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Protein

Protein furry homolog-like

Gene

FRYL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei2302Breakpoint for insertion to form KMT2A/MLL1-AFF4 fusion protein1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cell morphogenesis Source: GO_Central
  • neuron projection development Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein furry homolog-like
Alternative name(s):
ALL1-fused gene from chromosome 4p12 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FRYL
Synonyms:AF4P12, KIAA0826
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000075539.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29127 FRYL

neXtProt; the human protein knowledge platform

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neXtProti
NX_O94915

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving FRYL is found in treatment-related acute lymphoblastic leukemia (ALL). Translocation t(4;11)(p12;q23) that forms a KMT2A/MLL1-FRYL fusion protein.1 Publication

Organism-specific databases

DisGeNET

More...
DisGeNETi
285527

Open Targets

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OpenTargetsi
ENSG00000075539

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134967984

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
FRYL

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002776192 – 3013Protein furry homolog-likeAdd BLAST3012

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserine1 Publication1
Modified residuei844PhosphoserineCombined sources1
Modified residuei1914PhosphoserineCombined sources1
Modified residuei1935PhosphoserineCombined sources1
Modified residuei1941PhosphoserineCombined sources1
Modified residuei1945PhosphoserineCombined sources1
Modified residuei1957PhosphoserineCombined sources1
Modified residuei1959PhosphothreonineCombined sources1
Modified residuei1978PhosphoserineCombined sources1
Modified residuei2272PhosphoserineCombined sources1
Modified residuei2454PhosphoserineCombined sources1
Modified residuei2499PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O94915

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O94915

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O94915

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O94915

PeptideAtlas

More...
PeptideAtlasi
O94915

PRoteomics IDEntifications database

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PRIDEi
O94915

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50549
50550 [O94915-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
O94915

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O94915

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O94915

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with higher expression in colon, placenta, brain and cells of lymphoid origin.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000075539 Expressed in 230 organ(s), highest expression level in corpus callosum

CleanEx database of gene expression profiles

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CleanExi
HS_FRYL

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O94915 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O94915 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA031106
HPA031107

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
130134, 31 interactors

Protein interaction database and analysis system

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IntActi
O94915, 20 interactors

Molecular INTeraction database

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MINTi
O94915

STRING: functional protein association networks

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STRINGi
9606.ENSP00000351113

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O94915

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the furry protein family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1825 Eukaryota
ENOG410XSZS LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00610000086058

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000112653

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG081541

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O94915

Identification of Orthologs from Complete Genome Data

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OMAi
HAQQVTI

Database of Orthologous Groups

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OrthoDBi
11874at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O94915

TreeFam database of animal gene trees

More...
TreeFami
TF313568

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR025614 Cell_morpho_N
IPR025481 Cell_Morphogen_C
IPR039867 Furry/Tao3/Mor2
IPR029473 MOR2-PAG1_mid

