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Protein

Thymocyte selection-associated high mobility group box protein TOX

Gene

TOX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in regulating T-cell development.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi261 – 329HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymocyte selection-associated high mobility group box protein TOX
Alternative name(s):
Thymus high mobility group box protein TOX
Gene namesi
Name:TOX
Synonyms:KIAA0808
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000198846.5
HGNCiHGNC:18988 TOX
MIMi606863 gene
neXtProtiNX_O94900

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9760
OpenTargetsiENSG00000198846
PharmGKBiPA162406704

Polymorphism and mutation databases

BioMutaiTOX

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002445691 – 526Thymocyte selection-associated high mobility group box protein TOXAdd BLAST526

Proteomic databases

EPDiO94900
MaxQBiO94900
PaxDbiO94900
PeptideAtlasiO94900
PRIDEiO94900
ProteomicsDBi50531
TopDownProteomicsiO94900

PTM databases

iPTMnetiO94900
PhosphoSitePlusiO94900

Expressioni

Gene expression databases

BgeeiENSG00000198846 Expressed in 169 organ(s), highest expression level in cerebral cortex
CleanExiHS_TOX
GenevisibleiO94900 HS

Organism-specific databases

HPAiHPA018322
HPA073241

Interactioni

Protein-protein interaction databases

BioGridi115107, 2 interactors
IntActiO94900, 7 interactors
STRINGi9606.ENSP00000354842

Structurei

3D structure databases

ProteinModelPortaliO94900
SMRiO94900
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi237 – 256Nuclear localization signalSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi417 – 420Poly-Pro4

Phylogenomic databases

eggNOGiKOG0381 Eukaryota
COG5648 LUCA
GeneTreeiENSGT00560000076898
HOGENOMiHOG000230949
HOVERGENiHBG051183
InParanoidiO94900
OMAiCRNPPAQ
OrthoDBiEOG091G0CPH
PhylomeDBiO94900
TreeFamiTF106481

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O94900-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVRFYPPPA QPAAAPDAPC LGPSPCLDPY YCNKFDGENM YMSMTEPSQD
60 70 80 90 100
YVPASQSYPG PSLESEDFNI PPITPPSLPD HSLVHLNEVE SGYHSLCHPM
110 120 130 140 150
NHNGLLPFHP QNMDLPEITV SNMLGQDGTL LSNSISVMPD IRNPEGTQYS
160 170 180 190 200
SHPQMAAMRP RGQPADIRQQ PGMMPHGQLT TINQSQLSAQ LGLNMGGSNV
210 220 230 240 250
PHNSPSPPGS KSATPSPSSS VHEDEGDDTS KINGGEKRPA SDMGKKPKTP
260 270 280 290 300
KKKKKKDPNE PQKPVSAYAL FFRDTQAAIK GQNPNATFGE VSKIVASMWD
310 320 330 340 350
GLGEEQKQVY KKKTEAAKKE YLKQLAAYRA SLVSKSYSEP VDVKTSQPPQ
360 370 380 390 400
LINSKPSVFH GPSQAHSALY LSSHYHQQPG MNPHLTAMHP SLPRNIAPKP
410 420 430 440 450
NNQMPVTVSI ANMAVSPPPP LQISPPLHQH LNMQQHQPLT MQQPLGNQLP
460 470 480 490 500
MQVQSALHSP TMQQGFTLQP DYQTIINPTS TAAQVVTQAM EYVRSGCRNP
510 520
PPQPVDWNND YCSSGGMQRD KALYLT
Length:526
Mass (Da):57,513
Last modified:June 27, 2006 - v3
Checksum:i5AE4C5B07F2EB8FF
GO

Sequence cautioni

The sequence BAA34528 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9P → V in AAH16665 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_064759267A → T Found in a renal cell carcinoma sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018351 mRNA Translation: BAA34528.2 Different initiation.
BC016665 mRNA Translation: AAH16665.1
CCDSiCCDS34897.1
RefSeqiNP_055544.1, NM_014729.2
UniGeneiHs.491805
Hs.634856

Genome annotation databases

EnsembliENST00000361421; ENSP00000354842; ENSG00000198846
GeneIDi9760
KEGGihsa:9760
UCSCiuc003xtw.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018351 mRNA Translation: BAA34528.2 Different initiation.
BC016665 mRNA Translation: AAH16665.1
CCDSiCCDS34897.1
RefSeqiNP_055544.1, NM_014729.2
UniGeneiHs.491805
Hs.634856

3D structure databases

ProteinModelPortaliO94900
SMRiO94900
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115107, 2 interactors
IntActiO94900, 7 interactors
STRINGi9606.ENSP00000354842

PTM databases

iPTMnetiO94900
PhosphoSitePlusiO94900

Polymorphism and mutation databases

BioMutaiTOX

Proteomic databases

EPDiO94900
MaxQBiO94900
PaxDbiO94900
PeptideAtlasiO94900
PRIDEiO94900
ProteomicsDBi50531
TopDownProteomicsiO94900

Protocols and materials databases

DNASUi9760
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361421; ENSP00000354842; ENSG00000198846
GeneIDi9760
KEGGihsa:9760
UCSCiuc003xtw.1 human

Organism-specific databases

CTDi9760
DisGeNETi9760
EuPathDBiHostDB:ENSG00000198846.5
GeneCardsiTOX
HGNCiHGNC:18988 TOX
HPAiHPA018322
HPA073241
MIMi606863 gene
neXtProtiNX_O94900
OpenTargetsiENSG00000198846
PharmGKBiPA162406704
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0381 Eukaryota
COG5648 LUCA
GeneTreeiENSGT00560000076898
HOGENOMiHOG000230949
HOVERGENiHBG051183
InParanoidiO94900
OMAiCRNPPAQ
OrthoDBiEOG091G0CPH
PhylomeDBiO94900
TreeFamiTF106481

Miscellaneous databases

ChiTaRSiTOX human
GeneWikiiTOX
GenomeRNAii9760
PROiPR:O94900
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198846 Expressed in 169 organ(s), highest expression level in cerebral cortex
CleanExiHS_TOX
GenevisibleiO94900 HS

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTOX_HUMAN
AccessioniPrimary (citable) accession number: O94900
Secondary accession number(s): Q96AV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: November 7, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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