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Entry version 132 (13 Feb 2019)
Sequence version 3 (30 Nov 2010)
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Protein

Transmembrane and coiled-coil domains protein 1

Gene

TMCC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission (PubMed:30220460). Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane and coiled-coil domains protein 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMCC11 PublicationImported
Synonyms:KIAA07791 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000172765.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29116 TMCC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616242 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O94876

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 591CytoplasmicSequence analysisAdd BLAST591
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei592 – 612HelicalSequence analysisAdd BLAST21
Transmembranei625 – 645HelicalSequence analysisAdd BLAST21
Topological domaini646 – 653CytoplasmicSequence analysis8

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23023

Open Targets

More...
OpenTargetsi
ENSG00000172765

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134951990

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMCC1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001845951 – 653Transmembrane and coiled-coil domains protein 1Add BLAST653

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei382PhosphoserineCombined sources1
Modified residuei414PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O94876

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O94876

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O94876

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94876

PeptideAtlas

More...
PeptideAtlasi
O94876

PRoteomics IDEntifications database

More...
PRIDEi
O94876

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50519

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O94876

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O94876

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172765 Expressed in 230 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O94876 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O94876 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA053894

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form homodimers and heterodimers with TMCC2 or TMCC3 via the coiled-coil domains (PubMed:24454821). Interacts with ribosomal proteins RPL4 and RPS6 (PubMed:24454821).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116663, 4 interactors

Protein interaction database and analysis system

More...
IntActi
O94876, 8 interactors

Molecular INTeraction database

More...
MINTi
O94876

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000376930

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O94876

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O94876

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili228 – 313Sequence analysisAdd BLAST86
Coiled coili458 – 576Sequence analysisAdd BLAST119

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TEX28 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3850 Eukaryota
ENOG410Y9KV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155189

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294160

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG057342

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O94876

Identification of Orthologs from Complete Genome Data

More...
OMAi
TKKQHES

Database of Orthologous Groups

More...
OrthoDBi
1175041at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O94876

TreeFam database of animal gene trees

More...
TreeFami
TF316292

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019394 TEX28/TMCC

The PANTHER Classification System

More...
PANTHERi
PTHR17613 PTHR17613, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10267 Tmemb_cc2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94876-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPSGSEQLF EDPDPGGKSQ DAEARKQTES EQKLSKMTHN ALENINVIGQ
60 70 80 90 100
GLKHLFQHQR RRSSVSPHDV QQIQADPEPE MDLESQNACA EIDGVPTHPT
110 120 130 140 150
ALNRVLQQIR VPPKMKRGTS LHSRRGKPEA PKGSPQINRK SGQEMTAVMQ
160 170 180 190 200
SGRPRSSSTT DAPTSSAMME IACAAAAAAA ACLPGEEGTA ERIERLEVSS
210 220 230 240 250
LAQTSSAVAS STDGSIHTDS VDGTPDPQRT KAAIAHLQQK ILKLTEQIKI
260 270 280 290 300
AQTARDDNVA EYLKLANSAD KQQAARIKQV FEKKNQKSAQ TILQLQKKLE
310 320 330 340 350
HYHRKLREVE QNGIPRQPKD VFRDMHQGLK DVGAKVTGFS EGVVDSVKGG
360 370 380 390 400
FSSFSQATHS AAGAVVSKPR EIASLIRNKF GSADNIPNLK DSLEEGQVDD
410 420 430 440 450
AGKALGVISN FQSSPKYGSE EDCSSATSGS VGANSTTGGI AVGASSSKTN
460 470 480 490 500
TLDMQSSGFD ALLHEIQEIR ETQARLEESF ETLKEHYQRD YSLIMQTLQE
510 520 530 540 550
ERYRCERLEE QLNDLTELHQ NEILNLKQEL ASMEEKIAYQ SYERARDIQE
560 570 580 590 600
ALEACQTRIS KMELQQQQQQ VVQLEGLENA TARNLLGKLI NILLAVMAVL
610 620 630 640 650
LVFVSTVANC VVPLMKTRNR TFSTLFLVVF IAFLWKHWDA LFSYVERFFS

SPR
Length:653
Mass (Da):72,083
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9C3A26AE9583FF2
GO
Isoform 2 (identifier: O94876-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MEPSGSEQLFEDP → MVQRFSLRRQLSK
     14-192: Missing.

