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Protein

F-BAR and double SH3 domains protein 2

Gene

FCHSD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • neuromuscular synaptic transmission Source: GO_Central
  • regulation of actin filament polymerization Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
F-BAR and double SH3 domains protein 2
Alternative name(s):
Carom
SH3 multiple domains protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FCHSD2
Synonyms:KIAA0769, SH3MD3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000137478.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29114 FCHSD2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617556 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O94868

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9873

Open Targets

More...
OpenTargetsi
ENSG00000137478

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394562

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FCHSD2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002782141 – 740F-BAR and double SH3 domains protein 2Add BLAST740

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei675PhosphoserineCombined sources1
Modified residuei681PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O94868

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O94868

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94868

PeptideAtlas

More...
PeptideAtlasi
O94868

PRoteomics IDEntifications database

More...
PRIDEi
O94868

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50505
50506 [O94868-2]
50507 [O94868-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O94868

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O94868

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Liver, brain, heart, placenta, skeletal muscle, pancreas, lung and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137478 Expressed in 216 organ(s), highest expression level in left coronary artery

CleanEx database of gene expression profiles

More...
CleanExi
HS_FCHSD2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O94868 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O94868 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038545
HPA038546

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CASK and MAGI1. CASK inhibits interaction with MAGI1.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115205, 30 interactors

Protein interaction database and analysis system

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IntActi
O94868, 53 interactors

Molecular INTeraction database

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MINTi
O94868

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000386722

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1740
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O94868

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O94868

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O94868

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 282F-BARPROSITE-ProRule annotationAdd BLAST275
Domaini469 – 530SH3 1PROSITE-ProRule annotationAdd BLAST62
Domaini567 – 629SH3 2PROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili356 – 397Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi718 – 721Poly-Pro4

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410INNZ Eukaryota
ENOG410XSX6 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00510000046732

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000046016

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG063540

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O94868

KEGG Orthology (KO)

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KOi
K20125

Database for complete collections of gene phylogenies

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PhylomeDBi
O94868

TreeFam database of animal gene trees

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TreeFami
TF324557

Family and domain databases

Conserved Domains Database

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CDDi
cd11894 SH3_FCHSD2_2, 1 hit
cd11761 SH3_FCHSD_1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.1270.60, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR034936 FCHSD
IPR034934 FCHSD2
IPR035556 FCHSD2_SH3_2
IPR035460 FCHSD_SH3_1
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

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PANTHERi
PTHR15735 PTHR15735, 1 hit
PTHR15735:SF11 PTHR15735:SF11, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00611 FCH, 1 hit
PF00018 SH3_1, 1 hit
PF14604 SH3_9, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00452 SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00055 FCH, 1 hit
SM00326 SH3, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51741 F_BAR, 1 hit
PS50002 SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94868-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQPPPRKVKV TQELKNIQVE QMTKLQAKHQ AECDLLEDMR TFSQKKAAIE
60 70 80 90 100
REYAQGMQKL ASQYLKRDWP GVKADDRNDY RSMYPVWKSF LEGTMQVAQS
110 120 130 140 150
RMNICENYKN FISEPARTVR SLKEQQLKRC VDQLTKIQTE LQETVKDLAK
160 170 180 190 200
GKKKYFETEQ MAHAVREKAD IEAKSKLSLF QSRISLQKAS VKLKARRSEC
210 220 230 240 250
NSKATHARND YLLTLAAANA HQDRYYQTDL VNIMKALDGN VYDHLKDYLI
260 270 280 290 300
AFSRTELETC QAVQNTFQFL LENSSKVVRD YNLQLFLQEN AVFHKPQPFQ
310 320 330 340 350
FQPCDSDTSR QLESETGTTE EHSLNKEARK WATRVAREHK NIVHQQRVLN
360 370 380 390 400
DLECHGAAVS EQSRAELEQK IDEARENIRK AEIIKLKAEA RLDLLKQIGV
410 420 430 440 450
SVDTWLKSAM NQVMEELENE RWARPPAVTS NGTLHSLNAD TEREEGEEFE
460 470 480 490 500
DNMDVFDDSS SSPSGTLRNY PLTCKVVYSY KASQPDELTI EEHEVLEVIE
510 520 530 540 550
DGDMEDWVKA RNKVGQVGYV PEKYLQFPTS NSLLSMLQSL AALDSRSHTS
560 570 580 590 600
SNSTEAELVS GSLNGDASVC FVKALYDYEG QTDDELSFPE GAIIRILNKE
610 620 630 640 650
NQDDDGFWEG EFNGRIGVFP SVLVEELSAS ENGDTPWMRE IQISPSPKPH
660 670 680 690 700
ASLPPLPLYD QPPSSPYPSP DKRSSLYFPR SPSANEKSLH AESPGFSQAS
710 720 730 740
RHTPETSYGK LRPVRAAPPP PTQNHRRPAE KIEDVEITLV
Length:740
Mass (Da):84,276
Last modified:February 20, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3AF4DAC3CAD24C28
GO
Isoform 2 (identifier: O94868-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Show »
Length:684
Mass (Da):77,752
Checksum:iFB03BEEB29F8D78F
GO
Isoform 3 (identifier: O94868-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.
     569-571: VCF → GKD
     572-740: Missing.

