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Entry version 151 (18 Sep 2019)
Sequence version 3 (18 Apr 2006)
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Protein

FERM, ARHGEF and pleckstrin domain-containing protein 2

Gene

FARP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O94887

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FERM, ARHGEF and pleckstrin domain-containing protein 2
Alternative name(s):
FERM domain-including RhoGEF
Short name:
FIR
FERM, RhoGEF and pleckstrin domain-containing protein 2
Pleckstrin homology domain-containing family C member 3
Short name:
PH domain-containing family C member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FARP2
Synonyms:KIAA0793, PLEKHC3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16460 FARP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617586 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O94887

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9855

Open Targets

More...
OpenTargetsi
ENSG00000006607

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134873245

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FARP2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002327551 – 1054FERM, ARHGEF and pleckstrin domain-containing protein 2Add BLAST1054

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei389PhosphoserineCombined sources1
Modified residuei439PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O94887

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O94887

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O94887

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O94887

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94887

PeptideAtlas

More...
PeptideAtlasi
O94887

PRoteomics IDEntifications database

More...
PRIDEi
O94887

ProteomicsDB human proteome resource

More...
ProteomicsDBi
24958
50524 [O94887-1]
50525 [O94887-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O94887

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O94887

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000006607 Expressed in 205 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O94887 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O94887 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031226
HPA055592

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor.

Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding.

Interacts with RAC1 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115189, 32 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O94887

Protein interaction database and analysis system

More...
IntActi
O94887, 23 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264042

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O94887

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 324FERMPROSITE-ProRule annotationAdd BLAST281
Domaini535 – 726DHPROSITE-ProRule annotationAdd BLAST192
Domaini755 – 852PH 1PROSITE-ProRule annotationAdd BLAST98
Domaini929 – 1026PH 2PROSITE-ProRule annotationAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi425 – 428Poly-Ser4
Compositional biasi453 – 511Pro-richAdd BLAST59

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3531 Eukaryota
ENOG410XP7Q LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158642

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007957

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O94887

KEGG Orthology (KO)