The PANTHER Classification System

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PANTHERi
PTHR12295 PTHR12295, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF14225 MOR2-PAG1_C, 1 hit
PF14228 MOR2-PAG1_mid, 4 hits
PF14222 MOR2-PAG1_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94915-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSNITIDPDV KPGEYVIKSL FAEFAVQAEK KIEVVMAEPL EKLLSRSLQR
60 70 80 90 100
GEDLQFDQLI SSMSSVAEHC LPSLLRTLFD WYRRQNGTED ESYEYRPRSS
110 120 130 140 150
TKSKGDEQQR ERDYLLERRD LAVDFIFCLV LVEVLKQIPV HPVPDPLVHE
160 170 180 190 200
VLNLAFKHFK HKEGYSGTNT GNVHIIADLY AEVIGVLAQS KFQAVRKKFV
210 220 230 240 250
TELKELRQKE QSPHVVQSVI SLIMGMKFFR VKMYPVEDFE ASFQFMQECA
260 270 280 290 300
QYFLEVKDKD IKHALAGLFV EILIPVAAAV KNEVNVPCLK NFVEMLYQTT
310 320 330 340 350
FELSSRKKHS LALYPLITCL LCVSQKQFFL NNWHIFLQNC LSHLKNKDPK
360 370 380 390 400
MSRVALESLY RLLWVYVIRI KCESNTVTQS RLMSIVSALF PKGSRSVVPR
410 420 430 440 450
DTPLNIFVKI IQFIAQERLD FAMKEIIFDL LSVGKSTKTF TINPERMNIG
460 470 480 490 500
LRVFLVIADS LQQKDGEPPM PTTGVILPSG NTLRVKKIFL NKTLTDEEAK
510 520 530 540 550
VIGMSVYYPQ VRKALDSILR HLDKEVGRPM CMTSVQMSNK EPEDMITGER
560 570 580 590 600
KPKIDLFRTC IAAIPRLIPD GMSRTDLIEL LARLTIHMDE ELRALAFNTL
610 620 630 640 650
QALMLDFPDW REDVLSGFVY FIVREVTDVH PTLLDNAVKM LVQLINQWKQ
660 670 680 690 700
AAQMHNKNQD TQHGVANGAS HPPPLERSPY SNVFHVVEGF ALVILCSSRP
710 720 730 740 750
ATRRLAVSVL REIRALFALL EIPKGDDELA IDVMDRLSPS ILESFIHLTG
760 770 780 790 800
ADQTTLLYCP SSIDLQTLAE WNSSPISHQF DVISPSHIWI FAHVTQGQDP
810 820 830 840 850
WIISLSSFLK QENLPKHCST AVSYAWMFAY TRLQLLSPQV DINSPINAKK
860 870 880 890 900
VNTTTSSDSY IGLWRNYLIL CCSAATSSSS TSAGSVRCSP PETLASTPDS
910 920 930 940 950
GYSIDSKIIG IPSPSSLFKH IVPMMRSESM EITESLVLGL GRTNPGAFRE
960 970 980 990 1000
LIEELHPIIK EALERRPENM KRRRRRDILR VQLVRIFELL ADAGVISHSA
1010 1020 1030 1040 1050
SGGLDNETHF LNNTLLEYVD LTRQLLEAEN EKDSDTLKDI RCHFSALVAN
1060 1070 1080 1090 1100
IIQNVPVHQR RSIFPQQSLR HSLFMLFSHW AGPFSIMFTP LDRYSDRNMQ
1110 1120 1130 1140 1150
INRHQYCALK AMSAVLCCGP VADNVGLSSD GYLYKWLDNI LDSLDKKVHQ
1160 1170 1180 1190 1200
LGCEAVTLLL ELNPDQSNLM YWAVDRCYTG SGRVAAGCFK AIANVFQNRD
1210 1220 1230 1240 1250
YQCDTVMLLN LILFKAADSS RSIYEVAMQL LQILEPKMFR YAHKLEVQRT
1260 1270 1280 1290 1300
DGVLSQLSPL PHLYSVSYYQ LSEELARAYP ELTLAIFSEI SQRIQTAHPA
1310 1320 1330 1340 1350
GRQVMLHYLL PWMNNIELVD LKPLPTARRH DEDEDDSLKD RELMVTSRRW
1360 1370 1380 1390 1400
LRGEGWGSPQ ATAMVLNNLM YMTAKYGDEL AWSEVENVWT TLADGWPKNL
1410 1420 1430 1440 1450
KIILHFLISI CGVNSEPSLL PYVKKVIVYL GRDKTMQLLE ELVSELQLTD
1460 1470 1480 1490 1500
PVSSGVTHMD NPPYYRITSS YKIPSVTSGT TSSSNTMVAP TDGNPDNKPI
1510 1520 1530 1540 1550
KENIEESYVH LDIYSGLNSH LNRQHHRLES RYSSSSGGSY EEEKSDSMPL
1560 1570 1580 1590 1600
YSNWRLKVME HNQGEPLPFP PAGGCWSPLV DYVPETSSPG LPLHRCNIAV
1610 1620 1630 1640 1650
ILLTDLIIDH SVKVEWGSYL HLLLHAIFIG FDHCHPEVYE HCKRLLLHLL
1660 1670 1680 1690 1700
IVMGPNSNIR TVASVLLRNK EFNEPRVLTV KQVAHLDYNF TAGINDFIPD
1710 1720 1730 1740 1750
YQPSPMTDSG LSSSSTSSSI SLGNNSAAIS HLHTTILNEV DISVEQDGKV
1760 1770 1780 1790 1800
KTLMEFITSR KRGPLWNHED VSAKNPSIKS AEQLTTFLKH VVSVFKQSSS
1810 1820 1830 1840 1850
EGIHLEHHLS EVALQTALSC SSRHYAGRSF QIFRALKQPL TATTLSDVLS
1860 1870 1880 1890 1900
RLVETVGDPG EDAQGFVIEL LLTLESAIDT LAETMKHYDL LSALSQTSYH
1910 1920 1930 1940 1950
DPIMGNKYAA NRKSTGQLNL STSPINSSSY LGYNSNARSN SLRLSLIGDR
1960 1970 1980 1990 2000
RGDRRRSNTL DIMDGRINHS SSLARTRSLS SLREKGMYDV QSTTEPTNLM
2010 2020 2030 2040 2050
ATIFWIAASL LESDYEYEYL LALRLLNKLL IHLPLDKSES REKIENVQSK
2060 2070 2080 2090 2100
LKWTNFPGLQ QLFLKGFTSA STQEMTVHLL SKLISVSKHT LVDPSQLSGF
2110 2120 2130 2140 2150
PLNILCLLPH LIQHFDSPTQ FCKETASRIA KVCAEEKCPT LVNLAHMMSL
2160 2170 2180 2190 2200
YSTHTYSRDC SNWINVVCRY LHDSFSDTTF NLVTYLAELL EKGLSSMQQS
2210 2220 2230 2240 2250
LLQIIYSLLS HIDLSAAPAK QFNLEIIKII GKYVQSPYWK EALNILKLVV
2260 2270 2280 2290 2300
SRSASLVVPS DIPKTYGGDT GSPEISFTKI FNNVSKELPG KTLDFHFDIS
2310 2320 2330 2340 2350
ETPIIGNKYG DQHSAAGRNG KPKVIAVTRS TSSTSSGSNS NALVPVSWKR
2360 2370 2380 2390 2400
PQLSQRRTRE KLMNVLSLCG PESGLPKNPS VVFSSNEDLE VGDQQTSLIS
2410 2420 2430 2440 2450
TTEDINQEEE VAVEDNSSEQ QFGVFKDFDF LDVELEDAEG ESMDNFNWGV
2460 2470 2480 2490 2500
RRRSLDSIDK GDTPSLQEYQ CSSSTPSLNL TNQEDTDESS EEEAALTASQ
2510 2520 2530 2540 2550
ILSRTQMLNS DSATDETIPD HPDLLLQSED STGSITTEEV LQIRDETPTL
2560 2570 2580 2590 2600
EASLDNANSR LPEDTTSVLK EEHVTTFEDE GSYIIQEQQE SLVCQGILDL
2610 2620 2630 2640 2650
EETEMPEPLA PESYPESVCE EDVTLALKEL DERCEEEEAD FSGLSSQDEE
2660 2670 2680 2690 2700
EQDGFPEVQT SPLPSPFLSA IIAAFQPVAY DDEEEAWRCH VNQMLSDTDG
2710 2720 2730 2740 2750
SSAVFTFHVF SRLFQTIQRK FGEITNEAVS FLGDSLQRIG TKFKSSLEVM
2760 2770 2780 2790 2800
MLCSECPTVF VDAETLMSCG LLETLKFGVL ELQEHLDTYN VKREAAEQWL
2810 2820 2830 2840 2850
DDCKRTFGAK EDMYRINTDA QQMEILAELE LCRRLYKLHF QLLLLFQAYC
2860 2870 2880 2890 2900
KLINQVNTIK NEAEVINMSE ELAQLESILK EAESASENEE IDISKAAQTT
2910 2920 2930 2940 2950
IETAIHSLIE TLKNKEFISA VAQVKAFRSL WPSDIFGSCE DDPVQTLLHI
2960 2970 2980 2990 3000
YFHHQTLGQT GSFAVIGSNL DMSEANYKLM ELNLEIRESL RMVQSYQLLA
3010
QAKPMGNMVS TGF
Length:3,013
Mass (Da):339,598
Last modified:February 6, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDFD7FEC47792DA1E
GO
Isoform 2 (identifier: O94915-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2604: Missing.
     2822-2827: Missing.

