1 Publication1
Alternative sequenceiVSP_05878667 – 81DASSA…MGGAC → GFASEAGSVCIKNDL in isoform B. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_05878782 – 1531Missing in isoform B. 1 PublicationAdd BLAST1450
Alternative sequenceiVSP_058788546Missing in isoform D. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF089824 mRNA Translation: AAD18136.1
AF134870 mRNA Translation: AAD38360.1
AF346509 mRNA Translation: AAK91166.1 Sequence problems.
AJ243298 mRNA Translation: CAC42764.1
AJ243299 mRNA Translation: CAC42765.1 Frameshift.
AB020634 mRNA Translation: BAA74850.2 Different initiation.
AC009032 Genomic DNA No translation available.
AC012321 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83281.1
BC131509 mRNA Translation: AAI31510.1
BC146765 mRNA Translation: AAI46766.1
AF163836 mRNA Translation: AAD48441.1
Z97016 mRNA Translation: CAB09693.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10881.1 [O94916-1]
CCDS10882.1 [O94916-2]
CCDS45518.1 [O94916-5]
CCDS45519.1 [O94916-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001106649.1, NM_001113178.2 [O94916-4]
NP_006590.1, NM_006599.3 [O94916-1]
NP_619727.2, NM_138713.3 [O94916-5]
NP_619728.2, NM_138714.3 [O94916-2]
NP_775321.1, NM_173214.2 [O94916-2]
NP_775322.1, NM_173215.2 [O94916-2]
XP_006721188.1, XM_006721125.3
XP_011521120.1, XM_011522818.2 [O94916-2]
XP_016878359.1, XM_017022870.1 [O94916-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000349945; ENSP00000338806; ENSG00000102908 [O94916-5]
ENST00000354436; ENSP00000346420; ENSG00000102908 [O94916-1]
ENST00000426654; ENSP00000413126; ENSG00000102908 [O94916-3]
ENST00000567239; ENSP00000457593; ENSG00000102908 [O94916-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10725

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10725

UCSC genome browser

More...
UCSCi
uc002exi.4 human [O94916-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089824 mRNA Translation: AAD18136.1
AF134870 mRNA Translation: AAD38360.1
AF346509 mRNA Translation: AAK91166.1 Sequence problems.
AJ243298 mRNA Translation: CAC42764.1
AJ243299 mRNA Translation: CAC42765.1 Frameshift.
AB020634 mRNA Translation: BAA74850.2 Different initiation.
AC009032 Genomic DNA No translation available.
AC012321 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83281.1
BC131509 mRNA Translation: AAI31510.1
BC146765 mRNA Translation: AAI46766.1
AF163836 mRNA Translation: AAD48441.1
Z97016 mRNA Translation: CAB09693.1 Frameshift.
CCDSiCCDS10881.1 [O94916-1]
CCDS10882.1 [O94916-2]
CCDS45518.1 [O94916-5]
CCDS45519.1 [O94916-4]
RefSeqiNP_001106649.1, NM_001113178.2 [O94916-4]
NP_006590.1, NM_006599.3 [O94916-1]
NP_619727.2, NM_138713.3 [O94916-5]
NP_619728.2, NM_138714.3 [O94916-2]
NP_775321.1, NM_173214.2 [O94916-2]
NP_775322.1, NM_173215.2 [O94916-2]
XP_006721188.1, XM_006721125.3
XP_011521120.1, XM_011522818.2 [O94916-2]
XP_016878359.1, XM_017022870.1 [O94916-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IMHX-ray2.86C/D264-544[»]
SMRiO94916
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi115949, 10 interactors
CORUMiO94916
DIPiDIP-58524N
IntActiO94916, 7 interactors
STRINGi9606.ENSP00000457593

PTM databases

iPTMnetiO94916
PhosphoSitePlusiO94916
SwissPalmiO94916

Polymorphism and mutation databases

BioMutaiNFAT5

Proteomic databases

EPDiO94916
jPOSTiO94916
MassIVEiO94916
MaxQBiO94916
PaxDbiO94916
PeptideAtlasiO94916
PRIDEiO94916
ProteomicsDBi20588
50551 [O94916-1]
50552 [O94916-2]
50553 [O94916-3]
50554 [O94916-4]

Genome annotation databases

EnsembliENST00000349945; ENSP00000338806; ENSG00000102908 [O94916-5]
ENST00000354436; ENSP00000346420; ENSG00000102908 [O94916-1]
ENST00000426654; ENSP00000413126; ENSG00000102908 [O94916-3]
ENST00000567239; ENSP00000457593; ENSG00000102908 [O94916-4]
GeneIDi10725
KEGGihsa:10725
UCSCiuc002exi.4 human [O94916-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10725
DisGeNETi10725

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NFAT5
HGNCiHGNC:7774 NFAT5
HPAiHPA057304
HPA069711
MalaCardsiNFAT5
MIMi604708 gene
neXtProtiNX_O94916
OpenTargetsiENSG00000102908
Orphaneti529980 Inflammatory bowel disease-recurrent sinopulmonary infections syndrome
PharmGKBiPA31581

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGY4 Eukaryota
ENOG41118Z9 LUCA
GeneTreeiENSGT00940000155213
HOGENOMiHOG000236245
InParanoidiO94916
KOiK17335
OMAiNADIFQQ
OrthoDBi95502at2759
PhylomeDBiO94916
TreeFamiTF326480

Enzyme and pathway databases

SIGNORiO94916

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NFAT5 human
EvolutionaryTraceiO94916

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NFAT5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10725
PharosiO94916

Protein Ontology

More...
PROi
PR:O94916

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000102908 Expressed in 215 organ(s), highest expression level in kidney
ExpressionAtlasiO94916 baseline and differential
GenevisibleiO94916 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR008366 NFAT
IPR015646 NFAT5
IPR008967 p53-like_TF_DNA-bd
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf
PANTHERiPTHR12533 PTHR12533, 1 hit
PTHR12533:SF10 PTHR12533:SF10, 1 hit
PfamiView protein in Pfam
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit
PRINTSiPR01789 NUCFACTORATC
SMARTiView protein in SMART
SM00429 IPT, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50254 REL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNFAT5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94916
Secondary accession number(s): A2RRB4
, A6H8V5, E9PHR7, O95693, Q7LA65, Q969Q8, Q96QH3, Q9UN18
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: October 16, 2019
This is version 197 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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