Show »
Length:515
Mass (Da):58,886
Checksum:i4243B84AF4CE48C3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PG19E9PG19_HUMAN
F-BAR and double SH3 domains protei...
FCHSD2
764Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ENZ2E7ENZ2_HUMAN
F-BAR and double SH3 domains protei...
FCHSD2
604Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6M2H0Y6M2_HUMAN
F-BAR and double SH3 domains protei...
FCHSD2
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JM66C9JM66_HUMAN
F-BAR and double SH3 domains protei...
FCHSD2
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YG35H0YG35_HUMAN
F-BAR and double SH3 domains protei...
FCHSD2
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B8ZZW8B8ZZW8_HUMAN
F-BAR and double SH3 domains protei...
FCHSD2
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA34489 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0231671 – 56Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST56
Alternative sequenceiVSP_023168569 – 571VCF → GKD in isoform 3. 1 Publication3
Alternative sequenceiVSP_023169572 – 740Missing in isoform 3. 1 PublicationAdd BLAST169

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB018312 mRNA Translation: BAA34489.2 Different initiation.
AP002381 Genomic DNA No translation available.
AP002455 Genomic DNA No translation available.
AK297928 mRNA Translation: BAG60245.1
AP004241 Genomic DNA No translation available.
BC010394 mRNA Translation: AAH10394.1
BC017751 mRNA Translation: AAH17751.1
AL133567 mRNA Translation: CAB63720.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS8218.2 [O94868-1]

Protein sequence database of the Protein Information Resource

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PIRi
T43489

NCBI Reference Sequences

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RefSeqi
NP_055639.2, NM_014824.2 [O94868-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.744959

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311172; ENSP00000308978; ENSG00000137478 [O94868-2]
ENST00000409418; ENSP00000386722; ENSG00000137478 [O94868-1]
ENST00000409853; ENSP00000386314; ENSG00000137478 [O94868-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9873

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9873

UCSC genome browser

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UCSCi
uc001oth.5 human [O94868-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018312 mRNA Translation: BAA34489.2 Different initiation.
AP002381 Genomic DNA No translation available.
AP002455 Genomic DNA No translation available.
AK297928 mRNA Translation: BAG60245.1
AP004241 Genomic DNA No translation available.
BC010394 mRNA Translation: AAH10394.1
BC017751 mRNA Translation: AAH17751.1
AL133567 mRNA Translation: CAB63720.1
CCDSiCCDS8218.2 [O94868-1]
PIRiT43489
RefSeqiNP_055639.2, NM_014824.2 [O94868-1]
UniGeneiHs.744959

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DL5NMR-A466-530[»]
2DL7NMR-A569-628[»]
6GBUX-ray3.44A/C/E/G567-629[»]
ProteinModelPortaliO94868
SMRiO94868
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115205, 30 interactors
IntActiO94868, 53 interactors
MINTiO94868
STRINGi9606.ENSP00000386722

PTM databases

iPTMnetiO94868
PhosphoSitePlusiO94868

Polymorphism and mutation databases

BioMutaiFCHSD2

Proteomic databases

EPDiO94868
MaxQBiO94868
PaxDbiO94868
PeptideAtlasiO94868
PRIDEiO94868
ProteomicsDBi50505
50506 [O94868-2]
50507 [O94868-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9873
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311172; ENSP00000308978; ENSG00000137478 [O94868-2]
ENST00000409418; ENSP00000386722; ENSG00000137478 [O94868-1]
ENST00000409853; ENSP00000386314; ENSG00000137478 [O94868-3]
GeneIDi9873
KEGGihsa:9873
UCSCiuc001oth.5 human [O94868-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9873
DisGeNETi9873
EuPathDBiHostDB:ENSG00000137478.14

GeneCards: human genes, protein and diseases

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GeneCardsi
FCHSD2

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0019675
HGNCiHGNC:29114 FCHSD2
HPAiHPA038545
HPA038546
MIMi617556 gene
neXtProtiNX_O94868
OpenTargetsiENSG00000137478
PharmGKBiPA128394562

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410INNZ Eukaryota
ENOG410XSX6 LUCA
GeneTreeiENSGT00510000046732
HOGENOMiHOG000046016
HOVERGENiHBG063540
InParanoidiO94868
KOiK20125
PhylomeDBiO94868
TreeFamiTF324557

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FCHSD2 human
EvolutionaryTraceiO94868

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FCHSD2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9873

Protein Ontology

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PROi
PR:O94868

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137478 Expressed in 216 organ(s), highest expression level in left coronary artery
CleanExiHS_FCHSD2
ExpressionAtlasiO94868 baseline and differential
GenevisibleiO94868 HS

Family and domain databases

CDDicd11894 SH3_FCHSD2_2, 1 hit
cd11761 SH3_FCHSD_1, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR034936 FCHSD
IPR034934 FCHSD2
IPR035556 FCHSD2_SH3_2
IPR035460 FCHSD_SH3_1
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR15735 PTHR15735, 1 hit
PTHR15735:SF11 PTHR15735:SF11, 1 hit
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF00018 SH3_1, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS50002 SH3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFCSD2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94868
Secondary accession number(s): B4DNI3
, Q7L8J9, Q8WVM2, Q96FV7, Q9UF77
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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