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Protein

Neurofascin

Gene

NFASC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-447043 Neurofascin interactions
R-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Neurofascin
Gene namesi
Name:NFASC
Synonyms:KIAA0756
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000163531.15
HGNCiHGNC:29866 NFASC
MIMi609145 gene
neXtProtiNX_O94856

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 1217ExtracellularSequence analysisAdd BLAST1193
Transmembranei1218 – 1238HelicalSequence analysisAdd BLAST21
Topological domaini1239 – 1347CytoplasmicSequence analysisAdd BLAST109

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23114
OpenTargetsiENSG00000163531
PharmGKBiPA128395771

Polymorphism and mutation databases

BioMutaiNFASC

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001504925 – 1347NeurofascinAdd BLAST1323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi63 ↔ 118PROSITE-ProRule annotation1 Publication
Disulfide bondi162 ↔ 213PROSITE-ProRule annotation1 Publication
Disulfide bondi268 ↔ 316PROSITE-ProRule annotation1 Publication
Glycosylationi305N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi358 ↔ 408PROSITE-ProRule annotation1 Publication
Glycosylationi409N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi446N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi452 ↔ 501PROSITE-ProRule annotation
Modified residuei481PhosphotyrosineCombined sources1
Glycosylationi483N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei485PhosphoserineCombined sources1
Disulfide bondi543 ↔ 592PROSITE-ProRule annotation
Glycosylationi752N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi778N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi973N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi988N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1267PhosphoserineBy similarity1
Modified residuei1281PhosphoserineBy similarity1
Modified residuei1294PhosphoserineBy similarity1
Modified residuei1297PhosphoserineBy similarity1
Modified residuei1333PhosphoserineBy similarity1
Modified residuei1334PhosphoserineBy similarity1
Modified residuei1338PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO94856
MaxQBiO94856
PaxDbiO94856
PeptideAtlasiO94856
PRIDEiO94856
ProteomicsDBi50490
50491 [O94856-10]
50492 [O94856-11]
50493 [O94856-12]
50494 [O94856-13]
50495 [O94856-2]
50496 [O94856-3]
50497 [O94856-4]
50498 [O94856-5]
50499 [O94856-6]
50500 [O94856-7]
50501 [O94856-8]
50502 [O94856-9]
TopDownProteomicsiO94856-2 [O94856-2]

PTM databases

CarbonylDBiO94856
GlyConnecti1552
iPTMnetiO94856
PhosphoSitePlusiO94856
SwissPalmiO94856

Expressioni

Gene expression databases

BgeeiENSG00000163531 Expressed in 203 organ(s), highest expression level in brain
ExpressionAtlasiO94856 baseline and differential
GenevisibleiO94856 HS

Organism-specific databases

HPAiHPA008832

Interactioni

Subunit structurei

Horseshoe-shaped homodimer. Probable constituent of a NFASC/NRCAM/ankyrin-G complex. Associates with the sodium channel beta-1 (SCN1B) and beta-3 (SCN3B) subunits. Interacts with GLDN/gliomedin (By similarity). Interacts with MYOC.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116737, 1 interactor
IntActiO94856, 7 interactors
STRINGi9606.ENSP00000344786

Structurei

Secondary structure

11347
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO94856
SMRiO94856
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO94856

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 137Ig-like C2-type 1Add BLAST97
Domaini143 – 230Ig-like C2-type 2Add BLAST88
Domaini244 – 332Ig-like C2-type 3Add BLAST89
Domaini337 – 424Ig-like C2-type 4Add BLAST88
Domaini429 – 517Ig-like C2-type 5Add BLAST89
Domaini521 – 603Ig-like C2-type 6Add BLAST83
Domaini630 – 725Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini730 – 823Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST94
Domaini828 – 930Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST103
Domaini934 – 1030Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST97
Domaini1114 – 1206Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST93

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1031 – 1108Thr-richAdd BLAST78

Domaini

Homophilic adhesion is primarily mediated by the interaction of the second Ig-like domains.

