UniProtKB - O94829 (IPO13_HUMAN)
Protein
Importin-13
Gene
IPO13
Organism
Homo sapiens (Human)
Status
Functioni
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.By similarity2 Publications
GO - Molecular functioni
- Ran GTPase binding Source: InterPro
GO - Biological processi
- protein import into nucleus Source: MGI
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | O94829 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Importin-13Short name: Imp13 Alternative name(s): Karyopherin-13 Short name: Kap13 Ran-binding protein 13 Short name: RanBP13 |
Gene namesi | Name:IPO13 Synonyms:KIAA0724, RANBP13 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000117408.10 |
HGNCi | HGNC:16853, IPO13 |
MIMi | 610411, gene |
neXtProti | NX_O94829 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 9670 |
OpenTargetsi | ENSG00000117408 |
PharmGKBi | PA134981096 |
Miscellaneous databases
Pharosi | O94829, Tbio |
Polymorphism and mutation databases
BioMutai | IPO13 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000120758 | 1 – 963 | Importin-13Add BLAST | 963 |
Proteomic databases
EPDi | O94829 |
jPOSTi | O94829 |
MassIVEi | O94829 |
MaxQBi | O94829 |
PaxDbi | O94829 |
PeptideAtlasi | O94829 |
PRIDEi | O94829 |
ProteomicsDBi | 50474 |
PTM databases
iPTMneti | O94829 |
PhosphoSitePlusi | O94829 |
Expressioni
Tissue specificityi
Expressed in fetal brain, heart, intestine and kidney.1 Publication
Gene expression databases
Bgeei | ENSG00000117408, Expressed in C1 segment of cervical spinal cord and 228 other tissues |
ExpressionAtlasi | O94829, baseline and differential |
Genevisiblei | O94829, HS |
Organism-specific databases
HPAi | ENSG00000117408, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
4 PublicationsBinary interactionsi
Hide detailsO94829
GO - Molecular functioni
- Ran GTPase binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 115025, 46 interactors |
CORUMi | O94829 |
IntActi | O94829, 36 interactors |
MINTi | O94829 |
STRINGi | 9606.ENSP00000361418 |
Miscellaneous databases
RNActi | O94829, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O94829 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O94829 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 24 – 54 | HEAT 11 PublicationAdd BLAST | 31 | |
Domaini | 45 – 111 | Importin N-terminalPROSITE-ProRule annotationAdd BLAST | 67 | |
Repeati | 56 – 88 | HEAT 21 PublicationAdd BLAST | 33 | |
Repeati | 95 – 135 | HEAT 31 PublicationAdd BLAST | 41 | |
Repeati | 142 – 179 | HEAT 41 PublicationAdd BLAST | 38 | |
Repeati | 194 – 231 | HEAT 51 PublicationAdd BLAST | 38 | |
Repeati | 236 – 268 | HEAT 61 PublicationAdd BLAST | 33 | |
Repeati | 276 – 325 | HEAT 71 PublicationAdd BLAST | 50 | |
Repeati | 330 – 372 | HEAT 81 PublicationAdd BLAST | 43 | |
Repeati | 375 – 438 | HEAT 91 PublicationAdd BLAST | 64 | |
Repeati | 440 – 476 | HEAT 101 PublicationAdd BLAST | 37 | |
Repeati | 487 – 522 | HEAT 111 PublicationAdd BLAST | 36 | |
Repeati | 524 – 558 | HEAT 121 PublicationAdd BLAST | 35 | |
Repeati | 562 – 600 | HEAT 131 PublicationAdd BLAST | 39 | |
Repeati | 603 – 648 | HEAT 141 PublicationAdd BLAST | 46 | |
Repeati | 676 – 716 | HEAT 151 PublicationAdd BLAST | 41 | |
Repeati | 720 – 754 | HEAT 161 PublicationAdd BLAST | 35 | |
Repeati | 761 – 803 | HEAT 171 PublicationAdd BLAST | 43 | |
Repeati | 815 – 845 | HEAT 181 PublicationAdd BLAST | 31 | |
Repeati | 860 – 893 | HEAT 191 PublicationAdd BLAST | 34 | |
Repeati | 897 – 931 | HEAT 201 PublicationAdd BLAST | 35 |
Sequence similaritiesi
Belongs to the importin beta family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2022, Eukaryota |
GeneTreei | ENSGT00530000063347 |
HOGENOMi | CLU_005996_3_0_1 |
InParanoidi | O94829 |
OMAi | DTFMYCY |
OrthoDBi | 1032285at2759 |
PhylomeDBi | O94829 |
TreeFami | TF314539 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR013598, Exportin-1/Importin-b-like IPR001494, Importin-beta_N IPR040709, Importin_rep_1 IPR040944, Importin_rep_2 IPR040520, Importin_rep_3 |
Pfami | View protein in Pfam PF03810, IBN_N, 1 hit PF18773, Importin_rep, 1 hit PF18786, Importin_rep_2, 2 hits PF18806, Importin_rep_3, 1 hit PF08389, Xpo1, 1 hit |
SMARTi | View protein in SMART SM00913, IBN_N, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50166, IMPORTIN_B_NT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O94829-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERREEQPGA AGAGAAPALD FTVENVEKAL HQLYYDPNIE NKNLAQKWLM
60 70 80 90 100
QAQVSPQAWH FSWQLLQPDK VPEIQYFGAS ALHIKISRYW SDIPTDQYES
110 120 130 140 150
LKAQLFTQIT RFASGSKIVL TRLCVALASL ALSMMPDAWP CAVADMVRLF
160 170 180 190 200
QAEDSPVDGQ GRCLALLELL TVLPEEFQTS RLPQYRKGLV RTSLAVECGA
210 220 230 240 250
VFPLLEQLLQ QPSSPSCVRQ KVLKCFSSWV QLEVPLQDCE ALIQAAFAAL
260 270 280 290 300
QDSELFDSSV EAIVNAISQP DAQRYVNTLL KLIPLVLGLQ EQLRQAVQNG
310 320 330 340 350
DMETSHGICR IAVALGENHS RALLDQVEHW QSFLALVNMI MFCTGIPGHY
360 370 380 390 400
PVNETTSSLT LTFWYTLQDD ILSFEAEKQA VYQQVYRPVY FQLVDVLLHK
410 420 430 440 450
AQFPSDEEYG FWSSDEKEQF RIYRVDISDT LMYVYEMLGA ELLSNLYDKL
460 470 480 490 500
GRLLTSSEEP YSWQHTEALL YGFQSIAETI DVNYSDVVPG LIGLIPRISI
510 520 530 540 550
SNVQLADTVM FTIGALSEWL ADHPVMINSV LPLVLHALGN PELSVSSVST
560 570 580 590 600
LKKICRECKY DLPPYAANIV AVSQDVLMKQ IHKTSQCMWL MQALGFLLSA
610 620 630 640 650
LQVEEILKNL HSLISPYIQQ LEKLAEEIPN PSNKLAIVHI LGLLSNLFTT
660 670 680 690 700
LDISHHEDDH EGPELRKLPV PQGPNPVVVV LQQVFQLIQK VLSKWLNDAQ
710 720 730 740 750
VVEAVCAIFE KSVKTLLDDF APMVPQLCEM LGRMYSTIPQ ASALDLTRQL
760 770 780 790 800
VHIFAHEPAH FPPIEALFLL VTSVTLTLFQ QGPRDHPDIV DSFMQLLAQA
810 820 830 840 850
LKRKPDLFLC ERLDVKAVFQ CAVLALKFPE APTVKASCGF FTELLPRCGE
860 870 880 890 900
VESVGKVVQE DGRMLLIAVL EAIGGQASRS LMDCFADILF ALNKHCFSLL
910 920 930 940 950
SMWIKEALQP PGFPSARLSP EQKDTFSQQI LRERVNKRRV KEMVKEFTLL
960
CRGLHGTDYT ADY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5T4X2 | Q5T4X2_HUMAN | Importin-13 | IPO13 | 181 | Annotation score: |
Sequence cautioni
The sequence BAA34444 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB14575 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 202 | F → V in CAB55966 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 715 | T → A in BAB14575 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 817 | A → S in AAH08194 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF267987 mRNA Translation: AAF73471.1 AB018267 mRNA Translation: BAA34444.2 Different initiation. AL357079 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07072.1 CH471059 Genomic DNA Translation: EAX07073.1 BC008194 mRNA Translation: AAH08194.1 AL117501 mRNA Translation: CAB55966.1 AK023441 mRNA Translation: BAB14575.1 Different initiation. |
CCDSi | CCDS503.1 |
PIRi | T17276 |
RefSeqi | NP_055467.3, NM_014652.3 |
Genome annotation databases
Ensembli | ENST00000372343; ENSP00000361418; ENSG00000117408 |
