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Protein

Neurofascin

Gene

NFASC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-447043 Neurofascin interactions
R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurofascin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NFASC
Synonyms:KIAA0756
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000163531.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29866 NFASC

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609145 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O94856

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 1217ExtracellularSequence analysisAdd BLAST1193
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1218 – 1238HelicalSequence analysisAdd BLAST21
Topological domaini1239 – 1347CytoplasmicSequence analysisAdd BLAST109

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23114

Open Targets

More...
OpenTargetsi
ENSG00000163531

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128395771

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NFASC

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001504925 – 1347NeurofascinAdd BLAST1323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi63 ↔ 118PROSITE-ProRule annotation1 Publication
Disulfide bondi162 ↔ 213PROSITE-ProRule annotation1 Publication
Disulfide bondi268 ↔ 316PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi305N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi358 ↔ 408PROSITE-ProRule annotation1 Publication
Glycosylationi409N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi446N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi452 ↔ 501PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei481PhosphotyrosineCombined sources1
Glycosylationi483N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei485PhosphoserineCombined sources1
Disulfide bondi543 ↔ 592PROSITE-ProRule annotation
Glycosylationi752N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi778N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi973N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi988N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1267PhosphoserineBy similarity1
Modified residuei1281PhosphoserineBy similarity1
Modified residuei1294PhosphoserineBy similarity1
Modified residuei1297PhosphoserineBy similarity1
Modified residuei1333PhosphoserineBy similarity1
Modified residuei1334PhosphoserineBy similarity1
Modified residuei1338PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O94856

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O94856

MaxQB - The MaxQuant DataBase

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MaxQBi
O94856

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O94856

PeptideAtlas

More...
PeptideAtlasi
O94856

PRoteomics IDEntifications database

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PRIDEi
O94856

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50490
50491 [O94856-10]
50492 [O94856-11]
50493 [O94856-12]
50494 [O94856-13]
50495 [O94856-2]
50496 [O94856-3]
50497 [O94856-4]
50498 [O94856-5]
50499 [O94856-6]
50500 [O94856-7]
50501 [O94856-8]
50502 [O94856-9]

Consortium for Top Down Proteomics

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TopDownProteomicsi
O94856-2 [O94856-2]

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
O94856

GlyConnect protein glycosylation platform

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GlyConnecti
1552

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O94856

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O94856

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O94856

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000163531 Expressed in 203 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O94856 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O94856 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA008832

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Horseshoe-shaped homodimer. Probable constituent of a NFASC/NRCAM/ankyrin-G complex. Associates with the sodium channel beta-1 (SCN1B) and beta-3 (SCN3B) subunits. Interacts with GLDN/gliomedin (By similarity). Interacts with MYOC.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116737, 1 interactor

Protein interaction database and analysis system

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IntActi
O94856, 7 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000344786

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11347
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P3YX-ray2.60A25-428[»]
3P40X-ray3.20A25-428[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O94856

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O94856

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O94856

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 137Ig-like C2-type 1Add BLAST97
Domaini143 – 230Ig-like C2-type 2Add BLAST88
Domaini244 – 332Ig-like C2-type 3Add BLAST89
Domaini337 – 424Ig-like C2-type 4Add BLAST88
Domaini429 – 517Ig-like C2-type 5Add BLAST89
Domaini521 – 603Ig-like C2-type 6Add BLAST83
Domaini630 – 725Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini730 – 823Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST94
Domaini828 – 930Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST103
Domaini934 – 1030Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST97
Domaini1114 – 1206Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST93

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1031 – 1108Thr-richAdd BLAST78

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Homophilic adhesion is primarily mediated by the interaction of the second Ig-like domains.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3513 Eukaryota
ENOG410XSVG LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157024

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000144

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O94856

KEGG Orthology (KO)

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KOi
K06757

Identification of Orthologs from Complete Genome Data

More...
OMAi
WEPQGDN

Database of Orthologous Groups

More...
OrthoDBi
434404at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O94856

TreeFam database of animal gene trees

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TreeFami
TF351098

Family and domain databases

Conserved Domains Database

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CDDi
cd00063 FN3, 5 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 11 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR026966 Neurofascin/L1/NrCAM_C
IPR026965 NFASC

