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Entry version 157 (17 Jun 2020)
Sequence version 3 (23 Oct 2007)
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Protein

Pre-mRNA cleavage complex 2 protein Pcf11

Gene

PCF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of pre-mRNA cleavage complex II.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing
R-HSA-73856 RNA Polymerase II Transcription Termination
R-HSA-77595 Processing of Intronless Pre-mRNAs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pre-mRNA cleavage complex 2 protein Pcf11
Alternative name(s):
Pre-mRNA cleavage complex II protein Pcf11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCF11
Synonyms:KIAA0824
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000165494.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30097 PCF11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608876 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O94913

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000165494

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671196

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O94913 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PCF11

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000582462 – 1555Pre-mRNA cleavage complex 2 protein Pcf11Add BLAST1554

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei169PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki291Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki328Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki456Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei459PhosphothreonineCombined sources1
Modified residuei489PhosphoserineCombined sources1
Modified residuei494PhosphoserineCombined sources1
Modified residuei509PhosphoserineCombined sources1
Modified residuei511PhosphoserineCombined sources1
Modified residuei645PhosphoserineCombined sources1
Cross-linki654Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei705PhosphoserineCombined sources1
Cross-linki723Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei728PhosphoserineCombined sources1
Modified residuei777PhosphoserineCombined sources1
Modified residuei785PhosphothreonineCombined sources1
Modified residuei794PhosphoserineCombined sources1
Modified residuei805Asymmetric dimethylarginineCombined sources1
Modified residuei820Asymmetric dimethylarginineCombined sources1
Modified residuei833Asymmetric dimethylarginineCombined sources1
Modified residuei851PhosphoserineCombined sources1
Modified residuei929Asymmetric dimethylarginineCombined sources1
Modified residuei942Asymmetric dimethylarginineCombined sources1
Modified residuei955Asymmetric dimethylarginineCombined sources1
Modified residuei981Asymmetric dimethylarginineCombined sources1
Modified residuei994Asymmetric dimethylarginineCombined sources1
Modified residuei1007Asymmetric dimethylarginineCombined sources1
Modified residuei1093Asymmetric dimethylarginineCombined sources1
Modified residuei1104Asymmetric dimethylarginineCombined sources1
Modified residuei1161PhosphoserineCombined sources1
Cross-linki1278Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1419Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1511Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1524Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1530PhosphothreonineCombined sources1
Cross-linki1546Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O94913

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O94913

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O94913

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O94913

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94913

PeptideAtlas

More...
PeptideAtlasi
O94913

PRoteomics IDEntifications database

More...
PRIDEi
O94913

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
50548

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O94913

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
O94913

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O94913

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O94913

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165494 Expressed in skin of abdomen and 194 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O94913 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O94913 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000165494 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119622, 50 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O94913

Database of interacting proteins

More...
DIPi
DIP-56825N

Protein interaction database and analysis system

More...
IntActi
O94913, 23 interactors

Molecular INTeraction database

More...
MINTi
O94913

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000298281

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O94913 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O94913

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 142CIDPROSITE-ProRule annotationAdd BLAST129

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili202 – 239Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi328 – 436Lys-richAdd BLAST109
Compositional biasi703 – 1080Gly-richAdd BLAST378

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2071 Eukaryota
ENOG410Y266 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000034259

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000976_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O94913

KEGG Orthology (KO)

More...
KOi
K14400

Identification of Orthologs from Complete Genome Data

More...
OMAi
DDYKPFQ

Database of Orthologous Groups

More...
OrthoDBi
321518at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O94913