Show »
Length:403
Mass (Da):45,597
Checksum:iAF556A9BE526EFF4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z2S2F2Z2S2_HUMAN
Protein furry homolog-like
FRYL
1,553Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2C9F2R7A0A2C9F2R7_HUMAN
Protein furry homolog-like
FRYL
1,716Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YEZ9A0A286YEZ9_HUMAN
Protein furry homolog-like
FRYL
1,563Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RJI4D6RJI4_HUMAN
Protein furry homolog-like
FRYL
471Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9X0H0Y9X0_HUMAN
Protein furry homolog-like
FRYL
1,455Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9B9D6R9B9_HUMAN
Protein furry homolog-like
FRYL
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_066994890P → S1 PublicationCorresponds to variant dbSNP:rs376571442Ensembl.1
Natural variantiVAR_0538321878I → V. Corresponds to variant dbSNP:rs7670111Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0230381 – 2604Missing in isoform 2. 1 PublicationAdd BLAST2604
Alternative sequenceiVSP_0230392822 – 2827Missing in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC068037 Genomic DNA No translation available.
AC096952 Genomic DNA No translation available.
BC021803 mRNA Translation: AAH21803.1
U80082 mRNA Translation: AAD00351.1
AB020633 mRNA Translation: BAA74849.1
AL137546 mRNA Translation: CAB70804.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43227.1 [O94915-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T46389

