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Protein

Probable phospholipid-transporting ATPase VB

Gene

ATP10B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4334-aspartylphosphate intermediateBy similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1055MagnesiumBy similarity1
Metal bindingi1059MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • magnesium ion binding Source: InterPro
  • phospholipid-translocating ATPase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processLipid transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-936837 Ion transport by P-type ATPases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase VB (EC:7.6.2.1)
Alternative name(s):
ATPase class V type 10B
P4-ATPase flippase complex alpha subunit ATP10B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP10B
Synonyms:ATPVB, KIAA0715
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000118322.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13543 ATP10B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O94823

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 82CytoplasmicSequence analysisAdd BLAST82
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei83 – 104HelicalSequence analysisAdd BLAST22
Topological domaini105 – 110Exoplasmic loopSequence analysis6
Transmembranei111 – 132HelicalSequence analysisAdd BLAST22
Topological domaini133 – 316CytoplasmicSequence analysisAdd BLAST184
Transmembranei317 – 338HelicalSequence analysisAdd BLAST22
Topological domaini339 – 368Exoplasmic loopSequence analysisAdd BLAST30
Transmembranei369 – 390HelicalSequence analysisAdd BLAST22
Topological domaini391 – 1111CytoplasmicSequence analysisAdd BLAST721
Transmembranei1112 – 1132HelicalSequence analysisAdd BLAST21
Topological domaini1133 – 1144Exoplasmic loopSequence analysisAdd BLAST12
Transmembranei1145 – 1164HelicalSequence analysisAdd BLAST20
Topological domaini1165 – 1194CytoplasmicSequence analysisAdd BLAST30
Transmembranei1195 – 1216HelicalSequence analysisAdd BLAST22
Topological domaini1217 – 1223Exoplasmic loopSequence analysis7
Transmembranei1224 – 1246HelicalSequence analysisAdd BLAST23
Topological domaini1247 – 1252CytoplasmicSequence analysis6
Transmembranei1253 – 1273HelicalSequence analysisAdd BLAST21
Topological domaini1274 – 1291Exoplasmic loopSequence analysisAdd BLAST18
Transmembranei1292 – 1316HelicalSequence analysisAdd BLAST25
Topological domaini1317 – 1461CytoplasmicSequence analysisAdd BLAST145

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000118322

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25098

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATP10B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000463811 – 1461Probable phospholipid-transporting ATPase VBAdd BLAST1461

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94823

PeptideAtlas

More...
PeptideAtlasi
O94823

PRoteomics IDEntifications database

More...
PRIDEi
O94823

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50465
50466 [O94823-2]
50467 [O94823-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O94823

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O94823

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in brain and in low levels in testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000118322 Expressed in 167 organ(s), highest expression level in colonic mucosa

CleanEx database of gene expression profiles

More...
CleanExi
HS_ATP10B

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O94823 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O94823 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA034574

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit.Curated

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116742, 1 interactor

Protein interaction database and analysis system

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IntActi
O94823, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000313600

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O94823

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0206 Eukaryota
ENOG410XSS0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159531

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000202528

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107129

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O94823

KEGG Orthology (KO)

More...
KOi
K01530

Identification of Orthologs from Complete Genome Data

More...
OMAi
KIRARTQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0139

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O94823

TreeFam database of animal gene trees

More...
TreeFami
TF354252

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1110.10, 2 hits
3.40.50.1000, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR030359 ATP10B
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c