TreeFam database of animal gene trees

More...
TreeFami
TF350069

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006569 CID_dom
IPR008942 ENTH_VHS
IPR006903 RNA_pol_II-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04818 CTD_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00582 RPR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48464 SSF48464, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51391 CID, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O94913-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEQTPAEAG AAGAREDACR DYQSSLEDLT FNSKPHINML TILAEENLPF
60 70 80 90 100
AKEIVSLIEA QTAKAPSSEK LPVMYLMDSI VKNVGREYLT AFTKNLVATF
110 120 130 140 150
ICVFEKVDEN TRKSLFKLRS TWDEIFPLKK LYALDVRVNS LDPAWPIKPL
160 170 180 190 200
PPNVNTSSIH VNPKFLNKSP EEPSTPGTVV SSPSISTPPI VPDIQKNLTQ
210 220 230 240 250
EQLIRQQLLA KQKQLLELQQ KKLELELEQA KAQLAVSLSV QQETSNLGPG
260 270 280 290 300
SAPSKLHVSQ IPPMAVKAPH QVPVQSEKSR PGPSLQIQDL KGTNRDPRLN
310 320 330 340 350
RISQHSHGKD QSHRKEFLMN TLNQSDTKTS KTIPSEKLNS SKQEKSKSGE
360 370 380 390 400
KITKKELDQL DSKSKSKSKS PSPLKNKLSH TKDLKNQESE SMRLSDMNKR
410 420 430 440 450
DPRLKKHLQD KTDGKDDDVK EKRKTAEKKD KDEHMKSSEH RLAGSRNKII
460 470 480 490 500
NGIVQKQDTI TEESEKQGTK PGRSSTRKRS RSRSPKSRSP IIHSPKRRDR
510 520 530 540 550
RSPKRRQRSM SPTSTPKAGK IRQSGAKQSH MEEFTPPSRE DRNAKRSTKQ
560 570 580 590 600
DIRDPRRMKK TEEERPQETT NQHSTKSGTE PKENVENWQS SKSAKRWKSG
610 620 630 640 650
WEENKSLQQV DEHSKPPHLR HRESWSSTKG ILSPRAPKQQ QHRLSVDANL
660 670 680 690 700
QIPKELTLAS KRELLQKTSE RLASGEITQD DFLVVVHQIR QLFQYQEGVR
710 720 730 740 750
EEQRSPFNDR FPLKRPRYED SDKPFVDSPA SRFAGLDTNQ RLTALAEDRP
760 770 780 790 800
LFDGPSRPSV ARDGPTKMIF EGPNKLSPRI DGPPTPASLR FDGSPGQMGG
810 820 830 840 850
GGPLRFEGPQ GQLGGGCPLR FEGPPGPVGT PLRFEGPIGQ AGGGGFRFEG
860 870 880 890 900
SPGLRFEGSP GGLRFEGPGG QPVGGLRFEG HRGQPVGGLR FEGPHGQPVG
910 920 930 940 950
GLRFDNPRGQ PVGGLRFEGG HGPSGAAIRF DGPHGQPGGG IRFEGPLLQQ
960 970 980 990 1000
GVGMRFEGPH GQSVAGLRFE GQHNQLGGNL RFEGPHGQPG VGIRFEGPLV
1010 1020 1030 1040 1050
QQGGGMRFEG PSVPGGGLRI EGPLGQGGPR FEGCHALRFD GQPGQPSLLP
1060 1070 1080 1090 1100
RFDGLHGQPG PRFERTPGQP GPQRFDGPPG QQVQPRFDGV PQRFDGPQHQ
1110 1120 1130 1140 1150
QASRFDIPLG LQGTRFDNHP SQRLESVSFN QTGPYNDPPG NAFNAPSQGL
1160 1170 1180 1190 1200
QFQRHEQIFD SPQGPNFNGP HGPGNQSFSN PLNRASGHYF DEKNLQSSQF
1210 1220 1230 1240 1250
GNFGNIPAPM TVGNIQASQQ VLSGVAQPVA FGQGQQFLPV HPQNPGFVQN
1260 1270 1280 1290 1300
PSGALPKAYP DNHLSQVDVN ELFSKLLKTG ILKLSQTDSA TTQVSEVTAQ
1310 1320 1330 1340 1350
PPPEEEEDQN EDQDVPDLTN FTVEELKQRY DSVINRLYTG IQCYSCGMRF
1360 1370 1380 1390 1400
TTSQTDVYAD HLDWHYRQNR TEKDVSRKVT HRRWYYSLTD WIEFEEIADL
1410 1420 1430 1440 1450
EERAKSQFFE KVHEEVVLKT QEAAKEKEFQ SVPAGPAGAV ESCEICQEQF
1460 1470 1480 1490 1500
EQYWDEEEEE WHLKNAIRVD GKIYHPSCYE DYQNTSSFDC TPSPSKTPVE
1510 1520 1530 1540 1550
NPLNIMLNIV KNELQEPCDS PKVKEERIDT PPACTEESIA TPSEIKTEND