The PANTHER Classification System

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PANTHERi
PTHR43951:SF4 PTHR43951:SF4, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF13882 Bravo_FIGEY, 1 hit
PF00041 fn3, 5 hits
PF07679 I-set, 2 hits
PF00047 ig, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 6 hits
SM00408 IGc2, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (13+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 13 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 13 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94856-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARQPPPPWV HAAFLLCLLS LGGAIEIPMD PSIQNELTQP PTITKQSAKD
60 70 80 90 100
HIVDPRDNIL IECEAKGNPA PSFHWTRNSR FFNIAKDPRV SMRRRSGTLV
110 120 130 140 150
IDFRSGGRPE EYEGEYQCFA RNKFGTALSN RIRLQVSKSP LWPKENLDPV
160 170 180 190 200
VVQEGAPLTL QCNPPPGLPS PVIFWMSSSM EPITQDKRVS QGHNGDLYFS
210 220 230 240 250
NVMLQDMQTD YSCNARFHFT HTIQQKNPFT LKVLTTRGVA ERTPSFMYPQ
260 270 280 290 300
GTASSQMVLR GMDLLLECIA SGVPTPDIAW YKKGGDLPSD KAKFENFNKA
310 320 330 340 350
LRITNVSEED SGEYFCLASN KMGSIRHTIS VRVKAAPYWL DEPKNLILAP
360 370 380 390 400
GEDGRLVCRA NGNPKPTVQW MVNGEPLQSA PPNPNREVAG DTIIFRDTQI
410 420 430 440 450
SSRAVYQCNT SNEHGYLLAN AFVSVLDVPP RMLSPRNQLI RVILYNRTRL
460 470 480 490 500
DCPFFGSPIP TLRWFKNGQG SNLDGGNYHV YENGSLEIKM IRKEDQGIYT
510 520 530 540 550
CVATNILGKA ENQVRLEVKD PTRIYRMPED QVARRGTTVQ LECRVKHDPS
560 570 580 590 600
LKLTVSWLKD DEPLYIGNRM KKEDDSLTIF GVAERDQGSY TCVASTELDQ
610 620 630 640 650
DLAKAYLTVL ADQATPTNRL AALPKGRPDR PRDLELTDLA ERSVRLTWIP
660 670 680 690 700
GDANNSPITD YVVQFEEDQF QPGVWHDHSK YPGSVNSAVL RLSPYVNYQF
710 720 730 740 750
RVIAINEVGS SHPSLPSERY RTSGAPPESN PGDVKGEGTR KNNMEITWTP
760 770 780 790 800
MNATSAFGPN LRYIVKWRRR ETREAWNNVT VWGSRYVVGQ TPVYVPYEIR
810 820 830 840 850
VQAENDFGKG PEPESVIGYS GEDYPRAAPT EVKVRVMNST AISLQWNRVY
860 870 880 890 900
SDTVQGQLRE YRAYYWRESS LLKNLWVSQK RQQASFPGDR LRGVVSRLFP
910 920 930 940 950
YSNYKLEMVV VNGRGDGPRS ETKEFTTPEG VPSAPRRFRV RQPNLETINL
960 970 980 990 1000
EWDHPEHPNG IMIGYTLKYV AFNGTKVGKQ IVENFSPNQT KFTVQRTDPV
1010 1020 1030 1040 1050
SRYRFTLSAR TQVGSGEAVT EESPAPPNEA TPTAAPPTLP PTTVGATGAV
1060 1070 1080 1090 1100
SSTDATAIAA TTEATTVPII PTVAPTTIAT TTTVATTTTT TAAATTTTES
1110 1120 1130 1140 1150
PPTTTSGTKI HESAPDEQSI WNVTVLPNSK WANITWKHNF GPGTDFVVEY
1160 1170 1180 1190 1200
IDSNHTKKTV PVKAQAQPIQ LTDLYPGMTY TLRVYSRDNE GISSTVITFM
1210 1220 1230 1240 1250
TSTAYTNNQA DIATQGWFIG LMCAIALLVL ILLIVCFIKR SRGGKYPVRE
1260 1270 1280 1290 1300
KKDVPLGPED PKEEDGSFDY SDEDNKPLQG SQTSLDGTIK QQESDDSLVD
1310 1320 1330 1340
YGEGGEGQFN EDGSFIGQYT VKKDKEETEG NESSEATSPV NAIYSLA
Note: No experimental confirmation available.
Length:1,347
Mass (Da):150,027
Last modified:December 6, 2005 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4DC555E5AA06C223
GO
Isoform 2 (identifier: O94856-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     611-619: ADQATPTNR → GNCPCSPWH
     620-1347: Missing.

Note: May be due to intron retention.
Show »
Length:619
Mass (Da):69,565
Checksum:i19677F073EA3925E
GO
Isoform 3 (identifier: O94856-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-36: Missing.
     236-236: T → NHPYNDSSLRNHPDMYSA
     611-625: Missing.
     1030-1203: Missing.

Note: No experimental confirmation available.
Show »
Length:1,169
Mass (Da):131,669
Checksum:i227C4122ABA8EDAD
GO
Isoform 4 (identifier: O94856-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     824-930: Missing.
     931-931: V → L
     1030-1203: Missing.

Note: No experimental confirmation available.
Show »
Length:1,066
Mass (Da):119,470
Checksum:iB254170D9F282A75
GO
Isoform 5 (identifier: O94856-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     611-625: Missing.
     1030-1043: ATPTAAPPTLPPTT → GRCMAAAPGVKGPS

Note: May be due to intron retention.
Show »
Length:1,332
Mass (Da):148,444
Checksum:iC8EB8885620764DF
GO
Isoform 6 (identifier: O94856-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1030-1152: Missing.
     1153-1153: S → G

Note: No experimental confirmation available.
Show »
Length:1,224
Mass (Da):137,531
Checksum:i345949AF7828A247
GO
Isoform 7 (identifier: O94856-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1114-1203: Missing.

Note: No experimental confirmation available.
Show »
Length:1,257
Mass (Da):139,881
Checksum:i4E9F5630EAB43566
GO
Isoform 8 (identifier: O94856-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-36: Missing.
     236-236: T → NHPYNDSSLRNHPDMYSA
     611-625: Missing.
     1035-1203: Missing.

Note: No experimental confirmation available.
Show »
Length:1,174
Mass (Da):132,111
Checksum:iB298E5CBDF6A66B6
GO
Isoform 9 (identifier: O94856-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     824-930: Missing.
     931-931: V → L

Note: No experimental confirmation available.
Show »
Length:1,240
Mass (Da):137,609
Checksum:i2A894288EB12B706
GO
Isoform 10 (identifier: O94856-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-36: Missing.
     611-625: Missing.
     1035-1203: Missing.

Note: No experimental confirmation available.
Show »
Length:1,157
Mass (Da):130,112
Checksum:iFD0DE3EBAA072F1F
GO
Isoform 11 (identifier: O94856-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-36: Missing.
     236-236: T → NHPYNDSSLRNHPDMYSA
     1035-1203: Missing.

Note: No experimental confirmation available.
Show »
Length:1,189
Mass (Da):133,659
Checksum:i0D8B3BD1CF541D66
GO
Isoform 12 (identifier: O94856-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     824-930: Missing.
     931-931: V → L
     1035-1203: Missing.

Note: No experimental confirmation available.
Show »
Length:1,071
Mass (Da):119,911
Checksum:i8D23FD7B6D7A4EE0
GO
Isoform 13 (identifier: O94856-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1035-1113: Missing.

