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UniProtKB - O94898 (LRIG2_HUMAN)
Protein
Leucine-rich repeats and immunoglobulin-like domains protein 2
Gene
LRIG2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- signaling receptor binding Source: Ensembl
GO - Biological processi
- innervation Source: Ensembl
- negative regulation of axon regeneration Source: Ensembl
- negative regulation of membrane protein ectodomain proteolysis Source: Ensembl
- positive regulation of protein localization to cell surface Source: Ensembl
- regulation of neuron migration Source: Ensembl
- regulation of platelet-derived growth factor receptor signaling pathway Source: Ensembl
- sensory perception of sound Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | O94898 |
SignaLinki | O94898 |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine-rich repeats and immunoglobulin-like domains protein 2Short name: LIG-2 |
Gene namesi | Name:LRIG2 Synonyms:KIAA0806, LIG2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20889, LRIG2 |
MIMi | 608869, gene |
neXtProti | NX_O94898 |
VEuPathDBi | HostDB:ENSG00000198799 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Extracellular region or secreted
- extracellular space Source: GO_Central
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-SubCell
- extracellular matrix Source: GO_Central
- growth cone Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
- intracellular vesicle Source: Ensembl
- neuronal cell body Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 41 – 807 | ExtracellularSequence analysisAdd BLAST | 767 | |
Transmembranei | 808 – 828 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 829 – 1065 | CytoplasmicSequence analysisAdd BLAST | 237 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Involvement in diseasei
Urofacial syndrome 2 (UFS2)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA rare autosomal recessive disorder characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void completely despite a lack of anatomical bladder outflow obstruction or overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure.
Related information in OMIMOrganism-specific databases
DisGeNETi | 9860 |
GeneReviewsi | LRIG2 |
MalaCardsi | LRIG2 |
MIMi | 615112, phenotype |
OpenTargetsi | ENSG00000198799 |
Orphaneti | 2704, Ochoa syndrome |
PharmGKBi | PA134905053 |
Miscellaneous databases
Pharosi | O94898, Tbio |
Genetic variation databases
BioMutai | LRIG2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 40 | Sequence analysisAdd BLAST | 40 | |
ChainiPRO_0000014829 | 41 – 1065 | Leucine-rich repeats and immunoglobulin-like domains protein 2Add BLAST | 1025 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 91 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 121 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 173 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 189 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 274 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 441 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 468 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 514 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 519 ↔ 580 | PROSITE-ProRule annotation | ||
Glycosylationi | 571 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 589 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 623 ↔ 675 | PROSITE-ProRule annotation | ||
Glycosylationi | 687 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 717 ↔ 766 | PROSITE-ProRule annotation | ||
Glycosylationi | 728 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 906 | PhosphotyrosineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | O94898 |
jPOSTi | O94898 |
MassIVEi | O94898 |
MaxQBi | O94898 |