GeneIDi | 9670 |
KEGGi | hsa:9670 |
UCSCi | uc001ckx.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF267987 mRNA Translation: AAF73471.1 AB018267 mRNA Translation: BAA34444.2 Different initiation. AL357079 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07072.1 CH471059 Genomic DNA Translation: EAX07073.1 BC008194 mRNA Translation: AAH08194.1 AL117501 mRNA Translation: CAB55966.1 AK023441 mRNA Translation: BAB14575.1 Different initiation. |
CCDSi | CCDS503.1 |
PIRi | T17276 |
RefSeqi | NP_055467.3, NM_014652.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2X19 | X-ray | 2.80 | B | 1-963 | [»] | |
2XWU | X-ray | 2.80 | B | 1-963 | [»] | |
3ZJY | X-ray | 3.60 | B/E/G | 1-963 | [»] | |
SMRi | O94829 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115025, 46 interactors |
CORUMi | O94829 |
IntActi | O94829, 36 interactors |
MINTi | O94829 |
STRINGi | 9606.ENSP00000361418 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
PTM databases
iPTMneti | O94829 |
PhosphoSitePlusi | O94829 |
Polymorphism and mutation databases
BioMutai | IPO13 |
Proteomic databases
EPDi | O94829 |
jPOSTi | O94829 |
MassIVEi | O94829 |
MaxQBi | O94829 |
PaxDbi | O94829 |
PeptideAtlasi | O94829 |
PRIDEi | O94829 |
ProteomicsDBi | 50474 |
Protocols and materials databases
Antibodypediai | 32405, 106 antibodies |
Genome annotation databases
Ensembli | ENST00000372343; ENSP00000361418; ENSG00000117408 |
GeneIDi | 9670 |
KEGGi | hsa:9670 |
UCSCi | uc001ckx.4, human |
Organism-specific databases
CTDi | 9670 |
DisGeNETi | 9670 |
EuPathDBi | HostDB:ENSG00000117408.10 |
GeneCardsi | IPO13 |
HGNCi | HGNC:16853, IPO13 |
HPAi | ENSG00000117408, Tissue enhanced (skeletal) |
MIMi | 610411, gene |
neXtProti | NX_O94829 |
OpenTargetsi | ENSG00000117408 |
PharmGKBi | PA134981096 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2022, Eukaryota |
GeneTreei | ENSGT00530000063347 |
HOGENOMi | CLU_005996_3_0_1 |
InParanoidi | O94829 |
OMAi | DTFMYCY |
OrthoDBi | 1032285at2759 |
PhylomeDBi | O94829 |
TreeFami | TF314539 |
Enzyme and pathway databases
PathwayCommonsi | O94829 |
Miscellaneous databases
BioGRID-ORCSi | 9670, 672 hits in 854 CRISPR screens |
ChiTaRSi | IPO13, human |
EvolutionaryTracei | O94829 |
GeneWikii | IPO13 |
GenomeRNAii | 9670 |
Pharosi | O94829, Tbio |
PROi | PR:O94829 |
RNActi | O94829, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000117408, Expressed in C1 segment of cervical spinal cord and 228 other tissues |
ExpressionAtlasi | O94829, baseline and differential |
Genevisiblei | O94829, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR013598, Exportin-1/Importin-b-like IPR001494, Importin-beta_N IPR040709, Importin_rep_1 IPR040944, Importin_rep_2 IPR040520, Importin_rep_3 |
Pfami | View protein in Pfam PF03810, IBN_N, 1 hit PF18773, Importin_rep, 1 hit PF18786, Importin_rep_2, 2 hits PF18806, Importin_rep_3, 1 hit PF08389, Xpo1, 1 hit |
SMARTi | View protein in SMART SM00913, IBN_N, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50166, IMPORTIN_B_NT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IPO13_HUMAN | |
Accessioni | O94829Primary (citable) accession number: O94829 Secondary accession number(s): D3DPY4 Q9UFR1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | July 19, 2004 | |
Last modified: | December 2, 2020 | |
This is version 167 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM