UniProtKB - O94911 (ABCA8_HUMAN)
ABC-type organic anion transporter ABCA8
ABCA8
Functioni
Catalyzes ATP-dependent import of organic anions such as taurocholate and estrone sulfate (PubMed:12379217).
In vitro, also imports ochratoxin A (PubMed:12379217).
Also mediates cholesterol efflux independent of apolipoprotein, and plays a role in sphingomyelin production in oligodendrocytes (PubMed:23560799).
2 PublicationsCatalyzes ATP-dependent efflux of cholesterol and taurocholate (PubMed:29300488).
Interaction with ABCA1 potentiates cholesterol efflux to lipid-free APOA1, which regulates high-density lipoprotein cholesterol levels (PubMed:28882873).
2 PublicationsCatalytic activityi
- This reaction proceeds in the forward1 Publication direction.This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward2 Publications direction.
- This reaction proceeds in the forward1 Publication direction.This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.This reaction proceeds in the forward1 Publication direction.
- 17β-estradiol 17-O-(β-D-glucuronate)(out) + ATP + H2O = 17β-estradiol 17-O-(β-D-glucuronate)(in) + ADP + H+ + phosphate1 PublicationThis reaction proceeds in the forward1 Publication direction.This reaction proceeds in the forward1 Publication direction.
Activity regulationi
Kineticsi
- KM=30.4 µM for estradiol-beta-glucuronide1 Publication
- KM=0.1 µM for LTC41 Publication
- KM=10.3 µM for taurochlorate1 Publication
- KM=5.0 µM for PAH1 Publication
- KM=0.5 µM for estrone sulfate1 Publication
- KM=0.4 µM for ochratoxin A1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 516 – 523 | ATP 1PROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1323 – 1330 | ATP 2PROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ABC-type transporter activity Source: UniProtKB
- ABC-type xenobiotic transporter activity Source: UniProtKB
- ATPase-coupled transmembrane transporter activity Source: MGI
- ATP binding Source: UniProtKB-KW
- lipid transporter activity Source: GO_Central
GO - Biological processi
- cholesterol efflux Source: UniProtKB
- cholesterol transport Source: UniProtKB
- lipid transport Source: GO_Central
- positive regulation of cholesterol efflux Source: UniProtKB
- regulation of cholesterol efflux Source: UniProtKB
- sphingomyelin biosynthetic process Source: UniProtKB
- transmembrane transport Source: Reactome
- xenobiotic transport Source: UniProtKB
Keywordsi
Molecular function | Translocase |
Biological process | Lipid transport, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | O94911 |
Reactomei | R-HSA-382556, ABC-family proteins mediated transport |
SABIO-RKi | O94911 |
SignaLinki | O94911 |
Protein family/group databases
TCDBi | 3.A.1.211.6, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: ABC-type organic anion transporter ABCA8 (EC:7.6.2.-1 Publication)Alternative name(s): ATP-binding cassette sub-family A member 8Curated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:38, ABCA8 |
MIMi | 612505, gene |
neXtProti | NX_O94911 |
VEuPathDBi | HostDB:ENSG00000141338 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Multi-pass membrane protein Curated
- Basolateral cell membrane By similarity
Note: Predominantly expressed on the sinusoidal plasma membrane.By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Plasma Membrane
- basolateral plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 30 – 50 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 220 – 240 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 268 – 288 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 299 – 319 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 327 – 347 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 359 – 379 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 397 – 417 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 864 – 884 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1019 – 1039 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1070 – 1090 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1106 – 1126 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1136 – 1156 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1161 – 1181 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1197 – 1217 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10351 |