The PANTHER Classification System

More...
PANTHERi
PTHR24092 PTHR24092, 1 hit
PTHR24092:SF79 PTHR24092:SF79, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01652 ATPase-Plipid, 2 hits
TIGR01494 ATPase_P-type, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: O94823-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALSVDSSWH RWQWRVRDGF PHCPSETTPL LSPEKGRQSY NLTQQRVVFP
60 70 80 90 100
NNSIFHQDWE EVSRRYPGNR TCTTKYTLFT FLPRNLFEQF HRWANLYFLF
110 120 130 140 150
LVILNWMPSM EVFHREITML PLAIVLFVIM IKDGMEDFKR HRFDKAINCS
160 170 180 190 200
NIRIYERKEQ TYVQKCWKDV RVGDFIQMKC NEIVPADILL LFSSDPNGIC
210 220 230 240 250
HLETASLDGE TNLKQRCVVK GFSQQEVQFE PELFHNTIVC EKPNNHLNKF
260 270 280 290 300
KGYMEHPDQT RTGFGCESLL LRGCTIRNTE MAVGIVIYAG HETKAMLNNS
310 320 330 340 350
GPRYKRSKIE RRMNIDIFFC IGILILMCLI GAVGHSIWNG TFEEHPPFDV
360 370 380 390 400
PDANGSFLPS ALGGFYMFLT MIILLQVLIP ISLYVSIELV KLGQVFFLSN
410 420 430 440 450
DLDLYDEETD LSIQCRALNI AEDLGQIQYI FSDKTGTLTE NKMVFRRCTI
460 470 480 490 500
MGSEYSHQEN AKRLETPKEL DSDGEEWTQY QCLSFSARWA QDPATMRSQK
510 520 530 540 550
GAQPLRRSQS ARVPIQGHYR QRSMGHRESS QPPVAFSSSI EKDVTPDKNL
560 570 580 590 600
LTKVRDAALW LETLSDSRPA KASLSTTSSI ADFFLALTIC NSVMVSTTTE
610 620 630 640 650
PRQRVTIKPS SKALGTSLEK IQQLFQKLKL LSLSQSFSST APSDTDLGES
660 670 680 690 700
LGANVATTDS DERDDASVCS GGDSTDDGGY RSSMWDQGDI LESGSGTSLE
710 720 730 740 750
EALEAPATDL ARPEFCYEAE SPDEAALVHA AHAYSFTLVS RTPEQVTVRL
760 770 780 790 800
PQGTCLTFSL LCTLGFDSVR KRMSVVVRHP LTGEIVVYTK GADSVIMDLL
810 820 830 840 850
EDPACVPDIN MEKKLRKIRA RTQKHLDLYA RDGLRTLCIA KKVVSEEDFR
860 870 880 890 900
RWASFRREAE ASLDNRDELL METAQHLENQ LTLLGATGIE DRLQEGVPDT
910 920 930 940 950
IATLREAGIQ LWVLTGDKQE TAVNIAHSCR LLNQTDTVYT INTENQETCE
960 970 980 990 1000
SILNCALEEL KQFRELQKPD RKLFGFRLPS KTPSITSEAV VPEAGLVIDG
1010 1020 1030 1040 1050
KTLNAIFQGK LEKKFLELTQ YCRSVLCCRS TPLQKSMIVK LVRDKLRVMT
1060 1070 1080 1090 1100
LSIGDGANDV SMIQAADIGI GISGQEGMQA VMSSDFAITR FKHLKKLLLV
1110 1120 1130 1140 1150
HGHWCYSRLA RMVVYYLYKN VCYVNLLFWY QFFCGFSSST MIDYWQMIFF
1160 1170 1180 1190 1200
NLFFTSLPPL VFGVLDKDIS AETLLALPEL YKSGQNSECY NLSTFWISMV
1210 1220 1230 1240 1250
DAFYQSLICF FIPYLAYKGS DIDVFTFGTP INTISLTTIL LHQAMEMKTW
1260 1270 1280 1290 1300
TIFHGVVLLG SFLMYFLVSL LYNATCVICN SPTNPYWVME GQLSNPTFYL
1310 1320 1330 1340 1350
VCFLTPVVAL LPRYFFLSLQ GTCGKSLISK AQKIDKLPPD KRNLEIQSWR
1360 1370 1380 1390 1400
SRQRPAPVPE VARPTHHPVS SITGQDFSAS TPKSSNPPKR KHVEESVLHE
1410 1420 1430 1440 1450
QRCGTECMRD DSCSGDSSAQ LSSGEHLLGP NRIMAYSRGQ TDMCRCSKRS
1460
SHRRSQSSLT I
Length:1,461
Mass (Da):165,391
Last modified:April 30, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2676B90416B6B541
GO
Isoform B (identifier: O94823-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     461-529: AKRLETPKEL...RQRSMGHRES → GIEAPKGSIP...TCKLSFVYKG
     530-1461: Missing.

Note: No experimental confirmation available.
Show »
Length:529
Mass (Da):61,243
Checksum:i048EAC8E3D5BBA0D
GO
Isoform C (identifier: O94823-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-156: MALSVDSSWH...INCSNIRIYE → MKKEGRKRWK...INNRECLIYS
     461-529: AKRLETPKEL...RQRSMGHRES → GIEAPKGSIP...TCKLSFVYKG
     530-1461: Missing.

