UniProtKB - O94829 (IPO13_HUMAN)

BLAST

>sp|O94829|IPO13_HUMAN Importin-13 OS=Homo sapiens OX=9606 GN=IPO13 PE=1 SV=3
MERREEQPGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWH
FSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVL
TRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDGQGRCLALLELLTVLPEEFQTS
RLPQYRKGLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCE
ALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQEQLRQAVQNG
DMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHYPVNETTSSLT
LTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQF
RIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETI
DVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGN
PELSVSSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSA
LQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTTLDISHHEDDH
EGPELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDF
APMVPQLCEMLGRMYSTIPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLTLFQ
QGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGF
FTELLPRCGEVESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLL
SMWIKEALQPPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYT
ADY

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History
Entry version 153 (07 Nov 2018)
Sequence version 3 (19 Jul 2004)
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Protein

Importin-13

Gene

IPO13

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.By similarity2 Publications

GO - Molecular functionⁱ

nuclear localization sequence binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
Ran GTPase binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein import into nucleus
Source: MGI
Inferred from direct assayⁱ
- 15964792

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Importin-13 Short name: Imp13 Alternative name(s): Karyopherin-13 Short name: Kap13 Ran-binding protein 13 Short name: RanBP13
Gene namesⁱ	Name:IPO13 Synonyms:KIAA0724, RANBP13
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000117408.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16853 IPO13
MIMⁱ	610411 gene
neXtProtⁱ	NX_O94829

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9670
Open Targets More...OpenTargetsⁱ	ENSG00000117408
PharmGKBⁱ	PA134981096

Polymorphism and mutation databases

BioMutaⁱ	IPO13

BioMutaⁱ

IPO13

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000120758	1 – 963	Importin-13Add BLAST		963

Proteomic databases

EPDⁱ	O94829
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O94829
PaxDbⁱ	O94829
PeptideAtlas More...PeptideAtlasⁱ	O94829
PRIDEⁱ	O94829
ProteomicsDBⁱ	50474

PTM databases

iPTMnetⁱ	O94829
PhosphoSitePlusⁱ	O94829

Expressionⁱ

Tissue specificityⁱ

Expressed in fetal brain, heart, intestine and kidney.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000117408 Expressed in 215 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_IPO13
ExpressionAtlasⁱ	O94829 baseline and differential
Genevisibleⁱ	O94829 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB070425

HPAⁱ

CAB070425

Interactionⁱ

Subunit structureⁱ

Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ALX1	Q15699	2	EBI-747310,EBI-750671
DUX4	Q9UBX2	2	EBI-747310,EBI-11600078
DUX4L9	Q6RFH8	2	EBI-747310,EBI-11599882
EIF1AX	P47813	14	EBI-747310,EBI-1045377
MAGOH	P61326	4	EBI-747310,EBI-299134
PBX4	Q9BYU1	5	EBI-747310,EBI-10302990
RAN	P62826	13	EBI-747310,EBI-286642
UBE2I	P63279	6	EBI-747310,EBI-80168

GO - Molecular functionⁱ

Ran GTPase binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115025, 38 interactors
CORUMⁱ	O94829
IntActⁱ	O94829, 19 interactors
Molecular INTeraction database More...MINTⁱ	O94829
STRINGⁱ	9606.ENSP00000361418