OpenTargetsi | ENSG00000141338 |
PharmGKBi | PA24383 |
Miscellaneous databases
Pharosi | O94911, Tbio |
Genetic variation databases
BioMutai | ABCA8 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000250677 | 1 – 1621 | ABC-type organic anion transporter ABCA8Add BLAST | 1621 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 71 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 84 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 194 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 243 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 484 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 555 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 616 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 724 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 797 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 919 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 948 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 967 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1270 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1308 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1373 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1435 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | O94911 |
MassIVEi | O94911 |
PaxDbi | O94911 |
PeptideAtlasi | O94911 |
PRIDEi | O94911 |
ProteomicsDBi | 11233 50546 [O94911-1] 50547 [O94911-2] |
PTM databases
GlyGeni | O94911, 16 sites |
iPTMneti | O94911 |
PhosphoSitePlusi | O94911 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000141338, Expressed in corpus callosum and 237 other tissues |
ExpressionAtlasi | O94911, baseline and differential |
Genevisiblei | O94911, HS |
Organism-specific databases
HPAi | ENSG00000141338, Low tissue specificity |
Interactioni
Subunit structurei
Protein-protein interaction databases
BioGRIDi | 115632, 5 interactors |
IntActi | O94911, 1 interactor |
STRINGi | 9606.ENSP00000467271 |
Miscellaneous databases
RNActi | O94911, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 480 – 715 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 236 | |
Domaini | 1285 – 1518 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 234 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0059, Eukaryota |
GeneTreei | ENSGT00940000162012 |
HOGENOMi | CLU_000604_19_1_1 |
InParanoidi | O94911 |
OMAi | IMTTHFL |
OrthoDBi | 131191at2759 |
PhylomeDBi | O94911 |
TreeFami | TF105192 |
Family and domain databases
Gene3Di | 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR026082, ABCA IPR030372, ABCA8 IPR027417, P-loop_NTPase |
PANTHERi | PTHR19229, PTHR19229, 1 hit PTHR19229:SF148, PTHR19229:SF148, 1 hit |
Pfami | View protein in Pfam PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRKRKISVCQ QTWALLCKNF LKKWRMKRES LMEWLNSLLL LLCLYIYPHS
60 70 80 90 100
HQVNDFSSLL TMDLGRVDTF NESRFSVVYT PVTNTTQQIM NKVASTPFLA
110 120 130 140 150
GKEVLGLPDE ESIKEFTANY PEEIVRVTFT NTYSYHLKFL LGHGMPAKKE
160 170 180 190 200
HKDHTAHCYE TNEDVYCEVS VFWKEGFVAL QAAINAAIIE ITTNHSVMEE
210 220 230 240 250
LMSVTGKNMK MHSFIGQSGV ITDLYLFSCI ISFSSFIYYA SVNVTRERKR
260 270 280 290 300
MKALMTMMGL RDSAFWLSWG LLYAGFIFIM ALFLALVIRS TQFIILSGFM
310 320 330 340 350
VVFSLFLLYG LSLVALAFLM SILVKKSFLT GLVVFLLTVF WGCLGFTSLY
360 370 380 390 400
RHLPASLEWI LSLLSPFAFM LGMAQLLHLD YDLNSNAFPH PSDGSNLIVA
410 420 430 440 450
TNFMLAFDTC LYLALAIYFE KILPNEYGHR RPPLFFLKSS FWSQTQKTDH
460 470 480 490 500
VALEDEMDAD PSFHDSFEQA PPEFQGKEAI RIRNVTKEYK GKPDKIEALK