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3513 Eukaryota
ENOG410XSVG LUCA
GeneTreeiENSGT00760000118840
HOVERGENiHBG000144
InParanoidiO94856
KOiK06757
OMAiYKLEMVV
OrthoDBiEOG091G00LY
PhylomeDBiO94856
TreeFamiTF351098

Family and domain databases

CDDicd00063 FN3, 5 hits
Gene3Di2.60.40.10, 11 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR026966 Neurofascin/L1/NrCAM_C
IPR026965 NFASC
PANTHERiPTHR43951:SF4 PTHR43951:SF4, 1 hit
PfamiView protein in Pfam
PF13882 Bravo_FIGEY, 1 hit
PF00041 fn3, 5 hits
PF07679 I-set, 2 hits
PF00047 ig, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 6 hits
SM00408 IGc2, 6 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 6 hits

Sequences (13+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 13 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 13 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94856-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARQPPPPWV HAAFLLCLLS LGGAIEIPMD PSIQNELTQP PTITKQSAKD
60 70 80 90 100
HIVDPRDNIL IECEAKGNPA PSFHWTRNSR FFNIAKDPRV SMRRRSGTLV
110 120 130 140 150
IDFRSGGRPE EYEGEYQCFA RNKFGTALSN RIRLQVSKSP LWPKENLDPV
160 170 180 190 200
VVQEGAPLTL QCNPPPGLPS PVIFWMSSSM EPITQDKRVS QGHNGDLYFS
210 220 230 240 250
NVMLQDMQTD YSCNARFHFT HTIQQKNPFT LKVLTTRGVA ERTPSFMYPQ
260 270 280 290 300
GTASSQMVLR GMDLLLECIA SGVPTPDIAW YKKGGDLPSD KAKFENFNKA
310 320 330 340 350
LRITNVSEED SGEYFCLASN KMGSIRHTIS VRVKAAPYWL DEPKNLILAP
360 370 380 390 400
GEDGRLVCRA NGNPKPTVQW MVNGEPLQSA PPNPNREVAG DTIIFRDTQI
410 420 430 440 450
SSRAVYQCNT SNEHGYLLAN AFVSVLDVPP RMLSPRNQLI RVILYNRTRL
460 470 480 490 500
DCPFFGSPIP TLRWFKNGQG SNLDGGNYHV YENGSLEIKM IRKEDQGIYT
510 520 530 540 550
CVATNILGKA ENQVRLEVKD PTRIYRMPED QVARRGTTVQ LECRVKHDPS
560 570 580 590 600
LKLTVSWLKD DEPLYIGNRM KKEDDSLTIF GVAERDQGSY TCVASTELDQ
610 620 630 640 650
DLAKAYLTVL ADQATPTNRL AALPKGRPDR PRDLELTDLA ERSVRLTWIP
660 670 680 690 700
GDANNSPITD YVVQFEEDQF QPGVWHDHSK YPGSVNSAVL RLSPYVNYQF
710 720 730 740 750
RVIAINEVGS SHPSLPSERY RTSGAPPESN PGDVKGEGTR KNNMEITWTP
760 770 780 790 800
MNATSAFGPN LRYIVKWRRR ETREAWNNVT VWGSRYVVGQ TPVYVPYEIR
810 820 830 840 850
VQAENDFGKG PEPESVIGYS GEDYPRAAPT EVKVRVMNST AISLQWNRVY
860 870 880 890 900
SDTVQGQLRE YRAYYWRESS LLKNLWVSQK RQQASFPGDR LRGVVSRLFP
910 920 930 940 950
YSNYKLEMVV VNGRGDGPRS ETKEFTTPEG VPSAPRRFRV RQPNLETINL
960 970 980 990 1000
EWDHPEHPNG IMIGYTLKYV AFNGTKVGKQ IVENFSPNQT KFTVQRTDPV
1010 1020 1030 1040 1050
SRYRFTLSAR TQVGSGEAVT EESPAPPNEA TPTAAPPTLP PTTVGATGAV
1060 1070 1080 1090 1100
SSTDATAIAA TTEATTVPII PTVAPTTIAT TTTVATTTTT TAAATTTTES
1110 1120 1130 1140 1150
PPTTTSGTKI HESAPDEQSI WNVTVLPNSK WANITWKHNF GPGTDFVVEY
1160 1170 1180 1190 1200
IDSNHTKKTV PVKAQAQPIQ LTDLYPGMTY TLRVYSRDNE GISSTVITFM
1210 1220 1230 1240 1250
TSTAYTNNQA DIATQGWFIG LMCAIALLVL ILLIVCFIKR SRGGKYPVRE
1260 1270 1280 1290 1300
KKDVPLGPED PKEEDGSFDY SDEDNKPLQG SQTSLDGTIK QQESDDSLVD
1310 1320 1330 1340
YGEGGEGQFN EDGSFIGQYT VKKDKEETEG NESSEATSPV NAIYSLA
Note: No experimental confirmation available.
Length:1,347
Mass (Da):150,027
Last modified:December 6, 2005 - v4
Checksum:i4DC555E5AA06C223
GO
Isoform 2 (identifier: O94856-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     611-619: ADQATPTNR → GNCPCSPWH
     620-1347: Missing.

Note: May be due to intron retention.
Show »
Length:619
Mass (Da):69,565
Checksum:i19677F073EA3925E
GO
Isoform 3 (identifier: O94856-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-36: Missing.
     236-236: T → NHPYNDSSLRNHPDMYSA
     611-625: Missing.
     1030-1203: Missing.

Note: No experimental confirmation available.
Show »
Length:1,169
Mass (Da):131,669
Checksum:i227C4122ABA8EDAD
GO
Isoform 4 (identifier: O94856-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     824-930: Missing.
     931-931: V → L
     1030-1203: Missing.

Note: No experimental confirmation available.
Show »
Length:1,066
Mass (Da):119,470
Checksum:iB254170D9F282A75
GO
Isoform 5 (identifier: O94856-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     611-625: Missing.
     1030-1043: ATPTAAPPTLPPTT → GRCMAAAPGVKGPS

Note: May be due to intron retention.
Show »
Length:1,332
Mass (Da):148,444
Checksum:iC8EB8885620764DF
GO
Isoform 6 (identifier: O94856-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1030-1152: Missing.
     1153-1153: S → G

Note: No experimental confirmation available.
Show »
Length:1,224
Mass (Da):137,531
Checksum:i345949AF7828A247
GO
Isoform 7 (identifier: O94856-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1114-1203: Missing.

Note: No experimental confirmation available.
Show »
Length:1,257
Mass (Da):139,881
Checksum:i4E9F5630EAB43566
GO
Isoform 8 (identifier: O94856-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-36: Missing.
     236-236: T → NHPYNDSSLRNHPDMYSA
     611-625: Missing.
     1035-1203: Missing.

Note: No experimental confirmation available.
Show »
Length:1,174
Mass (Da):132,111
Checksum:iB298E5CBDF6A66B6
GO
Isoform 9 (identifier: O94856-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     824-930: Missing.
     931-931: V → L

Note: No experimental confirmation available.
Show »
Length:1,240
Mass (Da):137,609
Checksum:i2A894288EB12B706
GO
Isoform 10 (identifier: O94856-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-36: Missing.
     611-625: Missing.
     1035-1203: Missing.

Note: No experimental confirmation available.
Show »
Length:1,157
Mass (Da):130,112
Checksum:iFD0DE3EBAA072F1F
GO
Isoform 11 (identifier: O94856-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-36: Missing.
     236-236: T → NHPYNDSSLRNHPDMYSA
     1035-1203: Missing.

Note: No experimental confirmation available.
Show »
Length:1,189
Mass (Da):133,659
Checksum:i0D8B3BD1CF541D66
GO
Isoform 12 (identifier: O94856-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     824-930: Missing.
     931-931: V → L
     1035-1203: Missing.

Note: No experimental confirmation available.
Show »
Length:1,071
Mass (Da):119,911
Checksum:i8D23FD7B6D7A4EE0
GO
Isoform 13 (identifier: O94856-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1035-1113: Missing.

Note: No experimental confirmation available.
Show »
Length:1,268
Mass (Da):142,474
Checksum:i860AFD7BD11A1BFE
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BY57H7BY57_HUMAN
Neurofascin
NFASC
1,041Annotation score:
H7C073H7C073_HUMAN
Neurofascin
NFASC
237Annotation score:
H7C0L6H7C0L6_HUMAN
Neurofascin
NFASC
298Annotation score:
X6RKN2X6RKN2_HUMAN
Neurofascin
NFASC
1,165Annotation score:
A0A0C4DG92A0A0C4DG92_HUMAN
Neurofascin
NFASC
218Annotation score:
D6RBU5D6RBU5_HUMAN
Neurofascin
NFASC
486Annotation score:
D6RHX4D6RHX4_HUMAN
Neurofascin
NFASC
129Annotation score:

Sequence cautioni

The sequence BAA34476 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55195 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC87577 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti807F → L in BAB55195 (PubMed:14702039).Curated1
Sequence conflicti972F → V in AK127424 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017251159T → M. Corresponds to variant dbSNP:rs3795564Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01642431 – 36Missing in isoform 3, isoform 8, isoform 10 and isoform 11. 2 Publications6
Alternative sequenceiVSP_016425236T → NHPYNDSSLRNHPDMYSA in isoform 3, isoform 8 and isoform 11. 2 Publications1
Alternative sequenceiVSP_008937611 – 625Missing in isoform 3, isoform 5, isoform 8 and isoform 10. 3 PublicationsAdd BLAST15
Alternative sequenceiVSP_016426611 – 619ADQATPTNR → GNCPCSPWH in isoform 2. 2 Publications9
Alternative sequenceiVSP_008938620 – 1347Missing in isoform 2. 2 PublicationsAdd BLAST728
Alternative sequenceiVSP_016427824 – 930Missing in isoform 4, isoform 9 and isoform 12. 1 PublicationAdd BLAST107
Alternative sequenceiVSP_016428931V → L in isoform 4, isoform 9 and isoform 12. 1 Publication1
Alternative sequenceiVSP_0089401030 – 1203Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST174
Alternative sequenceiVSP_0164301030 – 1152Missing in isoform 6. 1 PublicationAdd BLAST123
Alternative sequenceiVSP_0164291030 – 1043ATPTA…LPPTT → GRCMAAAPGVKGPS in isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0164321035 – 1203Missing in isoform 8, isoform 10, isoform 11 and isoform 12. CuratedAdd BLAST169
Alternative sequenceiVSP_0164311035 – 1113Missing in isoform 13. CuratedAdd BLAST79
Alternative sequenceiVSP_0164331114 – 1203Missing in isoform 7. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_0164341153S → G in isoform 6. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018299 mRNA Translation: BAA34476.3 Different initiation.
AK027553 mRNA Translation: BAB55195.1 Different initiation.
AK090639 mRNA Translation: BAG52203.1
AK127424 mRNA No translation available.
AK128699 mRNA Translation: BAC87577.1 Different initiation.
AC096675 Genomic DNA No translation available.
AL391822 Genomic DNA No translation available.
BC008124 mRNA Translation: AAH08124.2
BC117674 mRNA Translation: AAI17675.2
BC137013 mRNA Translation: AAI37014.1
BC144454 mRNA Translation: AAI44455.1
AB177861 mRNA Translation: BAD66839.1
BX537841 mRNA Translation: CAD97852.1
CR749402 mRNA Translation: CAH18247.1
CCDSiCCDS30982.1 [O94856-3]
CCDS53460.1 [O94856-9]
CCDS53461.1 [O94856-2]
CCDS53462.1 [O94856-8]
RefSeqiNP_001005388.2, NM_001005388.2 [O94856-9]
NP_001005389.2, NM_001005389.1 [O94856-2]
NP_001153803.1, NM_001160331.1 [O94856-11]
NP_001153804.1, NM_001160332.1 [O94856-8]
NP_001153805.1, NM_001160333.1
NP_055905.2, NM_015090.3 [O94856-3]
XP_011507621.1, XM_011509319.1 [O94856-1]
XP_011507630.1, XM_011509328.1
UniGeneiHs.13349

Genome annotation databases

EnsembliENST00000339876; ENSP00000344786; ENSG00000163531 [O94856-9]
ENST00000360049; ENSP00000353154; ENSG00000163531 [O94856-3]
ENST00000401399; ENSP00000385637; ENSG00000163531 [O94856-9]
ENST00000403080; ENSP00000384875; ENSG00000163531 [O94856-2]
ENST00000404076; ENSP00000385676; ENSG00000163531 [O94856-10]
ENST00000404907; ENSP00000384061; ENSG00000163531 [O94856-8]
ENST00000513543; ENSP00000425908; ENSG00000163531 [O94856-3]
ENST00000539706; ENSP00000438614; ENSG00000163531 [O94856-8]
GeneIDi23114
KEGGihsa:23114
UCSCiuc001hbh.4 human [O94856-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018299 mRNA Translation: BAA34476.3 Different initiation.
AK027553 mRNA Translation: BAB55195.1 Different initiation.
AK090639 mRNA Translation: BAG52203.1
AK127424 mRNA No translation available.
AK128699 mRNA Translation: BAC87577.1 Different initiation.
AC096675 Genomic DNA No translation available.
AL391822 Genomic DNA No translation available.
BC008124 mRNA Translation: AAH08124.2
BC117674 mRNA Translation: AAI17675.2
BC137013 mRNA Translation: AAI37014.1
BC144454 mRNA Translation: AAI44455.1
AB177861 mRNA Translation: BAD66839.1
BX537841 mRNA Translation: CAD97852.1
CR749402 mRNA Translation: CAH18247.1
CCDSiCCDS30982.1 [O94856-3]
CCDS53460.1 [O94856-9]
CCDS53461.1 [O94856-2]
CCDS53462.1 [O94856-8]
RefSeqiNP_001005388.2, NM_001005388.2 [O94856-9]
NP_001005389.2, NM_001005389.1 [O94856-2]
NP_001153803.1, NM_001160331.1 [O94856-11]
NP_001153804.1, NM_001160332.1 [O94856-8]
NP_001153805.1, NM_001160333.1
NP_055905.2, NM_015090.3 [O94856-3]
XP_011507621.1, XM_011509319.1 [O94856-1]
XP_011507630.1, XM_011509328.1
UniGeneiHs.13349

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P3YX-ray2.60A25-428[»]
3P40X-ray3.20A25-428[»]
ProteinModelPortaliO94856
SMRiO94856
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116737, 1 interactor
IntActiO94856, 7 interactors
STRINGi9606.ENSP00000344786

PTM databases

CarbonylDBiO94856
GlyConnecti1552
iPTMnetiO94856
PhosphoSitePlusiO94856
SwissPalmiO94856

Polymorphism and mutation databases

BioMutaiNFASC

Proteomic databases

EPDiO94856
MaxQBiO94856
PaxDbiO94856
PeptideAtlasiO94856
PRIDEiO94856
ProteomicsDBi50490
50491 [O94856-10]
50492 [O94856-11]
50493 [O94856-12]
50494 [O94856-13]
50495 [O94856-2]
50496 [O94856-3]
50497 [O94856-4]
50498 [O94856-5]
50499 [O94856-6]
50500 [O94856-7]
50501 [O94856-8]
50502 [O94856-9]
TopDownProteomicsiO94856-2 [O94856-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339876; ENSP00000344786; ENSG00000163531 [O94856-9]
ENST00000360049; ENSP00000353154; ENSG00000163531 [O94856-3]
ENST00000401399; ENSP00000385637; ENSG00000163531 [O94856-9]
ENST00000403080; ENSP00000384875; ENSG00000163531 [O94856-2]
ENST00000404076; ENSP00000385676; ENSG00000163531 [O94856-10]
ENST00000404907; ENSP00000384061; ENSG00000163531 [O94856-8]
ENST00000513543; ENSP00000425908; ENSG00000163531 [O94856-3]
ENST00000539706; ENSP00000438614; ENSG00000163531 [O94856-8]
GeneIDi23114
KEGGihsa:23114
UCSCiuc001hbh.4 human [O94856-1]

Organism-specific databases

CTDi23114
DisGeNETi23114
EuPathDBiHostDB:ENSG00000163531.15
GeneCardsiNFASC
HGNCiHGNC:29866 NFASC
HPAiHPA008832
MIMi609145 gene
neXtProtiNX_O94856
OpenTargetsiENSG00000163531
PharmGKBiPA128395771
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3513 Eukaryota
ENOG410XSVG LUCA
GeneTreeiENSGT00760000118840
HOVERGENiHBG000144
InParanoidiO94856
KOiK06757
OMAiYKLEMVV
OrthoDBiEOG091G00LY
PhylomeDBiO94856
TreeFamiTF351098

Enzyme and pathway databases

ReactomeiR-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-447043 Neurofascin interactions
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiNFASC human
EvolutionaryTraceiO94856
GeneWikiiNFASC
GenomeRNAii23114
PROiPR:O94856
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163531 Expressed in 203 organ(s), highest expression level in brain
ExpressionAtlasiO94856 baseline and differential
GenevisibleiO94856 HS

Family and domain databases

CDDicd00063 FN3, 5 hits
Gene3Di2.60.40.10, 11 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR026966 Neurofascin/L1/NrCAM_C
IPR026965 NFASC
PANTHERiPTHR43951:SF4 PTHR43951:SF4, 1 hit
PfamiView protein in Pfam
PF13882 Bravo_FIGEY, 1 hit
PF00041 fn3, 5 hits
PF07679 I-set, 2 hits
PF00047 ig, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 6 hits
SM00408 IGc2, 6 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNFASC_HUMAN
AccessioniPrimary (citable) accession number: O94856
Secondary accession number(s): B2RNN8
, B3KQZ1, B5MDP6, B5MDR6, B7ZMD8, Q149P5, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: December 6, 2005
Last modified: October 10, 2018
This is version 170 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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