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Entry version 153 (13 Feb 2019)
Sequence version 3 (11 Oct 2004)
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Protein

Leucine-rich repeats and immunoglobulin-like domains protein 2

Gene

LRIG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeats and immunoglobulin-like domains protein 2
Short name:
LIG-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRIG2
Synonyms:KIAA0806, LIG2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000198799.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20889 LRIG2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608869 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O94898

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini41 – 807ExtracellularSequence analysisAdd BLAST767
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei808 – 828HelicalSequence analysisAdd BLAST21
Topological domaini829 – 1065CytoplasmicSequence analysisAdd BLAST237

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Urofacial syndrome 2 (UFS2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare autosomal recessive disorder characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void completely despite a lack of anatomical bladder outflow obstruction or overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure.
See also OMIM:615112

Organism-specific databases

DisGeNET

More...
DisGeNETi
9860

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
LRIG2

MalaCards human disease database

More...
MalaCardsi
LRIG2
MIMi615112 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000198799

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2704 Ochoa syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134905053

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRIG2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 40Sequence analysisAdd BLAST40
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001482941 – 1065Leucine-rich repeats and immunoglobulin-like domains protein 2Add BLAST1025

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi441N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi468N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi514N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi519 ↔ 580PROSITE-ProRule annotation
Glycosylationi571N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi589N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi623 ↔ 675PROSITE-ProRule annotation
Glycosylationi687N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi717 ↔ 766PROSITE-ProRule annotation
Glycosylationi728N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei906PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O94898

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O94898

MaxQB - The MaxQuant DataBase

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MaxQBi
O94898

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94898

PeptideAtlas

More...
PeptideAtlasi
O94898

PRoteomics IDEntifications database

More...
PRIDEi
O94898

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50530

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O94898

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O94898

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in all tissues analyzed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198799 Expressed in 204 organ(s), highest expression level in forebrain

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O94898 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA015538

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115194, 8 interactors

Protein interaction database and analysis system

More...
IntActi
O94898, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000355396

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O94898

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O94898

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 75LRRNTAdd BLAST35
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati76 – 97LRR 1Add BLAST22
Repeati98 – 119LRR 2Add BLAST22
Repeati121 – 142LRR 3Add BLAST22
Repeati145 – 166LRR 4Add BLAST22
Repeati168 – 189LRR 5Add BLAST22
Repeati193 – 214LRR 6Add BLAST22
Repeati216 – 237LRR 7Add BLAST22
Repeati240 – 261LRR 8Add BLAST22
Repeati264 – 285LRR 9Add BLAST22
Repeati288 – 309LRR 10Add BLAST22
Repeati312 – 333LRR 11Add BLAST22
Repeati336 – 357LRR 12Add BLAST22
Repeati360 – 382LRR 13Add BLAST23
Repeati387 – 408LRR 14Add BLAST22
Repeati411 – 432LRR 15Add BLAST22
Domaini443 – 494LRRCTAdd BLAST52
Domaini498 – 597Ig-like C2-type 1Add BLAST100
Domaini602 – 691Ig-like C2-type 2Add BLAST90
Domaini696 – 785Ig-like C2-type 3Add BLAST90

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4194 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158791

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113380

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052353

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O94898

Identification of Orthologs from Complete Genome Data

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OMAi
LVWVIVI

Database of Orthologous Groups

More...
OrthoDBi
161719at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O94898