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KOi
K06082

Identification of Orthologs from Complete Genome Data

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OMAi
WMEVIKR

Database for complete collections of gene phylogenies

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PhylomeDBi
O94887

TreeFam database of animal gene trees

More...
TreeFami
TF351276

Family and domain databases

Conserved Domains Database

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CDDi
cd14473 FERM_B-lobe, 1 hit
cd13193 FERM_C_FARP1-like, 1 hit
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 3 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR019749 Band_41_domain
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR000798 Ez/rad/moesin-like
IPR041788 FARP1/FARP2/FRMD7_FERM_C
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00169 PH, 2 hits
PF00621 RhoGEF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00935 BAND41
PR00661 ERMFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031 SSF47031, 1 hit
SSF48065 SSF48065, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010 DH_2, 1 hit
PS00660 FERM_1, 1 hit
PS50057 FERM_3, 1 hit
PS50003 PH_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94887-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGEIEGTYRV LQTAGMRLGA QTPVGVSTLE PGQTLLPRMQ EKHLHLRVKL
60 70 80 90 100
LDNTMEIFDI EPKCDGQVLL TQVWKRLNLV ECDYFGMEFQ NTQSYWIWLE
110 120 130 140 150
PMKPIIRQIR RPKNVVLRLA VKFFPPDPGQ LQEEYTRYLF ALQLKRDLLE
160 170 180 190 200
ERLTCADTTA ALLTSHLLQS EIGDYDETLD REHLKVNEYL PGQQHCLEKI
210 220 230 240 250
LEFHQKHVGQ TPAESDFQVL EIARKLEMYG IRFHMASDRE GTKIQLAVSH
260 270 280 290 300
MGVLVFQGTT KINTFNWSKV RKLSFKRKRF LIKLHPEVHG PYQDTLEFLL
310 320 330 340 350
GSRDECKNFW KICVEYHTFF RLLDQPKPKA KAVFFSRGSS FRYSGRTQKQ
360 370 380 390 400
LVDYFKDSGM KRIPYERRHS KTHTSVRALT ADLPKQSISF PEGLRTPASP
410 420 430 440 450
SSANAFYSLS PSTLVPSGLP EFKDSSSSLT DPQVSYVKSP AAERRSGAVA
460 470 480 490 500
GGPDTPSAQP LGPPALQPGP GLSTKSPQPS PSSRKSPLSL SPAFQVPLGP
510 520 530 540 550
AEQGSSPLLS PVLSDAGGAG MDCEEPRHKR VPADEAYFIV KEILATERTY
560 570 580 590 600
LKDLEVITVW FRSAVVKEDA MPATLMTLLF SNIDPIYEFH RGFLREVEQR
610 620 630 640 650
LALWEGPSKA HTKGSHQRIG DILLRNMRQL KEFTSYFQRH DEVLTELEKA
660 670 680 690 700
TKRCKKLEAV YKEFELQKVC YLPLNTFLLK PIQRLLHYRL LLRRLCGHYS
710 720 730 740 750
PGHHDYADCH DALKAITEVT TTLQHILIRL ENLQKLTELQ RDLVGIENLI
760 770 780 790 800
APGREFIREG CLHKLTKKGL QQRMFFLFSD MLLYTSKGVA GTSHFRIRGL
810 820 830 840 850
LPLQGMLVEE SDNEWSVPHC FTIYAAQKTI VVAASTRLEK EKWMLDLNSA
860 870 880 890 900
IQAAKSGGDT APALPGRTVC TRPPRSPNEV SLEQESEDDA RGVRSSLEGH
910 920 930 940 950
GQHRANTTMH VCWYRNTSVS RADHSAAVEN QLSGYLLRKF KNSHGWQKLW
960 970 980 990 1000
VVFTNFCLFF YKTHQDDYPL ASLPLLGYSV SIPREADGIH KDYVFKLQFK
1010 1020 1030 1040 1050
SHVYFFRAES KYTFERWMEV IQGASSSAGR APSIVQDGPQ PSSGLEGMVR

GKEE
Length:1,054
Mass (Da):119,888
Last modified:April 18, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7DC279F69A307E5A
GO
Isoform 2 (identifier: O94887-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     632-647: EFTSYFQRHDEVLTEL → VFQLHEGHVAGVTKME
     648-1054: Missing.

Show »
Length:647
Mass (Da):73,269
Checksum:i3BE8B9358E241A88
GO
Isoform 3 (identifier: O94887-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     632-638: EFTSYFQ → AAHEFTT
     639-1054: Missing.

Note: No experimental confirmation available.
Show »
Length:638
Mass (Da):72,263
Checksum:i13555C937B09C568
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C447H7C447_HUMAN
FERM, ARHGEF and pleckstrin domain-...
FARP2
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3M7H7C3M7_HUMAN
FERM, ARHGEF and pleckstrin domain-...
FARP2
482Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3E4H7C3E4_HUMAN
FERM, ARHGEF and pleckstrin domain-...
FARP2
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JVQ5C9JVQ5_HUMAN
FERM, ARHGEF and pleckstrin domain-...
FARP2
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWM9C9JWM9_HUMAN
FERM, ARHGEF and pleckstrin domain-...
FARP2
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C210H7C210_HUMAN
FERM, ARHGEF and pleckstrin domain-...
FARP2
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA34513 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti366E → G in BAH13284 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048363185K → N. Corresponds to variant dbSNP:rs16843643Ensembl.1
Natural variantiVAR_048364260T → I. Corresponds to variant dbSNP:rs757978Ensembl.1
Natural variantiVAR_048365643V → I. Corresponds to variant dbSNP:rs41342147Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017977632 – 647EFTSY…VLTEL → VFQLHEGHVAGVTKME in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_054840632 – 638EFTSYFQ → AAHEFTT in isoform 3. 1 Publication7
Alternative sequenceiVSP_054841639 – 1054Missing in isoform 3. 1 PublicationAdd BLAST416
Alternative sequenceiVSP_017978648 – 1054Missing in isoform 2. 1 PublicationAdd BLAST407

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB018336 mRNA Translation: BAA34513.2 Different initiation.
AK300435 mRNA Translation: BAH13284.1
AC005104 Genomic DNA No translation available.
AC110299 Genomic DNA Translation: AAY14682.1
BC021301 mRNA Translation: AAH21301.1
AL122052 mRNA Translation: CAB59185.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS33424.1 [O94887-1]
CCDS63197.1 [O94887-2]
CCDS63198.1 [O94887-3]

Protein sequence database of the Protein Information Resource

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PIRi
T34541

NCBI Reference Sequences

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RefSeqi
NP_001269912.1, NM_001282983.1 [O94887-2]
NP_001269913.1, NM_001282984.1 [O94887-3]
NP_055623.1, NM_014808.3 [O94887-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000264042; ENSP00000264042; ENSG00000006607 [O94887-1]
ENST00000373287; ENSP00000362384; ENSG00000006607 [O94887-2]
ENST00000627550; ENSP00000486597; ENSG00000006607 [O94887-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9855

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9855

UCSC genome browser

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UCSCi
uc002wbi.4 human [O94887-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018336 mRNA Translation: BAA34513.2 Different initiation.
AK300435 mRNA Translation: BAH13284.1
AC005104 Genomic DNA No translation available.
AC110299 Genomic DNA Translation: AAY14682.1
BC021301 mRNA Translation: AAH21301.1
AL122052 mRNA Translation: CAB59185.1
CCDSiCCDS33424.1 [O94887-1]
CCDS63197.1 [O94887-2]
CCDS63198.1 [O94887-3]
PIRiT34541
RefSeqiNP_001269912.1, NM_001282983.1 [O94887-2]
NP_001269913.1, NM_001282984.1 [O94887-3]
NP_055623.1, NM_014808.3 [O94887-1]

3D structure databases

SMRiO94887
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115189, 32 interactors
CORUMiO94887
IntActiO94887, 23 interactors
STRINGi9606.ENSP00000264042

PTM databases

iPTMnetiO94887
PhosphoSitePlusiO94887

Polymorphism and mutation databases

BioMutaiFARP2

Proteomic databases

EPDiO94887
jPOSTiO94887
MassIVEiO94887
MaxQBiO94887
PaxDbiO94887
PeptideAtlasiO94887
PRIDEiO94887
ProteomicsDBi24958
50524 [O94887-1]
50525 [O94887-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9855
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264042; ENSP00000264042; ENSG00000006607 [O94887-1]
ENST00000373287; ENSP00000362384; ENSG00000006607 [O94887-2]
ENST00000627550; ENSP00000486597; ENSG00000006607 [O94887-3]
GeneIDi9855
KEGGihsa:9855
UCSCiuc002wbi.4 human [O94887-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9855
DisGeNETi9855

GeneCards: human genes, protein and diseases

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GeneCardsi
FARP2
HGNCiHGNC:16460 FARP2
HPAiHPA031226
HPA055592
MIMi617586 gene
neXtProtiNX_O94887
OpenTargetsiENSG00000006607
PharmGKBiPA134873245

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3531 Eukaryota
ENOG410XP7Q LUCA
GeneTreeiENSGT00940000158642
HOGENOMiHOG000007957
InParanoidiO94887
KOiK06082
OMAiWMEVIKR
PhylomeDBiO94887
TreeFamiTF351276

Enzyme and pathway databases

ReactomeiR-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
SIGNORiO94887

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FARP2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FARP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9855

Pharos

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Pharosi
O94887

Protein Ontology

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PROi
PR:O94887

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000006607 Expressed in 205 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiO94887 baseline and differential
GenevisibleiO94887 HS

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd13193 FERM_C_FARP1-like, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.20.80.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 3 hits
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR000798 Ez/rad/moesin-like
IPR041788 FARP1/FARP2/FRMD7_FERM_C
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00169 PH, 2 hits
PF00621 RhoGEF, 1 hit
PRINTSiPR00935 BAND41
PR00661 ERMFAMILY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF48065 SSF48065, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS00660 FERM_1, 1 hit
PS50057 FERM_3, 1 hit
PS50003 PH_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFARP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94887
Secondary accession number(s): B7Z6J8
, F5GZ84, Q53QM5, Q8WU27, Q9UFE7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 18, 2006
Last modified: September 18, 2019
This is version 151 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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