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UniProtKB - O94827 (PKHG5_HUMAN)

Entry version 172 (25 May 2022)
Sequence version 4 (07 Apr 2021)
Previous versions | rss
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Protein

Pleckstrin homology domain-containing family G member 5

Gene

PLEKHG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons (By similarity).

Involved in the control of neuronal cell differentiation (PubMed:11704860).

Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts (PubMed:23777631).

By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O94827

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-193648, NRAGE signals death through JNK
R-HSA-416482, G alpha (12/13) signalling events
R-HSA-8980692, RHOA GTPase cycle
R-HSA-9696264, RND3 GTPase cycle
R-HSA-9696273, RND1 GTPase cycle

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O94827

SIGNOR Signaling Network Open Resource

More...SIGNORi		O94827

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleckstrin homology domain-containing family G member 5
Short name:
PH domain-containing family G member 5
Alternative name(s):
Guanine nucleotide exchange factor 720
Short name:
GEF720
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLEKHG5
Synonyms:KIAA0720
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29105, PLEKHG5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611101, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O94827

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000171680

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Distal spinal muscular atrophy, autosomal recessive, 4 (DSMA4)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA neuromuscular disorder. Distal spinal muscular atrophy, also known as distal hereditary motor neuronopathy, represents a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. DSMA4 is characterized by childhood onset, generalized muscle weakness and atrophy with denervation and normal sensation. Bulbar symptoms and pyramidal signs are absent.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035357647F → S in DSMA4; stability and intracellular location affected severely impairing the NF-kappa-B transduction pathway. 1 PublicationCorresponds to variant dbSNP:rs63750315EnsemblClinVar.1
Charcot-Marie-Tooth disease, recessive, intermediate type, C (CMTRIC)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Recessive intermediate forms of Charcot-Marie-Tooth disease are characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070217663T → M in CMTRIC; in vitro assay suggests a defect in activating the NF-kappa-B signaling pathway. 1 PublicationCorresponds to variant dbSNP:rs397515456EnsemblClinVar.1
Natural variantiVAR_070218820G → R in CMTRIC; in vitro assay suggests a defect in activating the NF-kappa-B signaling pathway. 1 PublicationCorresponds to variant dbSNP:rs202191898EnsemblClinVar.1

Keywords - Diseasei

Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNET

More...DisGeNETi		57449

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		PLEKHG5

MalaCards human disease database

More...MalaCardsi		PLEKHG5
MIMi611067, phenotype
615376, phenotype

Open Targets

More...OpenTargetsi		ENSG00000171680

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		369867, Autosomal recessive intermediate Charcot-Marie-Tooth disease type C
206580, Autosomal recessive lower motor neuron disease with childhood onset

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671164

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O94827, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PLEKHG5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003071341 – 1006Pleckstrin homology domain-containing family G member 5Add BLAST1006

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei729PhosphothreonineBy similarity1
Modified residuei734PhosphoserineBy similarity1
Modified residuei851PhosphoserineBy similarity1
Modified residuei876PhosphoserineBy similarity1
Modified residuei881PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O94827

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O94827

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O94827

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O94827

PeptideAtlas

More...PeptideAtlasi		O94827

PRoteomics IDEntifications database

More...PRIDEi		O94827

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		24913
25662
50471 [O94827-3]
50472 [O94827-4]
50473 [O94827-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O94827

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O94827

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in the peripheral nervous system and brain. Highest expression is observed in heart, lung, kidney, testis and moderate expression is present in spleen, pancreas, skeletal muscle, ovary and liver. Weakly expressed in glioblastoma (GBM) cell lines.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000171680, Expressed in right hemisphere of cerebellum and 142 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O94827, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O94827, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000171680, Tissue enhanced (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GIPC1/synectin and RHOA.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121522, 28 interactors

Protein interaction database and analysis system

More...IntActi		O94827, 18 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000439625

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O94827, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		O94827

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O94827

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini336 – 528DHPROSITE-ProRule annotationAdd BLAST193
Domaini584 – 684PHPROSITE-ProRule annotationAdd BLAST101

