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Protein

Mitochondrial import receptor subunit TOM70

Gene

TOMM70

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor that accelerates the import of all mitochondrial precursor proteins.By similarity

GO - Molecular functioni

  • protein transmembrane transporter activity Source: BHF-UCL

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1268020 Mitochondrial protein import
R-HSA-5205685 Pink/Parkin Mediated Mitophagy
R-HSA-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM70
Alternative name(s):
Mitochondrial precursor proteins import receptor
Translocase of outer membrane 70 kDa subunit
Translocase of outer mitochondrial membrane protein 70Imported
Gene namesi
Name:TOMM70Imported
Synonyms:KIAA0719, TOM70, TOMM70A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000154174.7
HGNCiHGNC:11985 TOMM70
MIMi606081 gene
neXtProtiNX_O94826

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 38Mitochondrial intermembraneSequence analysisAdd BLAST37
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 608CytoplasmicSequence analysisAdd BLAST549

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9868
OpenTargetsiENSG00000154174
PharmGKBiPA36669

Polymorphism and mutation databases

BioMutaiTOMM70A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001063362 – 608Mitochondrial import receptor subunit TOM70Add BLAST607

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei71Omega-N-methylarginineCombined sources1
Modified residuei91PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei110PhosphoserineCombined sources1
Modified residuei185N6-acetyllysineCombined sources1
Cross-linki275Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei434PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO94826
MaxQBiO94826
PaxDbiO94826
PeptideAtlasiO94826
PRIDEiO94826
ProteomicsDBi50468

PTM databases

iPTMnetiO94826
PhosphoSitePlusiO94826
SwissPalmiO94826

Expressioni

Gene expression databases

BgeeiENSG00000154174 Expressed in 245 organ(s), highest expression level in caudate nucleus
CleanExiHS_TOMM70A
GenevisibleiO94826 HS

Organism-specific databases

HPAiCAB017156
HPA014589
HPA048020

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with CAPN8 (By similarity).By similarity

Protein-protein interaction databases

BioGridi115201, 37 interactors
CORUMiO94826
IntActiO94826, 22 interactors
MINTiO94826
STRINGi9606.ENSP00000284320

Structurei

3D structure databases

ProteinModelPortaliO94826
SMRiO94826
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati114 – 147TPR 1Add BLAST34
Repeati153 – 186TPR 2Add BLAST34
Repeati294 – 327TPR 3Add BLAST34
Repeati329 – 362TPR 4Add BLAST34
Repeati367 – 400TPR 5Add BLAST34
Repeati401 – 434TPR 6Add BLAST34
Repeati440 – 475TPR 7Add BLAST36
Repeati476 – 509TPR 8Add BLAST34
Repeati511 – 544TPR 9Add BLAST34
Repeati545 – 578TPR 10Add BLAST34

Sequence similaritiesi

Belongs to the Tom70 family.Curated

Keywords - Domaini

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0547 Eukaryota
ENOG410YVNZ LUCA
GeneTreeiENSGT00900000140844
HOGENOMiHOG000264237
HOVERGENiHBG062335
InParanoidiO94826
KOiK17768
OMAiWKQDLDK
OrthoDBiEOG091G0CYZ
PhylomeDBiO94826
TreeFamiTF106203

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00515 TPR_1, 1 hit
PF13181 TPR_8, 4 hits
SMARTiView protein in SMART
SM00028 TPR, 10 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 7 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94826-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASKPVEAA VVAAAVPSSG SGVGGGGTAG PGTGGLPRWQ LALAVGAPLL
60 70 80 90 100
LGAGAIYLWS RQQRRREARG RGDASGLKRN SERKTPEGRA SPAPGSGHPE
110 120 130 140 150
GPGAHLDMNS LDRAQAAKNK GNKYFKAGKY EQAIQCYTEA ISLCPTEKNV
160 170 180 190 200
DLSTFYQNRA AAFEQLQKWK EVAQDCTKAV ELNPKYVKAL FRRAKAHEKL
210 220 230 240 250
DNKKECLEDV TAVCILEGFQ NQQSMLLADK VLKLLGKEKA KEKYKNREPL
260 270 280 290 300
MPSPQFIKSY FSSFTDDIIS QPMLKGEKSD EDKDKEGEAL EVKENSGYLK
310 320 330 340 350
AKQYMEEENY DKIISECSKE IDAEGKYMAE ALLLRATFYL LIGNANAAKP
360 370 380 390 400
DLDKVISLKE ANVKLRANAL IKRGSMYMQQ QQPLLSTQDF NMAADIDPQN
410 420 430 440 450
ADVYHHRGQL KILLDQVEEA VADFDECIRL RPESALAQAQ KCFALYRQAY
460 470 480 490 500
TGNNSSQIQA AMKGFEEVIK KFPRCAEGYA LYAQALTDQQ QFGKADEMYD
510 520 530 540 550
KCIDLEPDNA TTYVHKGLLQ LQWKQDLDRG LELISKAIEI DNKCDFAYET
560 570 580 590 600
MGTIEVQRGN MEKAIDMFNK AINLAKSEME MAHLYSLCDA AHAQTEVAKK