TVESV
Length:1,555
Mass (Da):173,050
Last modified:October 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0AEAE04D7CB4A34F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PKN0E9PKN0_HUMAN
Pre-mRNA cleavage complex 2 protein...
PCF11
784Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQ01E9PQ01_HUMAN
Pre-mRNA cleavage complex 2 protein...
PCF11
998Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNY7E9PNY7_HUMAN
Pre-mRNA cleavage complex 2 protein...
PCF11
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQF9E9PQF9_HUMAN
Pre-mRNA cleavage complex 2 protein...
PCF11
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC03107 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAC03107 differs from that shown. Reason: Frameshift.Curated
The sequence BAA74847 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti783P → L in AAC03107 (Ref. 4) Curated1
Sequence conflicti784P → R in AAC03107 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036878651Q → H. Corresponds to variant dbSNP:rs7935175Ensembl.1
Natural variantiVAR_0368791119H → Y. Corresponds to variant dbSNP:rs17513642Ensembl.1
Natural variantiVAR_0368801402E → K. Corresponds to variant dbSNP:rs11233510Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB020631 mRNA Translation: BAA74847.1 Different initiation.
CH471076 Genomic DNA Translation: EAW75083.1
BC065384 mRNA Translation: AAH65384.2
BC146778 mRNA Translation: AAI46779.1
AF046935 mRNA Translation: AAC03107.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS44689.1

NCBI Reference Sequences

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RefSeqi
NP_056969.2, NM_015885.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000298281; ENSP00000298281; ENSG00000165494

Database of genes from NCBI RefSeq genomes

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GeneIDi
51585

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51585

UCSC genome browser

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UCSCi
uc001ozx.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020631 mRNA Translation: BAA74847.1 Different initiation.
CH471076 Genomic DNA Translation: EAW75083.1
BC065384 mRNA Translation: AAH65384.2
BC146778 mRNA Translation: AAI46779.1
AF046935 mRNA Translation: AAC03107.1 Sequence problems.
CCDSiCCDS44689.1
RefSeqiNP_056969.2, NM_015885.3

3D structure databases

SMRiO94913
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119622, 50 interactors
CORUMiO94913
DIPiDIP-56825N
IntActiO94913, 23 interactors
MINTiO94913
STRINGi9606.ENSP00000298281

PTM databases

iPTMnetiO94913
MetOSiteiO94913
PhosphoSitePlusiO94913
SwissPalmiO94913

Polymorphism and mutation databases

BioMutaiPCF11

Proteomic databases

EPDiO94913
jPOSTiO94913
MassIVEiO94913
MaxQBiO94913
PaxDbiO94913
PeptideAtlasiO94913
PRIDEiO94913
ProteomicsDBi50548

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
48189 60 antibodies

Genome annotation databases

EnsembliENST00000298281; ENSP00000298281; ENSG00000165494
GeneIDi51585
KEGGihsa:51585
UCSCiuc001ozx.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51585
EuPathDBiHostDB:ENSG00000165494.10

GeneCards: human genes, protein and diseases

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GeneCardsi
PCF11
HGNCiHGNC:30097 PCF11
HPAiENSG00000165494 Low tissue specificity
MIMi608876 gene
neXtProtiNX_O94913
OpenTargetsiENSG00000165494
PharmGKBiPA142671196

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2071 Eukaryota
ENOG410Y266 LUCA
GeneTreeiENSGT00440000034259
HOGENOMiCLU_000976_0_0_1
InParanoidiO94913
KOiK14400
OMAiDDYKPFQ
OrthoDBi321518at2759
PhylomeDBiO94913
TreeFamiTF350069

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing
R-HSA-73856 RNA Polymerase II Transcription Termination
R-HSA-77595 Processing of Intronless Pre-mRNAs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
51585 635 hits in 799 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PCF11 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51585
PharosiO94913 Tbio

Protein Ontology

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PROi
PR:O94913
RNActiO94913 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000165494 Expressed in skin of abdomen and 194 other tissues
ExpressionAtlasiO94913 baseline and differential
GenevisibleiO94913 HS

Family and domain databases

Gene3Di1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR006569 CID_dom
IPR008942 ENTH_VHS
IPR006903 RNA_pol_II-bd
PfamiView protein in Pfam
PF04818 CTD_bind, 1 hit
SMARTiView protein in SMART
SM00582 RPR, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS51391 CID, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCF11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94913
Secondary accession number(s): A6H8W7, O43671, Q6P0X8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 23, 2007
Last modified: June 17, 2020
This is version 157 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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