510 520 530 540 550
DLVFDIYEGQ ITAILGHSGA GKSTLLNILS GLSVPTKGSV TIYNNKLSEM
560 570 580 590 600
ADLENLSKLT GVCPQSNVQF DFLTVRENLR LFAKIKGILP QEVDKEIQRV
610 620 630 640 650
LLELEMKNIQ DVLAQNLSGG QKRKLTFGIA ILGDPQIFLL DEPTAGLDPF
660 670 680 690 700
SRHQVWNLLK ERKTDRVILF STQFMDEADI LADRKVFLSQ GKLKCAGSSL
710 720 730 740 750
FLKKKWGIGY HLSLQLNEIC VEENITSLVK QHIPDAKLSA KSEGKLIYTL
760 770 780 790 800
PLERTNKFPE LYKDLDSYPD LGIENYGVSM TTLNEVFLKL EGKSTINESD
810 820 830 840 850
IAILGEVQAE KADDTERLVE MEQVLSSLNK MRKTIGGVAL WRQQICAIAR
860 870 880 890 900
VRLLKLKHER KALLALLLIL MAGFCPLLVE YTMVKIYQNS YTWELSPHLY
910 920 930 940 950
FLAPGQQPHD PLTQLLIINK TGASIDDFIQ SVEHQNIALE VDAFGTRNGT
960 970 980 990 1000
DDPSYNGAIT VCCNEKNYSF SLACNAKRLN CFPVLMDIVS NGLLGMVKPS
1010 1020 1030 1040 1050
VHIRTERSTF LENGQDNPIG FLAYIMFWLV LTSSCPPYIA MSSIDDYKNR
1060 1070 1080 1090 1100
ARSQLRISGL SPSAYWFGQA LVDVSLYFLV FVFIYLMSYI SNFEDMLLTI
1110 1120 1130 1140 1150
IHIIQIPCAV GYSFSLIFMT YVISFIFRKG RKNSGIWSFC FYVVTVFSVA
1160 1170 1180 1190 1200
GFAFSIFESD IPFIFTFLIP PATMIGCLFL SSHLLFSSLF SEERMDVQPF
1210 1220 1230 1240 1250
LVFLIPFLHF IIFLFTLRCL EWKFGKKSMR KDPFFRISPR SSDVCQNPEE
1260 1270 1280 1290 1300
PEGEDEDVQM ERVRTANALN STNFDEKPVI IASCLRKEYA GKRKGCFSKR
1310 1320 1330 1340 1350
KNKIATRNVS FCVRKGEVLG LLGHNGAGKS TSIKVITGDT KPTAGQVLLK
1360 1370 1380 1390 1400
GSGGGDALEF LGYCPQENAL WPNLTVRQHL EVYAAVKGLR KGDAEVAITR
1410 1420 1430 1440 1450
LVDALKLQDQ LKSPVKTLSE GIKRKLCFVL SILGNPSVVL LDEPSTGMDP
1460 1470 1480 1490 1500
EGQQQMWQAI RATFRNTERG ALLTTHYMAE AEAVCDRVAI MVSGRLRCIG
1510 1520 1530 1540 1550
SIQHLKSKFG KDYLLEMKVK NLAQVEPLHA EILRLFPQAA RQERYSSLMV
1560 1570 1580 1590 1600
YKLPVEDVQP LAQAFFKLEK VKQSFDLEEY SLSQSTLEQV FLELSKEQEL
1610 1620
GDFEEDFDPS VKWKLLPQEE P
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MSU4 | A0A0A0MSU4_HUMAN | ABC-type organic anion transporter ... | ABCA8 | 1,616 | Annotation score: | ||
A0A075B774 | A0A075B774_HUMAN | ABC-type organic anion transporter ... | ABCA8 | 702 | Annotation score: | ||
Q49AI9 | Q49AI9_HUMAN | ABC-type organic anion transporter ... | ABCA8 | 156 | Annotation score: | ||
K7ELK9 | K7ELK9_HUMAN | ABC-type organic anion transporter ... | ABCA8 | 115 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027590 | 256 | T → A. Corresponds to variant dbSNP:rs16973446Ensembl. | 1 | |
Natural variantiVAR_027591 | 331 | G → S1 PublicationCorresponds to variant dbSNP:rs4147979Ensembl. | 1 | |
Natural variantiVAR_048130 | 416 | A → V1 PublicationCorresponds to variant dbSNP:rs35621847Ensembl. | 1 | |
Natural variantiVAR_027592 | 489 | Y → F. Corresponds to variant dbSNP:rs12150510Ensembl. | 1 | |
Natural variantiVAR_084139 | 649 | P → R Affects localization at the plasma membrane; loss of cholesterol efflux to APOA1. 1 PublicationCorresponds to variant dbSNP:rs144777539Ensembl. | 1 | |
Natural variantiVAR_048131 | 659 | L → R. Corresponds to variant dbSNP:rs35844316Ensembl. | 1 | |
Natural variantiVAR_027593 | 720 | C → G. Corresponds to variant dbSNP:rs16973424Ensembl. | 1 | |
Natural variantiVAR_084140 | 781 – 1621 | Missing Loss of expression; loss of cholesterol efflux to APOA1. 1 PublicationAdd BLAST | 841 | |
Natural variantiVAR_048132 | 1470 | G → S. Corresponds to variant dbSNP:rs35403175Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_060911 | 267 – 1621 | Missing in isoform 2. Add BLAST | 1355 | |
Alternative sequenceiVSP_060912 | 598 – 637 | Missing in isoform 1. Add BLAST | 40 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB020629 mRNA Translation: BAA74845.2 Different initiation. AC005922 Genomic DNA No translation available. AC015844 Genomic DNA No translation available. BC024003 mRNA Translation: AAH24003.1 BC047765 mRNA Translation: AAH47765.1 BC094689 mRNA Translation: AAH94689.1 BC130280 mRNA Translation: AAI30281.1 |
CCDSi | CCDS11680.1 [O94911-1] CCDS74139.1 [O94911-3] |