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	23 – 35	Combined sources	13
Helixⁱ	39 – 54	Combined sources	16
Helixⁱ	58 – 65	Combined sources	8
Helixⁱ	72 – 88	Combined sources	17
Helixⁱ	90 – 92	Combined sources	3
Helixⁱ	95 – 97	Combined sources	3
Helixⁱ	98 – 111	Combined sources	14
Turnⁱ	112 – 114	Combined sources	3
Helixⁱ	117 – 134	Combined sources	18
Turnⁱ	135 – 138	Combined sources	4
Helixⁱ	142 – 150	Combined sources	9
Helixⁱ	160 – 177	Combined sources	18
Helixⁱ	195 – 197	Combined sources	3
Helixⁱ	198 – 209	Combined sources	12
Helixⁱ	216 – 230	Combined sources	15
Turnⁱ	231 – 233	Combined sources	3
Helixⁱ	236 – 238	Combined sources	3
Helixⁱ	240 – 249	Combined sources	10
Turnⁱ	253 – 255	Combined sources	3
Helixⁱ	256 – 267	Combined sources	12
Helixⁱ	272 – 274	Combined sources	3
Helixⁱ	276 – 287	Combined sources	12
Helixⁱ	290 – 298	Combined sources	9
Helixⁱ	302 – 325	Combined sources	24
Helixⁱ	327 – 329	Combined sources	3
Helixⁱ	330 – 344	Combined sources	15
Turnⁱ	350 – 353	Combined sources	4
Helixⁱ	355 – 360	Combined sources	6
Helixⁱ	361 – 371	Combined sources	11
Helixⁱ	376 – 401	Combined sources	26
Helixⁱ	406 – 410	Combined sources	5
Helixⁱ	414 – 438	Combined sources	25
Helixⁱ	440 – 455	Combined sources	16
Helixⁱ	463 – 476	Combined sources	14
Turnⁱ	483 – 486	Combined sources	4
Helixⁱ	487 – 494	Combined sources	8
Helixⁱ	495 – 497	Combined sources	3
Helixⁱ	503 – 515	Combined sources	13
Helixⁱ	517 – 522	Combined sources	6
Helixⁱ	524 – 527	Combined sources	4
Turnⁱ	528 – 530	Combined sources	3
Helixⁱ	531 – 537	Combined sources	7
Helixⁱ	541 – 543	Combined sources	3
Helixⁱ	544 – 557	Combined sources	14
Helixⁱ	559 – 561	Combined sources	3
Turnⁱ	563 – 565	Combined sources	3
Helixⁱ	566 – 578	Combined sources	13
Helixⁱ	584 – 598	Combined sources	15
Helixⁱ	603 – 625	Combined sources	23
Helixⁱ	631 – 650	Combined sources	20
Helixⁱ	676 – 695	Combined sources	20
Helixⁱ	699 – 715	Combined sources	17
Beta strandⁱ	716 – 718	Combined sources	3
Helixⁱ	721 – 723	Combined sources	3
Helixⁱ	724 – 737	Combined sources	14
Helixⁱ	741 – 754	Combined sources	14
Turnⁱ	758 – 760	Combined sources	3
Helixⁱ	762 – 781	Combined sources	20
Turnⁱ	783 – 785	Combined sources	3
Helixⁱ	787 – 803	Combined sources	17
Helixⁱ	805 – 809	Combined sources	5
Helixⁱ	815 – 825	Combined sources	11
Helixⁱ	831 – 844	Combined sources	14
Helixⁱ	845 – 847	Combined sources	3
Helixⁱ	853 – 857	Combined sources	5
Turnⁱ	858 – 860	Combined sources	3
Helixⁱ	862 – 873	Combined sources	12
Turnⁱ	874 – 876	Combined sources	3
Helixⁱ	879 – 881	Combined sources	3
Helixⁱ	882 – 895	Combined sources	14
Helixⁱ	897 – 907	Combined sources	11
Helixⁱ	920 – 930	Combined sources	11
Helixⁱ	937 – 952	Combined sources	16

Show more details

3D structure databases

ProteinModelPortalⁱ	O94829
SMRⁱ	O94829
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O94829

EvolutionaryTraceⁱ

O94829

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	24 – 54	HEAT 11 PublicationAdd BLAST	31
Domainⁱ	45 – 111	Importin N-terminalPROSITE-ProRule annotationAdd BLAST	67
Repeatⁱ	56 – 88	HEAT 21 PublicationAdd BLAST	33
Repeatⁱ	95 – 135	HEAT 31 PublicationAdd BLAST	41
Repeatⁱ	142 – 179	HEAT 41 PublicationAdd BLAST	38
Repeatⁱ	194 – 231	HEAT 51 PublicationAdd BLAST	38
Repeatⁱ	236 – 268	HEAT 61 PublicationAdd BLAST	33
Repeatⁱ	276 – 325	HEAT 71 PublicationAdd BLAST	50
Repeatⁱ	330 – 372	HEAT 81 PublicationAdd BLAST	43
Repeatⁱ	375 – 438	HEAT 91 PublicationAdd BLAST	64
Repeatⁱ	440 – 476	HEAT 101 PublicationAdd BLAST	37
Repeatⁱ	487 – 522	HEAT 111 PublicationAdd BLAST	36
Repeatⁱ	524 – 558	HEAT 121 PublicationAdd BLAST	35
Repeatⁱ	562 – 600	HEAT 131 PublicationAdd BLAST	39
Repeatⁱ	603 – 648	HEAT 141 PublicationAdd BLAST	46
Repeatⁱ	676 – 716	HEAT 151 PublicationAdd BLAST	41
Repeatⁱ	720 – 754	HEAT 161 PublicationAdd BLAST	35
Repeatⁱ	761 – 803	HEAT 171 PublicationAdd BLAST	43
Repeatⁱ	815 – 845	HEAT 181 PublicationAdd BLAST	31
Repeatⁱ	860 – 893	HEAT 191 PublicationAdd BLAST	34
Repeatⁱ	897 – 931	HEAT 201 PublicationAdd BLAST	35

