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Protein

[F-actin]-monooxygenase MICAL2

Gene

MICAL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:24440334). In the absence of actin, it also functions as a NADPH oxidase producing H2O2 (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (PubMed:24440334).By similarity1 Publication

Catalytic activityi

[F-actin]-L-methionine + NADPH + O2 + H+ = [F-actin]-L-methionine-(R)-S-oxide + NADP+ + H2O.1 Publication

Cofactori

FADBy similarity

Activity regulationi

Specifically inhibited by CCG-1423, a small molecule inhibitor of SRF:MKL1/MRTF-A-dependent transcription.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei97FADBy similarity1
Binding sitei183FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei298FADBy similarity1
Binding sitei398FADBy similarity1
Metal bindingi1002Zinc 1By similarity1
Metal bindingi1005Zinc 1By similarity1
Metal bindingi1023Zinc 1; via pros nitrogenBy similarity1
Metal bindingi1026Zinc 1By similarity1
Metal bindingi1029Zinc 2By similarity1
Metal bindingi1032Zinc 2By similarity1
Metal bindingi1052Zinc 2By similarity1
Metal bindingi1055Zinc 2; via pros nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi116 – 118FADBy similarity3
Nucleotide bindingi123 – 125FADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Monooxygenase, Oxidoreductase
LigandFAD, Flavoprotein, Metal-binding, NADP, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
[F-actin]-monooxygenase MICAL2 (EC:1.14.13.2251 Publication)
Alternative name(s):
Molecule interacting with CasL protein 2
Short name:
MICAL-2
Gene namesi
Name:MICAL2
Synonyms:KIAA0750, MICAL2PV1, MICAL2PV2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000133816.13
HGNCiHGNC:24693 MICAL2
MIMi608881 gene
neXtProtiNX_O94851

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi95G → V: Blocks FAD binding and abolishes catalytic activity. 1 Publication1
Mutagenesisi677 – 681KRRRK → AAAAA in MICAL-2NLSMut; abolishes nuclear localization. 1 Publication5

Organism-specific databases

DisGeNETi9645
OpenTargetsiENSG00000133816
PharmGKBiPA142671453

Polymorphism and mutation databases

BioMutaiMICAL2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758441 – 1124[F-actin]-monooxygenase MICAL2Add BLAST1124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei631PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO94851
MaxQBiO94851
PaxDbiO94851
PeptideAtlasiO94851
PRIDEiO94851
ProteomicsDBi50480
50481 [O94851-2]
50482 [O94851-3]
50483 [O94851-4]
50484 [O94851-5]
50485 [O94851-6]

PTM databases

iPTMnetiO94851
PhosphoSitePlusiO94851

Expressioni

Gene expression databases

BgeeiENSG00000133816 Expressed in 236 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_MICAL2
ExpressionAtlasiO94851 baseline and differential
GenevisibleiO94851 HS

Organism-specific databases

HPAiHPA030437

Interactioni

Subunit structurei

Interacts with PLXNA4 (By similarity). Interacts with RAB1B (PubMed:15694364).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115003, 3 interactors
IntActiO94851, 7 interactors
MINTiO94851
STRINGi9606.ENSP00000256194

Structurei

Secondary structure

11124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO94851
SMRiO94851
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO94851

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini516 – 619Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST104
Domaini1000 – 1062LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 494Monooxygenase domainBy similarityAdd BLAST493

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi660 – 681Nuclear localization signal1 PublicationAdd BLAST22

Sequence similaritiesi

Belongs to the Mical family.Curated

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiKOG1700 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000118856
HOGENOMiHOG000047263
HOVERGENiHBG052474
InParanoidiO94851
KOiK19947
OMAiCSVCATT
OrthoDBiEOG091G009H
PhylomeDBiO94851
TreeFamiTF324129

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR002938 FAD-bd
IPR036188 FAD/NAD-bd_sf
IPR029939 MICAL2
IPR001781 Znf_LIM
PANTHERiPTHR44265:SF3 PTHR44265:SF3, 1 hit
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF01494 FAD_binding_3, 1 hit
PF00412 LIM, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00132 LIM, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF51905 SSF51905, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94851-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGENEDEKQA QAGQVFENFV QASTCKGTLQ AFNILTRHLD LDPLDHRNFY
60 70 80 90 100
SKLKSKVTTW KAKALWYKLD KRGSHKEYKR GKSCTNTKCL IVGGGPCGLR
110 120 130 140 150
TAIELAYLGA KVVVVEKRDS FSRNNVLHLW PFTIHDLRGL GAKKFYGKFC
160 170 180 190 200
AGSIDHISIR QLQLILFKVA LMLGVEIHVN VEFVKVLEPP EDQENQKIGW
210 220 230 240 250
RAEFLPTDHS LSEFEFDVII GADGRRNTLE GFRRKEFRGK LAIAITANFI
260 270 280 290 300
NRNSTAEAKV EEISGVAFIF NQKFFQDLKE ETGIDLENIV YYKDCTHYFV
310 320 330 340 350
MTAKKQSLLD KGVIINDYID TEMLLCAENV NQDNLLSYAR EAADFATNYQ
360 370 380 390 400
LPSLDFAMNH YGQPDVAMFD FTCMYASENA ALVRERQAHQ LLVALVGDSL
410 420 430 440 450
LEPFWPMGTG CARGFLAAFD TAWMVKSWNQ GTPPLELLAE RESLYRLLPQ
460 470 480 490 500
TTPENINKNF EQYTLDPGTR YPNLNSHCVR PHQVKHLYIT KELEHYPLER
510 520 530 540 550
LGSVRRSVNL SRKESDIRPS KLLTWCQQQT EGYQHVNVTD LTTSWRSGLA
560 570 580 590 600
LCAIIHRFRP ELINFDSLNE DDAVENNQLA FDVAEREFGI PPVTTGKEMA
610 620 630 640 650
SAQEPDKLSM VMYLSKFYEL FRGTPLRPVD SWRKNYGENA DLSLAKSSIS
660 670 680 690 700
NNYLNLTFPR KRTPRVDGQT GENDMNKRRR KGFTNLDEPS NFSSRSLGSN
710 720 730 740 750
QECGSSKEGG NQNKVKSMAN QLLAKFEEST RNPSLMKQER RVSGIGKPVL
760 770 780 790 800
CSSSGPPVHS CCPKPEEATP SPSPPLKRQF PSVVVTGHVL RELKQVSAGS
810 820 830 840 850
ECLSRPWRAR AKSDLQLGGT ENFATLPSTR PRAQALSGVL WRLQQVEEKI
860 870 880 890 900
LQKRAQNLAN REFHTKNIKE KAAHLASMFG HGDFPQNKLL SKGLSHTHPP
910 920 930 940 950
SPPSRLPSPD PAASSSPSTV DSASPARKEK KSPSGFHFHP SHLRTVHPQL
960 970 980 990 1000
TVGKVSSGIG AAAEVLVNLY MNDHRPKAQA TSPDLESMRK SFPLNLGGSD
1010 1020 1030 1040 1050
TCYFCKKRVY VMERLSAEGH FFHRECFRCS ICATTLRLAA YTFDCDEGKF
1060 1070 1080 1090 1100
YCKPHFIHCK TNSKQRKRRA ELKQQREEEA TWQEQEAPRR DTPTESSCAV
1110 1120
AAIGTLEGSP PVHFSLPVLH PLLG
Length:1,124
Mass (Da):126,689
Last modified:May 1, 1999 - v1
Checksum:i1C276C42D17B64DF
GO
Isoform 2 (identifier: O94851-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.
     740-986: Missing.
     1112-1124: VHFSLPVLHPLLG → GISTSFFRKV...VLRCFPVKLR

Show »
Length:784
Mass (Da):89,890
Checksum:i114E5873F13E5C61
GO
Isoform 3 (identifier: O94851-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     929-949: Missing.

Show »
Length:1,103
Mass (Da):124,253
Checksum:iEAB33EE2B2DB4BA1
GO
Isoform 4 (identifier: O94851-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     739-928: Missing.
     950-985: Missing.
     1112-1124: VHFSLPVLHPLLG → GISTSFFRKV...VLRCFPVKLR

Show »
Length:976
Mass (Da):111,652
Checksum:iD8B4E819D43FDA7E
GO
Isoform 5 (identifier: O94851-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     739-928: Missing.

Show »
Length:934
Mass (Da):106,211
Checksum:i5CB357AB0F7D4B9E
GO
Isoform 6 (identifier: O94851-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     739-985: Missing.
     1112-1124: VHFSLPVLHPLLG → GISTSFFRKV...VLRCFPVKLR

Show »
Length:955
Mass (Da):109,216
Checksum:i583E6EF7AC29A939
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YFA9A0A2R8YFA9_HUMAN
[F-actin]-monooxygenase MICAL2
MICAL2
1,957Annotation score:
E9PNC3E9PNC3_HUMAN
[F-actin]-monooxygenase MICAL2
MICAL2
120Annotation score:
E9PKI3E9PKI3_HUMAN
[F-actin]-monooxygenase MICAL2
MICAL2
134Annotation score:
E9PRE0E9PRE0_HUMAN
[F-actin]-monooxygenase MICAL2
MICAL2
98Annotation score:
E9PJB0E9PJB0_HUMAN
[F-actin]-monooxygenase MICAL2
MICAL2
88Annotation score:
E9PL42E9PL42_HUMAN
[F-actin]-monooxygenase MICAL2
MICAL2
101Annotation score:
E9PKW5E9PKW5_HUMAN
[F-actin]-monooxygenase MICAL2
MICAL2
88Annotation score:
E9PRG5E9PRG5_HUMAN
[F-actin]-monooxygenase MICAL2
MICAL2
115Annotation score:
A0A2R8Y7K9A0A2R8Y7K9_HUMAN
[F-actin]-monooxygenase MICAL2
MICAL2
130Annotation score:
A0A2R8Y771A0A2R8Y771_HUMAN
[F-actin]-monooxygenase MICAL2
MICAL2
69Annotation score:

Sequence cautioni

The sequence BAA34470 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19F → S in BAG57951 (PubMed:14702039).Curated1
Sequence conflicti208D → G in CAD97967 (PubMed:17974005).Curated1
Sequence conflicti296T → A in CAD97967 (PubMed:17974005).Curated1
Sequence conflicti529Q → H in BAG57951 (PubMed:14702039).Curated1
Sequence conflicti563I → V in BAG57951 (PubMed:14702039).Curated1
Sequence conflicti631S → Y in CAD97967 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050155145F → L. Corresponds to variant dbSNP:rs2706656Ensembl.1
Natural variantiVAR_021992220I → V. Corresponds to variant dbSNP:rs2306727Ensembl.1
Natural variantiVAR_050156687D → E. Corresponds to variant dbSNP:rs3794084Ensembl.1
Natural variantiVAR_0202571089R → Q. Corresponds to variant dbSNP:rs2270515Ensembl.1
Natural variantiVAR_0245231106L → P1 PublicationCorresponds to variant dbSNP:rs1027335Ensembl.1
Natural variantiVAR_0501571110P → S. Corresponds to variant dbSNP:rs35518829Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0098591 – 171Missing in isoform 2. 1 PublicationAdd BLAST171
Alternative sequenceiVSP_042593739 – 985Missing in isoform 6. 1 PublicationAdd BLAST247
Alternative sequenceiVSP_042594739 – 928Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST190
Alternative sequenceiVSP_009860740 – 986Missing in isoform 2. 1 PublicationAdd BLAST247
Alternative sequenceiVSP_042595929 – 949Missing in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_042596950 – 985Missing in isoform 4. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_0098611112 – 1124VHFSL…HPLLG → GISTSFFRKVLGWPLRLPRD LCNWMQGLLQAAGLHIRDNA YNYCYMYELLSLGLPLLWAF SEVLAAMYRESEGSLESICN WVLRCFPVKLR in isoform 2, isoform 4 and isoform 6. 2 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB110785 mRNA Translation: BAD83656.1
AB110786 mRNA Translation: BAD83657.1
AB018293 mRNA Translation: BAA34470.2 Different initiation.
AK294845 mRNA Translation: BAG57951.1
AK302893 mRNA Translation: BAH13835.1
BX538021 mRNA Translation: CAD97967.1
BX641163 mRNA Translation: CAE46072.1
AC025106 Genomic DNA No translation available.
AC079329 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68528.1
CH471064 Genomic DNA Translation: EAW68529.1
CH471064 Genomic DNA Translation: EAW68531.1
BC044577 mRNA Translation: AAH44577.1
BK000462 mRNA Translation: DAA01341.1
CCDSiCCDS60726.1 [O94851-3]
CCDS60727.1 [O94851-5]
CCDS60728.1 [O94851-4]
CCDS7809.1 [O94851-1]
RefSeqiNP_001269592.1, NM_001282663.1 [O94851-1]
NP_001269593.1, NM_001282664.1 [O94851-3]
NP_001269594.1, NM_001282665.1 [O94851-5]
NP_001269595.1, NM_001282666.1 [O94851-4]
NP_001269596.1, NM_001282667.1 [O94851-6]
NP_001333221.1, NM_001346292.1 [O94851-1]
NP_001333222.1, NM_001346293.1 [O94851-3]
NP_001333223.1, NM_001346294.1 [O94851-3]
NP_001333224.1, NM_001346295.1 [O94851-3]
NP_001333225.1, NM_001346296.1 [O94851-3]
NP_001333226.1, NM_001346297.1 [O94851-3]
NP_001333227.1, NM_001346298.1 [O94851-3]
NP_001333228.1, NM_001346299.1 [O94851-3]
NP_055447.1, NM_014632.3 [O94851-1]
XP_016874078.1, XM_017018589.1
XP_016874079.1, XM_017018590.1
XP_016874080.1, XM_017018591.1
UniGeneiHs.501928

Genome annotation databases

EnsembliENST00000256194; ENSP00000256194; ENSG00000133816 [O94851-1]
ENST00000342902; ENSP00000344894; ENSG00000133816 [O94851-3]
ENST00000379612; ENSP00000368932; ENSG00000133816 [O94851-4]
ENST00000527546; ENSP00000433965; ENSG00000133816 [O94851-5]
ENST00000537344; ENSP00000441689; ENSG00000133816 [O94851-1]
GeneIDi9645
KEGGihsa:9645
UCSCiuc001mjz.5 human [O94851-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB110785 mRNA Translation: BAD83656.1
AB110786 mRNA Translation: BAD83657.1
AB018293 mRNA Translation: BAA34470.2 Different initiation.
AK294845 mRNA Translation: BAG57951.1
AK302893 mRNA Translation: BAH13835.1
BX538021 mRNA Translation: CAD97967.1
BX641163 mRNA Translation: CAE46072.1
AC025106 Genomic DNA No translation available.
AC079329 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68528.1
CH471064 Genomic DNA Translation: EAW68529.1
CH471064 Genomic DNA Translation: EAW68531.1
BC044577 mRNA Translation: AAH44577.1
BK000462 mRNA Translation: DAA01341.1
CCDSiCCDS60726.1 [O94851-3]
CCDS60727.1 [O94851-5]
CCDS60728.1 [O94851-4]
CCDS7809.1 [O94851-1]
RefSeqiNP_001269592.1, NM_001282663.1 [O94851-1]
NP_001269593.1, NM_001282664.1 [O94851-3]
NP_001269594.1, NM_001282665.1 [O94851-5]
NP_001269595.1, NM_001282666.1 [O94851-4]
NP_001269596.1, NM_001282667.1 [O94851-6]
NP_001333221.1, NM_001346292.1 [O94851-1]
NP_001333222.1, NM_001346293.1 [O94851-3]
NP_001333223.1, NM_001346294.1 [O94851-3]
NP_001333224.1, NM_001346295.1 [O94851-3]
NP_001333225.1, NM_001346296.1 [O94851-3]
NP_001333226.1, NM_001346297.1 [O94851-3]
NP_001333227.1, NM_001346298.1 [O94851-3]
NP_001333228.1, NM_001346299.1 [O94851-3]
NP_055447.1, NM_014632.3 [O94851-1]
XP_016874078.1, XM_017018589.1
XP_016874079.1, XM_017018590.1
XP_016874080.1, XM_017018591.1
UniGeneiHs.501928

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E9KNMR-A516-629[»]
ProteinModelPortaliO94851
SMRiO94851
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115003, 3 interactors
IntActiO94851, 7 interactors
MINTiO94851
STRINGi9606.ENSP00000256194

PTM databases

iPTMnetiO94851
PhosphoSitePlusiO94851

Polymorphism and mutation databases

BioMutaiMICAL2

Proteomic databases

EPDiO94851
MaxQBiO94851
PaxDbiO94851
PeptideAtlasiO94851
PRIDEiO94851
ProteomicsDBi50480
50481 [O94851-2]
50482 [O94851-3]
50483 [O94851-4]
50484 [O94851-5]
50485 [O94851-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256194; ENSP00000256194; ENSG00000133816 [O94851-1]
ENST00000342902; ENSP00000344894; ENSG00000133816 [O94851-3]
ENST00000379612; ENSP00000368932; ENSG00000133816 [O94851-4]
ENST00000527546; ENSP00000433965; ENSG00000133816 [O94851-5]
ENST00000537344; ENSP00000441689; ENSG00000133816 [O94851-1]
GeneIDi9645
KEGGihsa:9645
UCSCiuc001mjz.5 human [O94851-1]

Organism-specific databases

CTDi9645
DisGeNETi9645
EuPathDBiHostDB:ENSG00000133816.13
GeneCardsiMICAL2
HGNCiHGNC:24693 MICAL2
HPAiHPA030437
MIMi608881 gene
neXtProtiNX_O94851
OpenTargetsiENSG00000133816
PharmGKBiPA142671453
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1700 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000118856
HOGENOMiHOG000047263
HOVERGENiHBG052474
InParanoidiO94851
KOiK19947
OMAiCSVCATT
OrthoDBiEOG091G009H
PhylomeDBiO94851
TreeFamiTF324129

Miscellaneous databases

ChiTaRSiMICAL2 human
EvolutionaryTraceiO94851
GeneWikiiMICAL2
GenomeRNAii9645
PROiPR:O94851
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133816 Expressed in 236 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_MICAL2
ExpressionAtlasiO94851 baseline and differential
GenevisibleiO94851 HS

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR002938 FAD-bd
IPR036188 FAD/NAD-bd_sf
IPR029939 MICAL2
IPR001781 Znf_LIM
PANTHERiPTHR44265:SF3 PTHR44265:SF3, 1 hit
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF01494 FAD_binding_3, 1 hit
PF00412 LIM, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00132 LIM, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF51905 SSF51905, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMICA2_HUMAN
AccessioniPrimary (citable) accession number: O94851
Secondary accession number(s): B4DGZ0
, B7Z849, D3DQW5, G3XAC8, Q5KTR3, Q5KTR4, Q7Z3A8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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