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Protein

Pyridoxal phosphate homeostasis protein

Gene

PLPBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.UniRule annotation1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • pyridoxal phosphate binding Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandPyridoxal phosphate

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pyridoxal phosphate homeostasis proteinUniRule annotation
Short name:
PLP homeostasis proteinUniRule annotation
Alternative name(s):
Proline synthase co-transcribed bacterial homolog proteinUniRule annotation
Pyridoxal phosphate-binding proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLPBPUniRule annotationImported
Synonyms:PROSCUniRule annotationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000147471.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9457 PLPBP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604436 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O94903

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Epilepsy, early-onset, vitamin B6-dependent (EPVB6D)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive neurologic disorder characterized by seizures responsive to treatment with activated vitamin B6 and/or pyridoxine. Most patients show delayed psychomotor development, mental retardation and learning disability. Seizures onset is in the first days or months of life.
See also OMIM:617290
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07800471 – 275Missing in EPVB6D. 1 PublicationAdd BLAST205
Natural variantiVAR_07800578 – 275Missing in EPVB6D; decreased expression at the mRNA level; undetectable at the protein level in patient's fibroblasts. 1 PublicationAdd BLAST198
Natural variantiVAR_07800687P → L in EPVB6D. 1 PublicationCorresponds to variant dbSNP:rs755946598EnsemblClinVar.1
Natural variantiVAR_078007175L → P in EPVB6D; decreased expression at the mRNA level; undetectable at the protein level in patient's fibroblasts. 1 PublicationCorresponds to variant dbSNP:rs752753379EnsemblClinVar.1
Natural variantiVAR_078008241R → Q in EPVB6D. 1 PublicationCorresponds to variant dbSNP:rs760609867EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Epilepsy

Organism-specific databases

DisGeNET

More...
DisGeNETi
11212

MalaCards human disease database

More...
MalaCardsi
PLPBP
MIMi617290 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000147471

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
3006 Pyridoxine-dependent epilepsy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33810

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00172 L-Proline
DB00114 Pyridoxal Phosphate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLPBP

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001632101 – 275Pyridoxal phosphate homeostasis proteinAdd BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6PhosphoserineCombined sources1
Modified residuei47N6-(pyridoxal phosphate)lysineUniRule annotation1
Modified residuei69PhosphotyrosineBy similarity1
Modified residuei125N6-succinyllysineBy similarity1
Modified residuei226PhosphoserineCombined sources1
Modified residuei244PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O94903

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O94903

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O94903

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94903

PeptideAtlas

More...
PeptideAtlasi
O94903

PRoteomics IDEntifications database

More...
PRIDEi
O94903

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50537

2D gel databases

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
O94903

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O94903

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O94903

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147471 Expressed in 241 organ(s), highest expression level in upper lobe of lung

CleanEx database of gene expression profiles

More...
CleanExi
HS_PROSC

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O94903 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O94903 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017033
HPA023646
HPA023733

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116381, 66 interactors

Protein interaction database and analysis system

More...
IntActi
O94903, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000333551

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O94903

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O94903

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3157 Eukaryota
COG0325 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004928

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053692

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O94903

KEGG Orthology (KO)

More...
KOi
K06997

Identification of Orthologs from Complete Genome Data

More...
OMAi
LQWHFIG

Database of Orthologous Groups

More...
OrthoDBi
1423577at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O94903

TreeFam database of animal gene trees

More...
TreeFami
TF314637

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_02087 PLP_homeostasis, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001608 Ala_racemase_N
IPR029066 PLP-binding_barrel
IPR011078 PyrdxlP_homeostasis