RefSeqi | NP_001275914.1, NM_001288985.1 [O94911-3] NP_001275915.1, NM_001288986.1 NP_009099.1, NM_007168.3 [O94911-1] XP_005256995.1, XM_005256938.2 |
Genome annotation databases
Ensembli | ENST00000269080; ENSP00000269080; ENSG00000141338 [O94911-1] ENST00000586539; ENSP00000467271; ENSG00000141338 |
GeneIDi | 10351 |
KEGGi | hsa:10351 |
MANE-Selecti | ENST00000586539.6; ENSP00000467271.1; NM_001288985.2; NP_001275914.1 |
UCSCi | uc002jhp.5, human [O94911-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
ABCMdb Database for mutations in ABC proteins |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB020629 mRNA Translation: BAA74845.2 Different initiation. AC005922 Genomic DNA No translation available. AC015844 Genomic DNA No translation available. BC024003 mRNA Translation: AAH24003.1 BC047765 mRNA Translation: AAH47765.1 BC094689 mRNA Translation: AAH94689.1 BC130280 mRNA Translation: AAI30281.1 |
CCDSi | CCDS11680.1 [O94911-1] CCDS74139.1 [O94911-3] |
RefSeqi | NP_001275914.1, NM_001288985.1 [O94911-3] NP_001275915.1, NM_001288986.1 NP_009099.1, NM_007168.3 [O94911-1] XP_005256995.1, XM_005256938.2 |
3D structure databases
SMRi | O94911 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115632, 5 interactors |
IntActi | O94911, 1 interactor |
STRINGi | 9606.ENSP00000467271 |
Protein family/group databases
TCDBi | 3.A.1.211.6, the atp-binding cassette (abc) superfamily |
PTM databases
GlyGeni | O94911, 16 sites |
iPTMneti | O94911 |
PhosphoSitePlusi | O94911 |
Genetic variation databases
BioMutai | ABCA8 |
Proteomic databases
jPOSTi | O94911 |
MassIVEi | O94911 |
PaxDbi | O94911 |
PeptideAtlasi | O94911 |
PRIDEi | O94911 |
ProteomicsDBi | 11233 50546 [O94911-1] 50547 [O94911-2] |
Protocols and materials databases
Antibodypediai | 31802, 136 antibodies from 27 providers |
DNASUi | 10351 |
Genome annotation databases
Ensembli | ENST00000269080; ENSP00000269080; ENSG00000141338 [O94911-1] ENST00000586539; ENSP00000467271; ENSG00000141338 |
GeneIDi | 10351 |
KEGGi | hsa:10351 |
MANE-Selecti | ENST00000586539.6; ENSP00000467271.1; NM_001288985.2; NP_001275914.1 |
UCSCi | uc002jhp.5, human [O94911-3] |
Organism-specific databases
CTDi | 10351 |
DisGeNETi | 10351 |
GeneCardsi | ABCA8 |
HGNCi | HGNC:38, ABCA8 |
HPAi | ENSG00000141338, Low tissue specificity |
MIMi | 612505, gene |
neXtProti | NX_O94911 |
OpenTargetsi | ENSG00000141338 |
PharmGKBi | PA24383 |
VEuPathDBi | HostDB:ENSG00000141338 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0059, Eukaryota |
GeneTreei | ENSGT00940000162012 |
HOGENOMi | CLU_000604_19_1_1 |
InParanoidi | O94911 |
OMAi | IMTTHFL |
OrthoDBi | 131191at2759 |
PhylomeDBi | O94911 |
TreeFami | TF105192 |
Enzyme and pathway databases
PathwayCommonsi | O94911 |
Reactomei | R-HSA-382556, ABC-family proteins mediated transport |
SABIO-RKi | O94911 |
SignaLinki | O94911 |
Miscellaneous databases
BioGRID-ORCSi | 10351, 7 hits in 1047 CRISPR screens |
ChiTaRSi | ABCA8, human |
GeneWikii | ABCA8 |
GenomeRNAii | 10351 |
Pharosi | O94911, Tbio |
PROi | PR:O94911 |
RNActi | O94911, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000141338, Expressed in corpus callosum and 237 other tissues |
ExpressionAtlasi | O94911, baseline and differential |
Genevisiblei | O94911, HS |
Family and domain databases
Gene3Di | 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR026082, ABCA IPR030372, ABCA8 IPR027417, P-loop_NTPase |
PANTHERi | PTHR19229, PTHR19229, 1 hit PTHR19229:SF148, PTHR19229:SF148, 1 hit |
Pfami | View protein in Pfam PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ABCA8_HUMAN | |
Accessioni | O94911Primary (citable) accession number: O94911 Secondary accession number(s): A1L3U3, C9JQE6, Q86WW0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | February 10, 2021 | |
Last modified: | February 23, 2022 | |
This is version 169 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families