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Protein

F-BAR and double SH3 domains protein 2

Gene

FCHSD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • neuromuscular synaptic transmission Source: GO_Central
  • regulation of actin filament polymerization Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
F-BAR and double SH3 domains protein 2
Alternative name(s):
Carom
SH3 multiple domains protein 3
Gene namesi
Name:FCHSD2
Synonyms:KIAA0769, SH3MD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000137478.14
HGNCiHGNC:29114 FCHSD2
MIMi617556 gene
neXtProtiNX_O94868

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9873
OpenTargetsiENSG00000137478
PharmGKBiPA128394562

Polymorphism and mutation databases

BioMutaiFCHSD2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002782141 – 740F-BAR and double SH3 domains protein 2Add BLAST740

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei675PhosphoserineCombined sources1
Modified residuei681PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO94868
MaxQBiO94868
PaxDbiO94868
PeptideAtlasiO94868
PRIDEiO94868
ProteomicsDBi50505
50506 [O94868-2]
50507 [O94868-3]

PTM databases

iPTMnetiO94868
PhosphoSitePlusiO94868

Expressioni

Tissue specificityi

Liver, brain, heart, placenta, skeletal muscle, pancreas, lung and kidney.1 Publication

Gene expression databases

BgeeiENSG00000137478 Expressed in 216 organ(s), highest expression level in left coronary artery
CleanExiHS_FCHSD2
ExpressionAtlasiO94868 baseline and differential
GenevisibleiO94868 HS

Organism-specific databases

HPAiHPA038545
HPA038546

Interactioni

Subunit structurei

Interacts with CASK and MAGI1. CASK inhibits interaction with MAGI1.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi115205, 30 interactors
IntActiO94868, 53 interactors
MINTiO94868
STRINGi9606.ENSP00000386722

Structurei

Secondary structure

1740
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO94868
SMRiO94868
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO94868

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 282F-BARPROSITE-ProRule annotationAdd BLAST275
Domaini469 – 530SH3 1PROSITE-ProRule annotationAdd BLAST62
Domaini567 – 629SH3 2PROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili356 – 397Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi718 – 721Poly-Pro4

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiENOG410INNZ Eukaryota
ENOG410XSX6 LUCA
GeneTreeiENSGT00510000046732
HOGENOMiHOG000046016
HOVERGENiHBG063540
InParanoidiO94868
KOiK20125
PhylomeDBiO94868
TreeFamiTF324557

Family and domain databases

CDDicd11894 SH3_FCHSD2_2, 1 hit
cd11761 SH3_FCHSD_1, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR034936 FCHSD
IPR034934 FCHSD2
IPR035556 FCHSD2_SH3_2
IPR035460 FCHSD_SH3_1
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR15735 PTHR15735, 1 hit
PTHR15735:SF11 PTHR15735:SF11, 1 hit
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF00018 SH3_1, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS50002 SH3, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94868-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQPPPRKVKV TQELKNIQVE QMTKLQAKHQ AECDLLEDMR TFSQKKAAIE
60 70 80 90 100
REYAQGMQKL ASQYLKRDWP GVKADDRNDY RSMYPVWKSF LEGTMQVAQS
110 120 130 140 150
RMNICENYKN FISEPARTVR SLKEQQLKRC VDQLTKIQTE LQETVKDLAK
160 170 180 190 200
GKKKYFETEQ MAHAVREKAD IEAKSKLSLF QSRISLQKAS VKLKARRSEC
210 220 230 240 250
NSKATHARND YLLTLAAANA HQDRYYQTDL VNIMKALDGN VYDHLKDYLI
260 270 280 290 300
AFSRTELETC QAVQNTFQFL LENSSKVVRD YNLQLFLQEN AVFHKPQPFQ
310 320 330 340 350
FQPCDSDTSR QLESETGTTE EHSLNKEARK WATRVAREHK NIVHQQRVLN
360 370 380 390 400
DLECHGAAVS EQSRAELEQK IDEARENIRK AEIIKLKAEA RLDLLKQIGV
410 420 430 440 450
SVDTWLKSAM NQVMEELENE RWARPPAVTS NGTLHSLNAD TEREEGEEFE
460 470 480 490 500
DNMDVFDDSS SSPSGTLRNY PLTCKVVYSY KASQPDELTI EEHEVLEVIE
510 520 530 540 550
DGDMEDWVKA RNKVGQVGYV PEKYLQFPTS NSLLSMLQSL AALDSRSHTS
560 570 580 590 600
SNSTEAELVS GSLNGDASVC FVKALYDYEG QTDDELSFPE GAIIRILNKE
610 620 630 640 650
NQDDDGFWEG EFNGRIGVFP SVLVEELSAS ENGDTPWMRE IQISPSPKPH
660 670 680 690 700
ASLPPLPLYD QPPSSPYPSP DKRSSLYFPR SPSANEKSLH AESPGFSQAS
710 720 730 740
RHTPETSYGK LRPVRAAPPP PTQNHRRPAE KIEDVEITLV
Length:740
Mass (Da):84,276
Last modified:February 20, 2007 - v3
Checksum:i3AF4DAC3CAD24C28
GO
Isoform 2 (identifier: O94868-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Show »
Length:684
Mass (Da):77,752
Checksum:iFB03BEEB29F8D78F
GO
Isoform 3 (identifier: O94868-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.
     569-571: VCF → GKD
     572-740: Missing.

Show »
Length:515
Mass (Da):58,886
Checksum:i4243B84AF4CE48C3
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PG19E9PG19_HUMAN
F-BAR and double SH3 domains protei...
FCHSD2
764Annotation score:
E7ENZ2E7ENZ2_HUMAN
F-BAR and double SH3 domains protei...
FCHSD2
604Annotation score:
H0Y6M2H0Y6M2_HUMAN
F-BAR and double SH3 domains protei...
FCHSD2
117Annotation score:
C9JM66C9JM66_HUMAN
F-BAR and double SH3 domains protei...
FCHSD2
140Annotation score:
H0YG35H0YG35_HUMAN
F-BAR and double SH3 domains protei...
FCHSD2
85Annotation score:
B8ZZW8B8ZZW8_HUMAN
F-BAR and double SH3 domains protei...
FCHSD2
101Annotation score:

Sequence cautioni

The sequence BAA34489 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0231671 – 56Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST56
Alternative sequenceiVSP_023168569 – 571VCF → GKD in isoform 3. 1 Publication3
Alternative sequenceiVSP_023169572 – 740Missing in isoform 3. 1 PublicationAdd BLAST169

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018312 mRNA Translation: BAA34489.2 Different initiation.
AP002381 Genomic DNA No translation available.
AP002455 Genomic DNA No translation available.
AK297928 mRNA Translation: BAG60245.1
AP004241 Genomic DNA No translation available.
BC010394 mRNA Translation: AAH10394.1
BC017751 mRNA Translation: AAH17751.1
AL133567 mRNA Translation: CAB63720.1
CCDSiCCDS8218.2 [O94868-1]
PIRiT43489
RefSeqiNP_055639.2, NM_014824.2 [O94868-1]
UniGeneiHs.744959

Genome annotation databases

EnsembliENST00000311172; ENSP00000308978; ENSG00000137478 [O94868-2]
ENST00000409418; ENSP00000386722; ENSG00000137478 [O94868-1]
ENST00000409853; ENSP00000386314; ENSG00000137478 [O94868-3]
GeneIDi9873
KEGGihsa:9873
UCSCiuc001oth.5 human [O94868-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018312 mRNA Translation: BAA34489.2 Different initiation.
AP002381 Genomic DNA No translation available.
AP002455 Genomic DNA No translation available.
AK297928 mRNA Translation: BAG60245.1
AP004241 Genomic DNA No translation available.
BC010394 mRNA Translation: AAH10394.1
BC017751 mRNA Translation: AAH17751.1
AL133567 mRNA Translation: CAB63720.1
CCDSiCCDS8218.2 [O94868-1]
PIRiT43489
RefSeqiNP_055639.2, NM_014824.2 [O94868-1]
UniGeneiHs.744959

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DL5NMR-A466-530[»]
2DL7NMR-A569-628[»]
6GBUX-ray3.44A/C/E/G567-629[»]
ProteinModelPortaliO94868
SMRiO94868
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115205, 30 interactors
IntActiO94868, 53 interactors
MINTiO94868
STRINGi9606.ENSP00000386722

PTM databases

iPTMnetiO94868
PhosphoSitePlusiO94868

Polymorphism and mutation databases

BioMutaiFCHSD2

Proteomic databases

EPDiO94868
MaxQBiO94868
PaxDbiO94868
PeptideAtlasiO94868
PRIDEiO94868
ProteomicsDBi50505
50506 [O94868-2]
50507 [O94868-3]

Protocols and materials databases

DNASUi9873
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311172; ENSP00000308978; ENSG00000137478 [O94868-2]
ENST00000409418; ENSP00000386722; ENSG00000137478 [O94868-1]
ENST00000409853; ENSP00000386314; ENSG00000137478 [O94868-3]
GeneIDi9873
KEGGihsa:9873
UCSCiuc001oth.5 human [O94868-1]

Organism-specific databases

CTDi9873
DisGeNETi9873
EuPathDBiHostDB:ENSG00000137478.14
GeneCardsiFCHSD2
H-InvDBiHIX0019675
HGNCiHGNC:29114 FCHSD2
HPAiHPA038545
HPA038546
MIMi617556 gene
neXtProtiNX_O94868
OpenTargetsiENSG00000137478
PharmGKBiPA128394562
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INNZ Eukaryota
ENOG410XSX6 LUCA
GeneTreeiENSGT00510000046732
HOGENOMiHOG000046016
HOVERGENiHBG063540
InParanoidiO94868
KOiK20125
PhylomeDBiO94868
TreeFamiTF324557

Miscellaneous databases

ChiTaRSiFCHSD2 human
EvolutionaryTraceiO94868
GeneWikiiFCHSD2
GenomeRNAii9873
PROiPR:O94868
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137478 Expressed in 216 organ(s), highest expression level in left coronary artery
CleanExiHS_FCHSD2
ExpressionAtlasiO94868 baseline and differential
GenevisibleiO94868 HS

Family and domain databases

CDDicd11894 SH3_FCHSD2_2, 1 hit
cd11761 SH3_FCHSD_1, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR034936 FCHSD
IPR034934 FCHSD2
IPR035556 FCHSD2_SH3_2
IPR035460 FCHSD_SH3_1
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR15735 PTHR15735, 1 hit
PTHR15735:SF11 PTHR15735:SF11, 1 hit
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF00018 SH3_1, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS50002 SH3, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFCSD2_HUMAN
AccessioniPrimary (citable) accession number: O94868
Secondary accession number(s): B4DNI3
, Q7L8J9, Q8WVM2, Q96FV7, Q9UF77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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