NCBI Reference Sequences

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RefSeqi
NP_055845.1, NM_015030.1 [O94915-1]
XP_016863535.1, XM_017008046.1 [O94915-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.595553

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000358350; ENSP00000351113; ENSG00000075539 [O94915-1]
ENST00000503238; ENSP00000426064; ENSG00000075539 [O94915-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
285527

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:285527

UCSC genome browser

More...
UCSCi
uc003gyh.1 human [O94915-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068037 Genomic DNA No translation available.
AC096952 Genomic DNA No translation available.
BC021803 mRNA Translation: AAH21803.1
U80082 mRNA Translation: AAD00351.1
AB020633 mRNA Translation: BAA74849.1
AL137546 mRNA Translation: CAB70804.1
CCDSiCCDS43227.1 [O94915-1]
PIRiT46389
RefSeqiNP_055845.1, NM_015030.1 [O94915-1]
XP_016863535.1, XM_017008046.1 [O94915-1]
UniGeneiHs.595553

3D structure databases

ProteinModelPortaliO94915
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130134, 31 interactors
IntActiO94915, 20 interactors
MINTiO94915
STRINGi9606.ENSP00000351113

PTM databases

CarbonylDBiO94915
iPTMnetiO94915
PhosphoSitePlusiO94915

Polymorphism and mutation databases

BioMutaiFRYL

Proteomic databases

EPDiO94915
jPOSTiO94915
MaxQBiO94915
PaxDbiO94915
PeptideAtlasiO94915
PRIDEiO94915
ProteomicsDBi50549
50550 [O94915-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358350; ENSP00000351113; ENSG00000075539 [O94915-1]
ENST00000503238; ENSP00000426064; ENSG00000075539 [O94915-1]
GeneIDi285527
KEGGihsa:285527
UCSCiuc003gyh.1 human [O94915-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
285527
DisGeNETi285527
EuPathDBiHostDB:ENSG00000075539.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FRYL

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0004200
HGNCiHGNC:29127 FRYL
HPAiHPA031106
HPA031107
neXtProtiNX_O94915
OpenTargetsiENSG00000075539
PharmGKBiPA134967984

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1825 Eukaryota
ENOG410XSZS LUCA
GeneTreeiENSGT00610000086058
HOGENOMiHOG000112653
HOVERGENiHBG081541
InParanoidiO94915
OMAiHAQQVTI
OrthoDBi11874at2759
PhylomeDBiO94915
TreeFamiTF313568

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FRYL human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
285527

Protein Ontology

More...
PROi
PR:O94915

Gene expression databases

BgeeiENSG00000075539 Expressed in 230 organ(s), highest expression level in corpus callosum
CleanExiHS_FRYL
ExpressionAtlasiO94915 baseline and differential
GenevisibleiO94915 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR025614 Cell_morpho_N
IPR025481 Cell_Morphogen_C
IPR039867 Furry/Tao3/Mor2
IPR029473 MOR2-PAG1_mid
PANTHERiPTHR12295 PTHR12295, 1 hit
PfamiView protein in Pfam
PF14225 MOR2-PAG1_C, 1 hit
PF14228 MOR2-PAG1_mid, 4 hits
PF14222 MOR2-PAG1_N, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFRYL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94915
Secondary accession number(s): O95640, Q8WTZ5, Q9NT40
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: January 16, 2019
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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