TOX

Functionⁱ

May play a role in regulating T-cell development.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	261 – 329	HMG boxPROSITE-ProRule annotationAdd BLAST		69

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

lymph node development Source: Ensembl
lymphocyte differentiation Source: Ensembl
Peyer's patch development Source: Ensembl
positive regulation of natural killer cell differentiation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding

Molecular function

DNA-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Thymocyte selection-associated high mobility group box protein TOX Alternative name(s): Thymus high mobility group box protein TOX
Gene namesⁱ	Name:TOX Synonyms:KIAA0808
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000198846.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18988 TOX
MIMⁱ	606863 gene
neXtProtⁱ	NX_O94900

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9760
Open Targets More...OpenTargetsⁱ	ENSG00000198846
PharmGKBⁱ	PA162406704

Polymorphism and mutation databases

BioMutaⁱ	TOX

BioMutaⁱ

TOX

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000244569	1 – 526	Thymocyte selection-associated high mobility group box protein TOXAdd BLAST		526

Proteomic databases

EPDⁱ	O94900
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O94900
PaxDbⁱ	O94900
PeptideAtlas More...PeptideAtlasⁱ	O94900
PRIDEⁱ	O94900
ProteomicsDBⁱ	50531
TopDownProteomicsⁱ	O94900

PTM databases

iPTMnetⁱ	O94900
PhosphoSitePlusⁱ	O94900

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000198846 Expressed in 169 organ(s), highest expression level in cerebral cortex
CleanExⁱ	HS_TOX
Genevisibleⁱ	O94900 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA018322 HPA073241

HPAⁱ

HPA018322
HPA073241

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	115107, 2 interactors
IntActⁱ	O94900, 7 interactors
STRINGⁱ	9606.ENSP00000354842

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O94900
SMRⁱ	O94900
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	237 – 256	Nuclear localization signalSequence analysisAdd BLAST		20

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	417 – 420	Poly-Pro		4

Phylogenomic databases

eggNOGⁱ	KOG0381 Eukaryota COG5648 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00560000076898
HOGENOMⁱ	HOG000230949
HOVERGENⁱ	HBG051183
InParanoidⁱ	O94900
OMAⁱ	CRNPPAQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CPH
PhylomeDBⁱ	O94900
TreeFamⁱ	TF106481

Family and domain databases

Gene3Dⁱ	1.10.30.10, 1 hit
InterProⁱ	View protein in InterPro IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00505 HMG_box, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 1 hit
SUPFAMⁱ	SSF47095 SSF47095, 1 hit
PROSITEⁱ	View protein in PROSITE PS50118 HMG_BOX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O94900-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDVRFYPPPA QPAAAPDAPC LGPSPCLDPY YCNKFDGENM YMSMTEPSQD 
        60         70         80         90        100
YVPASQSYPG PSLESEDFNI PPITPPSLPD HSLVHLNEVE SGYHSLCHPM 
       110        120        130        140        150
NHNGLLPFHP QNMDLPEITV SNMLGQDGTL LSNSISVMPD IRNPEGTQYS 
       160        170        180        190        200
SHPQMAAMRP RGQPADIRQQ PGMMPHGQLT TINQSQLSAQ LGLNMGGSNV 
       210        220        230        240        250
PHNSPSPPGS KSATPSPSSS VHEDEGDDTS KINGGEKRPA SDMGKKPKTP 
       260        270        280        290        300
KKKKKKDPNE PQKPVSAYAL FFRDTQAAIK GQNPNATFGE VSKIVASMWD 
       310        320        330        340        350
GLGEEQKQVY KKKTEAAKKE YLKQLAAYRA SLVSKSYSEP VDVKTSQPPQ 
       360        370        380        390        400
LINSKPSVFH GPSQAHSALY LSSHYHQQPG MNPHLTAMHP SLPRNIAPKP 
       410        420        430        440        450
NNQMPVTVSI ANMAVSPPPP LQISPPLHQH LNMQQHQPLT MQQPLGNQLP 
       460        470        480        490        500
MQVQSALHSP TMQQGFTLQP DYQTIINPTS TAAQVVTQAM EYVRSGCRNP 
       510        520 
PPQPVDWNND YCSSGGMQRD KALYLT

Length:526

Mass (Da):57,513

Last modified:June 27, 2006 - v3

Checksum:ⁱ5AE4C5B07F2EB8FF

GO

Sequence cautionⁱ

The sequence BAA34528 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	9	P → V in AAH16665 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_064759	267	A → T Found in a renal cell carcinoma sample; somatic mutation. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB018351 mRNA Translation: BAA34528.2 Different initiation. BC016665 mRNA Translation: AAH16665.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34897.1
NCBI Reference Sequences More...RefSeqⁱ	NP_055544.1, NM_014729.2
UniGeneⁱ	Hs.491805 Hs.634856

