TMEM63A

Functionⁱ

Acts as an osmosensitive calcium-permeable cation channel.By similarity

GO - Molecular functionⁱ

nucleic acid binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ion transport Source: UniProtKB-KW
neutrophil degranulation Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel
Biological process	Ion transport, Transport
Ligand	Calcium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation

Reactomeⁱ

R-HSA-6798695 Neutrophil degranulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CSC1-like protein 1 Alternative name(s): Transmembrane protein 63A
Gene namesⁱ	Name:TMEM63A Synonyms:KIAA0489, KIAA0792
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000196187.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29118 TMEM63A
neXtProtⁱ	NX_O94886

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	50 – 70	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	146 – 166	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	191 – 211	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	423 – 443	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	462 – 482	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	508 – 528	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	553 – 573	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	620 – 640	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	665 – 685	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	698 – 718	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Lysosome, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9725
Open Targets More...OpenTargetsⁱ	ENSG00000196187
PharmGKBⁱ	PA142670776

Polymorphism and mutation databases

BioMutaⁱ	TMEM63A

BioMutaⁱ

TMEM63A

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000280725	1 – 807	CSC1-like protein 1Add BLAST		807

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	739	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O94886
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O94886
PaxDbⁱ	O94886
PeptideAtlas More...PeptideAtlasⁱ	O94886
PRIDEⁱ	O94886
ProteomicsDBⁱ	50523

PTM databases

iPTMnetⁱ	O94886
PhosphoSitePlusⁱ	O94886
SwissPalmⁱ	O94886

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000196187
CleanExⁱ	HS_TMEM63A
ExpressionAtlasⁱ	O94886 baseline and differential
Genevisibleⁱ	O94886 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA066504 HPA066936 HPA068918

HPAⁱ

HPA066504
HPA066936
HPA068918

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	115074, 45 interactors
IntActⁱ	O94886, 1 interactor
STRINGⁱ	9606.ENSP00000355800

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O94886
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the CSC1 (TC 1.A.17) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1134 Eukaryota COG5594 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011855
HOGENOMⁱ	HOG000006559
HOVERGENⁱ	HBG056752
InParanoidⁱ	O94886
KEGG Orthology (KO) More...KOⁱ	K21989
OMAⁱ	KHMVDRH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02SZ
PhylomeDBⁱ	O94886
TreeFamⁱ	TF324300

Family and domain databases

InterProⁱ	View protein in InterPro IPR032880 Csc1_N IPR027815 PHM7_cyt IPR035979 RBD_domain_sf IPR003864 RSN1_7TM IPR026957 TMEM63A
PANTHERⁱ	PTHR13018:SF24 PTHR13018:SF24, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14703 PHM7_cyt, 1 hit PF02714 RSN1_7TM, 1 hit PF13967 RSN1_TM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

O94886-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MMDSPFLELW QSKAVSIREQ LGLGDRPNDS YCYNSAKNST VLQGVTFGGI 
        60         70         80         90        100
PTVLLIDVSC FLFLILVFSI IRRRFWDYGR IALVSEADSE SRFQRLSSTS 
       110        120        130        140        150
SSGQQDFENE LGCCPWLTAI FRLHDDQILE WCGEDAIHYL SFQRHIIFLL 
       160        170        180        190        200
VVVSFLSLCV ILPVNLSGDL LDKDPYSFGR TTIANLQTDN DLLWLHTIFA 
       210        220        230        240        250
VIYLFLTVGF MRHHTQSIKY KEENLVRRTL FITGLPRDAR KETVESHFRD 
       260        270        280        290        300
AYPTCEVVDV QLCYNVAKLI YLCKEKKKTE KSLTYYTNLQ VKTGQRTLIN 
       310        320        330        340        350
PKPCGQFCCC EVLGCEWEDA ISYYTRMKDR LLERITEEER HVQDQPLGMA 
       360        370        380        390        400
FVTFQEKSMA TYILKDFNAC KCQSLQCKGE PQPSSHSREL YTSKWTVTFA 
       410        420        430        440        450
ADPEDICWKN LSIQGLRWWL QWLGINFTLF LGLFFLTTPS IILSTMDKFN 
       460        470        480        490        500
VTKPIHALNN PIISQFFPTL LLWSFSALLP SIVYYSTLLE SHWTKSGENQ 
       510        520        530        540        550
IMMTKVYIFL IFMVLILPSL GLTSLDFFFR WLFDKTSSEA SIRLECVFLP 
       560        570        580        590        600
DQGAFFVNYV IASAFIGNGM ELLRLPGLIL YTFRMIMAKT AADRRNVKQN 
       610        620        630        640        650
QAFQYEFGAM YAWMLCVFTV IVAYSITCPI IAPFGLIYIL LKHMVDRHNL 
       660        670        680        690        700
YFVYLPAKLE KGIHFAAVNQ ALAAPILCLF WLYFFSFLRL GMKAPATLFT 
       710        720        730        740        750
FLVLLLTILV CLAHTCFGCF KHLSPLNYKT EEPASDKGSE AEAHMPPPFT 
       760        770        780        790        800
PYVPRILNGL ASERTALSPQ QQQQQTYGAI HNISGTIPGQ CLAQSATGSV 

AAAPQEA

Length:807

Mass (Da):92,126

Last modified:March 20, 2007 - v3

Checksum:ⁱD7C32A11F7FEDF63

GO

Sequence cautionⁱ

The sequence BAA34512 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence BAD96654 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence BAD96664 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	5	P → L in BAD96654 (Ref. 2) Curated	1
Sequence conflictⁱ	5	P → L in BAD96664 (Ref. 2) Curated	1
Sequence conflictⁱ	206	L → F in BAA34512 (PubMed:9872452).Curated	1
Sequence conflictⁱ	547	V → I in BAD96654 (Ref. 2) Curated	1
Sequence conflictⁱ	547	V → I in BAD96664 (Ref. 2) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_061813	121	F → I. Corresponds to variant dbSNP:rs57306966Ensembl.		1
Natural variantⁱVAR_031191	622	V → M. Corresponds to variant dbSNP:rs1009668Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB018335 mRNA Translation: BAA34512.2 Different initiation. AK222944 mRNA Translation: BAD96664.1 Different initiation. AK222934 mRNA Translation: BAD96654.1 Different initiation. AL117348 Genomic DNA No translation available. AL591895 Genomic DNA No translation available. BC030245 mRNA Translation: AAH30245.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31042.1
NCBI Reference Sequences More...RefSeqⁱ	NP_055513.2, NM_014698.2 XP_011542630.1, XM_011544328.2 XP_011542631.1, XM_011544329.2 XP_011542632.1, XM_011544330.2
UniGeneⁱ	Hs.119387

Genome annotation databases

Ensemblⁱ	ENST00000366835; ENSP00000355800; ENSG00000196187
GeneIDⁱ	9725
KEGGⁱ	hsa:9725
UCSC genome browser More...UCSCⁱ	uc001hpm.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
O94886	Transmembrane protein 63A, isoform CRA_a		HUMAN		807
UPI000626C516		AOTNA		875
Transmembrane protein 63A		GORGO		814
UPI00083BB36B		RHIBE		810
UPI000C2ADFE9		Ugandan red Colobus		809
+81

Protein	Similar proteins		Species	Score	Length
O94886	Transmembrane protein 63A, isoform CRA_a		HUMAN		807
UPI000626C516		AOTNA		875
Transmembrane protein 63A		GORGO		814
UPI00083BB36B		RHIBE		810
UPI000C2ADFE9		Ugandan red Colobus		809
+245

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB018335 mRNA Translation: BAA34512.2 Different initiation. AK222944 mRNA Translation: BAD96664.1 Different initiation. AK222934 mRNA Translation: BAD96654.1 Different initiation. AL117348 Genomic DNA No translation available. AL591895 Genomic DNA No translation available. BC030245 mRNA Translation: AAH30245.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31042.1
NCBI Reference Sequences More...RefSeqⁱ	NP_055513.2, NM_014698.2 XP_011542630.1, XM_011544328.2 XP_011542631.1, XM_011544329.2 XP_011542632.1, XM_011544330.2
UniGeneⁱ	Hs.119387

3D structure databases

ProteinModelPortalⁱ	O94886
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115074, 45 interactors
IntActⁱ	O94886, 1 interactor
STRINGⁱ	9606.ENSP00000355800

PTM databases

iPTMnetⁱ	O94886
PhosphoSitePlusⁱ	O94886
SwissPalmⁱ	O94886

Polymorphism and mutation databases

BioMutaⁱ	TMEM63A

BioMutaⁱ

TMEM63A

Proteomic databases

EPDⁱ	O94886
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O94886
PaxDbⁱ	O94886
PeptideAtlas More...PeptideAtlasⁱ	O94886
PRIDEⁱ	O94886
ProteomicsDBⁱ	50523

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000366835; ENSP00000355800; ENSG00000196187
GeneIDⁱ	9725
KEGGⁱ	hsa:9725
UCSC genome browser More...UCSCⁱ	uc001hpm.3 human

Organism-specific databases

CTDⁱ	9725
DisGeNET More...DisGeNETⁱ	9725
EuPathDBⁱ	HostDB:ENSG00000196187.11
GeneCardsⁱ	TMEM63A
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29118 TMEM63A
Human Protein Atlas More...HPAⁱ	HPA066504 HPA066936 HPA068918
neXtProtⁱ	NX_O94886
Open Targets More...OpenTargetsⁱ	ENSG00000196187
PharmGKBⁱ	PA142670776
HUGEⁱ	Search... Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1134 Eukaryota COG5594 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011855
HOGENOMⁱ	HOG000006559
HOVERGENⁱ	HBG056752
InParanoidⁱ	O94886
KEGG Orthology (KO) More...KOⁱ	K21989
OMAⁱ	KHMVDRH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02SZ
PhylomeDBⁱ	O94886
TreeFamⁱ	TF324300

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation

Reactomeⁱ

R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSⁱ	TMEM63A human
GeneWikiⁱ	TMEM63A
GenomeRNAiⁱ	9725
Protein Ontology More...PROⁱ	PR:O94886

Gene expression databases

Bgeeⁱ	ENSG00000196187
CleanExⁱ	HS_TMEM63A
ExpressionAtlasⁱ	O94886 baseline and differential
Genevisibleⁱ	O94886 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR032880 Csc1_N IPR027815 PHM7_cyt IPR035979 RBD_domain_sf IPR003864 RSN1_7TM IPR026957 TMEM63A
PANTHERⁱ	PTHR13018:SF24 PTHR13018:SF24, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14703 PHM7_cyt, 1 hit PF02714 RSN1_7TM, 1 hit PF13967 RSN1_TM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CSCL1_HUMAN
Accessionⁱ	O94886Primary (citable) accession number: O94886 Secondary accession number(s): Q53GI7, Q5TE96, Q8N2U2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
	Last sequence update:	March 20, 2007
	Last modified:	July 18, 2018
	This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
SIMILARITY comments
Index of protein domains and families

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Supporting data

UniProtKB - O94886 (CSCL1_HUMAN)

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CSC1-like protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

Cytoskeleton

Extracellular region or secreted

Lysosome

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