The PANTHER Classification System

More...
PANTHERi
PTHR10146 PTHR10146, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01168 Ala_racemase_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF004848 YBL036c_PLPDEIII, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51419 SSF51419, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00044 TIGR00044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01211 UPF0001, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O94903-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWRAGSMSAE LGVGCALRAV NERVQQAVAR RPRDLPAIQP RLVAVSKTKP
60 70 80 90 100
ADMVIEAYGH GQRTFGENYV QELLEKASNP KILSLCPEIK WHFIGHLQKQ
110 120 130 140 150
NVNKLMAVPN LFMLETVDSV KLADKVNSSW QRKGSPERLK VMVQINTSGE
160 170 180 190 200
ESKHGLPPSE TIAIVEHINA KCPNLEFVGL MTIGSFGHDL SQGPNPDFQL
210 220 230 240 250
LLSLREELCK KLNIPADQVE LSMGMSADFQ HAVEVGSTNV RIGSTIFGER
260 270
DYSKKPTPDK CAADVKAPLE VAQEH
Length:275
Mass (Da):30,344
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA81049432B1A8732
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RFX7E5RFX7_HUMAN
Pyridoxal phosphate homeostasis pro...
PLPBP
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RG77E5RG77_HUMAN
Pyridoxal phosphate homeostasis pro...
PLPBP
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBG2H0YBG2_HUMAN
Pyridoxal phosphate homeostasis pro...
PLPBP
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFZ4E5RFZ4_HUMAN
Pyridoxal phosphate homeostasis pro...
PLPBP
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05247624V → M. Corresponds to variant dbSNP:rs35423325EnsemblClinVar.1
Natural variantiVAR_07800471 – 275Missing in EPVB6D. 1 PublicationAdd BLAST205
Natural variantiVAR_07800578 – 275Missing in EPVB6D; decreased expression at the mRNA level; undetectable at the protein level in patient's fibroblasts. 1 PublicationAdd BLAST198
Natural variantiVAR_07800687P → L in EPVB6D. 1 PublicationCorresponds to variant dbSNP:rs755946598EnsemblClinVar.1
Natural variantiVAR_078007175L → P in EPVB6D; decreased expression at the mRNA level; undetectable at the protein level in patient's fibroblasts. 1 PublicationCorresponds to variant dbSNP:rs752753379EnsemblClinVar.1
Natural variantiVAR_078008241R → Q in EPVB6D. 1 PublicationCorresponds to variant dbSNP:rs760609867EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB018566 Genomic DNA Translation: BAA36842.1
AL136616 mRNA Translation: CAB66551.1
CR533532 mRNA Translation: CAG38563.1
BC012334 mRNA Translation: AAH12334.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6096.1

NCBI Reference Sequences

More...
RefSeqi
NP_009129.1, NM_007198.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.304792
Hs.608177

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000328195; ENSP00000333551; ENSG00000147471

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11212

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11212

UCSC genome browser

More...
UCSCi
uc003xkh.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018566 Genomic DNA Translation: BAA36842.1
AL136616 mRNA Translation: CAB66551.1
CR533532 mRNA Translation: CAG38563.1
BC012334 mRNA Translation: AAH12334.1
CCDSiCCDS6096.1
RefSeqiNP_009129.1, NM_007198.3
UniGeneiHs.304792
Hs.608177

3D structure databases

ProteinModelPortaliO94903
SMRiO94903
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116381, 66 interactors
IntActiO94903, 14 interactors
STRINGi9606.ENSP00000333551

Chemistry databases

DrugBankiDB00172 L-Proline
DB00114 Pyridoxal Phosphate

PTM databases

iPTMnetiO94903
PhosphoSitePlusiO94903

Polymorphism and mutation databases

BioMutaiPLPBP

2D gel databases

UCD-2DPAGEiO94903

Proteomic databases

EPDiO94903
jPOSTiO94903
MaxQBiO94903
PaxDbiO94903
PeptideAtlasiO94903
PRIDEiO94903
ProteomicsDBi50537

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
11212
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328195; ENSP00000333551; ENSG00000147471
GeneIDi11212
KEGGihsa:11212
UCSCiuc003xkh.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11212
DisGeNETi11212
EuPathDBiHostDB:ENSG00000147471.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PLPBP
HGNCiHGNC:9457 PLPBP
HPAiCAB017033
HPA023646
HPA023733
MalaCardsiPLPBP
MIMi604436 gene
617290 phenotype
neXtProtiNX_O94903
OpenTargetsiENSG00000147471
Orphaneti3006 Pyridoxine-dependent epilepsy
PharmGKBiPA33810

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3157 Eukaryota
COG0325 LUCA
GeneTreeiENSGT00390000004928
HOVERGENiHBG053692
InParanoidiO94903
KOiK06997
OMAiLQWHFIG
OrthoDBi1423577at2759
PhylomeDBiO94903
TreeFamiTF314637

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PROSC human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PROSC

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11212

Protein Ontology

More...
PROi
PR:O94903

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000147471 Expressed in 241 organ(s), highest expression level in upper lobe of lung
CleanExiHS_PROSC
ExpressionAtlasiO94903 baseline and differential
GenevisibleiO94903 HS

Family and domain databases

Gene3Di3.20.20.10, 1 hit
HAMAPiMF_02087 PLP_homeostasis, 1 hit
InterProiView protein in InterPro
IPR001608 Ala_racemase_N
IPR029066 PLP-binding_barrel
IPR011078 PyrdxlP_homeostasis
PANTHERiPTHR10146 PTHR10146, 1 hit
PfamiView protein in Pfam
PF01168 Ala_racemase_N, 1 hit
PIRSFiPIRSF004848 YBL036c_PLPDEIII, 1 hit
SUPFAMiSSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00044 TIGR00044, 1 hit
PROSITEiView protein in PROSITE
PS01211 UPF0001, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLPHP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94903
Secondary accession number(s): Q6FI94
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: January 16, 2019
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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