Genome annotation databases

Ensemblⁱ	ENST00000361421; ENSP00000354842; ENSG00000198846
GeneIDⁱ	9760
KEGGⁱ	hsa:9760
UCSC genome browser More...UCSCⁱ	uc003xtw.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O94900	TOX isoform 1		PANTR		526	UniRef100_O94900
Uncharacterized protein		PANPA		464

Protein	Similar proteins		Species	Score	Length	Source
O94900	TOX isoform 1		PANTR		526	UniRef90_O94900
Uncharacterized protein		PANPA		464
Thymocyte selection-associated high mobility group box protein TOX		MYOBR		527
Thymocyte selection-associated high mobility group box protein TOX		MYODS		527
Thymocyte selection associated high mobility group box		MYOLU		389
+107

Protein	Similar proteins		Species	Score	Length	Source
O94900	TOX isoform 1		PANTR		526	UniRef50_O94900
Uncharacterized protein		PANPA		464
Thymocyte selection associated high mobility group box		AILME		527
Thymocyte selection-associated high mobility group box protein TOX		MYOBR		527
Thymocyte selection-associated high mobility group box protein TOX		MYODS		527
+115

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB018351 mRNA Translation: BAA34528.2 Different initiation. BC016665 mRNA Translation: AAH16665.1
CCDSⁱ	CCDS34897.1
RefSeqⁱ	NP_055544.1, NM_014729.2
UniGeneⁱ	Hs.491805 Hs.634856

3D structure databases

ProteinModelPortalⁱ	O94900
SMRⁱ	O94900
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115107, 2 interactors
IntActⁱ	O94900, 7 interactors
STRINGⁱ	9606.ENSP00000354842

PTM databases

iPTMnetⁱ	O94900
PhosphoSitePlusⁱ	O94900

Polymorphism and mutation databases

BioMutaⁱ	TOX

BioMutaⁱ

TOX

Proteomic databases

EPDⁱ	O94900
MaxQBⁱ	O94900
PaxDbⁱ	O94900
PeptideAtlasⁱ	O94900
PRIDEⁱ	O94900
ProteomicsDBⁱ	50531
TopDownProteomicsⁱ	O94900

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9760
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000361421; ENSP00000354842; ENSG00000198846
GeneIDⁱ	9760
KEGGⁱ	hsa:9760
UCSCⁱ	uc003xtw.1 human

Organism-specific databases

CTDⁱ	9760
DisGeNETⁱ	9760
EuPathDBⁱ	HostDB:ENSG00000198846.5
GeneCardsⁱ	TOX
HGNCⁱ	HGNC:18988 TOX
HPAⁱ	HPA018322 HPA073241
MIMⁱ	606863 gene
neXtProtⁱ	NX_O94900
OpenTargetsⁱ	ENSG00000198846
PharmGKBⁱ	PA162406704
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0381 Eukaryota COG5648 LUCA
GeneTreeⁱ	ENSGT00560000076898
HOGENOMⁱ	HOG000230949
HOVERGENⁱ	HBG051183
InParanoidⁱ	O94900
OMAⁱ	CRNPPAQ
OrthoDBⁱ	EOG091G0CPH
PhylomeDBⁱ	O94900
TreeFamⁱ	TF106481

Miscellaneous databases

ChiTaRSⁱ	TOX human
GeneWikiⁱ	TOX
GenomeRNAiⁱ	9760
Protein Ontology More...PROⁱ	PR:O94900
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000198846 Expressed in 169 organ(s), highest expression level in cerebral cortex
CleanExⁱ	HS_TOX
Genevisibleⁱ	O94900 HS

Family and domain databases

Gene3Dⁱ	1.10.30.10, 1 hit
InterProⁱ	View protein in InterPro IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf
Pfamⁱ	View protein in Pfam PF00505 HMG_box, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 1 hit
SUPFAMⁱ	SSF47095 SSF47095, 1 hit
PROSITEⁱ	View protein in PROSITE PS50118 HMG_BOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TOX_HUMAN
Accessionⁱ	O94900Primary (citable) accession number: O94900 Secondary accession number(s): Q96AV5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
	Last sequence update:	June 27, 2006
	Last modified:	November 7, 2018
	This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - O94900 (TOX_HUMAN)

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Thymocyte selection-associated high mobility group box protein TOX

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