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Protein

Rho-related BTB domain-containing protein 1

Gene

RHOBTB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 28GTPSequence analysis8
Nucleotide bindingi84 – 88GTPSequence analysis5
Nucleotide bindingi140 – 143GTPSequence analysis4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: GO_Central
  • protein kinase binding Source: GO_Central

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related BTB domain-containing protein 1
Gene namesi
Name:RHOBTB1
Synonyms:KIAA0740
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000072422.16
HGNCiHGNC:18738 RHOBTB1
MIMi607351 gene
neXtProtiNX_O94844

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9886
OpenTargetsiENSG00000072422
PharmGKBiPA38664

Polymorphism and mutation databases

BioMutaiRHOBTB1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001989601 – 696Rho-related BTB domain-containing protein 1Add BLAST696

Proteomic databases

EPDiO94844
PaxDbiO94844
PeptideAtlasiO94844
PRIDEiO94844
ProteomicsDBi50478

PTM databases

iPTMnetiO94844
PhosphoSitePlusiO94844

Expressioni

Tissue specificityi

Ubiquitous, with highest levels in skeletal muscle, placenta, testis, stomach, and kidney, followed by uterus and adrenal gland. Expressed in a variety of fetal tissues.1 Publication

Gene expression databases

BgeeiENSG00000072422 Expressed in 221 organ(s), highest expression level in placenta
CleanExiHS_RHOBTB1
ExpressionAtlasiO94844 baseline and differential
GenevisibleiO94844 HS

Organism-specific databases

HPAiHPA040205
HPA040226

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115217, 22 interactors
IntActiO94844, 2 interactors
STRINGi9606.ENSP00000338671

Structurei

3D structure databases

ProteinModelPortaliO94844
SMRiO94844
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini266 – 427BTB 1PROSITE-ProRule annotationAdd BLAST162
Domaini485 – 552BTB 2PROSITE-ProRule annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 210Rho-likeAdd BLAST210

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000119020
HOGENOMiHOG000007723
HOVERGENiHBG054987
InParanoidiO94844
KOiK07868
OMAiEMQVNPV
OrthoDBiEOG091G03I3
PhylomeDBiO94844
TreeFamiTF323347

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR027417 P-loop_NTPase
IPR011333 SKP1/BTB/POZ_sf
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00651 BTB, 2 hits
PF00071 Ras, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 2 hits
SUPFAMiSSF52540 SSF52540, 1 hit
SSF54695 SSF54695, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 2 hits
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

O94844-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDADMDYERP NVETIKCVVV GDNAVGKTRL ICARACNTTL TQYQLLATHV
60 70 80 90 100
PTVWAIDQYR VCQEVLERSR DVVDEVSVSL RLWDTFGDHH KDRRFAYGRS
110 120 130 140 150
DVVVLCFSIA NPNSLNHVKS MWYPEIKHFC PRTPVILVGC QLDLRYADLE
160 170 180 190 200
AVNRARRPLA RPIKRGDILP PEKGREVAKE LGLPYYETSV FDQFGIKDVF
210 220 230 240 250
DNAIRAALIS RRHLQFWKSH LKKVQKPLLQ APFLPPKAPP PVIKIPECPS
260 270 280 290 300
MGTNEAACLL DNPLCADVLF ILQDQEHIFA HRIYLATSSS KFYDLFLMEC
310 320 330 340 350
EESPNGSEGA CEKEKQSRDF QGRILSVDPE EEREEGPPRI PQADQWKSSN
360 370 380 390 400
KSLVEALGLE AEGAVPETQT LTGWSKGFIG MHREMQVNPI SKRMGPMTVV
410 420 430 440 450
RMDASVQPGP FRTLLQFLYT GQLDEKEKDL VGLAQIAEVL EMFDLRMMVE
460 470 480 490 500
NIMNKEAFMN QEITKAFHVR KANRIKECLS KGTFSDVTFK LDDGAISAHK
510 520 530 540 550
PLLICSCEWM AAMFGGSFVE SANSEVYLPN INKISMQAVL DYLYTKQLSP
560 570 580 590 600
NLDLDPLELI ALANRFCLPH LVALAEQHAV QELTKAATSG VGIDGEVLSY
610 620 630 640 650
LELAQFHNAH QLAAWCLHHI CTNYNSVCSK FRKEIKSKSA DNQEYFERHR
660 670 680 690
WPPVWYLKEE DHYQRVKRER EKEDIALNKH RSRRKWCFWN SSPAVA
Length:696
Mass (Da):79,417
Last modified:May 1, 2000 - v2
Checksum:i41ECB4425CD32A1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018283 mRNA Translation: BAA34460.2
AK075129 mRNA Translation: BAC11421.1
BC032848 mRNA Translation: AAH32848.1
BC041791 mRNA Translation: AAH41791.1
CCDSiCCDS7261.1
RefSeqiNP_001229288.1, NM_001242359.1
NP_055651.1, NM_014836.4
XP_006718147.1, XM_006718084.1
XP_006718148.1, XM_006718085.1
XP_011538726.1, XM_011540424.1
XP_016872489.1, XM_017017000.1
XP_016872490.1, XM_017017001.1
UniGeneiHs.737374

Genome annotation databases

EnsembliENST00000337910; ENSP00000338671; ENSG00000072422
ENST00000357917; ENSP00000350595; ENSG00000072422
GeneIDi9886
KEGGihsa:9886
UCSCiuc001jlh.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018283 mRNA Translation: BAA34460.2
AK075129 mRNA Translation: BAC11421.1
BC032848 mRNA Translation: AAH32848.1
BC041791 mRNA Translation: AAH41791.1
CCDSiCCDS7261.1
RefSeqiNP_001229288.1, NM_001242359.1
NP_055651.1, NM_014836.4
XP_006718147.1, XM_006718084.1
XP_006718148.1, XM_006718085.1
XP_011538726.1, XM_011540424.1
XP_016872489.1, XM_017017000.1
XP_016872490.1, XM_017017001.1
UniGeneiHs.737374

3D structure databases

ProteinModelPortaliO94844
SMRiO94844
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115217, 22 interactors
IntActiO94844, 2 interactors
STRINGi9606.ENSP00000338671

PTM databases

iPTMnetiO94844
PhosphoSitePlusiO94844

Polymorphism and mutation databases

BioMutaiRHOBTB1

Proteomic databases

EPDiO94844
PaxDbiO94844
PeptideAtlasiO94844
PRIDEiO94844
ProteomicsDBi50478

Protocols and materials databases

DNASUi9886
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337910; ENSP00000338671; ENSG00000072422
ENST00000357917; ENSP00000350595; ENSG00000072422
GeneIDi9886
KEGGihsa:9886
UCSCiuc001jlh.4 human

Organism-specific databases

CTDi9886
DisGeNETi9886
EuPathDBiHostDB:ENSG00000072422.16
GeneCardsiRHOBTB1
HGNCiHGNC:18738 RHOBTB1
HPAiHPA040205
HPA040226
MIMi607351 gene
neXtProtiNX_O94844
OpenTargetsiENSG00000072422
PharmGKBiPA38664
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000119020
HOGENOMiHOG000007723
HOVERGENiHBG054987
InParanoidiO94844
KOiK07868
OMAiEMQVNPV
OrthoDBiEOG091G03I3
PhylomeDBiO94844
TreeFamiTF323347

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRSiRHOBTB1 human
GeneWikiiRHOBTB1
GenomeRNAii9886
PROiPR:O94844
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000072422 Expressed in 221 organ(s), highest expression level in placenta
CleanExiHS_RHOBTB1
ExpressionAtlasiO94844 baseline and differential
GenevisibleiO94844 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR027417 P-loop_NTPase
IPR011333 SKP1/BTB/POZ_sf
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00651 BTB, 2 hits
PF00071 Ras, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 2 hits
SUPFAMiSSF52540 SSF52540, 1 hit
SSF54695 SSF54695, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 2 hits
PS51420 RHO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRHBT1_HUMAN
AccessioniPrimary (citable) accession number: O94844
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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