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Protein

[F-actin]-monooxygenase MICAL2

Gene

MICAL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:24440334). In the absence of actin, it also functions as a NADPH oxidase producing H2O2 (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (PubMed:24440334).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADBy similarity

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Specifically inhibited by CCG-1423, a small molecule inhibitor of SRF:MKL1/MRTF-A-dependent transcription.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei97FADBy similarity1
Binding sitei183FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei298FADBy similarity1
Binding sitei398FADBy similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1002Zinc 1By similarity1
Metal bindingi1005Zinc 1By similarity1
Metal bindingi1023Zinc 1; via pros nitrogenBy similarity1
Metal bindingi1026Zinc 1By similarity1
Metal bindingi1029Zinc 2By similarity1
Metal bindingi1032Zinc 2By similarity1
Metal bindingi1052Zinc 2By similarity1
Metal bindingi1055Zinc 2; via pros nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi116 – 118FADBy similarity3
Nucleotide bindingi123 – 125FADBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Monooxygenase, Oxidoreductase
LigandFAD, Flavoprotein, Metal-binding, NADP, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
[F-actin]-monooxygenase MICAL2 (EC:1.14.13.2251 Publication)
Alternative name(s):
Molecule interacting with CasL protein 2
Short name:
MICAL-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MICAL2
Synonyms:KIAA0750, MICAL2PV1, MICAL2PV2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000133816.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24693 MICAL2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608881 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O94851

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi95G → V: Blocks FAD binding and abolishes catalytic activity. 1 Publication1
Mutagenesisi677 – 681KRRRK → AAAAA in MICAL-2NLSMut; abolishes nuclear localization. 1 Publication5

Organism-specific databases

DisGeNET

More...
DisGeNETi
9645

Open Targets

More...
OpenTargetsi
ENSG00000133816

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671453

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MICAL2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000758441 – 1124[F-actin]-monooxygenase MICAL2Add BLAST1124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei631PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O94851

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O94851

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O94851

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94851

PeptideAtlas

More...
PeptideAtlasi
O94851

PRoteomics IDEntifications database

More...
PRIDEi
O94851

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50480
50481 [O94851-2]
50482 [O94851-3]
50483 [O94851-4]
50484 [O94851-5]
50485 [O94851-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O94851

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O94851

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000133816 Expressed in 236 organ(s), highest expression level in right hemisphere of cerebellum

CleanEx database of gene expression profiles

More...
CleanExi
HS_MICAL2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O94851 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O94851 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030437

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PLXNA4 (By similarity). Interacts with RAB1B (PubMed:15694364).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115003, 5 interactors

Protein interaction database and analysis system

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IntActi
O94851, 7 interactors

Molecular INTeraction database

More...
MINTi
O94851

STRING: functional protein association networks

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STRINGi
9606.ENSP00000256194

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E9KNMR-A516-629[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O94851

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O94851

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O94851

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini516 – 619Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST104
Domaini1000 – 1062LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 494Monooxygenase domainBy similarityAdd BLAST493

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi660 – 681Nuclear localization signal1 PublicationAdd BLAST22

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mical family.Curated

Keywords - Domaini

LIM domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1700 Eukaryota
COG5069 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158780

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000047263

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052474

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O94851

KEGG Orthology (KO)

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KOi
K19947

Identification of Orthologs from Complete Genome Data

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OMAi
CSVCATT

Database of Orthologous Groups

More...
OrthoDBi
430978at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O94851

TreeFam database of animal gene trees

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TreeFami
TF324129

Family and domain databases

Conserved Domains Database

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CDDi
cd00014 CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR002938 FAD-bd
IPR036188 FAD/NAD-bd_sf
IPR029939 MICAL2
IPR001781 Znf_LIM

The PANTHER Classification System

More...
PANTHERi
PTHR44265:SF3 PTHR44265:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 1 hit
PF01494 FAD_binding_3, 1 hit
PF00412 LIM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 1 hit
SM00132 LIM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF51905 SSF51905, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021 CH, 1 hit
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94851-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGENEDEKQA QAGQVFENFV QASTCKGTLQ AFNILTRHLD LDPLDHRNFY
60 70 80 90 100
SKLKSKVTTW KAKALWYKLD KRGSHKEYKR GKSCTNTKCL IVGGGPCGLR
110 120 130 140 150
TAIELAYLGA KVVVVEKRDS FSRNNVLHLW PFTIHDLRGL GAKKFYGKFC
160 170 180 190 200
AGSIDHISIR QLQLILFKVA LMLGVEIHVN VEFVKVLEPP EDQENQKIGW
210 220 230 240 250
RAEFLPTDHS LSEFEFDVII GADGRRNTLE GFRRKEFRGK LAIAITANFI
260 270 280 290 300
NRNSTAEAKV EEISGVAFIF NQKFFQDLKE ETGIDLENIV YYKDCTHYFV
310 320 330 340 350
MTAKKQSLLD KGVIINDYID TEMLLCAENV NQDNLLSYAR EAADFATNYQ
360 370 380 390 400
LPSLDFAMNH YGQPDVAMFD FTCMYASENA ALVRERQAHQ LLVALVGDSL
410 420 430 440 450
LEPFWPMGTG CARGFLAAFD TAWMVKSWNQ GTPPLELLAE RESLYRLLPQ
460 470 480 490 500
TTPENINKNF EQYTLDPGTR YPNLNSHCVR PHQVKHLYIT KELEHYPLER
510 520 530 540 550
LGSVRRSVNL SRKESDIRPS KLLTWCQQQT EGYQHVNVTD LTTSWRSGLA
560 570 580 590 600
LCAIIHRFRP ELINFDSLNE DDAVENNQLA FDVAEREFGI PPVTTGKEMA
610 620 630 640 650
SAQEPDKLSM VMYLSKFYEL FRGTPLRPVD SWRKNYGENA DLSLAKSSIS
660 670 680 690 700
NNYLNLTFPR KRTPRVDGQT GENDMNKRRR KGFTNLDEPS NFSSRSLGSN
710 720 730 740 750
QECGSSKEGG NQNKVKSMAN QLLAKFEEST RNPSLMKQER RVSGIGKPVL
760 770 780 790 800
CSSSGPPVHS CCPKPEEATP SPSPPLKRQF PSVVVTGHVL RELKQVSAGS
810 820 830 840 850
ECLSRPWRAR AKSDLQLGGT ENFATLPSTR PRAQALSGVL WRLQQVEEKI
860 870 880 890 900
LQKRAQNLAN REFHTKNIKE KAAHLASMFG HGDFPQNKLL SKGLSHTHPP
910 920 930 940 950
SPPSRLPSPD PAASSSPSTV DSASPARKEK KSPSGFHFHP SHLRTVHPQL
960 970 980 990 1000
TVGKVSSGIG AAAEVLVNLY MNDHRPKAQA TSPDLESMRK SFPLNLGGSD
1010 1020 1030 1040 1050
TCYFCKKRVY VMERLSAEGH FFHRECFRCS ICATTLRLAA YTFDCDEGKF
1060 1070 1080 1090 1100
YCKPHFIHCK TNSKQRKRRA ELKQQREEEA TWQEQEAPRR DTPTESSCAV
1110 1120
AAIGTLEGSP PVHFSLPVLH PLLG
Length:1,124
Mass (Da):126,689
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1C276C42D17B64DF
GO
Isoform 2 (identifier: O94851-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.
     740-986: Missing.
     1112-1124: VHFSLPVLHPLLG → GISTSFFRKV...VLRCFPVKLR

Show »
Length:784
Mass (Da):89,890
Checksum:i114E5873F13E5C61
GO
Isoform 3 (identifier: O94851-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     929-949: Missing.

Show »
Length:1,103
Mass (Da):124,253
Checksum:iEAB33EE2B2DB4BA1
GO
Isoform 4 (identifier: O94851-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     739-928: Missing.
     950-985: Missing.
     1112-1124: VHFSLPVLHPLLG → GISTSFFRKV...VLRCFPVKLR

Show »
Length:976
Mass (Da):111,652
Checksum:iD8B4E819D43FDA7E
GO
Isoform 5 (identifier: O94851-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     739-928: Missing.

Show »
Length:934
Mass (Da):106,211
Checksum:i5CB357AB0F7D4B9E
GO
Isoform 6 (identifier: O94851-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     739-985: Missing.
     1112-1124: VHFSLPVLHPLLG → GISTSFFRKV...VLRCFPVKLR

Show »
Length:955
Mass (Da):109,216
Checksum:i583E6EF7AC29A939
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YFA9A0A2R8YFA9_HUMAN
[F-actin]-monooxygenase MICAL2
MICAL2
1,957Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNC3E9PNC3_HUMAN
[F-actin]-monooxygenase MICAL2
MICAL2
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKI3E9PKI3_HUMAN
[F-actin]-monooxygenase MICAL2
MICAL2
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRE0E9PRE0_HUMAN
[F-actin]-monooxygenase MICAL2
MICAL2
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PL42E9PL42_HUMAN
[F-actin]-monooxygenase MICAL2
MICAL2
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJB0E9PJB0_HUMAN
[F-actin]-monooxygenase MICAL2
MICAL2
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKW5E9PKW5_HUMAN
[F-actin]-monooxygenase MICAL2
MICAL2
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRG5E9PRG5_HUMAN
[F-actin]-monooxygenase MICAL2
MICAL2
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y771A0A2R8Y771_HUMAN
[F-actin]-monooxygenase MICAL2
MICAL2
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7K9A0A2R8Y7K9_HUMAN
[F-actin]-monooxygenase MICAL2
MICAL2
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA34470 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti19F → S in BAG57951 (PubMed:14702039).Curated1
Sequence conflicti208D → G in CAD97967 (PubMed:17974005).Curated1
Sequence conflicti296T → A in CAD97967 (PubMed:17974005).Curated1
Sequence conflicti529Q → H in BAG57951 (PubMed:14702039).Curated1
Sequence conflicti563I → V in BAG57951 (PubMed:14702039).Curated1
Sequence conflicti631S → Y in CAD97967 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050155145F → L. Corresponds to variant dbSNP:rs2706656Ensembl.1
Natural variantiVAR_021992220I → V. Corresponds to variant dbSNP:rs2306727Ensembl.1
Natural variantiVAR_050156687D → E. Corresponds to variant dbSNP:rs3794084Ensembl.1
Natural variantiVAR_0202571089R → Q. Corresponds to variant dbSNP:rs2270515Ensembl.1
Natural variantiVAR_0245231106L → P1 PublicationCorresponds to variant dbSNP:rs1027335Ensembl.1
Natural variantiVAR_0501571110P → S. Corresponds to variant dbSNP:rs35518829Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0098591 – 171Missing in isoform 2. 1 PublicationAdd BLAST171
Alternative sequenceiVSP_042593739 – 985Missing in isoform 6. 1 PublicationAdd BLAST247
Alternative sequenceiVSP_042594739 – 928Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST190
Alternative sequenceiVSP_009860740 – 986Missing in isoform 2. 1 PublicationAdd BLAST247
Alternative sequenceiVSP_042595929 – 949Missing in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_042596950 – 985Missing in isoform 4. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_0098611112 – 1124VHFSL…HPLLG → GISTSFFRKVLGWPLRLPRD LCNWMQGLLQAAGLHIRDNA YNYCYMYELLSLGLPLLWAF SEVLAAMYRESEGSLESICN WVLRCFPVKLR in isoform 2, isoform 4 and isoform 6. 2 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB110785 mRNA Translation: BAD83656.1
AB110786 mRNA Translation: BAD83657.1
AB018293 mRNA Translation: BAA34470.2 Different initiation.
AK294845 mRNA Translation: BAG57951.1
AK302893 mRNA Translation: BAH13835.1
BX538021 mRNA Translation: CAD97967.1
BX641163 mRNA Translation: CAE46072.1
AC025106 Genomic DNA No translation available.
AC079329 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68528.1
CH471064 Genomic DNA Translation: EAW68529.1
CH471064 Genomic DNA Translation: EAW68531.1
BC044577 mRNA Translation: AAH44577.1
BK000462 mRNA Translation: DAA01341.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS60726.1 [O94851-3]
CCDS60727.1 [O94851-5]
CCDS60728.1 [O94851-4]
CCDS7809.1 [O94851-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001269592.1, NM_001282663.1 [O94851-1]
NP_001269593.1, NM_001282664.1 [O94851-3]
NP_001269594.1, NM_001282665.1 [O94851-5]
NP_001269595.1, NM_001282666.1 [O94851-4]
NP_001269596.1, NM_001282667.1 [O94851-6]
NP_001333221.1, NM_001346292.1 [O94851-1]
NP_001333222.1, NM_001346293.1 [O94851-3]
NP_001333223.1, NM_001346294.1 [O94851-3]
NP_001333224.1, NM_001346295.1 [O94851-3]
NP_001333225.1, NM_001346296.1 [O94851-3]
NP_001333226.1, NM_001346297.1 [O94851-3]
NP_001333227.1, NM_001346298.1 [O94851-3]
NP_001333228.1, NM_001346299.1 [O94851-3]
NP_055447.1, NM_014632.3 [O94851-1]
XP_016874078.1, XM_017018589.1
XP_016874079.1, XM_017018590.1
XP_016874080.1, XM_017018591.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.501928

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000256194; ENSP00000256194; ENSG00000133816 [O94851-1]
ENST00000527546; ENSP00000433965; ENSG00000133816 [O94851-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9645

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9645

UCSC genome browser

More...
UCSCi
uc001mjz.5 human [O94851-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB110785 mRNA Translation: BAD83656.1
AB110786 mRNA Translation: BAD83657.1
AB018293 mRNA Translation: BAA34470.2 Different initiation.
AK294845 mRNA Translation: BAG57951.1
AK302893 mRNA Translation: BAH13835.1
BX538021 mRNA Translation: CAD97967.1
BX641163 mRNA Translation: CAE46072.1
AC025106 Genomic DNA No translation available.
AC079329 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68528.1
CH471064 Genomic DNA Translation: EAW68529.1
CH471064 Genomic DNA Translation: EAW68531.1
BC044577 mRNA Translation: AAH44577.1
BK000462 mRNA Translation: DAA01341.1
CCDSiCCDS60726.1 [O94851-3]
CCDS60727.1 [O94851-5]
CCDS60728.1 [O94851-4]
CCDS7809.1 [O94851-1]
RefSeqiNP_001269592.1, NM_001282663.1 [O94851-1]
NP_001269593.1, NM_001282664.1 [O94851-3]
NP_001269594.1, NM_001282665.1 [O94851-5]
NP_001269595.1, NM_001282666.1 [O94851-4]
NP_001269596.1, NM_001282667.1 [O94851-6]
NP_001333221.1, NM_001346292.1 [O94851-1]
NP_001333222.1, NM_001346293.1 [O94851-3]
NP_001333223.1, NM_001346294.1 [O94851-3]
NP_001333224.1, NM_001346295.1 [O94851-3]
NP_001333225.1, NM_001346296.1 [O94851-3]
NP_001333226.1, NM_001346297.1 [O94851-3]
NP_001333227.1, NM_001346298.1 [O94851-3]
NP_001333228.1, NM_001346299.1 [O94851-3]
NP_055447.1, NM_014632.3 [O94851-1]
XP_016874078.1, XM_017018589.1
XP_016874079.1, XM_017018590.1
XP_016874080.1, XM_017018591.1
UniGeneiHs.501928

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E9KNMR-A516-629[»]
ProteinModelPortaliO94851
SMRiO94851
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115003, 5 interactors
IntActiO94851, 7 interactors
MINTiO94851
STRINGi9606.ENSP00000256194

PTM databases

iPTMnetiO94851
PhosphoSitePlusiO94851

Polymorphism and mutation databases

BioMutaiMICAL2

Proteomic databases

EPDiO94851
jPOSTiO94851
MaxQBiO94851
PaxDbiO94851
PeptideAtlasiO94851
PRIDEiO94851
ProteomicsDBi50480
50481 [O94851-2]
50482 [O94851-3]
50483 [O94851-4]
50484 [O94851-5]
50485 [O94851-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256194; ENSP00000256194; ENSG00000133816 [O94851-1]
ENST00000527546; ENSP00000433965; ENSG00000133816 [O94851-5]
GeneIDi9645
KEGGihsa:9645
UCSCiuc001mjz.5 human [O94851-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9645
DisGeNETi9645
EuPathDBiHostDB:ENSG00000133816.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MICAL2
HGNCiHGNC:24693 MICAL2
HPAiHPA030437
MIMi608881 gene
neXtProtiNX_O94851
OpenTargetsiENSG00000133816
PharmGKBiPA142671453

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1700 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00940000158780
HOGENOMiHOG000047263
HOVERGENiHBG052474
InParanoidiO94851
KOiK19947
OMAiCSVCATT
OrthoDBi430978at2759
PhylomeDBiO94851
TreeFamiTF324129

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MICAL2 human
EvolutionaryTraceiO94851

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MICAL2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9645

Protein Ontology

More...
PROi
PR:O94851

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000133816 Expressed in 236 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_MICAL2
ExpressionAtlasiO94851 baseline and differential
GenevisibleiO94851 HS

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR002938 FAD-bd
IPR036188 FAD/NAD-bd_sf
IPR029939 MICAL2
IPR001781 Znf_LIM
PANTHERiPTHR44265:SF3 PTHR44265:SF3, 1 hit
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF01494 FAD_binding_3, 1 hit
PF00412 LIM, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00132 LIM, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF51905 SSF51905, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMICA2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94851
Secondary accession number(s): B4DGZ0
, B7Z849, D3DQW5, G3XAC8, Q5KTR3, Q5KTR4, Q7Z3A8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 1, 1999
Last modified: January 16, 2019
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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