Sequence similaritiesⁱ

Belongs to the importin beta family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG2022 Eukaryota ENOG410XT8Y LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063347
HOVERGENⁱ	HBG052141
InParanoidⁱ	O94829
OMAⁱ	VLNRLCI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01CP
PhylomeDBⁱ	O94829
TreeFamⁱ	TF314539

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR013598 Exportin-1/Importin-b-like IPR001494 Importin-beta_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03810 IBN_N, 1 hit PF08389 Xpo1, 1 hit
SMARTⁱ	View protein in SMART SM00913 IBN_N, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
PROSITEⁱ	View protein in PROSITE PS50166 IMPORTIN_B_NT, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

O94829-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MERREEQPGA AGAGAAPALD FTVENVEKAL HQLYYDPNIE NKNLAQKWLM 
        60         70         80         90        100
QAQVSPQAWH FSWQLLQPDK VPEIQYFGAS ALHIKISRYW SDIPTDQYES 
       110        120        130        140        150
LKAQLFTQIT RFASGSKIVL TRLCVALASL ALSMMPDAWP CAVADMVRLF 
       160        170        180        190        200
QAEDSPVDGQ GRCLALLELL TVLPEEFQTS RLPQYRKGLV RTSLAVECGA 
       210        220        230        240        250
VFPLLEQLLQ QPSSPSCVRQ KVLKCFSSWV QLEVPLQDCE ALIQAAFAAL 
       260        270        280        290        300
QDSELFDSSV EAIVNAISQP DAQRYVNTLL KLIPLVLGLQ EQLRQAVQNG 
       310        320        330        340        350
DMETSHGICR IAVALGENHS RALLDQVEHW QSFLALVNMI MFCTGIPGHY 
       360        370        380        390        400
PVNETTSSLT LTFWYTLQDD ILSFEAEKQA VYQQVYRPVY FQLVDVLLHK 
       410        420        430        440        450
AQFPSDEEYG FWSSDEKEQF RIYRVDISDT LMYVYEMLGA ELLSNLYDKL 
       460        470        480        490        500
GRLLTSSEEP YSWQHTEALL YGFQSIAETI DVNYSDVVPG LIGLIPRISI 
       510        520        530        540        550
SNVQLADTVM FTIGALSEWL ADHPVMINSV LPLVLHALGN PELSVSSVST 
       560        570        580        590        600
LKKICRECKY DLPPYAANIV AVSQDVLMKQ IHKTSQCMWL MQALGFLLSA 
       610        620        630        640        650
LQVEEILKNL HSLISPYIQQ LEKLAEEIPN PSNKLAIVHI LGLLSNLFTT 
       660        670        680        690        700
LDISHHEDDH EGPELRKLPV PQGPNPVVVV LQQVFQLIQK VLSKWLNDAQ 
       710        720        730        740        750
VVEAVCAIFE KSVKTLLDDF APMVPQLCEM LGRMYSTIPQ ASALDLTRQL 
       760        770        780        790        800
VHIFAHEPAH FPPIEALFLL VTSVTLTLFQ QGPRDHPDIV DSFMQLLAQA 
       810        820        830        840        850
LKRKPDLFLC ERLDVKAVFQ CAVLALKFPE APTVKASCGF FTELLPRCGE 
       860        870        880        890        900
VESVGKVVQE DGRMLLIAVL EAIGGQASRS LMDCFADILF ALNKHCFSLL 
       910        920        930        940        950
SMWIKEALQP PGFPSARLSP EQKDTFSQQI LRERVNKRRV KEMVKEFTLL 
       960 
CRGLHGTDYT ADY

Length:963

Mass (Da):108,195

Last modified:July 19, 2004 - v3

Checksum:ⁱ8C696EE2B92365F0

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q5T4X2	Q5T4X2_HUMAN		cDNA FLJ34246 fis, clone FCBBF40000... cDNA FLJ34246 fis, clone FCBBF4000061, highly similar to Importin-13	IPO13	181	Annotation score:

Sequence cautionⁱ

The sequence BAA34444 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence BAB14575 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	202	F → V in CAB55966 (PubMed:17974005).Curated	1
Sequence conflictⁱ	715	T → A in BAB14575 (PubMed:14702039).Curated	1
Sequence conflictⁱ	817	A → S in AAH08194 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF267987 mRNA Translation: AAF73471.1 AB018267 mRNA Translation: BAA34444.2 Different initiation. AL357079 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07072.1 CH471059 Genomic DNA Translation: EAX07073.1 BC008194 mRNA Translation: AAH08194.1 AL117501 mRNA Translation: CAB55966.1 AK023441 mRNA Translation: BAB14575.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS503.1
PIRⁱ	T17276
NCBI Reference Sequences More...RefSeqⁱ	NP_055467.3, NM_014652.3
UniGeneⁱ	Hs.158497

