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Protein

UBX domain-containing protein 7

Gene

UBXN7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates.1 Publication

GO - Molecular functioni

  • transcription factor binding Source: BHF-UCL
  • ubiquitin binding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: BHF-UCL

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 7
Gene namesi
Name:UBXN7
Synonyms:KIAA0794, UBXD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163960.11
HGNCiHGNC:29119 UBXN7
MIMi616379 gene
neXtProtiNX_O94888

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi288S → A or D: No effect on interactions with CUL2 and HIF1A. 1 Publication1
Mutagenesisi297S → A or H: Severely reduces interaction with neddylated CUL2. 1 Publication1
Mutagenesisi459P → G: Abolishes interaction with VCP/p97. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000163960
PharmGKBiPA162408447

Polymorphism and mutation databases

BioMutaiUBXN7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002110352 – 489UBX domain-containing protein 7Add BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Cross-linki84Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki99Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Cross-linki134Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei278PhosphoserineCombined sources1
Modified residuei280PhosphoserineCombined sources1
Modified residuei285PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei306PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO94888
MaxQBiO94888
PaxDbiO94888
PeptideAtlasiO94888
PRIDEiO94888
ProteomicsDBi50526

PTM databases

iPTMnetiO94888
PhosphoSitePlusiO94888

Miscellaneous databases

PMAP-CutDBiO94888

Expressioni

Gene expression databases

BgeeiENSG00000163960
CleanExiHS_UBXN7
ExpressionAtlasiO94888 baseline and differential
GenevisibleiO94888 HS

Organism-specific databases

HPAiHPA048441
HPA049442

Interactioni

Subunit structurei

Interacts with neddylated CUL2, ubiquitinated HIF1A, and VCP/p97.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • transcription factor binding Source: BHF-UCL
  • ubiquitin binding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi117507, 115 interactors
DIPiDIP-47029N
IntActiO94888, 57 interactors
STRINGi9606.ENSP00000296328

Structurei

Secondary structure

1489
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 23Combined sources13
Helixi28 – 36Combined sources9
Turni37 – 39Combined sources3
Helixi42 – 51Combined sources10
Turni146 – 148Combined sources3
Helixi154 – 164Combined sources11
Beta strandi167 – 173Combined sources7
Turni177 – 179Combined sources3
Helixi180 – 186Combined sources7
Turni187 – 189Combined sources3
Helixi191 – 199Combined sources9
Beta strandi201 – 210Combined sources10
Helixi211 – 220Combined sources10
Beta strandi224 – 231Combined sources8
Turni233 – 235Combined sources3
Beta strandi240 – 244Combined sources5
Helixi247 – 260Combined sources14
Beta strandi412 – 418Combined sources7
Beta strandi424 – 430Combined sources7
Helixi435 – 444Combined sources10
Turni449 – 451Combined sources3
Beta strandi452 – 456Combined sources5
Turni457 – 460Combined sources4
Helixi463 – 465Combined sources3
Beta strandi468 – 470Combined sources3
Helixi472 – 475Combined sources4
Beta strandi479 – 487Combined sources9

3D structure databases

ProteinModelPortaliO94888
SMRiO94888
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO94888

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 54UBAAdd BLAST53
Domaini285 – 304UIMAdd BLAST20
Domaini408 – 485UBXPROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi337 – 342Poly-Glu6

Domaini

The UIM (ubiquitin-interacting motif) is required to engage the NEDD8 modification on cullins.1 Publication
The UBX domain mediates interaction with VCP/p97.1 Publication
The UBA domain is required for binding ubiquitinated-protein substrates.1 Publication

Phylogenomic databases

eggNOGiKOG0260 Eukaryota
KOG1364 Eukaryota
ENOG410XSZZ LUCA
GeneTreeiENSGT00390000018687
HOGENOMiHOG000143398
HOVERGENiHBG057394
InParanoidiO94888
OMAiICAFPRK
OrthoDBiEOG091G0FPX
PhylomeDBiO94888
TreeFamiTF323635

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR006577 UAS
IPR009060 UBA-like_sf
IPR029071 Ubiquitin-like_domsf
IPR017346 UBX_7/2
IPR001012 UBX_dom
PfamiView protein in Pfam
PF00789 UBX, 1 hit
PIRSFiPIRSF037991 UCP037991_UBX7/2, 1 hit
SMARTiView protein in SMART
SM00594 UAS, 1 hit
SM00166 UBX, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF52833 SSF52833, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50033 UBX, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAHGGSAAS SALKGLIQQF TTITGASESV GKHMLEACNN NLEMAVTMFL
60 70 80 90 100
DGGGIAEEPS TSSASVSTVR PHTEEEVRAP IPQKQEILVE PEPLFGAPKR
110 120 130 140 150
RRPARSIFDG FRDFQTETIR QEQELRNGGA IDKKLTTLAD LFRPPIDLMH
160 170 180 190 200
KGSFETAKEC GQMQNKWLMI NIQNVQDFAC QCLNRDVWSN EAVKNIIREH
210 220 230 240 250
FIFWQVYHDS EEGQRYIQFY KLGDFPYVSI LDPRTGQKLV EWHQLDVSSF
260 270 280 290 300
LDQVTGFLGE HGQLDGLSSS PPKKCARSES LIDASEDSQL EAAIRASLQE
310 320 330 340 350
THFDSTQTKQ DSRSDEESES ELFSGSEEFI SVCGSDEEEE VENLAKSRKS
360 370 380 390 400
PHKDLGHRKE ENRRPLTEPP VRTDPGTATN HQGLPAVDSE ILEMPPEKAD
410 420 430 440 450
GVVEGIDVNG PKAQLMLRYP DGKREQITLP EQAKLLALVK HVQSKGYPNE
460 470 480
RFELLTNFPR RKLSHLDYDI TLQEAGLCPQ ETVFVQERN
Length:489
Mass (Da):54,862
Last modified:August 16, 2005 - v2
Checksum:i3C894533B1A2C41A
GO

Sequence cautioni

The sequence BAA34514 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC85247 differs from that shown. Unlikely isoform. Aberrant splice sites.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018337 mRNA Translation: BAA34514.1 Different initiation.
AK129880 mRNA Translation: BAC85247.1 Sequence problems.
CH471191 Genomic DNA Translation: EAW53652.1
CH471191 Genomic DNA Translation: EAW53654.1
BC028986 mRNA Translation: AAH28986.1
CCDSiCCDS43191.1
RefSeqiNP_056377.1, NM_015562.1
UniGeneiHs.518524

Genome annotation databases

EnsembliENST00000296328; ENSP00000296328; ENSG00000163960
GeneIDi26043
KEGGihsa:26043
UCSCiuc003fwm.5 human

Similar proteinsi

Entry informationi

Entry nameiUBXN7_HUMAN
AccessioniPrimary (citable) accession number: O94888
Secondary accession number(s): D3DXB3
, Q6ZP77, Q86X20, Q8N327
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: July 18, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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