YGLKPPTL
Length:608
Mass (Da):67,455
Last modified:May 1, 1999 - v1
Checksum:i5AAF5CAAA8582480
GO

Sequence cautioni

The sequence BAA34439 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018262 mRNA Translation: BAA34439.2 Different initiation.
CH471052 Genomic DNA Translation: EAW79822.1
CH471052 Genomic DNA Translation: EAW79823.1
BC003633 mRNA Translation: AAH03633.1
BC052994 mRNA Translation: AAH52994.1
CCDSiCCDS33807.1
RefSeqiNP_055635.3, NM_014820.4
UniGeneiHs.227253

Genome annotation databases

EnsembliENST00000284320; ENSP00000284320; ENSG00000154174
GeneIDi9868
KEGGihsa:9868
UCSCiuc003dtw.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018262 mRNA Translation: BAA34439.2 Different initiation.
CH471052 Genomic DNA Translation: EAW79822.1
CH471052 Genomic DNA Translation: EAW79823.1
BC003633 mRNA Translation: AAH03633.1
BC052994 mRNA Translation: AAH52994.1
CCDSiCCDS33807.1
RefSeqiNP_055635.3, NM_014820.4
UniGeneiHs.227253

3D structure databases

ProteinModelPortaliO94826
SMRiO94826
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115201, 37 interactors
CORUMiO94826
IntActiO94826, 22 interactors
MINTiO94826
STRINGi9606.ENSP00000284320

PTM databases

iPTMnetiO94826
PhosphoSitePlusiO94826
SwissPalmiO94826

Polymorphism and mutation databases

BioMutaiTOMM70A

Proteomic databases

EPDiO94826
MaxQBiO94826
PaxDbiO94826
PeptideAtlasiO94826
PRIDEiO94826
ProteomicsDBi50468

Protocols and materials databases

DNASUi9868
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284320; ENSP00000284320; ENSG00000154174
GeneIDi9868
KEGGihsa:9868
UCSCiuc003dtw.4 human

Organism-specific databases

CTDi9868
DisGeNETi9868
EuPathDBiHostDB:ENSG00000154174.7
GeneCardsiTOMM70
HGNCiHGNC:11985 TOMM70
HPAiCAB017156
HPA014589
HPA048020
MIMi606081 gene
neXtProtiNX_O94826
OpenTargetsiENSG00000154174
PharmGKBiPA36669
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0547 Eukaryota
ENOG410YVNZ LUCA
GeneTreeiENSGT00900000140844
HOGENOMiHOG000264237
HOVERGENiHBG062335
InParanoidiO94826
KOiK17768
OMAiWKQDLDK
OrthoDBiEOG091G0CYZ
PhylomeDBiO94826
TreeFamiTF106203

Enzyme and pathway databases

ReactomeiR-HSA-1268020 Mitochondrial protein import
R-HSA-5205685 Pink/Parkin Mediated Mitophagy
R-HSA-5689880 Ub-specific processing proteases

Miscellaneous databases

ChiTaRSiTOMM70 human
GeneWikiiTOMM70A
GenomeRNAii9868
PROiPR:O94826
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154174 Expressed in 245 organ(s), highest expression level in caudate nucleus
CleanExiHS_TOMM70A
GenevisibleiO94826 HS

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00515 TPR_1, 1 hit
PF13181 TPR_8, 4 hits
SMARTiView protein in SMART
SM00028 TPR, 10 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 7 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTOM70_HUMAN
AccessioniPrimary (citable) accession number: O94826
Secondary accession number(s): D3DN48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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