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Protein

STAGA complex 65 subunit gamma

Gene

SUPT7L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein heterodimerization activity Source: InterPro
  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones

Names & Taxonomyi

Protein namesi
Recommended name:
STAGA complex 65 subunit gamma
Alternative name(s):
Adenocarcinoma antigen ART1
SPTF-associated factor 65 gamma
Short name:
STAF65gamma
Suppressor of Ty 7-like
Gene namesi
Name:SUPT7L
Synonyms:KIAA0764
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000119760.15
HGNCiHGNC:30632 SUPT7L
MIMi612762 gene
neXtProtiNX_O94864

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9913
OpenTargetsiENSG00000119760
PharmGKBiPA142670854

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000722331 – 414STAGA complex 65 subunit gammaAdd BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108PhosphoserineCombined sources1
Cross-linki271Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei323PhosphoserineCombined sources1
Modified residuei334PhosphoserineCombined sources1

Post-translational modificationi

Sumoylated.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO94864
MaxQBiO94864
PaxDbiO94864
PeptideAtlasiO94864
PRIDEiO94864
ProteomicsDBi50503
50504 [O94864-2]

PTM databases

iPTMnetiO94864
PhosphoSitePlusiO94864

Expressioni

Tissue specificityi

Expressed at high levels in adenocarcinomas and gliomas and low in esophageal cancers and malignant hematological disease. Also expressed at high level in the thymus, low in peripheral blood mononuclear cells, and lowest in the stomach, small intestine, and skeletal muscle.

Gene expression databases

BgeeiENSG00000119760 Expressed in 222 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_SUPT7L
GenevisibleiO94864 HS

Organism-specific databases

HPAiHPA039565
HPA063643

Interactioni

Subunit structurei

Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, SUPT7L, GCN5L2, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12 and TAF9.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115242, 32 interactors
ComplexPortaliCPX-900 SAGA complex
CORUMiO94864
IntActiO94864, 6 interactors
STRINGi9606.ENSP00000336750

Structurei

3D structure databases

ProteinModelPortaliO94864
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410INFQ Eukaryota
ENOG410YK24 LUCA
GeneTreeiENSGT00390000005572
HOGENOMiHOG000072711
HOVERGENiHBG023396
InParanoidiO94864
KOiK11316
OMAiHAGFESA
OrthoDBiEOG091G0C0B
PhylomeDBiO94864
TreeFamiTF328615

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR006565 BTP
IPR009072 Histone-fold
IPR039460 SUPT7L
PANTHERiPTHR28598 PTHR28598, 1 hit
PfamiView protein in Pfam
PF07524 Bromo_TP, 1 hit
SMARTiView protein in SMART
SM00576 BTP, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O94864-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNLQRYWGEI PISSSQTNRS SFDLLPREFR LVEVHDPPLH QPSANKPKPP
60 70 80 90 100
TMLDIPSEPC SLTIHTIQLI QHNRRLRNLI ATAQAQNQQQ TEGVKTEESE
110 120 130 140 150
PLPSCPGSPP LPDDLLPLDC KNPNAPFQIR HSDPESDFYR GKGEPVTELS
160 170 180 190 200
WHSCRQLLYQ AVATILAHAG FDCANESVLE TLTDVAHEYC LKFTKLLRFA
210 220 230 240 250
VDREARLGQT PFPDVMEQVF HEVGIGSVLS LQKFWQHRIK DYHSYMLQIS
260 270 280 290 300
KQLSEEYERI VNPEKATEDA KPVKIKEEPV SDITFPVSEE LEADLASGDQ
310 320 330 340 350
SLPMGVLGAQ SERFPSNLEV EASPQASSAE VNASPLWNLA HVKMEPQESE
360 370 380 390 400
EGNVSGHGVL GSDVFEEPMS GMSEAGIPQS PDDSDSSYGS HSTDSLMGSS
410
PVFNQRCKKR MRKI
Length:414
Mass (Da):46,193
Last modified:May 1, 1999 - v1
Checksum:i59724A96353D44D5
GO
Isoform 2 (identifier: O94864-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MNLQ → ML

Note: No experimental confirmation available.
Show »
Length:412
Mass (Da):45,951
Checksum:i99A3830B2E4D3E22
GO
Isoform 3 (identifier: O94864-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     5-140: RYWGEIPISS...HSDPESDFYR → S

Note: No experimental confirmation available.
Show »
Length:279
Mass (Da):30,876
Checksum:i5200DB7BD9101EEE
GO

Sequence cautioni

The sequence BAA34484 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0039741 – 4MNLQ → ML in isoform 2. 1 Publication4
Alternative sequenceiVSP_0548395 – 140RYWGE…SDFYR → S in isoform 3. 1 PublicationAdd BLAST136

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF197954 mRNA Translation: AAG28523.1
AF224759 mRNA Translation: AAG47636.1
AB018307 mRNA Translation: BAA34484.2 Different initiation.
AK304889 mRNA Translation: BAG65625.1
CR456983 mRNA Translation: CAG33264.1
AC074091 Genomic DNA Translation: AAX93202.1
BC074000 mRNA Translation: AAH74000.1
CCDSiCCDS42667.1 [O94864-1]
CCDS62885.1 [O94864-2]
CCDS62886.1 [O94864-4]
RefSeqiNP_001269658.1, NM_001282729.1 [O94864-1]
NP_001269659.1, NM_001282730.1 [O94864-2]
NP_001269660.1, NM_001282731.1 [O94864-2]
NP_001269661.1, NM_001282732.1 [O94864-4]
NP_055675.1, NM_014860.2 [O94864-1]
XP_005264729.1, XM_005264672.4 [O94864-2]
UniGeneiHs.6232

Genome annotation databases

EnsembliENST00000337768; ENSP00000336750; ENSG00000119760 [O94864-1]
ENST00000404798; ENSP00000385218; ENSG00000119760 [O94864-4]
ENST00000405491; ENSP00000384469; ENSG00000119760 [O94864-2]
ENST00000406540; ENSP00000385436; ENSG00000119760 [O94864-2]
ENST00000464789; ENSP00000441110; ENSG00000119760 [O94864-2]
GeneIDi9913
KEGGihsa:9913
UCSCiuc002rli.3 human [O94864-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF197954 mRNA Translation: AAG28523.1
AF224759 mRNA Translation: AAG47636.1
AB018307 mRNA Translation: BAA34484.2 Different initiation.
AK304889 mRNA Translation: BAG65625.1
CR456983 mRNA Translation: CAG33264.1
AC074091 Genomic DNA Translation: AAX93202.1
BC074000 mRNA Translation: AAH74000.1
CCDSiCCDS42667.1 [O94864-1]
CCDS62885.1 [O94864-2]
CCDS62886.1 [O94864-4]
RefSeqiNP_001269658.1, NM_001282729.1 [O94864-1]
NP_001269659.1, NM_001282730.1 [O94864-2]
NP_001269660.1, NM_001282731.1 [O94864-2]
NP_001269661.1, NM_001282732.1 [O94864-4]
NP_055675.1, NM_014860.2 [O94864-1]
XP_005264729.1, XM_005264672.4 [O94864-2]
UniGeneiHs.6232

3D structure databases

ProteinModelPortaliO94864
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115242, 32 interactors
ComplexPortaliCPX-900 SAGA complex
CORUMiO94864
IntActiO94864, 6 interactors
STRINGi9606.ENSP00000336750

PTM databases

iPTMnetiO94864
PhosphoSitePlusiO94864

Proteomic databases

EPDiO94864
MaxQBiO94864
PaxDbiO94864
PeptideAtlasiO94864
PRIDEiO94864
ProteomicsDBi50503
50504 [O94864-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337768; ENSP00000336750; ENSG00000119760 [O94864-1]
ENST00000404798; ENSP00000385218; ENSG00000119760 [O94864-4]
ENST00000405491; ENSP00000384469; ENSG00000119760 [O94864-2]
ENST00000406540; ENSP00000385436; ENSG00000119760 [O94864-2]
ENST00000464789; ENSP00000441110; ENSG00000119760 [O94864-2]
GeneIDi9913
KEGGihsa:9913
UCSCiuc002rli.3 human [O94864-1]

Organism-specific databases

CTDi9913
DisGeNETi9913
EuPathDBiHostDB:ENSG00000119760.15
GeneCardsiSUPT7L
HGNCiHGNC:30632 SUPT7L
HPAiHPA039565
HPA063643
MIMi612762 gene
neXtProtiNX_O94864
OpenTargetsiENSG00000119760
PharmGKBiPA142670854
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INFQ Eukaryota
ENOG410YK24 LUCA
GeneTreeiENSGT00390000005572
HOGENOMiHOG000072711
HOVERGENiHBG023396
InParanoidiO94864
KOiK11316
OMAiHAGFESA
OrthoDBiEOG091G0C0B
PhylomeDBiO94864
TreeFamiTF328615

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones

Miscellaneous databases

ChiTaRSiSUPT7L human
GeneWikiiSUPT7L
GenomeRNAii9913
PROiPR:O94864
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119760 Expressed in 222 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_SUPT7L
GenevisibleiO94864 HS

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR006565 BTP
IPR009072 Histone-fold
IPR039460 SUPT7L
PANTHERiPTHR28598 PTHR28598, 1 hit
PfamiView protein in Pfam
PF07524 Bromo_TP, 1 hit
SMARTiView protein in SMART
SM00576 BTP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiST65G_HUMAN
AccessioniPrimary (citable) accession number: O94864
Secondary accession number(s): B4E3W3, Q6IB21, Q9H2T6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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