TreeFam database of animal gene trees

More...
TreeFami
TF325380

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 3 hits
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679 I-set, 2 hits
PF13855 LRR_8, 4 hits
PF01463 LRRCT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00369 LRR_TYP, 11 hits
SM00082 LRRCT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS51450 LRR, 14 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O94898-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPAPLGVPE EQLLGCRSRV LSRLLFIAQT ALLLLPAAGA GLCPAPCSCR
60 70 80 90 100
IPLLDCSRRK LPAPSWRALS GLLPPDTAIL DFSHNRLSNW NISLESQTLQ
110 120 130 140 150
EVKMNYNELT EIPYFGEPTS NITLLSLVHN IIPEINAQAL QFYPALESLD
160 170 180 190 200
LSSNIISEIK TSSFPRMQLK YLNLSNNRIT TLEAGCFDNL SSSLLVVKLN
210 220 230 240 250
RNRMSMIPPK IFKLPHLQFL ELKRNRIKIV EGLTFQGLDS LRSLKMQRNG
260 270 280 290 300
ISKLKDGAFF GLNNMEELEL EHNNLTRVNK GWLYGLRMLQ QLYVSQNAIE
310 320 330 340 350
RISPDAWEFC QRLSELDLSY NQLTRLDESA FVGLSLLERL NLGDNRVTHI
360 370 380 390 400
ADGVFRFLSN LQTLDLRNNE ISWAIEDASE AFAGLTSLTK LILQGNQIKS
410 420 430 440 450
ITKKAFIGLE SLEHLDLNNN AIMSIQENAF SQTHLKELIL NTSSLLCDCH
460 470 480 490 500
LKWLLQWLVD NNFQHSVNVS CAHPEWLAGQ SILNVDLKDF VCDDFLKPQI
510 520 530 540 550
RTHPETIIAL RGMNVTLTCT AVSSSDSPMS TVWRKDSEIL YDVDTENFVR
560 570 580 590 600
YWQQAGEALE YTSILHLFNV NFTDEGKYQC IVTNHFGSNY SQKAKLTVNE
610 620 630 640 650
MPSFLKTPMD LTIRTGAMAR LECAAEGHPA PQISWQKDGG TDFPAARERR
660 670 680 690 700
MHVMPEDDVF FIANVKIEDM GIYSCMAQNT AGGLSANASL TVLETPSFIR
710 720 730 740 750
PLEDKTVTRG ETAVLQCIAG GSPAPRLNWT KDDGPLLVTE RHFFAAANQL
760 770 780 790 800
LIIVDAGLED AGKYTCIMSN TLGTERGHIY LNVISSPNCD SSQSSIGHED
810 820 830 840 850
DGWTTVGIVI IVVVCCVVGT SLIWVIVIYH MRRKNEDYSI TNTEELNLPA
860 870 880 890 900
DIPSYLSSQG TLSEPQEGYS NSEAGSHQQL MPPANGYIHK GTDGGTGTRV
910 920 930 940 950
ICSDCYDNAN IYSRTREYCP YTYIAEEDVL DQTLSSLMVQ MPKETYLVHP
960 970 980 990 1000
PQDTTALESL IPSANREPSA FPTNHERISE KKLPSTQMSG ETLQRPVWNI
1010 1020 1030 1040 1050
NRELGLPHPP FSQQPVHESP QLHQNEGLAG REPDCSASSM SCHRLQDHAF
1060
DFSRTRNIQD GSEGT
Length:1,065
Mass (Da):118,965
Last modified:October 11, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD2903A861DC4887
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA34526 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB018349 mRNA Translation: BAA34526.2 Different initiation.
AL161998 mRNA Translation: CAB82328.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30808.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T47152

NCBI Reference Sequences

More...
RefSeqi
NP_001299615.1, NM_001312686.1
NP_055628.1, NM_014813.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.448972

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361127; ENSP00000355396; ENSG00000198799

Database of genes from NCBI RefSeq genomes

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GeneIDi
9860

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9860

UCSC genome browser

More...
UCSCi
uc001edf.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018349 mRNA Translation: BAA34526.2 Different initiation.
AL161998 mRNA Translation: CAB82328.2
CCDSiCCDS30808.1
PIRiT47152
RefSeqiNP_001299615.1, NM_001312686.1
NP_055628.1, NM_014813.2
UniGeneiHs.448972

3D structure databases

ProteinModelPortaliO94898
SMRiO94898
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115194, 8 interactors
IntActiO94898, 2 interactors
STRINGi9606.ENSP00000355396

PTM databases

iPTMnetiO94898
PhosphoSitePlusiO94898

Polymorphism and mutation databases

BioMutaiLRIG2

Proteomic databases

EPDiO94898
jPOSTiO94898
MaxQBiO94898
PaxDbiO94898
PeptideAtlasiO94898
PRIDEiO94898
ProteomicsDBi50530

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361127; ENSP00000355396; ENSG00000198799
GeneIDi9860
KEGGihsa:9860
UCSCiuc001edf.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9860
DisGeNETi9860
EuPathDBiHostDB:ENSG00000198799.11

GeneCards: human genes, protein and diseases

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GeneCardsi
LRIG2
GeneReviewsiLRIG2
HGNCiHGNC:20889 LRIG2
HPAiHPA015538
MalaCardsiLRIG2
MIMi608869 gene
615112 phenotype
neXtProtiNX_O94898
OpenTargetsiENSG00000198799
Orphaneti2704 Ochoa syndrome
PharmGKBiPA134905053

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4194 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000158791
HOGENOMiHOG000113380
HOVERGENiHBG052353
InParanoidiO94898
OMAiLVWVIVI
OrthoDBi161719at2759
PhylomeDBiO94898
TreeFamiTF325380

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LRIG2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9860

Protein Ontology

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PROi
PR:O94898

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000198799 Expressed in 204 organ(s), highest expression level in forebrain
GenevisibleiO94898 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF13855 LRR_8, 4 hits
PF01463 LRRCT, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00369 LRR_TYP, 11 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS51450 LRR, 14 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRIG2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94898
Secondary accession number(s): Q9NSN2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: February 13, 2019
This is version 153 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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