PaxDbi | O94898 |
PeptideAtlasi | O94898 |
PRIDEi | O94898 |
ProteomicsDBi | 50530 |
PTM databases
GlyGeni | O94898, 12 sites |
iPTMneti | O94898 |
PhosphoSitePlusi | O94898 |
Expressioni
Tissue specificityi
Detected in all tissues analyzed.1 Publication
Gene expression databases
Bgeei | ENSG00000198799, Expressed in forebrain and 220 other tissues |
Genevisiblei | O94898, HS |
Organism-specific databases
HPAi | ENSG00000198799, Low tissue specificity |
Interactioni
Binary interactionsi
GO - Molecular functioni
- signaling receptor binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 115194, 56 interactors |
IntActi | O94898, 6 interactors |
STRINGi | 9606.ENSP00000355396 |
Miscellaneous databases
RNActi | O94898, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 75 | LRRNTAdd BLAST | 35 | |
Repeati | 76 – 97 | LRR 1Add BLAST | 22 | |
Repeati | 98 – 119 | LRR 2Add BLAST | 22 | |
Repeati | 121 – 142 | LRR 3Add BLAST | 22 | |
Repeati | 145 – 166 | LRR 4Add BLAST | 22 | |
Repeati | 168 – 189 | LRR 5Add BLAST | 22 | |
Repeati | 193 – 214 | LRR 6Add BLAST | 22 | |
Repeati | 216 – 237 | LRR 7Add BLAST | 22 | |
Repeati | 240 – 261 | LRR 8Add BLAST | 22 | |
Repeati | 264 – 285 | LRR 9Add BLAST | 22 | |
Repeati | 288 – 309 | LRR 10Add BLAST | 22 | |
Repeati | 312 – 333 | LRR 11Add BLAST | 22 | |
Repeati | 336 – 357 | LRR 12Add BLAST | 22 | |
Repeati | 360 – 382 | LRR 13Add BLAST | 23 | |
Repeati | 387 – 408 | LRR 14Add BLAST | 22 | |
Repeati | 411 – 432 | LRR 15Add BLAST | 22 | |
Domaini | 443 – 494 | LRRCTAdd BLAST | 52 | |
Domaini | 498 – 597 | Ig-like C2-type 1Add BLAST | 100 | |
Domaini | 602 – 691 | Ig-like C2-type 2Add BLAST | 90 | |
Domaini | 696 – 785 | Ig-like C2-type 3Add BLAST | 90 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 962 – 990 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 1003 – 1040 | DisorderedSequence analysisAdd BLAST | 38 |
Keywords - Domaini
Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4194, Eukaryota |
GeneTreei | ENSGT00940000158791 |
HOGENOMi | CLU_000288_18_24_1 |
InParanoidi | O94898 |
OMAi | TDEMNLP |
OrthoDBi | 161719at2759 |
PhylomeDBi | O94898 |
TreeFami | TF325380 |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF07679, I-set, 2 hits PF13855, LRR_8, 4 hits PF01463, LRRCT, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 3 hits SM00408, IGc2, 3 hits SM00369, LRR_TYP, 11 hits SM00082, LRRCT, 1 hit |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS51450, LRR, 14 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O94898-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPAPLGVPE EQLLGCRSRV LSRLLFIAQT ALLLLPAAGA GLCPAPCSCR
60 70 80 90 100
IPLLDCSRRK LPAPSWRALS GLLPPDTAIL DFSHNRLSNW NISLESQTLQ
110 120 130 140 150
EVKMNYNELT EIPYFGEPTS NITLLSLVHN IIPEINAQAL QFYPALESLD
160 170 180 190 200
LSSNIISEIK TSSFPRMQLK YLNLSNNRIT TLEAGCFDNL SSSLLVVKLN
210 220 230 240 250
RNRMSMIPPK IFKLPHLQFL ELKRNRIKIV EGLTFQGLDS LRSLKMQRNG
260 270 280 290 300
ISKLKDGAFF GLNNMEELEL EHNNLTRVNK GWLYGLRMLQ QLYVSQNAIE
310 320 330 340 350
RISPDAWEFC QRLSELDLSY NQLTRLDESA FVGLSLLERL NLGDNRVTHI
360 370 380 390 400
ADGVFRFLSN LQTLDLRNNE ISWAIEDASE AFAGLTSLTK LILQGNQIKS
410 420 430 440 450
ITKKAFIGLE SLEHLDLNNN AIMSIQENAF SQTHLKELIL NTSSLLCDCH
460 470 480 490 500
LKWLLQWLVD NNFQHSVNVS CAHPEWLAGQ SILNVDLKDF VCDDFLKPQI
510 520 530 540 550
RTHPETIIAL RGMNVTLTCT AVSSSDSPMS TVWRKDSEIL YDVDTENFVR
560 570 580 590 600
YWQQAGEALE YTSILHLFNV NFTDEGKYQC IVTNHFGSNY SQKAKLTVNE
610 620 630 640 650
MPSFLKTPMD LTIRTGAMAR LECAAEGHPA PQISWQKDGG TDFPAARERR
660 670 680 690 700
MHVMPEDDVF FIANVKIEDM GIYSCMAQNT AGGLSANASL TVLETPSFIR
710 720 730 740 750
PLEDKTVTRG ETAVLQCIAG GSPAPRLNWT KDDGPLLVTE RHFFAAANQL
760 770 780 790 800
LIIVDAGLED AGKYTCIMSN TLGTERGHIY LNVISSPNCD SSQSSIGHED