Note: No experimental confirmation available.
Show »
Length:501
Mass (Da):57,465
Checksum:iD12B13EC2EC2E3D5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YDI5A0A2R8YDI5_HUMAN
Phospholipid-transporting ATPase
ATP10B hCG_1979529
1,433Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q2YDW8Q2YDW8_HUMAN
ATP10B protein
ATP10B
556Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA34435 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti234F → S in BAC03528 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048384217C → R1 PublicationCorresponds to variant dbSNP:rs958912Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0073051 – 156MALSV…IRIYE → MKKEGRKRWKRKEDKKRVVV SNLLFEGWSHKENPNRHHRG NQIKTSKYTVLSFVPKNIFE QLHRFANLYFVGIAVLNFIP VVNAFQPEVSMIPICVILAV TAIKDAWEDLRRYKSDKVIN NRECLIYS in isoform C. 1 PublicationAdd BLAST156
Alternative sequenceiVSP_007306461 – 529AKRLE…GHRES → GIEAPKGSIPLSKRKYPALL RNEEIKDILLALLEAVWHFH KLLPVSLWSSLSQIRAVPIT CKLSFVYKG in isoform B and isoform C. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_007307530 – 1461Missing in isoform B and isoform C. 1 PublicationAdd BLAST932

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB018258 mRNA Translation: BAA34435.2 Different initiation.
AK090832 mRNA Translation: BAC03528.1
AK025130 mRNA Translation: BAB15074.1
AC008456 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS43394.1 [O94823-1]

NCBI Reference Sequences

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RefSeqi
NP_079429.2, NM_025153.2 [O94823-1]
XP_006714896.1, XM_006714833.2 [O94823-1]
XP_011532770.1, XM_011534468.2 [O94823-1]
XP_011532771.1, XM_011534469.1 [O94823-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.109358

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000327245; ENSP00000313600; ENSG00000118322 [O94823-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23120

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23120

UCSC genome browser

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UCSCi
uc003lym.1 human [O94823-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018258 mRNA Translation: BAA34435.2 Different initiation.
AK090832 mRNA Translation: BAC03528.1
AK025130 mRNA Translation: BAB15074.1
AC008456 Genomic DNA No translation available.
CCDSiCCDS43394.1 [O94823-1]
RefSeqiNP_079429.2, NM_025153.2 [O94823-1]
XP_006714896.1, XM_006714833.2 [O94823-1]
XP_011532770.1, XM_011534468.2 [O94823-1]
XP_011532771.1, XM_011534469.1 [O94823-1]
UniGeneiHs.109358

3D structure databases

ProteinModelPortaliO94823
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116742, 1 interactor
IntActiO94823, 1 interactor
STRINGi9606.ENSP00000313600

PTM databases

iPTMnetiO94823
PhosphoSitePlusiO94823

Polymorphism and mutation databases

BioMutaiATP10B

Proteomic databases

PaxDbiO94823
PeptideAtlasiO94823
PRIDEiO94823
ProteomicsDBi50465
50466 [O94823-2]
50467 [O94823-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
23120
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327245; ENSP00000313600; ENSG00000118322 [O94823-1]
GeneIDi23120
KEGGihsa:23120
UCSCiuc003lym.1 human [O94823-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23120
EuPathDBiHostDB:ENSG00000118322.12

GeneCards: human genes, protein and diseases

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GeneCardsi
ATP10B
HGNCiHGNC:13543 ATP10B
HPAiHPA034574
neXtProtiNX_O94823
OpenTargetsiENSG00000118322
PharmGKBiPA25098

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0206 Eukaryota
ENOG410XSS0 LUCA
GeneTreeiENSGT00940000159531
HOGENOMiHOG000202528
HOVERGENiHBG107129
InParanoidiO94823
KOiK01530
OMAiKIRARTQ
OrthoDBiEOG091G0139
PhylomeDBiO94823
TreeFamiTF354252

Enzyme and pathway databases

ReactomeiR-HSA-936837 Ion transport by P-type ATPases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ATP10B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23120

Protein Ontology

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PROi
PR:O94823

Gene expression databases

BgeeiENSG00000118322 Expressed in 167 organ(s), highest expression level in colonic mucosa
CleanExiHS_ATP10B
ExpressionAtlasiO94823 baseline and differential
GenevisibleiO94823 HS

Family and domain databases

Gene3Di3.40.1110.10, 2 hits
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR030359 ATP10B
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PTHR24092:SF79 PTHR24092:SF79, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01652 ATPase-Plipid, 2 hits
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAT10B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94823
Secondary accession number(s): Q9H725
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 30, 2003
Last modified: December 5, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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