Note: No experimental confirmation available.
Show »
Length:1,268
Mass (Da):142,474
Checksum:i860AFD7BD11A1BFE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C0L6H7C0L6_HUMAN
Neurofascin
NFASC
298Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BY57H7BY57_HUMAN
Neurofascin
NFASC
1,041Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RKN2X6RKN2_HUMAN
Neurofascin
NFASC
1,165Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C073H7C073_HUMAN
Neurofascin
NFASC
237Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DG92A0A0C4DG92_HUMAN
Neurofascin
NFASC
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBU5D6RBU5_HUMAN
Neurofascin
NFASC
486Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHX4D6RHX4_HUMAN
Neurofascin
NFASC
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA34476 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55195 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC87577 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti807F → L in BAB55195 (PubMed:14702039).Curated1
Sequence conflicti972F → V in AK127424 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017251159T → M. Corresponds to variant dbSNP:rs3795564Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01642431 – 36Missing in isoform 3, isoform 8, isoform 10 and isoform 11. 2 Publications6
Alternative sequenceiVSP_016425236T → NHPYNDSSLRNHPDMYSA in isoform 3, isoform 8 and isoform 11. 2 Publications1
Alternative sequenceiVSP_008937611 – 625Missing in isoform 3, isoform 5, isoform 8 and isoform 10. 3 PublicationsAdd BLAST15
Alternative sequenceiVSP_016426611 – 619ADQATPTNR → GNCPCSPWH in isoform 2. 2 Publications9
Alternative sequenceiVSP_008938620 – 1347Missing in isoform 2. 2 PublicationsAdd BLAST728
Alternative sequenceiVSP_016427824 – 930Missing in isoform 4, isoform 9 and isoform 12. 1 PublicationAdd BLAST107
Alternative sequenceiVSP_016428931V → L in isoform 4, isoform 9 and isoform 12. 1 Publication1
Alternative sequenceiVSP_0089401030 – 1203Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST174
Alternative sequenceiVSP_0164301030 – 1152Missing in isoform 6. 1 PublicationAdd BLAST123
Alternative sequenceiVSP_0164291030 – 1043ATPTA…LPPTT → GRCMAAAPGVKGPS in isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0164321035 – 1203Missing in isoform 8, isoform 10, isoform 11 and isoform 12. CuratedAdd BLAST169
Alternative sequenceiVSP_0164311035 – 1113Missing in isoform 13. CuratedAdd BLAST79
Alternative sequenceiVSP_0164331114 – 1203Missing in isoform 7. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_0164341153S → G in isoform 6. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB018299 mRNA Translation: BAA34476.3 Different initiation.
AK027553 mRNA Translation: BAB55195.1 Different initiation.
AK090639 mRNA Translation: BAG52203.1
AK127424 mRNA No translation available.
AK128699 mRNA Translation: BAC87577.1 Different initiation.
AC096675 Genomic DNA No translation available.
AL391822 Genomic DNA No translation available.
BC008124 mRNA Translation: AAH08124.2
BC117674 mRNA Translation: AAI17675.2
BC137013 mRNA Translation: AAI37014.1
BC144454 mRNA Translation: AAI44455.1
AB177861 mRNA Translation: BAD66839.1
BX537841 mRNA Translation: CAD97852.1
CR749402 mRNA Translation: CAH18247.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30982.1 [O94856-3]
CCDS53460.1 [O94856-9]
CCDS53461.1 [O94856-2]
CCDS53462.1 [O94856-8]

NCBI Reference Sequences

More...
RefSeqi
NP_001005388.2, NM_001005388.2 [O94856-9]
NP_001005389.2, NM_001005389.1 [O94856-2]
NP_001153803.1, NM_001160331.1 [O94856-11]
NP_001153804.1, NM_001160332.1 [O94856-8]
NP_001153805.1, NM_001160333.1
NP_055905.2, NM_015090.3 [O94856-3]
XP_011507621.1, XM_011509319.1 [O94856-1]
XP_011507630.1, XM_011509328.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.13349

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000339876; ENSP00000344786; ENSG00000163531 [O94856-9]
ENST00000360049; ENSP00000353154; ENSG00000163531 [O94856-3]
ENST00000401399; ENSP00000385637; ENSG00000163531 [O94856-9]
ENST00000403080; ENSP00000384875; ENSG00000163531 [O94856-2]
ENST00000404076; ENSP00000385676; ENSG00000163531 [O94856-10]
ENST00000404907; ENSP00000384061; ENSG00000163531 [O94856-8]
ENST00000513543; ENSP00000425908; ENSG00000163531 [O94856-3]
ENST00000539706; ENSP00000438614; ENSG00000163531 [O94856-8]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23114

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23114

UCSC genome browser

More...
UCSCi
uc001hbh.4 human [O94856-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018299 mRNA Translation: BAA34476.3 Different initiation.
AK027553 mRNA Translation: BAB55195.1 Different initiation.
AK090639 mRNA Translation: BAG52203.1
AK127424 mRNA No translation available.
AK128699 mRNA Translation: BAC87577.1 Different initiation.
AC096675 Genomic DNA No translation available.
AL391822 Genomic DNA No translation available.
BC008124 mRNA Translation: AAH08124.2
BC117674 mRNA Translation: AAI17675.2
BC137013 mRNA Translation: AAI37014.1
BC144454 mRNA Translation: AAI44455.1
AB177861 mRNA Translation: BAD66839.1
BX537841 mRNA Translation: CAD97852.1
CR749402 mRNA Translation: CAH18247.1
CCDSiCCDS30982.1 [O94856-3]
CCDS53460.1 [O94856-9]
CCDS53461.1 [O94856-2]
CCDS53462.1 [O94856-8]
RefSeqiNP_001005388.2, NM_001005388.2 [O94856-9]
NP_001005389.2, NM_001005389.1 [O94856-2]
NP_001153803.1, NM_001160331.1 [O94856-11]
NP_001153804.1, NM_001160332.1 [O94856-8]
NP_001153805.1, NM_001160333.1
NP_055905.2, NM_015090.3 [O94856-3]
XP_011507621.1, XM_011509319.1 [O94856-1]
XP_011507630.1, XM_011509328.1
UniGeneiHs.13349

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P3YX-ray2.60A25-428[»]
3P40X-ray3.20A25-428[»]
ProteinModelPortaliO94856
SMRiO94856
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116737, 1 interactor
IntActiO94856, 7 interactors
STRINGi9606.ENSP00000344786

PTM databases

CarbonylDBiO94856
GlyConnecti1552
iPTMnetiO94856
PhosphoSitePlusiO94856
SwissPalmiO94856

Polymorphism and mutation databases

BioMutaiNFASC

Proteomic databases

EPDiO94856
jPOSTiO94856
MaxQBiO94856
PaxDbiO94856
PeptideAtlasiO94856
PRIDEiO94856
ProteomicsDBi50490
50491 [O94856-10]
50492 [O94856-11]
50493 [O94856-12]
50494 [O94856-13]
50495 [O94856-2]
50496 [O94856-3]
50497 [O94856-4]
50498 [O94856-5]
50499 [O94856-6]
50500 [O94856-7]
50501 [O94856-8]
50502 [O94856-9]
TopDownProteomicsiO94856-2 [O94856-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339876; ENSP00000344786; ENSG00000163531 [O94856-9]
ENST00000360049; ENSP00000353154; ENSG00000163531 [O94856-3]
ENST00000401399; ENSP00000385637; ENSG00000163531 [O94856-9]
ENST00000403080; ENSP00000384875; ENSG00000163531 [O94856-2]
ENST00000404076; ENSP00000385676; ENSG00000163531 [O94856-10]
ENST00000404907; ENSP00000384061; ENSG00000163531 [O94856-8]
ENST00000513543; ENSP00000425908; ENSG00000163531 [O94856-3]
ENST00000539706; ENSP00000438614; ENSG00000163531 [O94856-8]
GeneIDi23114
KEGGihsa:23114
UCSCiuc001hbh.4 human [O94856-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23114
DisGeNETi23114
EuPathDBiHostDB:ENSG00000163531.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NFASC
HGNCiHGNC:29866 NFASC
HPAiHPA008832
MIMi609145 gene
neXtProtiNX_O94856
OpenTargetsiENSG00000163531
PharmGKBiPA128395771

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3513 Eukaryota
ENOG410XSVG LUCA
GeneTreeiENSGT00940000157024
HOVERGENiHBG000144
InParanoidiO94856
KOiK06757
OMAiWEPQGDN
OrthoDBi434404at2759
PhylomeDBiO94856
TreeFamiTF351098

Enzyme and pathway databases

ReactomeiR-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-447043 Neurofascin interactions
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NFASC human
EvolutionaryTraceiO94856

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NFASC

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23114

Protein Ontology

More...
PROi
PR:O94856

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163531 Expressed in 203 organ(s), highest expression level in brain
ExpressionAtlasiO94856 baseline and differential
GenevisibleiO94856 HS

Family and domain databases

CDDicd00063 FN3, 5 hits
Gene3Di2.60.40.10, 11 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR026966 Neurofascin/L1/NrCAM_C
IPR026965 NFASC
PANTHERiPTHR43951:SF4 PTHR43951:SF4, 1 hit
PfamiView protein in Pfam
PF13882 Bravo_FIGEY, 1 hit
PF00041 fn3, 5 hits
PF07679 I-set, 2 hits
PF00047 ig, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 6 hits
SM00408 IGc2, 6 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNFASC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94856
Secondary accession number(s): B2RNN8
, B3KQZ1, B5MDP6, B5MDR6, B7ZMD8, Q149P5, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: December 6, 2005
Last modified: January 16, 2019
This is version 173 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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