810 820 830 840 850
DGWTTVGIVI IVVVCCVVGT SLIWVIVIYH MRRKNEDYSI TNTEELNLPA
860 870 880 890 900
DIPSYLSSQG TLSEPQEGYS NSEAGSHQQL MPPANGYIHK GTDGGTGTRV
910 920 930 940 950
ICSDCYDNAN IYSRTREYCP YTYIAEEDVL DQTLSSLMVQ MPKETYLVHP
960 970 980 990 1000
PQDTTALESL IPSANREPSA FPTNHERISE KKLPSTQMSG ETLQRPVWNI
1010 1020 1030 1040 1050
NRELGLPHPP FSQQPVHESP QLHQNEGLAG REPDCSASSM SCHRLQDHAF
1060
DFSRTRNIQD GSEGT
Sequence cautioni
The sequence BAA34526 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB018349 mRNA Translation: BAA34526.2 Different initiation. AL161998 mRNA Translation: CAB82328.2 |
CCDSi | CCDS30808.1 |
PIRi | T47152 |
RefSeqi | NP_001299615.1, NM_001312686.1 NP_055628.1, NM_014813.2 |
Genome annotation databases
Ensembli | ENST00000361127; ENSP00000355396; ENSG00000198799 |
GeneIDi | 9860 |
KEGGi | hsa:9860 |
MANE-Selecti | ENST00000361127.6; ENSP00000355396.4; NM_014813.3; NP_055628.1 |
UCSCi | uc001edf.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB018349 mRNA Translation: BAA34526.2 Different initiation. AL161998 mRNA Translation: CAB82328.2 |
CCDSi | CCDS30808.1 |
PIRi | T47152 |
RefSeqi | NP_001299615.1, NM_001312686.1 NP_055628.1, NM_014813.2 |
3D structure databases
SMRi | O94898 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115194, 56 interactors |
IntActi | O94898, 6 interactors |
STRINGi | 9606.ENSP00000355396 |
PTM databases
GlyGeni | O94898, 12 sites |
iPTMneti | O94898 |
PhosphoSitePlusi | O94898 |
Genetic variation databases
BioMutai | LRIG2 |
Proteomic databases
EPDi | O94898 |
jPOSTi | O94898 |
MassIVEi | O94898 |
MaxQBi | O94898 |
PaxDbi | O94898 |
PeptideAtlasi | O94898 |
PRIDEi | O94898 |
ProteomicsDBi | 50530 |
Protocols and materials databases
Antibodypediai | 2748, 141 antibodies from 19 providers |
DNASUi | 9860 |
Genome annotation databases
Ensembli | ENST00000361127; ENSP00000355396; ENSG00000198799 |
GeneIDi | 9860 |
KEGGi | hsa:9860 |
MANE-Selecti | ENST00000361127.6; ENSP00000355396.4; NM_014813.3; NP_055628.1 |
UCSCi | uc001edf.2, human |
Organism-specific databases
CTDi | 9860 |
DisGeNETi | 9860 |
GeneCardsi | LRIG2 |
GeneReviewsi | LRIG2 |
HGNCi | HGNC:20889, LRIG2 |
HPAi | ENSG00000198799, Low tissue specificity |
MalaCardsi | LRIG2 |
MIMi | 608869, gene 615112, phenotype |
neXtProti | NX_O94898 |
OpenTargetsi | ENSG00000198799 |
Orphaneti | 2704, Ochoa syndrome |
PharmGKBi | PA134905053 |
VEuPathDBi | HostDB:ENSG00000198799 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4194, Eukaryota |
GeneTreei | ENSGT00940000158791 |
HOGENOMi | CLU_000288_18_24_1 |
InParanoidi | O94898 |
OMAi | TDEMNLP |
OrthoDBi | 161719at2759 |
PhylomeDBi | O94898 |
TreeFami | TF325380 |
Enzyme and pathway databases
PathwayCommonsi | O94898 |
SignaLinki | O94898 |
Miscellaneous databases
BioGRID-ORCSi | 9860, 7 hits in 1042 CRISPR screens |
ChiTaRSi | LRIG2, human |
GenomeRNAii | 9860 |
Pharosi | O94898, Tbio |
PROi | PR:O94898 |
RNActi | O94898, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198799, Expressed in forebrain and 220 other tissues |
Genevisiblei | O94898, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF07679, I-set, 2 hits PF13855, LRR_8, 4 hits PF01463, LRRCT, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 3 hits SM00408, IGc2, 3 hits SM00369, LRR_TYP, 11 hits SM00082, LRRCT, 1 hit |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS51450, LRR, 14 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | LRIG2_HUMAN | |
Accessioni | O94898Primary (citable) accession number: O94898 Secondary accession number(s): Q9NSN2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | October 11, 2004 | |
Last modified: | February 23, 2022 | |
This is version 167 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot