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Protein

Importin-13

Gene

IPO13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.By similarity2 Publications

GO - Molecular functioni

  • nuclear localization sequence binding Source: GO_Central
  • protein transporter activity Source: GO_Central
  • Ran GTPase binding Source: InterPro

GO - Biological processi

  • protein import into nucleus Source: MGI

Keywordsi

Biological processProtein transport, Transport

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Importin-13
Short name:
Imp13
Alternative name(s):
Karyopherin-13
Short name:
Kap13
Ran-binding protein 13
Short name:
RanBP13
Gene namesi
Name:IPO13
Synonyms:KIAA0724, RANBP13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117408.10
HGNCiHGNC:16853 IPO13
MIMi610411 gene
neXtProtiNX_O94829

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9670
OpenTargetsiENSG00000117408
PharmGKBiPA134981096

Polymorphism and mutation databases

BioMutaiIPO13

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207581 – 963Importin-13Add BLAST963

Proteomic databases

EPDiO94829
MaxQBiO94829
PaxDbiO94829
PeptideAtlasiO94829
PRIDEiO94829
ProteomicsDBi50474

PTM databases

iPTMnetiO94829
PhosphoSitePlusiO94829

Expressioni

Tissue specificityi

Expressed in fetal brain, heart, intestine and kidney.1 Publication

Gene expression databases

BgeeiENSG00000117408 Expressed in 215 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_IPO13
ExpressionAtlasiO94829 baseline and differential
GenevisibleiO94829 HS

Organism-specific databases

HPAiCAB070425

Interactioni

Subunit structurei

Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115025, 38 interactors
CORUMiO94829
IntActiO94829, 19 interactors
MINTiO94829
STRINGi9606.ENSP00000361418

Structurei

Secondary structure

1963
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO94829
SMRiO94829
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO94829

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 54HEAT 11 PublicationAdd BLAST31
Domaini45 – 111Importin N-terminalPROSITE-ProRule annotationAdd BLAST67
Repeati56 – 88HEAT 21 PublicationAdd BLAST33
Repeati95 – 135HEAT 31 PublicationAdd BLAST41
Repeati142 – 179HEAT 41 PublicationAdd BLAST38
Repeati194 – 231HEAT 51 PublicationAdd BLAST38
Repeati236 – 268HEAT 61 PublicationAdd BLAST33
Repeati276 – 325HEAT 71 PublicationAdd BLAST50
Repeati330 – 372HEAT 81 PublicationAdd BLAST43
Repeati375 – 438HEAT 91 PublicationAdd BLAST64
Repeati440 – 476HEAT 101 PublicationAdd BLAST37
Repeati487 – 522HEAT 111 PublicationAdd BLAST36
Repeati524 – 558HEAT 121 PublicationAdd BLAST35
Repeati562 – 600HEAT 131 PublicationAdd BLAST39
Repeati603 – 648HEAT 141 PublicationAdd BLAST46
Repeati676 – 716HEAT 151 PublicationAdd BLAST41
Repeati720 – 754HEAT 161 PublicationAdd BLAST35
Repeati761 – 803HEAT 171 PublicationAdd BLAST43
Repeati815 – 845HEAT 181 PublicationAdd BLAST31
Repeati860 – 893HEAT 191 PublicationAdd BLAST34
Repeati897 – 931HEAT 201 PublicationAdd BLAST35

Sequence similaritiesi

Belongs to the importin beta family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2022 Eukaryota
ENOG410XT8Y LUCA
GeneTreeiENSGT00530000063347
HOVERGENiHBG052141
InParanoidiO94829
OMAiVLNRLCI
OrthoDBiEOG091G01CP
PhylomeDBiO94829
TreeFamiTF314539

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013598 Exportin-1/Importin-b-like
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
PF08389 Xpo1, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O94829-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERREEQPGA AGAGAAPALD FTVENVEKAL HQLYYDPNIE NKNLAQKWLM
60 70 80 90 100
QAQVSPQAWH FSWQLLQPDK VPEIQYFGAS ALHIKISRYW SDIPTDQYES
110 120 130 140 150
LKAQLFTQIT RFASGSKIVL TRLCVALASL ALSMMPDAWP CAVADMVRLF
160 170 180 190 200
QAEDSPVDGQ GRCLALLELL TVLPEEFQTS RLPQYRKGLV RTSLAVECGA
210 220 230 240 250
VFPLLEQLLQ QPSSPSCVRQ KVLKCFSSWV QLEVPLQDCE ALIQAAFAAL
260 270 280 290 300
QDSELFDSSV EAIVNAISQP DAQRYVNTLL KLIPLVLGLQ EQLRQAVQNG
310 320 330 340 350
DMETSHGICR IAVALGENHS RALLDQVEHW QSFLALVNMI MFCTGIPGHY
360 370 380 390 400
PVNETTSSLT LTFWYTLQDD ILSFEAEKQA VYQQVYRPVY FQLVDVLLHK
410 420 430 440 450
AQFPSDEEYG FWSSDEKEQF RIYRVDISDT LMYVYEMLGA ELLSNLYDKL
460 470 480 490 500
GRLLTSSEEP YSWQHTEALL YGFQSIAETI DVNYSDVVPG LIGLIPRISI
510 520 530 540 550
SNVQLADTVM FTIGALSEWL ADHPVMINSV LPLVLHALGN PELSVSSVST
560 570 580 590 600
LKKICRECKY DLPPYAANIV AVSQDVLMKQ IHKTSQCMWL MQALGFLLSA
610 620 630 640 650
LQVEEILKNL HSLISPYIQQ LEKLAEEIPN PSNKLAIVHI LGLLSNLFTT
660 670 680 690 700
LDISHHEDDH EGPELRKLPV PQGPNPVVVV LQQVFQLIQK VLSKWLNDAQ
710 720 730 740 750
VVEAVCAIFE KSVKTLLDDF APMVPQLCEM LGRMYSTIPQ ASALDLTRQL
760 770 780 790 800
VHIFAHEPAH FPPIEALFLL VTSVTLTLFQ QGPRDHPDIV DSFMQLLAQA
810 820 830 840 850
LKRKPDLFLC ERLDVKAVFQ CAVLALKFPE APTVKASCGF FTELLPRCGE
860 870 880 890 900
VESVGKVVQE DGRMLLIAVL EAIGGQASRS LMDCFADILF ALNKHCFSLL
910 920 930 940 950
SMWIKEALQP PGFPSARLSP EQKDTFSQQI LRERVNKRRV KEMVKEFTLL
960
CRGLHGTDYT ADY
Length:963
Mass (Da):108,195
Last modified:July 19, 2004 - v3
Checksum:i8C696EE2B92365F0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T4X2Q5T4X2_HUMAN
cDNA FLJ34246 fis, clone FCBBF40000...
IPO13
181Annotation score:

Sequence cautioni

The sequence BAA34444 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB14575 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti202F → V in CAB55966 (PubMed:17974005).Curated1
Sequence conflicti715T → A in BAB14575 (PubMed:14702039).Curated1
Sequence conflicti817A → S in AAH08194 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267987 mRNA Translation: AAF73471.1
AB018267 mRNA Translation: BAA34444.2 Different initiation.
AL357079 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07072.1
CH471059 Genomic DNA Translation: EAX07073.1
BC008194 mRNA Translation: AAH08194.1
AL117501 mRNA Translation: CAB55966.1
AK023441 mRNA Translation: BAB14575.1 Different initiation.
CCDSiCCDS503.1
PIRiT17276
RefSeqiNP_055467.3, NM_014652.3
UniGeneiHs.158497

Genome annotation databases

EnsembliENST00000372343; ENSP00000361418; ENSG00000117408
GeneIDi9670
KEGGihsa:9670
UCSCiuc001ckx.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267987 mRNA Translation: AAF73471.1
AB018267 mRNA Translation: BAA34444.2 Different initiation.
AL357079 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07072.1
CH471059 Genomic DNA Translation: EAX07073.1
BC008194 mRNA Translation: AAH08194.1
AL117501 mRNA Translation: CAB55966.1
AK023441 mRNA Translation: BAB14575.1 Different initiation.
CCDSiCCDS503.1
PIRiT17276
RefSeqiNP_055467.3, NM_014652.3
UniGeneiHs.158497

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2X19X-ray2.80B1-963[»]
2XWUX-ray2.80B1-963[»]
3ZJYX-ray3.60B/E/G1-963[»]
ProteinModelPortaliO94829
SMRiO94829
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115025, 38 interactors
CORUMiO94829
IntActiO94829, 19 interactors
MINTiO94829
STRINGi9606.ENSP00000361418

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiO94829
PhosphoSitePlusiO94829

Polymorphism and mutation databases

BioMutaiIPO13

Proteomic databases

EPDiO94829
MaxQBiO94829
PaxDbiO94829
PeptideAtlasiO94829
PRIDEiO94829
ProteomicsDBi50474

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372343; ENSP00000361418; ENSG00000117408
GeneIDi9670
KEGGihsa:9670
UCSCiuc001ckx.4 human

Organism-specific databases

CTDi9670
DisGeNETi9670
EuPathDBiHostDB:ENSG00000117408.10
GeneCardsiIPO13
HGNCiHGNC:16853 IPO13
HPAiCAB070425
MIMi610411 gene
neXtProtiNX_O94829
OpenTargetsiENSG00000117408
PharmGKBiPA134981096
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2022 Eukaryota
ENOG410XT8Y LUCA
GeneTreeiENSGT00530000063347
HOVERGENiHBG052141
InParanoidiO94829
OMAiVLNRLCI
OrthoDBiEOG091G01CP
PhylomeDBiO94829
TreeFamiTF314539

Miscellaneous databases

ChiTaRSiIPO13 human
EvolutionaryTraceiO94829
GeneWikiiIPO13
GenomeRNAii9670
PROiPR:O94829
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000117408 Expressed in 215 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_IPO13
ExpressionAtlasiO94829 baseline and differential
GenevisibleiO94829 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013598 Exportin-1/Importin-b-like
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
PF08389 Xpo1, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIPO13_HUMAN
AccessioniPrimary (citable) accession number: O94829
Secondary accession number(s): D3DPY4
, Q5T4X3, Q7LC04, Q96HS3, Q9H8N3, Q9UFR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 7, 2018
This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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