Note: No experimental confirmation available.
Show »
Length:474
Mass (Da):53,004
Checksum:i27C602553169ADCA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6N039Q6N039_HUMAN
cDNA FLJ42680 fis, clone BRAMY20405...
TMCC1 DKFZp686H13261
329Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PC87E9PC87_HUMAN
Transmembrane and coiled-coil domai...
TMCC1
539Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBT7D6RBT7_HUMAN
Transmembrane and coiled-coil domai...
TMCC1
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RH19D6RH19_HUMAN
Transmembrane and coiled-coil domai...
TMCC1
17Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti166S → T in BAF84137 (PubMed:14702039).Curated1
Sequence conflicti639D → G in BAF84137 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047918165S → GCombined sources3 PublicationsCorresponds to variant dbSNP:rs784689Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0539241 – 13MEPSG…LFEDP → MVQRFSLRRQLSK in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_05392514 – 192Missing in isoform 2. 1 PublicationAdd BLAST179

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK291448 mRNA Translation: BAF84137.1
AK293408 mRNA Translation: BAG56915.1
AC023162 Genomic DNA No translation available.
AC083799 Genomic DNA No translation available.
AC117492 Genomic DNA No translation available.
AL449209 Genomic DNA No translation available.
BC039859 mRNA Translation: AAH39859.1
CR749206 mRNA Translation: CAH18064.2
AB018322 mRNA Translation: BAA34499.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33855.1 [O94876-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001017395.2, NM_001017395.3 [O94876-1]
NP_001121696.1, NM_001128224.2
XP_006713605.1, XM_006713542.3
XP_006713606.1, XM_006713543.3
XP_006713607.1, XM_006713544.1 [O94876-1]
XP_011510874.1, XM_011512572.2
XP_011510875.1, XM_011512573.2 [O94876-1]
XP_011510878.1, XM_011512576.2
XP_011510881.1, XM_011512579.2
XP_011510884.1, XM_011512582.1
XP_016861420.1, XM_017005931.1 [O94876-1]
XP_016861421.1, XM_017005932.1
XP_016861422.1, XM_017005933.1 [O94876-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.477547

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000393238; ENSP00000376930; ENSG00000172765 [O94876-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23023

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23023

UCSC genome browser

More...
UCSCi
uc021xdy.2 human [O94876-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291448 mRNA Translation: BAF84137.1
AK293408 mRNA Translation: BAG56915.1
AC023162 Genomic DNA No translation available.
AC083799 Genomic DNA No translation available.
AC117492 Genomic DNA No translation available.
AL449209 Genomic DNA No translation available.
BC039859 mRNA Translation: AAH39859.1
CR749206 mRNA Translation: CAH18064.2
AB018322 mRNA Translation: BAA34499.1
CCDSiCCDS33855.1 [O94876-1]
RefSeqiNP_001017395.2, NM_001017395.3 [O94876-1]
NP_001121696.1, NM_001128224.2
XP_006713605.1, XM_006713542.3
XP_006713606.1, XM_006713543.3
XP_006713607.1, XM_006713544.1 [O94876-1]
XP_011510874.1, XM_011512572.2
XP_011510875.1, XM_011512573.2 [O94876-1]
XP_011510878.1, XM_011512576.2
XP_011510881.1, XM_011512579.2
XP_011510884.1, XM_011512582.1
XP_016861420.1, XM_017005931.1 [O94876-1]
XP_016861421.1, XM_017005932.1
XP_016861422.1, XM_017005933.1 [O94876-1]
UniGeneiHs.477547

3D structure databases

ProteinModelPortaliO94876
SMRiO94876
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116663, 4 interactors
IntActiO94876, 8 interactors
MINTiO94876
STRINGi9606.ENSP00000376930

PTM databases

iPTMnetiO94876
PhosphoSitePlusiO94876

Polymorphism and mutation databases

BioMutaiTMCC1

Proteomic databases

EPDiO94876
jPOSTiO94876
MaxQBiO94876
PaxDbiO94876
PeptideAtlasiO94876
PRIDEiO94876
ProteomicsDBi50519

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393238; ENSP00000376930; ENSG00000172765 [O94876-1]
GeneIDi23023
KEGGihsa:23023
UCSCiuc021xdy.2 human [O94876-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23023
DisGeNETi23023
EuPathDBiHostDB:ENSG00000172765.16

GeneCards: human genes, protein and diseases

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GeneCardsi
TMCC1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0003672
HGNCiHGNC:29116 TMCC1
HPAiHPA053894
MIMi616242 gene
neXtProtiNX_O94876
OpenTargetsiENSG00000172765
PharmGKBiPA134951990

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3850 Eukaryota
ENOG410Y9KV LUCA
GeneTreeiENSGT00940000155189
HOGENOMiHOG000294160
HOVERGENiHBG057342
InParanoidiO94876
OMAiTKKQHES
OrthoDBi1175041at2759
PhylomeDBiO94876
TreeFamiTF316292

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TMCC1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23023

Protein Ontology

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PROi
PR:O94876

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000172765 Expressed in 230 organ(s), highest expression level in testis
ExpressionAtlasiO94876 baseline and differential
GenevisibleiO94876 HS

Family and domain databases

InterProiView protein in InterPro
IPR019394 TEX28/TMCC
PANTHERiPTHR17613 PTHR17613, 1 hit
PfamiView protein in Pfam
PF10267 Tmemb_cc2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMCC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94876
Secondary accession number(s): A8K5Y3
, B4DE04, Q68E06, Q8IXM8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: November 30, 2010
Last modified: February 13, 2019
This is version 132 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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