Genome annotation databases

Ensemblⁱ	ENST00000372343; ENSP00000361418; ENSG00000117408
GeneIDⁱ	9670
KEGGⁱ	hsa:9670
UCSC genome browser More...UCSCⁱ	uc001ckx.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O94829	IPO13 isoform 1		PANTR		963	UniRef100_O94829
Importin-13		MACMU		963
Importin 13		MACFA		963
IPO13 isoform 1		PONAB		963
Uncharacterized protein		CERAT		963
+8

Protein	Similar proteins		Species	Score	Length	Source
O94829	Importin-13		BOVIN		963	UniRef90_O94829
Importin-13		MOUSE		963
Importin-13		PONAB		963
Importin-13		RAT		963
IPO13 isoform 1		PANTR		963
+115

Protein	Similar proteins		Species	Score	Length	Source
O94829	Importin-13		RAT		963	UniRef50_O94829
Importin-13		PONAB		963
Importin-13		MOUSE		963
Importin-13		BOVIN		963
IPO13 isoform 1		PANTR		963
+444

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF267987 mRNA Translation: AAF73471.1 AB018267 mRNA Translation: BAA34444.2 Different initiation. AL357079 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07072.1 CH471059 Genomic DNA Translation: EAX07073.1 BC008194 mRNA Translation: AAH08194.1 AL117501 mRNA Translation: CAB55966.1 AK023441 mRNA Translation: BAB14575.1 Different initiation.
CCDSⁱ	CCDS503.1
PIRⁱ	T17276
RefSeqⁱ	NP_055467.3, NM_014652.3
UniGeneⁱ	Hs.158497

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2X19	X-ray	2.80	B	1-963	[»]
	2XWU	X-ray	2.80	B	1-963	[»]
	3ZJY	X-ray	3.60	B/E/G	1-963	[»]
ProteinModelPortalⁱ	O94829
SMRⁱ	O94829
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115025, 38 interactors
CORUMⁱ	O94829
IntActⁱ	O94829, 19 interactors
MINTⁱ	O94829
STRINGⁱ	9606.ENSP00000361418

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetⁱ	O94829
PhosphoSitePlusⁱ	O94829

Polymorphism and mutation databases

BioMutaⁱ	IPO13

BioMutaⁱ

IPO13

Proteomic databases

EPDⁱ	O94829
MaxQBⁱ	O94829
PaxDbⁱ	O94829
PeptideAtlasⁱ	O94829
PRIDEⁱ	O94829
ProteomicsDBⁱ	50474

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000372343; ENSP00000361418; ENSG00000117408
GeneIDⁱ	9670
KEGGⁱ	hsa:9670
UCSCⁱ	uc001ckx.4 human

Organism-specific databases

CTDⁱ	9670
DisGeNETⁱ	9670
EuPathDBⁱ	HostDB:ENSG00000117408.10
GeneCardsⁱ	IPO13
HGNCⁱ	HGNC:16853 IPO13
HPAⁱ	CAB070425
MIMⁱ	610411 gene
neXtProtⁱ	NX_O94829
OpenTargetsⁱ	ENSG00000117408
PharmGKBⁱ	PA134981096
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2022 Eukaryota ENOG410XT8Y LUCA
GeneTreeⁱ	ENSGT00530000063347
HOVERGENⁱ	HBG052141
InParanoidⁱ	O94829
OMAⁱ	VLNRLCI
OrthoDBⁱ	EOG091G01CP
PhylomeDBⁱ	O94829
TreeFamⁱ	TF314539

Miscellaneous databases

ChiTaRSⁱ	IPO13 human
EvolutionaryTraceⁱ	O94829
GeneWikiⁱ	IPO13
GenomeRNAiⁱ	9670
Protein Ontology More...PROⁱ	PR:O94829
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000117408 Expressed in 215 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_IPO13
ExpressionAtlasⁱ	O94829 baseline and differential
Genevisibleⁱ	O94829 HS

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR013598 Exportin-1/Importin-b-like IPR001494 Importin-beta_N
Pfamⁱ	View protein in Pfam PF03810 IBN_N, 1 hit PF08389 Xpo1, 1 hit
SMARTⁱ	View protein in SMART SM00913 IBN_N, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
PROSITEⁱ	View protein in PROSITE PS50166 IMPORTIN_B_NT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IPO13_HUMAN
Accessionⁱ	O94829Primary (citable) accession number: O94829 Secondary accession number(s): D3DPY4 , Q5T4X3, Q7LC04, Q96HS3, Q9H8N3, Q9UFR1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
	Last sequence update:	July 19, 2004
	Last modified:	November 7, 2018
	This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Annotation systems

Supporting data

UniProtKB - O94829 (IPO13_HUMAN)

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Importin-13

IPO13

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