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 71DisorderedSequence analysisAdd BLAST71
Regioni148 – 198DisorderedSequence analysisAdd BLAST51
Regioni212 – 242DisorderedSequence analysisAdd BLAST31
Regioni690 – 754DisorderedSequence analysisAdd BLAST65
Regioni768 – 820DisorderedSequence analysisAdd BLAST53
Regioni837 – 863DisorderedSequence analysisAdd BLAST27
Regioni950 – 979DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi218 – 242Polar residuesSequence analysisAdd BLAST25
Compositional biasi703 – 727Acidic residuesSequence analysisAdd BLAST25
Compositional biasi728 – 754Polar residuesSequence analysisAdd BLAST27
Compositional biasi774 – 801Polar residuesSequence analysisAdd BLAST28
Compositional biasi845 – 859Pro residuesSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3521, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00510000046843

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005851_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O94827

Database of Orthologous Groups

More...OrthoDBi		556467at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O94827

TreeFam database of animal gene trees

More...TreeFami		TF316755

Family and domain databases

Conserved Domains Database

More...CDDi		cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR040181, PKHG5/7
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...PANTHERi		PTHR13217, PTHR13217, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48065, SSF48065, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94827-5) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHYDGHVRFD LPPQGSVLAR NVSTRSCPPR TSPAVDLEEE EEESSVDGKG 
        60         70         80         90        100
DRKSTGLKLS KKKARRRHTD DPSKECFTLK FDLNVDIETE IVPAMKKKSL 
       110        120        130        140        150
GEVLLPVFER KGIALGKVDI YLDQSNTPLS LTFEAYRFGG HYLRVKAPAK 
       160        170        180        190        200
PGDEGKVEQG MKDSKSLSLP ILRPAGTGPP ALERVDAQSR RESLDILAPG 
       210        220        230        240        250
RRRKNMSEFL GEASIPGQEP PTPSSCSLPS GSSGSTNTGD SWKNRAASRF 
       260        270        280        290        300
SGFFSSGPST SAFGREVDKM EQLEGKLHTY SLFGLPRLPR GLRFDHDSWE 
       310        320        330        340        350
EEYDEDEDED NACLRLEDSW RELIDGHEKL TRRQCHQQEA VWELLHTEAS 
       360        370        380        390        400
YIRKLRVIIN LFLCCLLNLQ ESGLLCEVEA ERLFSNIPEI AQLHRRLWAS 
       410        420        430        440        450
VMAPVLEKAR RTRALLQPGD FLKGFKMFGS LFKPYIRYCM EEEGCMEYMR 
       460        470        480        490        500
GLLRDNDLFR AYITWAEKHP QCQRLKLSDM LAKPHQRLTK YPLLLKSVLR 
       510        520        530        540        550
KTEEPRAKEA VVAMIGSVER FIHHVNACMR QRQERQRLAA VVSRIDAYEV 
       560        570        580        590        600
VESSSDEVDK LLKEFLHLDL TAPIPGASPE ETRQLLLEGS LRMKEGKDSK 
       610        620        630        640        650
MDVYCFLFTD LLLVTKAVKK AERTRVIRPP LLVDKIVCRE LRDPGSFLLI 
       660        670        680        690        700
YLNEFHSAVG AYTFQASGQA LCRGWVDTIY NAQNQLQQLR AQEPPGSQQP 
       710        720        730        740        750
LQSLEEEEDE QEEEEEEEEE EEEGEDSGTS AASSPTIMRK SSGSPDSQHC 
       760        770        780        790        800
ASDGSTETLA MVVVEPGDTL SSPEFDSGPF SSQSDETSLS TTASSATPTS 
       810        820        830        840        850
ELLPLGPVDG RSCSMDSAYG TLSPTSLQDF VAPGPMAELV PRAPESPRVP 
       860        870        880        890        900
SPPPSPRLRR RTPVQLLSCP PHLLKSKSEA SLLQLLAGAG THGTPSAPSR 
       910        920        930        940        950
SLSELCLAVP APGIRTQGSP QEAGPSWDCR GAPSPGSGPG LVGCLAGEPA 
       960        970        980        990       1000
GSHRKRCGDL PSGASPRVQP EPPPGVSAQH RKLTLAQLYR IRTTLLLNST 

LTASEV
Length:1,006
Mass (Da):111,231
Last modified:April 7, 2021 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2260D175D3C27D76
GO
Isoform 2 (identifier: O94827-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MDKGRAAKVCHHADCQQLHRRGPLNLCEACDSKFHSTM

Show »
Length:1,043
Mass (Da):115,378
Checksum:i561BF06557096D6C
GO
Isoform 3 (identifier: O94827-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     913-930: GIRTQGSPQEAGPSWDCR → AQEADPGPALPNQDHPAA
     931-1006: Missing.

Show »
Length:930
Mass (Da):103,364
Checksum:i8938A81803D1B6FD
GO
Isoform 4 (identifier: O94827-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGTGPGVSGRLAASRPGPGLPLRDSEPSWAGGRARDGESQVCHHADCQQLHRRGPLNLCEACDSKFHSTM

Show »
Length:1,075
Mass (Da):118,493
Checksum:iFEA316D35C9033A3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SY18Q5SY18_HUMAN
Pleckstrin homology domain-containi...
PLEKHG5
852Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZHW8A0A5F9ZHW8_HUMAN
Pleckstrin homology domain-containi...
PLEKHG5
1,105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A804EMX3A0A804EMX3_HUMAN
Pleckstrin homology domain-containi...
PLEKHG5
1,075Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PG76A0A6Q8PG76_HUMAN
Pleckstrin homology domain-containi...
PLEKHG5
775Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2PMD6A0A7I2PMD6_HUMAN
Pleckstrin homology domain-containi...
PLEKHG5
1,064Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PF22A0A6Q8PF22_HUMAN
Pleckstrin homology domain-containi...
PLEKHG5
295Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PHJ1A0A6Q8PHJ1_HUMAN
Pleckstrin homology domain-containi...
PLEKHG5
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PHR5A0A6Q8PHR5_HUMAN
Pleckstrin homology domain-containi...
PLEKHG5
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PHD3A0A6Q8PHD3_HUMAN
Pleckstrin homology domain-containi...
PLEKHG5
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PHS0A0A6Q8PHS0_HUMAN
Pleckstrin homology domain-containi...
PLEKHG5
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA34440 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAC77354 differs from that shown. Aberrant splicing.Curated
The sequence BAC85124 differs from that shown. Probable cloning artifact.Curated
The sequence BAG53269 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAH11909 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti106P → L in BAH11909 (PubMed:14702039).Curated1
Sequence conflicti238T → S in BAA34440 (PubMed:9872452).Curated1
Sequence conflicti514M → T in BAG53269 (PubMed:14702039).Curated1
Sequence conflicti904E → G in BAG53269 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035357647F → S in DSMA4; stability and intracellular location affected severely impairing the NF-kappa-B transduction pathway. 1 PublicationCorresponds to variant dbSNP:rs63750315EnsemblClinVar.1
Natural variantiVAR_070217663T → M in CMTRIC; in vitro assay suggests a defect in activating the NF-kappa-B signaling pathway. 1 PublicationCorresponds to variant dbSNP:rs397515456EnsemblClinVar.1
Natural variantiVAR_070218820G → R in CMTRIC; in vitro assay suggests a defect in activating the NF-kappa-B signaling pathway. 1 PublicationCorresponds to variant dbSNP:rs202191898EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0609591M → MDKGRAAKVCHHADCQQLHR RGPLNLCEACDSKFHSTM in isoform 2. 1
Alternative sequenceiVSP_0609601M → MGTGPGVSGRLAASRPGPGL PLRDSEPSWAGGRARDGESQ VCHHADCQQLHRRGPLNLCE ACDSKFHSTM in isoform 4. 1
Alternative sequenceiVSP_060961913 – 930GIRTQ…SWDCR → AQEADPGPALPNQDHPAA in isoform 3. Add BLAST18
Alternative sequenceiVSP_060962931 – 1006Missing in isoform 3. Add BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB018263 mRNA Translation: BAA34440.2 Different initiation.
AK096347 mRNA Translation: BAG53269.1 Different initiation.
AK294875 mRNA Translation: BAH11909.1 Different initiation.
AK299523 mRNA Translation: BAH13058.1
AL591866 Genomic DNA No translation available.
AL158217 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71539.1
CH471130 Genomic DNA Translation: EAW71547.1
BC015231 mRNA Translation: AAH15231.1
BC042606 mRNA No translation available.
AB097001 mRNA Translation: BAC77354.1 Sequence problems.
AK131074 mRNA Translation: BAC85124.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41240.1 [O94827-5]
CCDS41241.1 [O94827-3]
CCDS57967.1 [O94827-4]
CCDS57968.1 [O94827-7]
CCDS57969.1 [O94827-3]
CCDS79.1 [O94827-5]

NCBI Reference Sequences

More...RefSeqi		NP_001036128.1, NM_001042663.1 [O94827-3]
NP_001036129.1, NM_001042664.1 [O94827-5]
NP_001036130.1, NM_001042665.1 [O94827-5]
NP_001252521.1, NM_001265592.1 [O94827-3]
NP_001252522.1, NM_001265593.1 [O94827-7]
NP_001252523.1, NM_001265594.1 [O94827-4]
NP_065682.2, NM_020631.4 [O94827-5]
NP_941374.2, NM_198681.3 [O94827-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000340850.10; ENSP00000344570.5; ENSG00000171680.23
ENST00000377725.5; ENSP00000366954.1; ENSG00000171680.23 [O94827-4]
ENST00000377728.8; ENSP00000366957.3; ENSG00000171680.23
ENST00000377732.5; ENSP00000366961.1; ENSG00000171680.23 [O94827-3]
ENST00000377740.5; ENSP00000366969.4; ENSG00000171680.23
ENST00000400913.6; ENSP00000383704.1; ENSG00000171680.23
ENST00000400915.8; ENSP00000383706.4; ENSG00000171680.23 [O94827-3]
ENST00000537245.6; ENSP00000439625.2; ENSG00000171680.23 [O94827-3]
ENST00000675694.1; ENSP00000501925.1; ENSG00000171680.23

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57449

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57449

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000377728.8; ENSP00000366957.3; NM_020631.6; NP_065682.2

UCSC genome browser

More...UCSCi		uc001ank.1, human [O94827-5]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018263 mRNA Translation: BAA34440.2 Different initiation.
AK096347 mRNA Translation: BAG53269.1 Different initiation.
AK294875 mRNA Translation: BAH11909.1 Different initiation.
AK299523 mRNA Translation: BAH13058.1
AL591866 Genomic DNA No translation available.
AL158217 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71539.1
CH471130 Genomic DNA Translation: EAW71547.1
BC015231 mRNA Translation: AAH15231.1
BC042606 mRNA No translation available.
AB097001 mRNA Translation: BAC77354.1 Sequence problems.
AK131074 mRNA Translation: BAC85124.1 Sequence problems.
CCDSiCCDS41240.1 [O94827-5]
CCDS41241.1 [O94827-3]
CCDS57967.1 [O94827-4]
CCDS57968.1 [O94827-7]
CCDS57969.1 [O94827-3]
CCDS79.1 [O94827-5]
RefSeqiNP_001036128.1, NM_001042663.1 [O94827-3]
NP_001036129.1, NM_001042664.1 [O94827-5]
NP_001036130.1, NM_001042665.1 [O94827-5]
NP_001252521.1, NM_001265592.1 [O94827-3]
NP_001252522.1, NM_001265593.1 [O94827-7]
NP_001252523.1, NM_001265594.1 [O94827-4]
NP_065682.2, NM_020631.4 [O94827-5]
NP_941374.2, NM_198681.3 [O94827-5]

3D structure databases

AlphaFoldDBiO94827
SMRiO94827
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121522, 28 interactors
IntActiO94827, 18 interactors
STRINGi9606.ENSP00000439625

PTM databases

iPTMnetiO94827
PhosphoSitePlusiO94827

Genetic variation databases

BioMutaiPLEKHG5

Proteomic databases

EPDiO94827
jPOSTiO94827
MassIVEiO94827
PaxDbiO94827
PeptideAtlasiO94827
PRIDEiO94827
ProteomicsDBi24913
25662
50471 [O94827-3]
50472 [O94827-4]
50473 [O94827-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27380, 151 antibodies from 25 providers

The DNASU plasmid repository

More...DNASUi		57449

Genome annotation databases

EnsembliENST00000340850.10; ENSP00000344570.5; ENSG00000171680.23
ENST00000377725.5; ENSP00000366954.1; ENSG00000171680.23 [O94827-4]
ENST00000377728.8; ENSP00000366957.3; ENSG00000171680.23
ENST00000377732.5; ENSP00000366961.1; ENSG00000171680.23 [O94827-3]
ENST00000377740.5; ENSP00000366969.4; ENSG00000171680.23
ENST00000400913.6; ENSP00000383704.1; ENSG00000171680.23
ENST00000400915.8; ENSP00000383706.4; ENSG00000171680.23 [O94827-3]
ENST00000537245.6; ENSP00000439625.2; ENSG00000171680.23 [O94827-3]
ENST00000675694.1; ENSP00000501925.1; ENSG00000171680.23
GeneIDi57449
KEGGihsa:57449
MANE-SelectiENST00000377728.8; ENSP00000366957.3; NM_020631.6; NP_065682.2
UCSCiuc001ank.1, human [O94827-5]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57449
DisGeNETi57449

GeneCards: human genes, protein and diseases

More...GeneCardsi		PLEKHG5
GeneReviewsiPLEKHG5
HGNCiHGNC:29105, PLEKHG5
HPAiENSG00000171680, Tissue enhanced (skin)
MalaCardsiPLEKHG5
MIMi611067, phenotype
611101, gene
615376, phenotype
neXtProtiNX_O94827
OpenTargetsiENSG00000171680
Orphaneti369867, Autosomal recessive intermediate Charcot-Marie-Tooth disease type C
206580, Autosomal recessive lower motor neuron disease with childhood onset
PharmGKBiPA142671164
VEuPathDBiHostDB:ENSG00000171680

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3521, Eukaryota
GeneTreeiENSGT00510000046843
HOGENOMiCLU_005851_0_0_1
InParanoidiO94827
OrthoDBi556467at2759
PhylomeDBiO94827
TreeFamiTF316755

Enzyme and pathway databases

PathwayCommonsiO94827
ReactomeiR-HSA-193648, NRAGE signals death through JNK
R-HSA-416482, G alpha (12/13) signalling events
R-HSA-8980692, RHOA GTPase cycle
R-HSA-9696264, RND3 GTPase cycle
R-HSA-9696273, RND1 GTPase cycle
SignaLinkiO94827
SIGNORiO94827

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57449, 22 hits in 1070 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PLEKHG5, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PLEKHG5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57449
PharosiO94827, Tbio

Protein Ontology

More...PROi		PR:O94827
RNActiO94827, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000171680, Expressed in right hemisphere of cerebellum and 142 other tissues
ExpressionAtlasiO94827, baseline and differential
GenevisibleiO94827, HS

Family and domain databases

CDDicd00160, RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR040181, PKHG5/7
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR13217, PTHR13217, 1 hit
PfamiView protein in Pfam
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKHG5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94827
Secondary accession number(s): B3KU07
, B7Z2M3, B7Z5X2, F5GZ21, F5H1I0, Q5SY17, Q5T8W5, Q5T8W9, Q6ZNM0, Q7Z436, Q86YD8, Q96BS1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: April 7, 2021
Last modified: May 25, 2022
This is version 172 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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