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Protein

FERM, ARHGEF and pleckstrin domain-containing protein 2

Gene

FARP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
SIGNORiO94887

Names & Taxonomyi

Protein namesi
Recommended name:
FERM, ARHGEF and pleckstrin domain-containing protein 2
Alternative name(s):
FERM domain-including RhoGEF
Short name:
FIR
FERM, RhoGEF and pleckstrin domain-containing protein 2
Pleckstrin homology domain-containing family C member 3
Short name:
PH domain-containing family C member 3
Gene namesi
Name:FARP2
Synonyms:KIAA0793, PLEKHC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000006607.13
HGNCiHGNC:16460 FARP2
MIMi617586 gene
neXtProtiNX_O94887

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9855
OpenTargetsiENSG00000006607
PharmGKBiPA134873245

Polymorphism and mutation databases

BioMutaiFARP2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002327551 – 1054FERM, ARHGEF and pleckstrin domain-containing protein 2Add BLAST1054

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei389PhosphoserineCombined sources1
Modified residuei439PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO94887
MaxQBiO94887
PaxDbiO94887
PeptideAtlasiO94887
PRIDEiO94887
ProteomicsDBi50524
50525 [O94887-2]

PTM databases

iPTMnetiO94887
PhosphoSitePlusiO94887

Expressioni

Gene expression databases

BgeeiENSG00000006607 Expressed in 205 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_FARP2
ExpressionAtlasiO94887 baseline and differential
GenevisibleiO94887 HS

Organism-specific databases

HPAiHPA031226
HPA055592

Interactioni

Subunit structurei

Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor. Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding. Interacts with RAC1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115189, 27 interactors
CORUMiO94887
IntActiO94887, 8 interactors
STRINGi9606.ENSP00000264042

Structurei

3D structure databases

ProteinModelPortaliO94887
SMRiO94887
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 324FERMPROSITE-ProRule annotationAdd BLAST281
Domaini535 – 726DHPROSITE-ProRule annotationAdd BLAST192
Domaini755 – 852PH 1PROSITE-ProRule annotationAdd BLAST98
Domaini929 – 1026PH 2PROSITE-ProRule annotationAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi425 – 428Poly-Ser4
Compositional biasi453 – 511Pro-richAdd BLAST59

Domaini

Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3531 Eukaryota
ENOG410XP7Q LUCA
GeneTreeiENSGT00920000148976
HOGENOMiHOG000007957
HOVERGENiHBG081521
InParanoidiO94887
KOiK06082
OMAiWMEVIKR
OrthoDBiEOG091G015W
PhylomeDBiO94887
TreeFamiTF351276

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.20.80.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 3 hits
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR000798 Ez/rad/moesin-like
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00169 PH, 2 hits
PF00621 RhoGEF, 1 hit
PRINTSiPR00935 BAND41
PR00661 ERMFAMILY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF48065 SSF48065, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS00660 FERM_1, 1 hit
PS50057 FERM_3, 1 hit
PS50003 PH_DOMAIN, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94887-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGEIEGTYRV LQTAGMRLGA QTPVGVSTLE PGQTLLPRMQ EKHLHLRVKL
60 70 80 90 100
LDNTMEIFDI EPKCDGQVLL TQVWKRLNLV ECDYFGMEFQ NTQSYWIWLE
110 120 130 140 150
PMKPIIRQIR RPKNVVLRLA VKFFPPDPGQ LQEEYTRYLF ALQLKRDLLE
160 170 180 190 200
ERLTCADTTA ALLTSHLLQS EIGDYDETLD REHLKVNEYL PGQQHCLEKI
210 220 230 240 250
LEFHQKHVGQ TPAESDFQVL EIARKLEMYG IRFHMASDRE GTKIQLAVSH
260 270 280 290 300
MGVLVFQGTT KINTFNWSKV RKLSFKRKRF LIKLHPEVHG PYQDTLEFLL
310 320 330 340 350
GSRDECKNFW KICVEYHTFF RLLDQPKPKA KAVFFSRGSS FRYSGRTQKQ
360 370 380 390 400
LVDYFKDSGM KRIPYERRHS KTHTSVRALT ADLPKQSISF PEGLRTPASP
410 420 430 440 450
SSANAFYSLS PSTLVPSGLP EFKDSSSSLT DPQVSYVKSP AAERRSGAVA
460 470 480 490 500
GGPDTPSAQP LGPPALQPGP GLSTKSPQPS PSSRKSPLSL SPAFQVPLGP
510 520 530 540 550
AEQGSSPLLS PVLSDAGGAG MDCEEPRHKR VPADEAYFIV KEILATERTY
560 570 580 590 600
LKDLEVITVW FRSAVVKEDA MPATLMTLLF SNIDPIYEFH RGFLREVEQR
610 620 630 640 650
LALWEGPSKA HTKGSHQRIG DILLRNMRQL KEFTSYFQRH DEVLTELEKA
660 670 680 690 700
TKRCKKLEAV YKEFELQKVC YLPLNTFLLK PIQRLLHYRL LLRRLCGHYS
710 720 730 740 750
PGHHDYADCH DALKAITEVT TTLQHILIRL ENLQKLTELQ RDLVGIENLI
760 770 780 790 800
APGREFIREG CLHKLTKKGL QQRMFFLFSD MLLYTSKGVA GTSHFRIRGL
810 820 830 840 850
LPLQGMLVEE SDNEWSVPHC FTIYAAQKTI VVAASTRLEK EKWMLDLNSA
860 870 880 890 900
IQAAKSGGDT APALPGRTVC TRPPRSPNEV SLEQESEDDA RGVRSSLEGH
910 920 930 940 950
GQHRANTTMH VCWYRNTSVS RADHSAAVEN QLSGYLLRKF KNSHGWQKLW
960 970 980 990 1000
VVFTNFCLFF YKTHQDDYPL ASLPLLGYSV SIPREADGIH KDYVFKLQFK
1010 1020 1030 1040 1050
SHVYFFRAES KYTFERWMEV IQGASSSAGR APSIVQDGPQ PSSGLEGMVR

GKEE
Length:1,054
Mass (Da):119,888
Last modified:April 18, 2006 - v3
Checksum:i7DC279F69A307E5A
GO
Isoform 2 (identifier: O94887-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     632-647: EFTSYFQRHDEVLTEL → VFQLHEGHVAGVTKME
     648-1054: Missing.

Show »
Length:647
Mass (Da):73,269
Checksum:i3BE8B9358E241A88
GO
Isoform 3 (identifier: O94887-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     632-638: EFTSYFQ → AAHEFTT
     639-1054: Missing.

Note: No experimental confirmation available.
Show »
Length:638
Mass (Da):72,263
Checksum:i13555C937B09C568
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C3E4H7C3E4_HUMAN
FERM, ARHGEF and pleckstrin domain-...
FARP2
79Annotation score:
C9JWM9C9JWM9_HUMAN
FERM, ARHGEF and pleckstrin domain-...
FARP2
93Annotation score:
C9JVQ5C9JVQ5_HUMAN
FERM, ARHGEF and pleckstrin domain-...
FARP2
134Annotation score:
H7C447H7C447_HUMAN
FERM, ARHGEF and pleckstrin domain-...
FARP2
196Annotation score:
H7C3M7H7C3M7_HUMAN
FERM, ARHGEF and pleckstrin domain-...
FARP2
482Annotation score:
H7C210H7C210_HUMAN
FERM, ARHGEF and pleckstrin domain-...
FARP2
56Annotation score:

Sequence cautioni

The sequence BAA34513 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti366E → G in BAH13284 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048363185K → N. Corresponds to variant dbSNP:rs16843643Ensembl.1
Natural variantiVAR_048364260T → I. Corresponds to variant dbSNP:rs757978Ensembl.1
Natural variantiVAR_048365643V → I. Corresponds to variant dbSNP:rs41342147Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017977632 – 647EFTSY…VLTEL → VFQLHEGHVAGVTKME in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_054840632 – 638EFTSYFQ → AAHEFTT in isoform 3. 1 Publication7
Alternative sequenceiVSP_054841639 – 1054Missing in isoform 3. 1 PublicationAdd BLAST416
Alternative sequenceiVSP_017978648 – 1054Missing in isoform 2. 1 PublicationAdd BLAST407

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018336 mRNA Translation: BAA34513.2 Different initiation.
AK300435 mRNA Translation: BAH13284.1
AC005104 Genomic DNA No translation available.
AC110299 Genomic DNA Translation: AAY14682.1
BC021301 mRNA Translation: AAH21301.1
AL122052 mRNA Translation: CAB59185.1
CCDSiCCDS33424.1 [O94887-1]
CCDS63197.1 [O94887-2]
CCDS63198.1 [O94887-3]
PIRiT34541
RefSeqiNP_001269912.1, NM_001282983.1 [O94887-2]
NP_001269913.1, NM_001282984.1 [O94887-3]
NP_055623.1, NM_014808.3 [O94887-1]
UniGeneiHs.726316

Genome annotation databases

EnsembliENST00000264042; ENSP00000264042; ENSG00000006607 [O94887-1]
ENST00000373287; ENSP00000362384; ENSG00000006607 [O94887-2]
ENST00000627550; ENSP00000486597; ENSG00000006607 [O94887-3]
GeneIDi9855
KEGGihsa:9855
UCSCiuc002wbi.4 human [O94887-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018336 mRNA Translation: BAA34513.2 Different initiation.
AK300435 mRNA Translation: BAH13284.1
AC005104 Genomic DNA No translation available.
AC110299 Genomic DNA Translation: AAY14682.1
BC021301 mRNA Translation: AAH21301.1
AL122052 mRNA Translation: CAB59185.1
CCDSiCCDS33424.1 [O94887-1]
CCDS63197.1 [O94887-2]
CCDS63198.1 [O94887-3]
PIRiT34541
RefSeqiNP_001269912.1, NM_001282983.1 [O94887-2]
NP_001269913.1, NM_001282984.1 [O94887-3]
NP_055623.1, NM_014808.3 [O94887-1]
UniGeneiHs.726316

3D structure databases

ProteinModelPortaliO94887
SMRiO94887
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115189, 27 interactors
CORUMiO94887
IntActiO94887, 8 interactors
STRINGi9606.ENSP00000264042

PTM databases

iPTMnetiO94887
PhosphoSitePlusiO94887

Polymorphism and mutation databases

BioMutaiFARP2

Proteomic databases

EPDiO94887
MaxQBiO94887
PaxDbiO94887
PeptideAtlasiO94887
PRIDEiO94887
ProteomicsDBi50524
50525 [O94887-2]

Protocols and materials databases

DNASUi9855
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264042; ENSP00000264042; ENSG00000006607 [O94887-1]
ENST00000373287; ENSP00000362384; ENSG00000006607 [O94887-2]
ENST00000627550; ENSP00000486597; ENSG00000006607 [O94887-3]
GeneIDi9855
KEGGihsa:9855
UCSCiuc002wbi.4 human [O94887-1]

Organism-specific databases

CTDi9855
DisGeNETi9855
EuPathDBiHostDB:ENSG00000006607.13
GeneCardsiFARP2
HGNCiHGNC:16460 FARP2
HPAiHPA031226
HPA055592
MIMi617586 gene
neXtProtiNX_O94887
OpenTargetsiENSG00000006607
PharmGKBiPA134873245
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3531 Eukaryota
ENOG410XP7Q LUCA
GeneTreeiENSGT00920000148976
HOGENOMiHOG000007957
HOVERGENiHBG081521
InParanoidiO94887
KOiK06082
OMAiWMEVIKR
OrthoDBiEOG091G015W
PhylomeDBiO94887
TreeFamiTF351276

Enzyme and pathway databases

ReactomeiR-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
SIGNORiO94887

Miscellaneous databases

ChiTaRSiFARP2 human
GeneWikiiFARP2
GenomeRNAii9855
PROiPR:O94887
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000006607 Expressed in 205 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_FARP2
ExpressionAtlasiO94887 baseline and differential
GenevisibleiO94887 HS

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.20.80.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 3 hits
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR000798 Ez/rad/moesin-like
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00169 PH, 2 hits
PF00621 RhoGEF, 1 hit
PRINTSiPR00935 BAND41
PR00661 ERMFAMILY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF48065 SSF48065, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS00660 FERM_1, 1 hit
PS50057 FERM_3, 1 hit
PS50003 PH_DOMAIN, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFARP2_HUMAN
AccessioniPrimary (citable) accession number: O94887
Secondary accession number(s): B7Z6J8
, F5GZ84, Q53QM5, Q8WU27, Q9UFE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 18, 2006
Last modified: November 7, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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